Pantoea agglomerans: A mysterious bacterium of evil and good. Part II -Deleterious effects: Dust-borne endotoxins and allergens-focus on grain dust, other agricultural dusts and wood dust

Annals of Agricultural and Environmental Medicine

Volumn 23, Issue 1, 2016, Pages 6-29

  Dutkiewicz, Jacek ^a   MacKiewicz, Barbara ^b   Lemieszek, Marta Kinga ^a   Golec, Marcin ^a   Skórska, Czesława ^a   Góra Florek, Anna ^a   Milanowski, Janusz ^b  

^a INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Agricultural dusts; Agricultural workers; Allergens; Animal experiments; Asthma; Endotoxins; Grain dust; Hypersensitivity pneumonitis; Immunologic response; Pantoea agglomerans; Toxic pneumonitis; Ultrastructure; Wood dust

Indexed keywords

ALLERGEN; BACTERIUM LIPOPOLYSACCHARIDE; CHEMOKINE; CHEMOTACTIC FACTOR; CORTICOSTEROID; ENDOTOXIN; INTERLEUKIN 1; NANOPARTICLE; SODIUM CHLORIDE; SUPEROXIDE; TOLL LIKE RECEPTOR; TRICHLOROACETIC ACID; DUST;

AGRICULTURAL DUST; AIR POLLUTION; AIRBORNE BACTERIUM; ALLERGIC DISEASE; ALLERGIC PNEUMONITIS; ANIMAL HUSBANDRY; ASTHMA; BACTERIAL LOAD; BACTERIAL VIABILITY; COLONY FORMING UNIT; DESENSITIZATION; DUST; FARM ANIMAL; GRAIN DUST; HEALTH HAZARD; HOUSE DUST; HUMAN; IMMUNE RESPONSE; INDUSTRY; INHALATION; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROSIS; MACROPHAGE ACTIVATION; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL LUNG DISEASE; PANTOEA AGGLOMERANS; PARTICLE SIZE; PNEUMONIA; REVIEW; SKIN ALLERGY; TEXTILE INDUSTRY; TOXIC PNEUMONITIS; TOXIN SYNTHESIS; WOOD DUST; WOOD INDUSTRY; AGRICULTURE; ANALYSIS; CHEMISTRY; ENTEROBACTERIACEAE INFECTION; FOOD GRAIN; IMMUNOLOGY; MICROBIOLOGY; PANTOEA; PATHOPHYSIOLOGY; PHYSIOLOGY; WOOD;

AGRICULTURE; ALLERGENS; DUST; EDIBLE GRAIN; ENDOTOXINS; ENTEROBACTERIACEAE INFECTIONS; HUMANS; PANTOEA; WOOD;

EID: 84960947268     PISSN: 12321966     EISSN: 18982263     Source Type: Journal    
DOI: 10.5604/12321966.1196848     Document Type: Review

References (167)

1. Magnus O. Historia de Gentibus Septentrionalibus (Description of the Northern Peoples). Johannes Maria de Viottis, in aedibus Birgittae, Rome, January 1555.
2. Ramazzini B. De Morbis Artificum Diatriba. (Diseases of Workers). 1713. Re-edition: Typographia Caroli Columbi, Roma 1953.
3. Dosman JA, Cotton DJ (Eds): Occupational Pulmonary Disease. Focus on Grain Dust and Health. Proceedings of the International Symposium on Grain Dust and Health held in Saskatoon, Canada, November 7-9, 1977. Academic Press. New York 1980.
4. Manfreda J, Warren CPW. The effects of grain dust. Rev Environ Health 1984; 4(3): 239-268.
5. Becklake M, Broder I, Chan-Yeung M, Dosman JA, Ernst P, Herbert FA, Kennedy SM, Warren PW. Recommendations for reducing the effect of grain dust on the lungs. Canadian Thoracic Society Standards Committee. CMAJ. 1996; 155: 1399-1403.
6. Cockcroft AE, McDermott MM, Edwards JH, McCarthy P. Grain exposure -symptoms and lung function. Eur J Respir Dis. 1983; 64: 189-196.
7. Hurst TS, Dosman JA. Characterization of health effects of grain dust exposures. Am J Ind Med. 1990; 17(1): 27-32.
8. Becklake MR. Grain dust and lung health: not just a nuisance dust. Can Respir J. 2007; 14(7): 423-425.
9. Lacey J. Grain dust and health. Postharvest News and Information 1990; 1(2): 113-117.
10. Baur X, Preisser A, Wegner R. Asthma due to grain dust. Pneumologie. 2003; 57(6): 335-339 (in German).
11. Jagielo PJ, Thorne PS, Watt JL, Frees KL, Quinn TJ, Schwartz DA. Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects. Chest 1996; 110: 263-270.
12. Rylander R. Endotoxin and occupational airway disease. Curr Opin Allergy Clin Immunol 2006; 6: 62-66.
13. Straumfors A, Heldal KK, Wouters IM, Eduard W. Work tasks as determinants of grain dust and microbial exposure in the Norwegian grain and compound feed industry. Ann Occup Hyg. 2015; 59: 724-736.
14. Dutkiewicz J. Studies on endotoxins of Erwinia herbicola and their biological activity. Zbl Bakt Hyg I Abt Orig A. 1976; 236: 487-508.
15. Dutkiewicz J. Exposure to dust-borne bacteria in agriculture. II. Immunological survey. Arch Environ Health. 1978; 33: 260-270.
16. Kuś L. Allergic alveolitis after exposure to antigens occurring in grain dust in the light of own clinical and experimental investigations. Med Wiejska. 1980; 15: 73-80 (in Polish).
17. Kuś L, Chibowski D, Siezieniewska Z, Dutkiewicz J, Stępień A. Histological and ultrastructural changes in the lungs of guinea pigs exposed to the extract of Erwinia herbicola. Ann Univ Mariae Curie-Skłodowska (Sectio D). 1984; 39(42): 325-336.
18. Pomorski ZJH, Dutkiewicz J, Taszkun I, Woźniak M, Sitkowski W, Skórska C, Cholewa G. Studies on allergic conditioning of cattle pneumopathy, resulting from breathing in pneumoallergens comprised in organic dusts. Ann UMCS (Sectio DD). 1993; 48: 183-193 (in Polish).
19. Milanowski J, Dutkiewicz J, Potoczna H, Kuś L, Urbanowicz B. Allergic alveolitis among agricultural workers in eastern Poland: A study of twenty cases. Ann Agric Environ Med. 1998; 5: 31-43.
20. Lemieszek M, Chilosi M, Golec M, Skórska C, Huaux F, Yakoub Y, Pastena C, Daniele I, Cholewa G, Sitkowska J, Lisowska W, Zwoliński J, Milanowski J, Mackiewicz B, Góra A, Dutkiewicz J. Mouse model of hypersensitivity pneumonitis after inhalation exposure to different microbial antigens associated with organic dusts. Ann Agric Environ Med. 2011; 18: 159-168.
21. Golec M, Lemieszek MK, Skórska C, Sitkowska J, Zwolinski J, Mackiewicz B, Góra-Florek A, Milanowski J, Dutkiewicz J. Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. Pathol Biol. 2015; 63: 130-135.
22. Walterson AM, Stavrinides J. Pantoea: insights into a highly versatile and diverse genus within the Enterobacteriaceae. FEMS Microbiol Rev. 2015; 39: 968-984.
23. Dutkiewicz J, Mackiewicz B, Lemieszek M, Golec M, Milanowski J. Pantoea agglomerans -a mysterious bacterium of evil and good. Part I. Deleterious effects: Dust-borne endotoxins and allergens -focus on cotton dust. Ann Agric Environ Med. 2015; 22(4): 576-588.
24. James N. Yellow chromogenic bacteria on wheat. I. Quantitative studies. Can J Microbiol. 1955; 1: 271-274.
25. Mishustin EN, Trisvyatskyi LA. Microbiology of grain and flour. Chleboizdat, Moskva 1960 (in Russian).
26. Chrzanowska H. Microbiological studies of grain before and after cleaning in a mill. Biuletyn Informacyjny Centralnego Laboratorium Technologii Przetwórstwa i Przechowalnictwa Zbóż 1963; 7: 6-11 (in Polish).
27. Chrzanowska H. Variability of the bacterial and fungal microflora of rye grain depending on the conditions of harvest and storage. Biuletyn Informacyjny Centralnego Laboratorium Technologii Przetwórstwa i Przechowalnictwa Zbóż 1964; 8: 73-84 (in Polish).
28. Spicher G. New viewpoints on the classification of the bacterial flora of grain and grain products. Bericht uber die Getreidechemiker-Tagung, Detmold 1963 (in German).
29. Dutkiewicz J. Exposure to dust-borne bacteria in agriculture. I. Environmental studies. Arch Environ Health. 1978; 33: 250-259.
30. Dutkiewicz J. The significance of the microflora of air as a factor of occupational hazard in agriculture with the particular recognition of Erwinia herbicola. Dissertation for the degree of Dr habil. Medical University, Lublin 1977 (in Polish).
31. Dutkiewicz J. Microbial hazards in plants processing grain and herbs. In: Rylander R, Peterson Y, Donham KJ (Eds): Health Effects of Organic Dusts in the Farm Environment. Proceedings of an International Workshop held in Skokloster, Sweden, April 23-25, 1985. Am J Ind Med. 1986; 10: 300-302.
32. Dutkiewicz J, Spychalski L, Klecha I, Smerdel-Skórska C, Krysińska-Traczyk E, Kobus W, Dynak Z. Cases of collective diseases of students as a result of their work with grain. I. Environmental and microbiological studies. Med Wiejska. 1981; 16: 121-131.
33. Mally B, Dutkiewicz J. Bio-pollutants in small country mills of the Cracow region. In: III Konferencja Naukowa n.t. “Biozanieczyszczenia w Budynkach a Zdrowie”, Referaty -cz. II. Zeszyty Naukowe AWF w Krakowie 1983; 35: 150-157 (in Polish).
34. DeLucca II AJ, Godshall MA, Palmgren MS. Gram-negative bacterial endotoxins in grain elevator dusts. Am Ind Hyg Assoc J. 1984; 45(5): 336-339.
35. DeLucca AJ II, Palmgren MS. Seasonal variation in aerobic bacterial populations and endotoxin concentrations in grain dust. Am Ind Hyg Assoc J. 1987; 48(2): 106-110.
36. Dutkiewicz J, Krysińska-Traczyk E, Skórska C, Dutkiewicz E, Babicz W. Occupational biological hazards in mushroom spawn-producing plant. I. Studies of working environment. Med Wiejska. 1984; 19: 177-188 (in Polish).
37. Pande BN, Krysińska-Traczyk E, Prażmo Z, Skórska C, Sitkowska J, Dutkiewicz J. Occupational biohazards in agricultural dusts from India. Ann Agric Environ Med. 2000; 7: 133-139.
38. Krysińska-Traczyk E, Dutkiewicz J, Sitkowska J, Skórska C, Cholewa G. Microflora of the air in agricultural working environment. In: III Konferencja Naukowa Łódź 2003 ”Rozkład i Korozja Mikrobiologiczna Materiałów Technicznych”, Materiały Konferencyjne, pp. 281-283. Politechnika Łódzka, Łódź 2003 (in Polish).
39. Dutkiewicz J. Microflora of the air as a hazardous factor of the work environment in a bakery. Med Wiejska. 1983; 18: 119-127.
40. Górny RL, Dutkiewicz J. Bacterial and fungal aerosols in indoor environment in Central and Eastern European countries. Ann Agric Environ Med. 2002; 9: 17-23.
41. Swan JR, Crook B. Airborne microorganisms associated with grain handling. Ann Agric Environ Med. 1998; 5: 7-15.
42. Verma KS, Pathak AK. Assessment of air-borne bacteria of urban grain-market area. Asian J Exp Sci. 2008; 22: 245-254.
43. Lacey J. The microflora of grain dusts. In: Dosman JA, Cotton DJ (Eds): Occupational Pulmonary Disease. Focus on Grain Dust and Health. Proceedings of the International Symposium on Grain Dust and Health held in Saskatoon, Canada, November 7-9, 1977. Academic Press. New York 1980, pp. 417-440.
44. Jimenez-Diaz C, Lahoz C, Canto G. The allergens of mill dust. Asthma in millers, farmers and others. Ann Allergy 1947; 5: 519-525.
45. Frankland AW, Lunn JA. Asthma caused by the grain weevil. Br J Ind Med. 1965; 22: 157-159.
46. Lunn JA. Millworker’s asthma: Allergic responses to the grain weevil (Sitophilus granarius). Br J Ind Med. 1966; 23: 149-152.
47. Dutkiewicz J, Krysińska-Traczyk E, Skórska C, Sitkowska J, Prażmo Z, Golec M. Exposure to airborne microorganisms and endotoxin in herb processing plants. Ann Agric Environ Med. 2001; 8: 201-211.
48. Skórska C, Sitkowska J, Krysińska-Traczyk E, Cholewa G, Dutkiewicz J. Exposure to airborne microorganisms, dust and endotoxin during processing of peppermint and chamomile herbs on farms. Ann Agric Environ Med. 2005; 12: 281-288.
49. Skórska C, Sitkowska J, Krysińska-Traczyk E, Cholewa G, Dutkiewicz J. Exposure to airborne microorganisms, dust and endotoxin during processing of valerian roots on farms. Ann Agric Environ Med. 2005; 12: 119-126.
50. Krysińska-Traczyk E, Dutkiewicz J, Skórska C, Prażmo Z, Cisak E, Sitkowska J, Cholewa G. Occupational exposure of farmers to bioaerosols present in thyme dust. Med Ogólna. 1999; 5: 186-193 (in Polish).
51. Larsson L, Szponar B, Ridha B, Pehrson C, Dutkiewicz J, Krysińska-Traczyk E, Sitkowska J. Identification of bacterial and fungal components in tobacco and tobacco smoke. Tobacco Induced Diseases 2008; Epub 4:4. http:\\www.tobaccoinduceddiseases.com/content/4/1/4.
52. Krysińska-Traczyk E, Skórska C, Prażmo Z, Sitkowska J, Cholewa G, Dutkiewicz J. Exposure to airborne microorganisms, dust and endotoxin during flax scutching on farms. Ann Agric Environ Med. 2004; 11: 309-317.
53. Góra A, Skórska C, Sitkowska J, Prażmo Z, Krysińska-Traczyk E, Urbanowicz B, Dutkiewicz J. Exposure of hop growers to bioaerosols. Ann Agric Environ Med. 2004; 11: 129-138.
54. Dutkiewicz J, Krysińska-Traczyk E, Skórska C, Dutkiewicz E, Babicz W. Mikroflora powietrza jako czynnik narażenia zawodowego w magazynach nasiennych. Med Wiejska. 1983; 18: 215-225.
55. Dutkiewicz J, Pomorski ZJH, Krysińska-Traczyk E, Skórska C, Cholewa G, Sitkowska J, Wójtowicz H, Taszkun I, Woźniak M. Studies on contamination level of the air of cowsheds with biological hazardous agents. Annales UMCS Sec DD. 1991; 46: 113-127 (in Polish).
56. Dutkiewicz J, Pomorski ZJH, Sitkowska J, Krysińska-Traczyk E, Prażmo Z, Skórska C, Cholewa G, Wójtowicz H, Taszkun I, Woźniak M. Studies on contamination level of the air of stables of purebred horses with microbiological hazardous agents. Annales UMCS Sec DD. 1993; 48: 195-215 (in Polish).
57. Dutkiewicz J, Pomorski ZJH, Krysińska-Traczyk E, Prażmo Z, Cholewa G, Stec A, Sitkowska J, Skórska C, Wójtowicz H. Studies on contamination level of the air of piggeries with microbiological hazardous agents. Annales UMCS Se DD. 1993; 48: 217-234 (in Polish).
58. Mackiewicz B. Study on exposure of pig farm workers to bioaerosols, immunologic reactivity and health effects. Ann Agric Environ Med. 1998; 5: 169-175.
59. Ławniczek-Wałczyk A, Górny RL, Gołofit-Szymczak M, Niesler A, Wlazło A. Occupational exposure to airborne microorganisms, endotoxins and β-glucans in poultry houses at different stages of the production cycle. Ann Agric Environ Med. 2013; 20: 259-267.
60. Dutkiewicz J, Sorenson WG, Lewis DM, Olenchock SA. Microbial contaminants of stored timber as potential respiratory hazards for sawmill workers. In: Proceedings of the VIIth International Pneumoconioses Conference, Pittsburgh, Pennsylvania, 23-26 August 1988. Part I, pp. 712-716. DHHS (NIOSH) Publication No. 90-108, Washington, D.C. 1990.
61. Prażmo Z, Dutkiewicz J, Cholewa G. Exposure of wood processing workers to allergenic and endotoxic Gram-negative bacteria. VIII Ogólnopolska Konferencja Ergonomiczna “Ergonomia i Ochrona Pracy w Drzewnictwie oraz w Produkcji Rolniczo-Leśnej” Poznań-Kiekrz, 15-17 września 1999 r. Zastosowania Ergonomii 1999; 2/3 (34/35): 163-172 (in Polish).
62. Prażmo Z, Dutkiewicz J. Gram-negative bacteria occurring in the coniferous and deciduous wood. I Ogólnokrajowa Konferencja Naukowa “Rozkład i Korozja Mikrobiologiczna Materiałów Technicznych”, Politechnika Łódzka, Łódź, 27 stycznia 2000 r., pp. 46-48 (in Polish).
63. Prażmo Z, Dutkiewicz J, Cholewa G. Gram-negative bacteria associated with timber as a potential respiratory hazard for woodworkers. Aerobiologia 2000; 16: 275-279.
64. Prażmo Z, Dutkiewicz J, Skórska C, Sitkowska J, Cholewa G. Exposure to airborne Gram-negative bacteria, dust and endotoxin in paper factories. Ann Agric Environ Med. 2003; 10, 93-100.
65. Dutkiewicz J, Krysińska-Traczyk E, Prażmo Z, Skórska C, Sitkowska J. Exposure to airborne microorganisms in Polish sawmills. Ann Agric Environ Med. 2001; 8: 71-80.
66. Dutkiewicz J, Olenchock SA, Krysińska-Traczyk E, Skórska C, Sitkowska J, Prażmo Z. Exposure to airborne microorganisms in fiberboard and chipboard factories. Ann Agric Environ Med. 2001; 8: 191-199.
67. Ławniczek-Wałczyk A, Gołofit-Szymczak M, Cyprowski M, Górny RL. Exposure to harmful microbiological agents during the handling of biomass for power production purposes. Med Pr. 2012; 63: 395-407.
68. Śpiewak R, Skórska C, Prażmo Z, Dutkiewicz J. Bacterial endotoxin associated with pollen as a potential factor aggravating pollinosis. Ann Agric Environ Med. 1996; 3: 57-59.
69. Hofman T, Wykrętowicz G, Stach A, Springer E, Kolasińska B, Ossowski M. A multicentre analysis of a population of patients with newly-diagnosed pollinosis in Poznań, Poland, in the year 1995. In: Obtułowicz K, Śpiewak R (Eds): 2nd Symposium “Pollens and Pollinosis: Current Problems, Lublin, Poland, 1-2 December 1995. Ann Agric Environ Med. 1996; 3: 171-177.
70. Horak B, Dutkiewicz J, Solarz K. Microflora and acarofauna of bed dust from homes in Upper Silesia, Poland. Ann Allergy Asthma Immunol. 1996; 76: 41-50.
71. Górny RL. Characterization of Particulate Aerosols and Bioaerosols in the Dwellings Located on the Territory of the Upper Silesia Conurbation. Ph.D. Thesis. Silesian Medical Academy, Katowice 1998 (in Polish).
72. Neal PA, Schneiter R, Caminita BH. Report on acute illness among rural mattress makers using lowgrade stained cotton. JAMA. 1942; 119: 1074-1082.
73. Pernis B, Vigliani EC, Cavagna G, Finulli M. The role of bacterial endotoxins in occupational diseases caused by inhaling vegetable dusts. Br J Ind Med. 1961; 18: 120-129.
74. Rylander R, Snella M-C. Acute inhalation toxicity of cotton plant dusts. Br J Ind Med. 1976; 33: 175-180.
75. Dutkiewicz J, Skórska C, Sitkowska J, Ochalska B, Kaczmarski F. Properties of the endotoxins produced by various gram-negative bacteria present in occupational environments. In: Jacobs RR, Wakelyn PJ, Rylander R, Burrell R (Eds): Cotton Dust. Proceedings of the 12th Cotton Dust Research Conference and of the Endotoxin Inhalation Workshop, 28-30 September 1987, Clearwater, Florida, pp. 187-189. National Cotton Council, Memphis, Tennessee, 1988.
76. Tsukioka D, Nishizawa T, Miyase T, Achiwa K, Suda T, Soma G, Mizuno D. Structural characterization of lipid A obtained from Pantoea agglomerans lipopolysaccharide. FEMS Microbiol Lett. 1997; 149(2): 239-244.
77. Cole RB, Domelsmith LN, David CM, Laine RA, DeLucca AJ. 252Cf plasma-desorption mass spectrometry of lipid A from Enterobacter agglomerans. Rapid Commun Mass Spectrom. 1992; 6(10): 616-622.
78. Boué SM, Cole RB. Confirmation of the structure of lipid A from Enterobacter agglomerans by electrospray ionization tandem mass spectrometry. J Mass Spectrom. 2000; 35(3): 361-368.
79. Karamanos Y, Kol O, Wieruszeski JM, Strecker G, Fournet B, Zalisz R. Structure of the O-specific polysaccharide chain of the lipopolysaccharide of Enterobacter agglomerans. Carbohydr Res. 1992; 231: 197-204.
80. Cimmino A, Marchi G, Surico G, Hanuszkiewicz A, Evidente A, Holst O. The structure of the O-specific polysaccharide of the lipopolysaccharide from Pantoea agglomerans strain FL1. Carbohydr Res. 2008; 343(2): 392-396.
81. Shimada M, Kadowaki T, Taniguchi Y, Inagawa H, Okazaki K, Soma G-I. The involvement of O-antigen polysaccharide in lipopolysaccharide in macrophage activation. Anticancer Res. 2012; 32: 2337-2342.
82. Olenchock SA, Mull JC, Major PC, Peach MJ 3rd, Gladish ME, Taylor G. In vitro activation of the alternative pathway of complement by settled grain dust. J Allergy Clin Immunol. 1978; 62(5): 295-300.
83. Olenchock SA. Endotoxins in various work environments in agriculture. Dev Ind Microbiol. 1990; 31: 193-197.
84. Olenchock SA. Presence of endotoxins in different agricultural environments. Am J Ind Med. 1990; 18: 279-284.
85. Liesivuori J. Airborne endotoxin concentrations in different work conditions. In: Rylander R, Peterson Y (Eds): Causative Agents for Organic Dust Related Disease. Proceedings of an International Workshop held in Skokloster, Sweden, April 6-9, 1992. Am J Ind Med. 1994; 25: 123-124.
86. Laitinen S, Kangas J, Husman K, Päivikki S. Evaluation of exposure to airborne bacterial endotoxins and peptidoglycans in selected work environments. Ann Agric Environ Med. 2001; 8: 213-219.
87. Dutkiewicz J, Krysińska-Traczyk E, Skórska C, Sitkowska J, Prażmo Z, Urbanowicz B. Exposure of agricultural workers to airborne microorganisms and endotoxin during handling of various vegetable products. Aerobiologia. 2000; 16: 193-198.
88. Góra A, Mackiewicz B, Krawczyk P, Golec M, Skórska C, Sitkowska J, Cholewa G, Larsson L, Jarosz M, Wójcik-Fatla A, Dutkiewicz J. Occupational exposure to organic dust, microorganisms, endotoxin and peptidoglycan among plants processing workers in Poland. Ann Agric Environ Med. 2009; 16: 143-150.
89. Halstensen AS, Nordby KC, Wouters IM, Eduard W. Determinants of microbial exposure in grain farming. Ann Occup Hyg. 2007; 51(7): 581-592.
90. Spaan S, Schinkel J, Wouters IM, Preller L, Tielemans E, Tjoe Nij E, Heederik D. Variability in endotoxin exposure levels and consequences for exposure assessment. Ann Occup Hyg. 2008; 52(5): 303-316.
91. Smit LAM, Wouters IM, Hobo MM, Eduard W, Doekes G, Heederik D. Agricultural seed dust as a potential cause of organic dust toxic syndrome. Occup Environ Med. 2006; 63: 59-67.
92. Madsen AM, Tendal K, Vivi Schlünssen V, Heltberg I. Organic dust toxic syndrome at a grass seed plant caused by exposure to high concentrations of bioaerosols. Ann Occup Hyg. 2012; 56 (7): 777-788.
93. Smid T, Heederik D, Houba R, Quanjer PH. Dust-and endotoxin related respiratory effects in the animal feed industry. Am Rev Respir Dis. 1992; 146: 1474-1479.
94. Dutkiewicz J, Pomorski ZJH, Sitkowska J, Krysińska-Traczyk E, Skórska C, Prażmo Z, Cholewa G, Wójtowicz H. Airborne microorganisms and endotoxin in animal houses. Grana.1994; 33: 85-90.
95. Schwartz DA, Thorne PS, Yagla SJ, Burmeister LF, Olenchock SA, Watt JL, Quinn TJ. The role of endotoxin in grain dust-induced lung disease. Am J Respir Crit Care Med. 1995; 152: 603-608.
96. Donham K, Haglind P, Peterson Y, Rylander R, Belin L. Environmental and health studies of farm workers in Swedish swine confinement buildings. Br J Ind Med. 1989; 46: 31-37.
97. Lantz RC, Birch K, Hinton DE, Burrell R. Morphometric changes of the lung induced by inhaled bacterial endotoxin. Exp Mol Pathol. 1985; 43: 305-320.
98. Karol MH, Ogundiran N, Ellakkani M, Fischer JJ, Foarde K. Inhalation studies of Enterobacter agglomerans derived solutions. In: Jacobs RR, Wakelyn PJ (eds.). Cotton Dust. Proceedings of the 10th Cotton Dust Research Conference, 8-9 January 1986, Las Vegas, NV, pp. 129-130. National Cotton Council, Memphis, TN 1986.
99. Rylander R, Bake B, Fischer JJ, Helander IM. Pulmonary function and symptoms after inhalation of endotoxin. Am Rev Respir Dis. 1989; 140: 981-986.
100. Ryan LK, Jin R, Boggs SS, Karol MH, Day BW. Mouse model for assessing endotoxin involvement in the lung inflammation and cytokine production resulting from inhaled organic dust. Inhal Toxicol. 1994; 6: 485-499.
101. Von Essen S. The role of endotoxin in grain dust exposure and airway obstruction. Curr Opin Pulm Med. 1997; 3(3): 198-202.
102. Burch JB, Svendsen E, Siegel PD, Wagner SE, von Essen S, Keefe T, Mehaffy J, Martinez AS, Bradford M, Baker L, Cranmer B, Saito R, Tessari J, Linda P, Andersen C, Christensen O, Koehncke N, Reynolds SJ. Endotoxin exposure and inflammation markers among agricultural workers in Colorado and Nebraska. J Toxicol Environ Health A. 2010; 73(1): 5-22.
103. Salkinoja-Salonen M, Helander I, Rylander R. Toxic bacterial dusts associated with plants. In: Rhodes-Roberts M, Skinner FA (Eds): Bacteria and Plants. Soc Appl Bact Symp Ser. No. 10, pp. 219-233, Academic Press, London 1982.
104. Górny RL, Dutkiewicz J. Evaluation of microorganisms and endotoxin levels of indoor air in living rooms occupied by cigarette smokers and non-smokers in Sosnowiec, Upper Silesia, Poland. Aerobiologia. 1998; 14: 235-239.
105. Hasday JD, Bascom R, Costa JJ, Fitzgerald T, Dubin W. Bacterial endotoxin is an active component of cigarette smoke. Chest. 1999; 115: 829-835.
106. Larsson L, Szponar B, Pehrson C. Tobacco smoking increases dramatically air concentrations of endotoxin. Indoor Air. 2004; 14: 421-424.
107. Varbanets LD, Brovarskaya OS, Bulygina TN, Garkavaya EG, Zhitkevich NV. Characterization of Pantoea agglomerans lipopolysaccharides. Microbiology. 2014; 83: 754-763.
108. Sebastian A, Pehrson C, Larsson L. Elevated concentrations of endotoxin in indoor air due to cigarette smoking. J Environ Monit. 2006; 8: 519-522.
109. Larsson L, Pehrson C, Dechen T, Crane-Godreau M. Microbiological components in mainstream and sidestream cigarette smoke. Tobacco Induced Diseases 2012; 10:13. http://www.tobaccoinduceddiseases.com/content/10/1/13
110. Szponar B, Pehrson C, Larsson L. Bacterial and fungal markers in tobacco smoke. Sci Total Environ. 2012; 438: 447-451.
111. Lounatmaa K, Helander I. Ultrastructure of Gram-negative cotton bacteria with different pulmonary toxicities. Infect Immun. 1982; 35 (1): 359-362.
112. Dutkiewicz J, Tucker J, Burrell R, Olenchock SA, Schwegler-Berry D, Keller III GE, Ochalska B, Kaczmarski F, Skórska C. Ultrastructure of the endotoxin produced by Gram-negative bacteria associated with organic dusts. System Appl Microbiol. 1992; 15: 474-485.
113. Dutkiewicz J, Tucker J, Woodfork K, Burrell R. The identification of extracellular endotoxin molecules by immunoelectron microscopy. In: Jacobs RR, Wakelyn PJ (eds.). Cotton Dust. Proceedings of the 13th Cotton Dust Research Conference, 5-6 January 1989, Nashville, TN, pp. 111-114. National Cotton Council, Memphis, TN, 1989.
114. Prażmo Z, Krysińska-Traczyk E, Skórska C, Sitkowska J, Cholewa G, Urbanowicz B, Dutkiewicz J. Birch wetwood as a source of potential bacterial hazard for woodworkers. Ann Agric Environ Med. 1996, 3: 67-70.
115. Kulp A, Kuehn MJ. Biological functions and biogenesis of secreted bacterial outer membrane vesicles. Annu Rev Microbiol. 2010; 64: 163-184.
116. Dutkiewicz J, Skórska C, Burrell R, Szuster-Ciesielska A, Sitkowska J. Immunostimulative effects of repeated inhalation exposure to microvesicle-bound endotoxin of Pantoea agglomerans. Ann Agric Environ Med. 2005; 12: 289-294.
117. Śpiewak R, Dutkiewicz J. In vitro study of pro-inflammatory and anti-tumour properties of microvesicles from bacterial cell wall of Pantoea agglomerans. Ann Agric Environ Med. 2008; 15: 153-161.
118. Dutkiewicz J. Bacteria in farming environment. In: Terho EO, Husman K, Kauppinen T (Eds): Proceedings of the International Symposium on Work-Related Respiratory Disorders among Farmers, 11-16 August 1985, Kuopio, Finland. Eur J Respir Dis. 1987; 71(Suppl. 154): 71-88.
119. Milanowski J, Dutkiewicz J. Increased superoxide anion generation by alveolar macrophages stimulated with antigens associated with organic dusts. Allergol Immunopathol (Madrid). 1990; 18: 211-215.
120. Rylander R. Toxicity of inhaled isolated and cell bound endotoxin. In: Jacobs RR, Wakelyn PJ, Rylander R, Burrell R. (eds.). Cotton Dust. Proceedings of the 12th Cotton Dust Research Conference and of the Endotoxin Inhalation Workshop, 28-30 September 1987, Clearwater, FL, pp. 202-203. National Cotton Council, Memphis, TN, 1988.
121. Milanowski J. Effects of Pantoea agglomerans on the respiratory system. Part I. Studies in vitro. Ann Agric Environ Med. 1994; 1: 44-51.
122. Milanowski J, Dutkiewicz J. Effect of organic dust-derived microbial agents on the function of alveolar macrophages in vitro. Pol J Immunol. (Immunol Pol.) 1992; 17: 353-366.
123. Milanowski J, Sorenson WG, Lewis DM, Dutkiewicz J. Stimulation of alveolar macrophage interleukin-1 production by organic dust-derived products. In: McDuffie HH, Dosman JA, Semchuk KM, Olenchock SA, Senthilselvan A (Eds): Supplement to Agricultural Health and Safety: Workplace, Environment, Sustainability, pp. 67-74. University of Saskatchewan, Saskatoon, SK, 1994.
124. Milanowski J, Sorenson WG, Lewis DM, Dutkiewicz J. Chemotaxis of alveolar macrophages and neutrophils in response to microbial products derived from organic dust. J Invest Allergol Clin Immunol. 1995; 5: 221-227.
125. Lewis DM. Stimulation of interleukin 1 production by alveolar macrophages by endotoxin from various bacterial species. In: Wakelyn PJ, Jacobs RR (eds.). Cotton Dust. Proceedings of the 9th Cotton Dust Research Conference, 9-11 January 1985, New Orleans, LA, pp. 157-159. National Cotton Council, Memphis, TN 1985.
126. Dutkiewicz J, Kuś L. Effect of an inhalation of exogenous bacterial alergen Erwinia herbicola on number of free cells in lungs. Immunol Pol. 1983; 8: 37-45 (in Polish).
127. Rylander R, Lundholm M. Bacterial contamination of cotton and cotton dust and effects on the lung. Br J Ind Med. 1978; 35: 204-207.
128. Milanowski J. Effects of Pantoea agglomerans on the respiratory system. Part II. Studies in vivo. Ann Agric Environ Med. 1994; 1: 52-56.
129. Milanowski J. Effect of inhalation of organic dust-derived microbial agents on the pulmonary phagocytic oxidative metabolism of guinea pigs. J Toxicol Environ Health A. 1998; 53(1): 5-18.
130. Kuś L. Allergic alveolitis after exposure to antigens occurring in grain dust in the light of own clinical and experimental investigations. Dissertation for the degree of Dr habil. Medical University, Lublin 1980 (in Polish).
131. Lemieszek MK, Chilosi M, Golec M, Skórska C, Dinnyes A, Mashayekhi K, Vierlinger K, Huaux F, Wielscher M, Hofner M, Yakoub Y, Pastena C, Daniele I, Cholewa G, Sitkowska J, Lisowska W, Zwoliński J, Milanowski J, Mackiewicz B, Góra-Florek A, Ziesche R, Dutkiewicz J. Age influence on hypersensitivity pneumonitis induced in mice by exposure to Pantoea agglomerans. Inhal Toxicol. 2013; 25: 640-650.
132. Golec M. Cathelicidin LL-37: LPS-neutralizing pleiotropic peptide. Ann Agric Environ Med. 2007; 14: 1-4.
133. Golec M, Reichel C, Lemieszek M, Mackiewicz B, Buczkowski J, Sitkowska J, Skòrska C, Dutkiewicz J, Milanowski J, Ziesche R. Cathelicidin LL-37 in bronchoalveolar lavage and epithelial lining fluids from COPD patients and healthy individuals. J Biol Regul Homeost Agents. 2012; 26: 617-625.
134. Lange JH. Reduced cancer rates in agricultural workers: a benefit of environmental and occupational endotoxin exposure. Med Hypotheses. 2000; 55: 383-385.
135. Laakkonen A, Pukkala E. Cancer incidence among Finnish farmers, 1995-2005. Scand J Work Environ Health. 2008; 34: 73-79.
136. Skórska C, Mackiewicz B, Dutkiewicz J, Krysińska-Traczyk E, Milanowski J, Feltovich H, Lange J, Thorne P.S. Effects of exposure to grain dust in Polish farmers: work-related symptoms and immunologic response to microbial antigens associated with dust. Ann Agric Environ Med. 1998, 5: 147-153.
137. Skórska C, Mackiewicz B, Dutkiewicz J. Effects of exposure to flax dust in Polish farmers: work-related symptoms and immunologic response to microbial antigens associated with dust. Ann Agric Environ Med. 2000; 7: 111-118.
138. Skórska C, Mackiewicz B, Góra A, Golec M, Dutkiewicz J. Health effects of exposure to inhalation of organic dust in hop farmers. Annales UMCS Sec D. 2003; 58: 459-465.
139. Golec M, Skórska C, Mackiewicz B, Dutkiewicz J. Immunologic reactivity to work-related airborne allergens in people occupationally exposed to dust from herbs. Ann Agric Environ Med. 2004; 11: 121-127.
140. Skórska C, Golec M, Mackiewicz B, Góra A, Dutkiewicz J. Health effects of exposure to herb dust in valerian growing farmers. Ann Agric Environ Med. 2005; 12: 247-252.
141. Skórska C, Dutkiewicz J, Mackiewicz B, Sitkowska J, Cholewa G. Reactivity of farmers breeding cattle and swine to biological allergens present in the working environment. Med Ogólna. 1999; 5: 289-299 (in Polish).
142. Dutkiewicz J, Umiński J, Dutkiewicz E, Szukiewicz Z, Minárik L, Votrubová V, Mayer M, Votruba R. Prevalence of antibodies directed against microorganisms of plant origin in agricultural workers with chronic lung diseases. Med Wiejska. 1978; 13: 53-63 (in Polish).
143. Minárik L, Mayer M, Votruba R, Votrubová V, Dutkiewicz J, Umiński J, Dutkiewicz E, Szukiewicz Z. Diagnostics of allergic alveolitis of farmer’s lung type in the light of own observations. Med Wiejska. 1978; 13: 199-207 (in Polish).
144. Durda M, Skublewski A, Borkowska L, Dutkiewicz J, Jakubowski R, Ziemecka-Rakowska E, Mołocznik A, Tymiński J, Bylina J, Dutkiewicz E, Krysińska-Traczyk E, Smerdel-Skórska C, Bartoszczyk H. Chronic respiratory diseases in men exposed to organic dusts. Med Komunikacyjna. 1986; 22: 125-132 (in Polish).
145. Thorn J. The inflammatory response in humans after inhalation of bacterial endotoxin: a review. Inflamm Res. 2001; 50(5): 254-261.
146. Dutkiewicz J, Kuś L, Dutkiewicz E, Warren CPW. Hypersensitivity pneumonitis in grain farmers due to sensitization to Erwinia herbicola. Ann Allergy. 1985; 54: 65-68.
147. Milanowski J. An attempt to the identification of the causative agent of allergic alveolitis in selected group of patients with the use of the microbiological and immunological methods. Pneumon Pol. 1988; 56: 100-105 (in Polish).
148. Lacey J, Crook B. Fungal and actinomycete spores as pollutants of the workplace and occupational allergens. Ann Occup Hyg. 1988; 32: 515-533.
149. Mackiewicz B, Skórska C, Dutkiewicz J, Michnar M, Milanowski J, Prażmo Z, Krysińska-Traczyk E, Cisak E. Allergic alveolitis due to herb dust exposure. Ann Agric Environ Med. 1999; 6: 167-170.
150. Sennekamp J, Joest M, Sander I, Engelhart S, Raulf-Heimsoth M. Farmer’s lung antigens in Germany. Pneumologie. 2012; 66: 297-30l.
151. Ojanen TH, Katila M-L, Mäntyjärvi R, Seppänen H, Muittari A, Kuusisto P, Virtanen P. Exposure of water consumer to mesophilic actinomycetes. J Hyg Camb. 1983; 91: 535-541.
152. Durda M, Dutkiewicz J, Skublewski A, Dutkiewicz E, Ziemecka-Rakowska E, Cichosz Z. Comparative studies on skin and inhalation tests with the allergen of Erwinia herbicola in patients with bronchial asthma and chronic obturative bronchitis. Pneumon Pol. 1980; 48: 699-706 (in Polish).
153. Durda M, Dutkiewicz J, Skublewski A, Borkowska L, Dutkiewicz E, Ziemecka-Rakowska E.: Relationship between skin tests and bronchial provocation tests with allergens found in organic dusts in patients with bronchial asthma. Allergol Immunopathol (Madrid). 1984; 12: 207-211.
154. Dutkiewicz J. Airborne bacteria as occupational allergens. In: Frankland AW, Stix E, Ziegler H. (Eds): The 1st International Conference on Aerobiology, München 13-15 August 1978: Proceedings, pp. 232-242. Umweltbundesamt Berichte 5/79. Erich Schmidt Verlag, Berlin 1980.
155. Von Mutius E, Braun-Fährlander C, Schierl R, Riedler J, Ehlermann S, Maisch S, Waser M, Nowak D. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy. 2000; 30: 1230-1234.
156. Durda M, Dutkiewicz J, Skublewski A, Dutkiewicz E, Ziemecka-Rakowska E. Early results of specific desensitization with the Erwinia herbicola allergen in patients with bronchial asthma. Pneumon Pol. 1980; 48: 707-713 (in Polish).
157. Douwes J, Thorne P, Pearce N, Heederik D. Review. Bioaerosol health effects and exposure assessment: progress and prospects. Ann Occup Hyg. 2003; 47(3): 187-200.
158. Śpiewak R, Skórska C, Góra A, Horoch A, Dutkiewicz J. Young farmers with cellular reactivity to airborne microbes suffer more frequently from work-related skin symptoms and allergic dermatitis. Ann Agric Environ Med. 2001; 8: 255-259.
159. Śpiewak R, Góra A, Dutkiewicz J. Work-related skin symptoms and type I allergy among eastern-Polish farmers growing hops and other crops. Ann Agric Environ Med. 2001; 8: 51-56.
160. Śpiewak R, Dutkiewicz J. Occupational airborne and hand dermatitis to hop (Humulus lupulus) with non-occupational relapses. Ann Agric Environ Med. 2002; 9: 249-252.
161. Śpiewak R, Dutkiewicz J. A farmer’s occupational airborne contact dermatitis masqueraded by coexisting rosacea: delayed diagnosis and legal acknowledgement. Ann Agric Environ Med. 2004; 11: 329-333.
162. Pomorski Z, Dutkiewicz J, Taszkun I, Woźniak M, Sitkowski W. Studies on the causes, diagnostics and clinical course of allergic alveolitis in cattle. Materials of the Scientific Session of the Clinical Section of the Polish Society of Veterinary Sciences, Olsztyn 18-19.10.1991, pp. 70-71 (in Polish).
163. Taszkun I, Pomorski Z. Natural exposure to the antigens of Erwinia herbicola (Enterobacter agglomerans) as a one of etiological factors of obstructive bronchopneumonia in cattle. Materials of the 2nd Symposium of the Polish Veterinary Immunologists, Szczecin-Świnoujście 12-14.05. 1994. Pol J Immunol. 1994; 19 (Suppl. 2): 83S-84S (in Polish).
164. Taszkun I, Pomorski Z. The role of Erwinia herbicola in the development of the hypersensitivity pneumonitis in cattle. Materials of the 10th Congress of the Polish Society of Veterinary Sciences, Wrocław 19-21.09.1996, p. 221 (in Polish).
165. Taszkun I, Pomorski Z, Dutkiewicz J, Milczak A. Chronic Obstructive Pulmonary Disease (COPD) in horses. Part II. Studies on immunologic determinants of COPD in horses. Mag Wet. 1997, 6(4): 264-267 (in Polish).
166. Rylander R. Organic dusts -from knowledge to prevention. Scand J Work Environ Health. 1994; 20 (special issue): 116-122.
167. Do Pico GA. Grain dust. In: Rylander R, Jacobs RR (Eds). Organic Dusts. Exposure, Effects and Prevention. CRC Press, Inc., Boca Raton, FL, 1994, 193-218.