Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies

Journal of Molecular Diagnostics

Volumn 18, Issue 2, 2016, Pages 299-315

  Fisher, Kevin E ^a,b,c   Zhang, Linsheng ^a   Wang, Jason ^a,d   Smith, Geoffrey H ^a   Newman, Scott ^e   Schneider, Thomas M ^a   Pillai, Rathi N ^a,e   Kudchadkar, Ragini R ^a,e   Owonikoko, Taofeek K ^a,e   Ramalingam, Suresh S ^a,e   Lawson, David H ^a,e   Delman, Keith A ^a,e   El Rayes, Bassel F ^a,e   Wilson, Malania M ^e   Sullivan, H Clifford ^a   Morrison, Annie S ^a   Balci, Serdar ^a   Adsay, N Volkan ^a   Gal, Anthony A ^a   Sica, Gabriel L ^a   Saxe, Debra F ^a   Mann, Karen P ^a   Hill, Charles E ^a   Khuri, Fadlo R ^a,e   Rossi, Michael R ^a   more..

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FORMALDEHYDE; NUCLEIC ACID; PARAFFIN; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERBB2 PROTEIN, HUMAN; PROTEIN P53; TP53 PROTEIN, HUMAN;

ARTICLE; BIOINFORMATICS; COLON ADENOCARCINOMA; DIGESTIVE SYSTEM CANCER; GENE MUTATION; GENE REARRANGEMENT; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; LABORATORY TEST; MAJOR CLINICAL STUDY; MELANOMA; NEXT GENERATION SEQUENCING; NON SMALL CELL LUNG CANCER; PANCREAS ADENOCARCINOMA; PYROSEQUENCING; QUALITY CONTROL; SEQUENCE ALIGNMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SOLID TUMOR; STOMACH ADENOCARCINOMA; VALIDATION STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GASTROINTESTINAL TUMOR; GENETICS; HIGH THROUGHPUT SEQUENCING; LIMIT OF DETECTION; LUNG TUMOR; MULTIPLEX POLYMERASE CHAIN REACTION; MUTATION; PROCEDURES; SENSITIVITY AND SPECIFICITY; STANDARDS;

CARCINOMA, NON-SMALL-CELL LUNG; GASTROINTESTINAL NEOPLASMS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LIMIT OF DETECTION; LUNG NEOPLASMS; MELANOMA; MULTIPLEX POLYMERASE CHAIN REACTION; MUTATION; PARAFFIN EMBEDDING; QUALITY CONTROL; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SENSITIVITY AND SPECIFICITY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84960939822     PISSN: 15251578     EISSN: 19437811     Source Type: Journal    
DOI: 10.1016/j.jmoldx.2015.11.006     Document Type: Article

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