Homology directed knockin of point mutations in the zebrafish tardbp and fus genes in ALS using the CRISPR/Cas9 system

PLoS ONE

Volumn 11, Issue 3, 2016, Pages

  Armstrong, Gary Alan Barclay ^a   Liao, Meijiang ^a   You, Zhipeng ^a   Lissouba, Alexandra ^a   Chen, Brian Edwin ^b   Drapeau, Pierre ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CRISPR ASSOCIATED PROTEIN; FUSED IN SARCOMA PROTEIN; DNA BINDING PROTEIN; OLIGODEOXYRIBONUCLEOTIDE; RNA BINDING PROTEIN FUS; SINGLE STRANDED DNA; TARDBP PROTEIN, ZEBRAFISH; ZEBRAFISH PROTEIN;

ADULT; AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASE PAIRING; CONTROLLED STUDY; DNA CLEAVAGE; DNA END JOINING REPAIR; FUS GENE; GENE; GENE SEQUENCE; HETEROZYGOSITY; HOMOZYGOSITY; NEUROPATHOLOGY; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; POINT MUTATION; SINGLE NUCLEOTIDE POLYMORPHISM; TARDBP GENE; ZEBRA FISH; AMINO ACID SEQUENCE; ANIMAL; CRISPR CAS SYSTEM; DISEASE MODEL; DNA REPAIR; GENE TARGETING; GENETICS; HUMAN; NUCLEOTIDE SEQUENCE; PROCEDURES; REPRODUCIBILITY; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BASE SEQUENCE; CRISPR-CAS SYSTEMS; DISEASE MODELS, ANIMAL; DNA REPAIR; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; GENE KNOCK-IN TECHNIQUES; HUMANS; OLIGODEOXYRIBONUCLEOTIDES; POINT MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS; RNA-BINDING PROTEIN FUS; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84960908143     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0150188     Document Type: Article

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