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Volumn 14, Issue 4, 2016, Pages 543-549

Infliximab Concentration Thresholds During Induction Therapy Are Associated With Short-term Mucosal Healing in Patients With Ulcerative Colitis

Author keywords

Anti TNF Agent; Antibodies to Infliximab; Mucosal Healing; Ulcerative Colitis

Indexed keywords

INFLIXIMAB; IMMUNOSUPPRESSIVE AGENT;

EID: 84960864810     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2015.11.014     Document Type: Article
Times cited : (154)

References (44)
  • 1
    • 84890148956 scopus 로고    scopus 로고
    • Targeting TNF-α for the treatment of inflammatory bowel disease
    • Billiet T., Rutgeerts P., Ferrante M., et al. Targeting TNF-α for the treatment of inflammatory bowel disease. Expert Opin Biol Ther 2014, 14:75-101.
    • (2014) Expert Opin Biol Ther , vol.14 , pp. 75-101
    • Billiet, T.1    Rutgeerts, P.2    Ferrante, M.3
  • 2
    • 84906790163 scopus 로고    scopus 로고
    • Treating beyond symptoms with a view to improving patient outcomes in inflammatory bowel diseases
    • Sandborn W.J., Hanauer S., Van Assche G., et al. Treating beyond symptoms with a view to improving patient outcomes in inflammatory bowel diseases. J Crohns Colitis 2014, 8:927-935.
    • (2014) J Crohns Colitis , vol.8 , pp. 927-935
    • Sandborn, W.J.1    Hanauer, S.2    Van Assche, G.3
  • 3
    • 84919455017 scopus 로고    scopus 로고
    • Mucosal healing in the era of biologic agents in treatment of inflammatory bowel disease
    • Florholmen J. Mucosal healing in the era of biologic agents in treatment of inflammatory bowel disease. Scand J Gastroenterol 2015, 50:43-52.
    • (2015) Scand J Gastroenterol , vol.50 , pp. 43-52
    • Florholmen, J.1
  • 4
    • 84922890759 scopus 로고    scopus 로고
    • Converging goals of treatment of inflammatory bowel disease from clinical trials and practice
    • Levesque B.G., Sandborn W.J., Ruel J., et al. Converging goals of treatment of inflammatory bowel disease from clinical trials and practice. Gastroenterology 2015, 148:37-51.
    • (2015) Gastroenterology , vol.148 , pp. 37-51
    • Levesque, B.G.1    Sandborn, W.J.2    Ruel, J.3
  • 5
    • 84925320962 scopus 로고    scopus 로고
    • A panel to predict long-term outcome of infliximab therapy for patients with ulcerative colitis
    • Arias M.T., Vande Casteele N., Vermeire S., et al. A panel to predict long-term outcome of infliximab therapy for patients with ulcerative colitis. Clin Gastroenterol Hepatol 2015, 13:531-538.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 531-538
    • Arias, M.T.1    Vande Casteele, N.2    Vermeire, S.3
  • 6
    • 48949099032 scopus 로고    scopus 로고
    • Long-term outcome after infliximab for refractory ulcerative colitis
    • Ferrante M., Vermeire S., Fidder H., et al. Long-term outcome after infliximab for refractory ulcerative colitis. J Crohns Colitis 2008, 2:219-225.
    • (2008) J Crohns Colitis , vol.2 , pp. 219-225
    • Ferrante, M.1    Vermeire, S.2    Fidder, H.3
  • 7
    • 84876486013 scopus 로고    scopus 로고
    • Impact of mucosal healing on longterm outcomes in ulcerative colitis treated with infliximab: a multicentre experience
    • Laharie D., Filippi J., Roblin X., et al. Impact of mucosal healing on longterm outcomes in ulcerative colitis treated with infliximab: a multicentre experience. Aliment Pharmacol Ther 2013, 37:998-1004.
    • (2013) Aliment Pharmacol Ther , vol.37 , pp. 998-1004
    • Laharie, D.1    Filippi, J.2    Roblin, X.3
  • 8
    • 80053130407 scopus 로고    scopus 로고
    • Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis
    • Colombel J.F., Rutgeerts P., Reinisch W., et al. Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 2011, 141:1194-1201.
    • (2011) Gastroenterology , vol.141 , pp. 1194-1201
    • Colombel, J.F.1    Rutgeerts, P.2    Reinisch, W.3
  • 9
    • 84894640694 scopus 로고    scopus 로고
    • Therapeutic drug monitoring in inflammatory bowel disease: current state and future perspectives
    • Vande Casteele N., Feagan B.G., Gils A., et al. Therapeutic drug monitoring in inflammatory bowel disease: current state and future perspectives. Curr Gastroenterol Rep 2014, 16:378.
    • (2014) Curr Gastroenterol Rep , vol.16 , pp. 378
    • Vande Casteele, N.1    Feagan, B.G.2    Gils, A.3
  • 10
    • 84930015437 scopus 로고    scopus 로고
    • Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease
    • Vande Casteele N., Ferrante M., Van Assche G., et al. Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease. Gastroenterology 2015, 148:1320-1329.
    • (2015) Gastroenterology , vol.148 , pp. 1320-1329
    • Vande Casteele, N.1    Ferrante, M.2    Van Assche, G.3
  • 11
    • 84925776153 scopus 로고    scopus 로고
    • Role for therapeutic drug monitoring during induction therapy with TNF antagonists in IBD: evolution in the definition and management of primary nonresponse
    • Papamichael K., Gils A., Rutgeerts P., et al. Role for therapeutic drug monitoring during induction therapy with TNF antagonists in IBD: evolution in the definition and management of primary nonresponse. Inflamm Bowel Dis 2015, 21:182-197.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 182-197
    • Papamichael, K.1    Gils, A.2    Rutgeerts, P.3
  • 12
    • 84909647171 scopus 로고    scopus 로고
    • Prior response to infliximab and early serum drug concentrations predict effects of adalimumab in ulcerative colitis
    • Baert F., Vande Casteele N., Tops S., et al. Prior response to infliximab and early serum drug concentrations predict effects of adalimumab in ulcerative colitis. Aliment Pharmacol Ther 2014, 40:1324-1332.
    • (2014) Aliment Pharmacol Ther , vol.40 , pp. 1324-1332
    • Baert, F.1    Vande Casteele, N.2    Tops, S.3
  • 13
    • 70350130547 scopus 로고    scopus 로고
    • Influence of trough serum levels and immunogenicity on long-term outcome of adalimumab therapy in Crohn's disease
    • Karmiris K., Paintaud G., Noman M., et al. Influence of trough serum levels and immunogenicity on long-term outcome of adalimumab therapy in Crohn's disease. Gastroenterology 2009, 137:1628-1640.
    • (2009) Gastroenterology , vol.137 , pp. 1628-1640
    • Karmiris, K.1    Paintaud, G.2    Noman, M.3
  • 14
    • 84892979466 scopus 로고    scopus 로고
    • Postinduction serum infliximab trough level and decrease of C-reactive protein level are associated with durable sustained response to infliximab: a retrospective analysis of the ACCENT I trial
    • Cornillie F., Hanauer S.B., Diamond R.H., et al. Postinduction serum infliximab trough level and decrease of C-reactive protein level are associated with durable sustained response to infliximab: a retrospective analysis of the ACCENT I trial. Gut 2014, 63:1721-1727.
    • (2014) Gut , vol.63 , pp. 1721-1727
    • Cornillie, F.1    Hanauer, S.B.2    Diamond, R.H.3
  • 15
    • 84925623006 scopus 로고    scopus 로고
    • Proactive therapeutic concentration monitoring of infliximab may improve outcomes for patients with inflammatory bowel disease: results from a pilot observational study
    • Vaughn B.P., Martinez-Vazquez M., Patwardhan V.R., et al. Proactive therapeutic concentration monitoring of infliximab may improve outcomes for patients with inflammatory bowel disease: results from a pilot observational study. Inflamm Bowel Dis 2014, 20:1996-2003.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 1996-2003
    • Vaughn, B.P.1    Martinez-Vazquez, M.2    Patwardhan, V.R.3
  • 16
    • 73449088039 scopus 로고    scopus 로고
    • Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis
    • Seow C.H., Newman A., Irwin S.P., et al. Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis. Gut 2010, 59:49-54.
    • (2010) Gut , vol.59 , pp. 49-54
    • Seow, C.H.1    Newman, A.2    Irwin, S.P.3
  • 17
    • 84893898345 scopus 로고    scopus 로고
    • Association between plasma concentrations of certolizumab pegol and endoscopic outcomes of patients with Crohn's disease
    • Colombel J.F., Sandborn W.J., Allez M., et al. Association between plasma concentrations of certolizumab pegol and endoscopic outcomes of patients with Crohn's disease. Clin Gastroenterol Hepatol 2014, 12:423-431.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 423-431
    • Colombel, J.F.1    Sandborn, W.J.2    Allez, M.3
  • 18
    • 33749432435 scopus 로고    scopus 로고
    • Association of trough serum infliximab to clinical outcome after scheduled maintenance treatment for Crohn's disease
    • Maser E.A., Villela R., Silverberg M.S., et al. Association of trough serum infliximab to clinical outcome after scheduled maintenance treatment for Crohn's disease. Clin Gastroenterol Hepatol 2006, 4:1248-1254.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1248-1254
    • Maser, E.A.1    Villela, R.2    Silverberg, M.S.3
  • 19
    • 84890219983 scopus 로고    scopus 로고
    • Association between pharmacokinetics of adalimumab and mucosal healing in patients with inflammatory bowel diseases
    • Roblin X., Marotte H., Rinaudo M., et al. Association between pharmacokinetics of adalimumab and mucosal healing in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol 2014, 12:80-84.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 80-84
    • Roblin, X.1    Marotte, H.2    Rinaudo, M.3
  • 20
    • 84925329456 scopus 로고    scopus 로고
    • Factors associated with short- and long-term outcomes of therapy for Crohn's disease
    • Reinisch W., Colombel J.F., Sandborn W.J., et al. Factors associated with short- and long-term outcomes of therapy for Crohn's disease. Clin Gastroenterol Hepatol 2015, 13:539-547.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 539-547
    • Reinisch, W.1    Colombel, J.F.2    Sandborn, W.J.3
  • 21
    • 84906236434 scopus 로고    scopus 로고
    • Adalimumab drug and antibody levels as predictors of clinical and laboratory response in patients with Crohn's disease
    • Mazor Y., Almog R., Kopylov U., et al. Adalimumab drug and antibody levels as predictors of clinical and laboratory response in patients with Crohn's disease. Aliment Pharmacol Ther 2014, 40:620-628.
    • (2014) Aliment Pharmacol Ther , vol.40 , pp. 620-628
    • Mazor, Y.1    Almog, R.2    Kopylov, U.3
  • 22
    • 84888322157 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of infliximab and mucosal healing in inflammatory bowel disease: a prospective study
    • Paul S., Del Tedesco E., Marotte H., et al. Therapeutic drug monitoring of infliximab and mucosal healing in inflammatory bowel disease: a prospective study. Inflamm Bowel Dis 2013, 19:2568-2576.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 2568-2576
    • Paul, S.1    Del Tedesco, E.2    Marotte, H.3
  • 23
    • 84890180643 scopus 로고    scopus 로고
    • Pharmacokinetics of infliximab in children with moderate-to-severe ulcerative colitis: results from a randomized, multicenter, open-label, phase 3 study
    • Adedokun O.J., Xu Z., Padgett L., et al. Pharmacokinetics of infliximab in children with moderate-to-severe ulcerative colitis: results from a randomized, multicenter, open-label, phase 3 study. Inflamm Bowel Dis 2013, 19:2753-2762.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 2753-2762
    • Adedokun, O.J.1    Xu, Z.2    Padgett, L.3
  • 24
    • 84913534923 scopus 로고    scopus 로고
    • Association between serum concentration of infliximab and efficacy in adult patients with ulcerative colitis
    • Adedokun O.J., Sandborn W.J., Feagan B.G., et al. Association between serum concentration of infliximab and efficacy in adult patients with ulcerative colitis. Gastroenterology 2014, 147:1296-1307.
    • (2014) Gastroenterology , vol.147 , pp. 1296-1307
    • Adedokun, O.J.1    Sandborn, W.J.2    Feagan, B.G.3
  • 25
    • 84866390993 scopus 로고    scopus 로고
    • Detection of infliximab concentrations and anti-infliximab antibodies: a comparison of three different assays
    • Vande Casteele N., Buurman D.J., Sturkenboom M.G., et al. Detection of infliximab concentrations and anti-infliximab antibodies: a comparison of three different assays. Aliment Pharmacol Ther 2012, 36:765-771.
    • (2012) Aliment Pharmacol Ther , vol.36 , pp. 765-771
    • Vande Casteele, N.1    Buurman, D.J.2    Sturkenboom, M.G.3
  • 26
    • 84940942570 scopus 로고    scopus 로고
    • An optimized anti-infliximab bridging enzyme-linked immunosorbent assay for harmonization of anti-infliximab antibody titers in patients with inflammatory bowel diseases
    • Van Stappen T., Billiet T., Vande Casteele N., et al. An optimized anti-infliximab bridging enzyme-linked immunosorbent assay for harmonization of anti-infliximab antibody titers in patients with inflammatory bowel diseases. Inflamm Bowel Dis 2015, 21:2172-2177.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 2172-2177
    • Van Stappen, T.1    Billiet, T.2    Vande Casteele, N.3
  • 27
    • 84899955509 scopus 로고    scopus 로고
    • Relationship between serum infliximab trough levels and endoscopic activities in patients with Crohn's disease under scheduled maintenance treatment
    • Imaeda H., Bamba S., Takahashi K., et al. Relationship between serum infliximab trough levels and endoscopic activities in patients with Crohn's disease under scheduled maintenance treatment. J Gastroenterol 2014, 49:674-682.
    • (2014) J Gastroenterol , vol.49 , pp. 674-682
    • Imaeda, H.1    Bamba, S.2    Takahashi, K.3
  • 28
    • 84925206269 scopus 로고    scopus 로고
    • Randomised clinical trial: deep remission in biologic and immunomodulator naïve patients with Crohn's disease-a SONIC post hoc analysis
    • Colombel J.F., Reinisch W., Mantzaris G.J., et al. Randomised clinical trial: deep remission in biologic and immunomodulator naïve patients with Crohn's disease-a SONIC post hoc analysis. Aliment Pharmacol Ther 2015, 41:734-746.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 734-746
    • Colombel, J.F.1    Reinisch, W.2    Mantzaris, G.J.3
  • 29
    • 84932174376 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of anti-tumor necrosis factor agents in patients with inflammatory bowel diseases
    • Yarur A.J., Rubin D.T. Therapeutic drug monitoring of anti-tumor necrosis factor agents in patients with inflammatory bowel diseases. Inflamm Bowel Dis 2015, 21:1709-1718.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 1709-1718
    • Yarur, A.J.1    Rubin, D.T.2
  • 30
    • 84960842091 scopus 로고    scopus 로고
    • First trough level of infliximab at week 2 predicts future outcomes of induction therapy in ulcerative colitis: results from a multicenter prospective randomized controlled trial and its post hoc analysis
    • [Epub ahead of print]
    • Kobayashi T., Suzuki Y., Motoya S., et al. First trough level of infliximab at week 2 predicts future outcomes of induction therapy in ulcerative colitis: results from a multicenter prospective randomized controlled trial and its post hoc analysis. J Gastroenterol 2015, [Epub ahead of print].
    • (2015) J Gastroenterol
    • Kobayashi, T.1    Suzuki, Y.2    Motoya, S.3
  • 31
    • 71249099165 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis of infliximab in patients with ulcerative colitis
    • Fasanmade A.A., Adedokun O.J., Ford J., et al. Population pharmacokinetic analysis of infliximab in patients with ulcerative colitis. Eur J Clin Pharmacol 2009, 65:1211-1228.
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 1211-1228
    • Fasanmade, A.A.1    Adedokun, O.J.2    Ford, J.3
  • 32
    • 84866457923 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of tumor necrosis factor antagonists in inflammatory bowel disease
    • Ordas I., Feagan B.G., Sandborn W.J. Therapeutic drug monitoring of tumor necrosis factor antagonists in inflammatory bowel disease. Clin Gastroenterol Hepatol 2012, 10:1079-1087.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 1079-1087
    • Ordas, I.1    Feagan, B.G.2    Sandborn, W.J.3
  • 33
    • 84925759693 scopus 로고    scopus 로고
    • Patient factors that increase infliximab clearance and shorten half-life in inflammatory bowel disease: a population pharmacokinetic study
    • Dotan I., Ron Y., Yanai H., et al. Patient factors that increase infliximab clearance and shorten half-life in inflammatory bowel disease: a population pharmacokinetic study. Inflamm Bowel Dis 2014, 20:2247-2259.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 2247-2259
    • Dotan, I.1    Ron, Y.2    Yanai, H.3
  • 34
    • 84958840838 scopus 로고    scopus 로고
    • The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS study
    • Yarur A.J., Jain A., Sussman D.A., et al. The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS study. Gut 2016, 65:249-255.
    • (2016) Gut , vol.65 , pp. 249-255
    • Yarur, A.J.1    Jain, A.2    Sussman, D.A.3
  • 35
    • 84929119171 scopus 로고    scopus 로고
    • Review article: applying pharmacokinetics to optimise dosing of anti-TNF biologics in acute severe ulcerative colitis
    • Rosen M.J., Minar P., Vinks A.A. Review article: applying pharmacokinetics to optimise dosing of anti-TNF biologics in acute severe ulcerative colitis. Aliment Pharmacol Ther 2015, 41:1094-1103.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 1094-1103
    • Rosen, M.J.1    Minar, P.2    Vinks, A.A.3
  • 36
    • 84927697296 scopus 로고    scopus 로고
    • An accelerated infliximab induction regimen reduces the need for early colectomy in patients with acute severe ulcerative colitis
    • Gibson D.J., Heetun Z.S., Redmond C.E., et al. An accelerated infliximab induction regimen reduces the need for early colectomy in patients with acute severe ulcerative colitis. Clin Gastroenterol Hepatol 2015, 13:330-335.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 330-335
    • Gibson, D.J.1    Heetun, Z.S.2    Redmond, C.E.3
  • 37
    • 84942566280 scopus 로고    scopus 로고
    • High-dose infliximab therapy in Crohn's disease: clinical experience, safety, and efficacy
    • Hendler S.A., Cohen B.L., Colombel J.F., et al. High-dose infliximab therapy in Crohn's disease: clinical experience, safety, and efficacy. J Crohns Colitis 2015, 9:266-275.
    • (2015) J Crohns Colitis , vol.9 , pp. 266-275
    • Hendler, S.A.1    Cohen, B.L.2    Colombel, J.F.3
  • 38
    • 84938090411 scopus 로고    scopus 로고
    • Loss of infliximab into feces is associated with lack of response to therapy in patients with severe ulcerative colitis
    • Brandse J.F., van den Brink G.R., Wildenberg M.E., et al. Loss of infliximab into feces is associated with lack of response to therapy in patients with severe ulcerative colitis. Gastroenterology 2015, 149:350-355.
    • (2015) Gastroenterology , vol.149 , pp. 350-355
    • Brandse, J.F.1    van den Brink, G.R.2    Wildenberg, M.E.3
  • 39
    • 84888400869 scopus 로고    scopus 로고
    • Clinical disease activity, Creactive protein normalisation and mucosal healing in Crohn's disease in the SONIC trial
    • Peyrin-Biroulet L., Reinisch W., Colombel J.F., et al. Clinical disease activity, Creactive protein normalisation and mucosal healing in Crohn's disease in the SONIC trial. Gut 2014, 63:88-95.
    • (2014) Gut , vol.63 , pp. 88-95
    • Peyrin-Biroulet, L.1    Reinisch, W.2    Colombel, J.F.3
  • 40
    • 44649090092 scopus 로고    scopus 로고
    • Withdrawal of immunosuppression in Crohn's disease treated with scheduled infliximab maintenance: a randomized trial
    • Van Assche G., Magdelaine-Beuzelin C., D'Haens G., et al. Withdrawal of immunosuppression in Crohn's disease treated with scheduled infliximab maintenance: a randomized trial. Gastroenterology 2008, 134:1861-1868.
    • (2008) Gastroenterology , vol.134 , pp. 1861-1868
    • Van Assche, G.1    Magdelaine-Beuzelin, C.2    D'Haens, G.3
  • 41
    • 84963716558 scopus 로고    scopus 로고
    • Clinical trials in ulcerative colitis: a historical perspective
    • Hindryckx P., Baert F., Hart A., et al. Clinical trials in ulcerative colitis: a historical perspective. J Crohns Colitis 2015, 9:580-588.
    • (2015) J Crohns Colitis , vol.9 , pp. 580-588
    • Hindryckx, P.1    Baert, F.2    Hart, A.3
  • 42
    • 84964291059 scopus 로고    scopus 로고
    • Histological inflammation in ulcerative colitis in deep remission under treatment with infliximab
    • Tursi A., Elisei W., Picchio M., et al. Histological inflammation in ulcerative colitis in deep remission under treatment with infliximab. Clin Res Hepatol Gastroenterol 2015, 39:107-113.
    • (2015) Clin Res Hepatol Gastroenterol , vol.39 , pp. 107-113
    • Tursi, A.1    Elisei, W.2    Picchio, M.3
  • 43
    • 84939563618 scopus 로고    scopus 로고
    • Preemptive dose optimization using therapeutic drug monitoring for biologic therapy of Crohn's disease: avoiding failure while lowering costs?
    • Vande Casteele N., Gils A. Preemptive dose optimization using therapeutic drug monitoring for biologic therapy of Crohn's disease: avoiding failure while lowering costs?. Dig Dis Sci 2015, 60:2571-2573.
    • (2015) Dig Dis Sci , vol.60 , pp. 2571-2573
    • Vande Casteele, N.1    Gils, A.2
  • 44
    • 84923359740 scopus 로고    scopus 로고
    • Pharmacokinetics of anti-TNF monoclonal antibodies in inflammatory bowel disease: adding value to current practice
    • Vande Casteele N., Gils A. Pharmacokinetics of anti-TNF monoclonal antibodies in inflammatory bowel disease: adding value to current practice. J Clin Pharmacol 2015, 55(Suppl 3):S39-S50.
    • (2015) J Clin Pharmacol , vol.55 , pp. S39-S50
    • Vande Casteele, N.1    Gils, A.2


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