Prolonged Electromechanical Interval Unmasks Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy in the Subclinical Stage

Journal of Cardiovascular Electrophysiology

Volumn 27, Issue 3, 2016, Pages 303-314

  Mast, Thomas P ^a   Teske, Arco J ^a   Te Riele, Anneline Sjm ^a,b   Groeneweg, Judith A ^a   Van Der Heijden, Jeroen F ^a   Velthuis, Birgitta K ^a   Loh, Peter ^a   Doevendans, Pieter A ^a   Van Veen, Toon A ^a   Dooijes, Dennis ^a   De Bakker, Jacques M ^a,c,d   Hauer, Richard N ^a,c   Cramer, Maarten J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d INTERUNIVERSITY CARDIOLOGY INSTITUTE OF THE NETHERLANDS   (Netherlands)

Author keywords

activation delay; arrhythmogenic right ventricular dysplasia cardiomyopathy; deformation imaging; diagnosis; echocardiography; risk stratification; ventricular arrhythmias

Indexed keywords

ADULT; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; ECG ABNORMALITY; ECHOCARDIOGRAPHY; FEMALE; FOLLOW UP; GENE MUTATION; HEART RIGHT VENTRICLE DYSPLASIA; HEART VENTRICLE ARRHYTHMIA; HOLTER MONITORING; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; OUTCOME ASSESSMENT; PERSONAL EXPERIENCE; PRIORITY JOURNAL; CINE MAGNETIC RESONANCE IMAGING; DIAGNOSTIC IMAGING; ELECTROCARDIOGRAPHY; MIDDLE AGED; PATHOPHYSIOLOGY; PROCEDURES; TIME FACTOR; YOUNG ADULT;

ADULT; ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MAGNETIC RESONANCE IMAGING, CINE; MALE; MIDDLE AGED; TIME FACTORS; YOUNG ADULT;

EID: 84960797447     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/jce.12882     Document Type: Article

References (40)

1. Marcus FI, Fontaine GH, Guiraudon G, Frank R, Laurenceau JL, Malergue C, Grosgogeat Y,: Right ventricular dysplasia: A report of 24 adult cases. Circulation 1982; 65: 384-398.
2. Bhonsale A, Groeneweg JA, James CA, Dooijes D, Tichnell C, Jongbloed JD, Murray B, te Riele AS, van den Berg MP, Bikker H, Atsma DE, de Groot NM, Houweling AC, van der Heijden JF, Russell SD, Doevendans PA, van Veen TA, Tandri H, Wilde AA, Judge DP, van Tintelen JP, Calkins H, Hauer RN,: Impact of genotype on clinical course in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated mutation carriers. Eur Heart J 2015; 36: 847-855.
3. Sen-Chowdhry S, Syrris P, Ward D, Asimaki A, Sevdalis E, McKenna WJ,: Clinical and genetic characterization of families with arrhythmogenic right ventricular dysplasia/cardiomyopathy provides novel insights into patterns of disease expression. Circulation 2007; 115: 1710-1720.
4. Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba W,: Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: Proposed modification of the task force criteria. Circulation 2010; 121: 1533-1541.
5. Basso C, Corrado D, Marcus FI, Nava A, Thiene G,: Arrhythmogenic right ventricular cardiomyopathy. Lancet 2009; 373: 1289-1300.
6. Sen-Chowdhry S, Syrris P, McKenna WJ,: Genetics of right ventricular cardiomyopathy. J Cardiovasc Electrophysiol 2005; 16: 927-935.
7. Cox MG, van der Zwaag PA, van der Werf C, van der Smagt JJ, Noorman M, Bhuiyan ZA, Wiesfeld AC, Volders PG, van Langen IM, Atsma DE, Dooijes D, van den Wijngaard A, Houweling AC, Jongbloed JD, Jordaens L, Cramer MJ, Doevendans PA, de Bakker JM, Wilde AA, van Tintelen JP, Hauer RN,: Arrhythmogenic right ventricular dysplasia/cardiomyopathy: Pathogenic desmosome mutations in index-patients predict outcome of family screening: Dutch arrhythmogenic right ventricular dysplasia/cardiomyopathy genotype-phenotype follow-up study. Circulation 2011; 123: 2690-2700.
8. Quarta G, Muir A, Pantazis A, Syrris P, Gehmlich K, Garcia-Pavia P, Ward D, Sen-Chowdhry S, Elliott PM, McKenna WJ,: Familial evaluation in arrhythmogenic right ventricular cardiomyopathy: Impact of genetics and revised task force criteria. Circulation 2011; 123: 2701-2709.
9. Noorman M, Hakim S, Kessler E, Groeneweg JA, Cox MG, Asimaki A, van Rijen HV, van Stuijvenberg L, Chkourko H, van der Heyden MA, Vos MA, de Jonge N, van der Smagt JJ, Dooijes D, Vink A, de Weger RA, Varro A, de Bakker JM, Saffitz JE, Hund TJ, Mohler PJ, Delmar M, Hauer RN, van Veen TA,: Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm 2013; 10: 412-419.
10. Cerrone M, Noorman M, Lin X, Chkourko H, Liang FX, van der Nagel R, Hund T, Birchmeier W, Mohler P, van Veen TA, van Rijen HV, Delmar M,: Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency. Cardiovasc Res 2012; 95: 460-468.
11. de Bakker JM, van Capelle FJ, Janse MJ, Tasseron S, Vermeulen JT, de Jonge N, Lahpor JR,: Slow conduction in the infarcted human heart. 'Zigzag' course of activation. Circulation 1993; 88: 915-926.
12. Fast VG, Kleber AG,: Role of wavefront curvature in propagation of cardiac impulse. Cardiovascular Research 1997; 33: 258-271.
13. Tandri H, Asimaki A, Abraham T, Dalal D, Tops L, Jain R, Saffitz JE, Judge DP, Russell SD, Halushka M, Bluemke DA, Kass DA, Calkins H,: Prolonged RV endocardial activation duration: A novel marker of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Rhythm 2009; 6: 769-775.
14. Haqqani HM, Tschabrunn CM, Betensky BP, Lavi N, Tzou WS, Zado ES, Marchlinski FE,: Layered activation of epicardial scar in arrhythmogenic right ventricular dysplasia: Possible substrate for confined epicardial circuits. Circ Arrhythm Electrophysiol 2012; 5: 796-803.
15. Tops LF, Prakasa K, Tandri H, Dalal D, Jain R, Dimaano VL, Dombroski D, James C, Tichnell C, Daly A, Marcus F, Schalij MJ, Bax JJ, Bluemke D, Calkins H, Abraham TP,: Prevalence and pathophysiologic attributes of ventricular dyssynchrony in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Am Coll Cardiol 2009; 54: 445-451.
16. Bhonsale A, James CA, Tichnell C, Murray B, Madhavan S, Philips B, Russell SD, Abraham T, Tandri H, Judge DP, Calkins H,: Risk stratification in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated desmosomal mutation carriers. Circ Arrhythm Electrophysiol 2013; 6: 569-578.
17. Corrado D, Basso C, Leoni L, Tokajuk B, Bauce B, Frigo G, Tarantini G, Napodano M, Turrini P, Ramondo A, Daliento L, Nava A, Buja G, Iliceto S, Thiene G,: Three-dimensional electroanatomic voltage mapping increases accuracy of diagnosing arrhythmogenic right ventricular cardiomyopathy/dysplasia. Circulation 2005; 111: 3042-3050.
18. Cox MG, Nelen MR, Wilde AA, Wiesfeld AC, van der Smagt JJ, Loh P, Cramer MJ, Doevendans PA, van Tintelen JP, de Bakker JM, Hauer RN,: Activation delay and VT parameters in arrhythmogenic right ventricular dysplasia/cardiomyopathy: Toward improvement of diagnostic ECG criteria. J Cardiovasc Electrophysiol 2008; 19: 775-781.
19. Durrer D, van Dam RT, Freud GE, Janse MJ, Meijler FL, Arzbaecher RC,: Total excitation of the isolated human heart. Circulation 1970; 41: 899-912.
20. De Boeck BW, Teske AJ, Leenders GE, Mohamed Hoesein FA, Loh P, van Driel VJ, Doevendans PA, Prinzen FW, Cramer MJ,: Detection and quantification by deformation imaging of the functional impact of septal compared to free wall preexcitation in the Wolff-Parkinson-White syndrome. Am J Cardiol 2010; 106: 539-546 e532.
21. Te Riele AS, James CA, Philips B, Rastegar N, Bhonsale A, Groeneweg JA, Murray B, Tichnell C, Judge DP, Van Der Heijden JF, Cramer MJ, Velthuis BK, Bluemke DA, Zimmerman SL, Kamel IR, Hauer RN, Calkins H, Tandri H,: Mutation-positive arrhyhmogenic right ventricular dysplasia/cardiomyopathy: The triangle of dysplasia displaced. J Cardiovasc Electrophysiol 2013; 24: 1311-1320.
22. Hamid MS, Norman M, Quraishi A, Firoozi S, Thaman R, Gimeno JR, Sachdev B, Rowland E, Elliott PM, McKenna WJ,: Prospective evaluation of relatives for familial arrhythmogenic right ventricular cardiomyopathy/dysplasia reveals a need to broaden diagnostic criteria. J Am Coll Cardiol 2002; 40: 1445-1450.
23. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ,: Recommendations for chamber quantification: A report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiog 2005; 18: 1440-1463.
24. Rudski LG, Lai WW, Afilalo J, Hua L, Handschumacher MD, Chandrasekaran K, Solomon SD, Louie EK, Schiller NB,: Guidelines for the echocardiographic assessment of the right heart in adults: A report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiog 2010; 23: 685-713.
25. Mast TP, Teske AJ, Doevendans PA, Cramer MJ,: Current and future role of echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Cardiol J 2015; 22: 362-374.
26. Teske AJ, De Boeck BW, Melman PG, Sieswerda GT, Doevendans PA, Cramer MJ,: Echocardiographic quantification of myocardial function using tissue deformation imaging, a guide to image acquisition and analysis using tissue Doppler and speckle tracking. Cardiovasc Ultrasound 2007; 5: 27.
27. Dalal D, Tandri H, Judge DP, Amat N, Macedo R, Jain R, Tichnell C, Daly A, James C, Russell SD, Abraham T, Bluemke DA, Calkins H,: Morphologic variants of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy a genetics-magnetic resonance imaging correlation study. J Am Coll Cardiol 2009; 53: 1289-1299.
28. Prinzen FW, Augustijn CH, Allessie MA, Arts T, Delhaas T, Reneman RS,: The time sequence of electrical and mechanical activation during spontaneous beating and ectopic stimulation. Eur Heart J 1992; 13: 535-543.
29. Wyman BT, Hunter WC, Prinzen FW, McVeigh ER,: Mapping propagation of mechanical activation in the paced heart with MRI tagging. Am J Physiol 1999; 276: H881-H891.
30. Russell K, Opdahl A, Remme EW, Gjesdal O, Skulstad H, Kongsgaard E, Edvardsen T, Smiseth OA,: Evaluation of left ventricular dyssynchrony by onset of active myocardial force generation: A novel method that differentiates between electrical and mechanical etiologies. Circ Cardiovasc Imaging 2010; 3: 405-414.
31. Russell K, Smiseth OA, Gjesdal O, Qvigstad E, Norseng PA, Sjaastad I, Opdahl A, Skulstad H, Edvardsen T, Remme EW,: Mechanism of prolonged electromechanical delay in late activated myocardium during left bundle branch block. Am J Physiol Heart Circ Physiol 2011; 301: H2334-H2343.
32. Suever JD, Hartlage GR, Magrath RP, Iravanian S, Lloyd MS, Oshinski JN,: Relationship between mechanical dyssynchrony and intra-operative electrical delay times in patients undergoing cardiac resynchronization therapy. J Cardiovasc Magn Reson 2014; 16: 4.
33. Corrado D, Basso C, Leoni L, Tokajuk B, Turrini P, Bauce B, Migliore F, Pavei A, Tarantini G, Napodano M, Ramondo A, Buja G, Iliceto S, Thiene G,: Three-dimensional electroanatomical voltage mapping and histologic evaluation of myocardial substrate in right ventricular outflow tract tachycardia. J Am Coll Cardiol 2008; 51: 731-739.
34. te Riele AS, James CA, Rastegar N, Bhonsale A, Murray B, Tichnell C, Judge DP, Bluemke DA, Zimmerman SL, Kamel IR, Calkins H, Tandri H,: Yield of serial evaluation in at-risk family members of patients with ARVD/C. J Am Coll Cardiol 2014; 64: 293-301.
35. Hariharan V, Asimaki A, Michaelson JE, Plovie E, MacRae CA, Saffitz JE, Huang H,: Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion. Cardiovasc Res 2014; 104: 280-289.
36. Bhonsale A, James CA, Tichnell C, Murray B, Gagarin D, Philips B, Dalal D, Tedford R, Russell SD, Abraham T, Tandri H, Judge DP, Calkins H,: Incidence and predictors of implantable cardioverter-defibrillator therapy in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy undergoing implantable cardioverter-defibrillator implantation for primary prevention. J Am Coll Cardiol 2011; 58: 1485-1496.
37. Sarvari SI, Haugaa KH, Anfinsen OG, Leren TP, Smiseth OA, Kongsgaard E, Amlie JP, Edvardsen T,: Right ventricular mechanical dispersion is related to malignant arrhythmias: A study of patients with arrhythmogenic right ventricular cardiomyopathy and subclinical right ventricular dysfunction. Eur Heart J 2011; 32: 1089-1096.
38. van Tintelen JP, Entius MM, Bhuiyan ZA, Jongbloed R, Wiesfeld AC, Wilde AA, van der Smagt J, Boven LG, Mannens MM, van Langen IM, Hofstra RM, Otterspoor LC, Doevendans PA, Rodriguez LM, van Gelder IC, Hauer RN,: Plakophilin-2 mutations are the major determinant of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circulation 2006; 113: 1650-1658.
39. Borgquist R, Haugaa KH, Gilljam T, Bundgaard H, Hansen J, Eschen O, Jensen HK, Holst AG, Edvardsen T, Svendsen JH, Platonov PG,: The diagnostic performance of imaging methods in ARVC using the 2010 Task Force criteria. Eur Heart J Cardiovasc Imaging 2014; 15: 1219-1225.
40. Mast TP, Teske AJ, Vd Heijden JF, Groeneweg JA, Te Riele AS, Velthuis BK, Hauer RN, Doevendans PA, Cramer MJ,: Left ventricular involvement in arrhythmogenic right ventricular dysplasia/cardiomyopathy assessed by echocardiography predicts adverse clinical outcome. J Am Soc Echocardiogr 2015; 28: 1103-1113.