The association of medication-use and frailty-related factors with gait performance in older patients

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  De Groot, Maartje H ^a,b   Van Campen, Jos P C M ^a   Kosse, Nienke M ^c,d   De Vries, Oscar J ^e   Beijnen, Jos H ^a,f   Lamoth, Claudine J C ^c  

^a MC Slotervaart ^*  (Netherlands)

^b THE HAGUE UNIVERSITY OF APPLIED SCIENCES   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d CNRS   (France)

^e ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

^f UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

LAXATIVE; PSYCHOTROPIC AGENT;

ACCELERATION; AGED; ARTICLE; ASSESSMENT OF HUMANS; CHARLSON COMORBIDITY INDEX; COMORBIDITY; COMPREHENSIVE GERIATRIC ASSESSMENT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DRUG USE; EXHAUSTION; FEMALE; FRAILTY RELATED FACTOR; GAIT; GAIT DISORDER; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN STRIDE TIME; MINI MENTAL STATE EXAMINATION; MUSCULOSKELETAL SYSTEM PARAMETERS; POLYPHARMACY; RISK FACTOR; SELF REPORT; SEX DIFFERENCE; STATISTICAL MODEL; STEP CONSISTENCY; TASK PERFORMANCE; TIME SERIES ANALYSIS; TRUNK ACCELERATION; UNINTENTIONAL WEIGHT LOSS; VERY ELDERLY; WALKING; WALKING SPEED; WEIGHT REDUCTION; AGE; DRUG EFFECTS; FRAIL ELDERLY; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; STATISTICS AND NUMERICAL DATA;

AGE FACTORS; AGED; AGED, 80 AND OVER; FEMALE; FRAIL ELDERLY; GAIT; HUMANS; MALE; PSYCHOMOTOR PERFORMANCE; PSYCHOTROPIC DRUGS; WALKING;

EID: 84960533296     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0149888     Document Type: Article

References (46)

1. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56: M146-M156. doi: 10.1093/gerona/56. 3.M146 PMID: 11253156
2. de Vries OJ, Peeters GMEE, Lips P, Deeg DJH. Does frailty predict increased risk of falls and fractures? A prospective population-based study. Osteoporos Int. 2013; 24: 2397-2403. PMID: 23430104
3. American Geriatrics Society, British Geriatrics Society, American Academy of Orthopaedic Surgeons Panel on Falls Prevention. Guideline for the prevention of falls in older persons. J Am Geriatr Soc. 2001; 49: 664-672. doi: 10.1046/j.1532-5415.2001.49115.x PMID: 11380764
4. Ham AC, Swart KMA, Enneman AW, van Dijk SC, Oliai Araghi S, van Wijngaarden JP, et al. Medication-related fall incidents in an older, ambulant population: The B-PROOF study. Drugs Aging. 2014; 31: 917-927. doi: 10.1007/s40266-014-0225-x PMID: 25398701
5. Bloch F, Thibaud M, Dugué B, Brèque C, Rigaud A-S, Kemoun G. Psychotropic drugs and falls in the elderly people: updated literature review and meta-analysis. J Aging Health. 2011; 23: 329-346. doi: 10.1177/0898264310381277 PMID: 20947876
6. Woolcott JC, Richardson KJ, Wiens MO, Patel B, Marin J, Khan KM, et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med. 2009; 169: 1952-1960. doi: 10.1001/archinternmed.2009.357 PMID: 19933955
7. Hartikainen S, Lönnroos E, Louhivuori K. Medication as a risk factor for falls: critical systematic review. J Gerontol A Biol Sci Med Sci. 2007; 62: 1172-1181. PMID: 17921433
8. de Groot MH, van Campen JPCM, Moek MA, Tulner LR, Beijnen JH, Lamoth CJC. The effects of fallrisk-increasing drugs on postural control: a literature review. Drugs Aging. 2013; 30: 901-920. doi: 10.1007/s40266-013-0113-9 PMID: 24005984
9. Ganz DA, Bao Y, Shekelle PG, Rubenstein LZ. Will my patient fall? JAMA. 2007; 297: 77-86. doi: 10.1001/jama.297.1.77 PMID: 17200478
10. Abellan van Kan G, Rolland Y, Andrieu S, Bauer JM, Beauchet O, Bonnefoy M, et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people. An International Academy on Nutrition and Aging (IANA) task force. J Nutr Heal Aging. 2009; 13: 881-889. doi: 10.1007/s12603-009-0246-z
11. Lamoth CJC, van Deudekom FJ, van Campen JPCM, Appels BA, de Vries OJ, Pijnappels M. Gait stability and variability measures show effects of impaired cognition and dual tasking in frail people. J Neuroeng Rehabil. 2011; 8: 2. doi: 10.1186/1743-0003-8-2 PMID: 21241487
12. Ijmker T, Lamoth CJC. Gait and cognition: the relationship between gait stability and variability with executive function in persons with and without dementia. Gait Posture. 2012; 35: 126-130. doi: 10.1016/j.gaitpost.2011.08.022 PMID: 21964053
13. Hamacher D, Singh NB, Van Dieen JH, Heller MO, Taylor WR. Kinematic measures for assessing gait stability in elderly individuals: a systematic review. J R Soc Interface. 2011; 8: 1682-1698. doi: 10.1098/rsif.2011.0416 PMID: 21880615
14. Menant JC, Schoene D, Lord SR. Single and dual task tests of gait speed are equivalent in the prediction of falls in older people: A systematic review and meta-analysis. Ageing Res Rev. 2014; doi: 10.1016/j.arr.2014.06.001
15. Montero-Odasso M, Muir SW, Hall M, Doherty TJ, Kloseck M, Beauchet O, et al. Gait variability is associated with frailty in community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2011; 66A: 568-576. doi: 10.1093/gerona/glr007
16. de Groot MH, van der Jagt-Willems HC, van Campen JPCM, Lems WF, Beijnen JH, Lamoth CJC. A flexed posture in elderly patients is associated with impairments in postural control during walking. Gait Posture. 2014; 39: 767-772. doi: 10.1016/j.gaitpost.2013.10.015 PMID: 24268470
17. Ellis G, Langhorne P. Comprehensive geriatric assessment for older hospital patients. Br Med Bull. 2004; 71: 45-59. doi: 10.1093/bmb/ldh033 PMID: 15684245
18. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12: 189-198. doi: 10.1016/0022-3956(75) 90026-6 PMID: 1202204
19. Tombaugh TN, McIntyre NJ. The Mini-Mental State Examination: A comprehensive review. J Am Geriatr Soc. 1992; 40: 922-935. doi: 10.1111/j.1532-5415.1992.tb01992.x PMID: 1512391
20. Pluijm SMF, Smit JH, Tromp EAM, Stel VS, Deeg DJH, Bouter LM, et al. A risk profile for identifying community-dwelling elderly with a high risk of recurrent falling: results of a 3-year prospective study. Osteoporos Int. 2006; 17: 417-425. doi: 10.1007/s00198-005-0002-0 PMID: 16416256
21. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987; 40: 373-383. doi: 10.1016/0021-9681(87)90171-8 PMID: 3558716
22. Eriksson L, Johansson E, Kettaneh-Wold N, Trygg J, Wikström C, Wold S. Multi- and megavariate data analysis. Part I-Basic principles and applications. Umea, Sweden: Umetrics; 2006.
23. WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment 2013. Oslo, Norway: Norwegian Institute of Public Health; 2012.
24. Roerdink M, Lamoth CJC, Kwakkel G, van Wieringen PCW, Beek PJ. Gait coordination after stroke: benefits of acoustically paced treadmill walking. Phys Ther. 2007; 87: 1009-1022. doi: 10.2522/ptj. 20050394 PMID: 17553922
25. Plotnik M, Giladi N, Hausdorff JM. A new measure for quantifying the bilateral coordination of human gait: effects of aging and Parkinson's disease. Exp Brain Res. 2007; 181: 561-570. doi: 10.1007/s00221-007-0955-7 PMID: 17503027
26. Wold H. Estimation of principal components and related models by iterative least squares. In: Krishnaiah PR, editor. Multivariate Analysis. New York, NY, USA: Academic Press; 1966. pp. 391-420.
27. Haenlein M, Kaplan AM. A beginner's guide to Partial Least Squares Analysis. Underst Stat. 2004; 3: 283-297. doi: 10.1207/s15328031us0304-4
28. Boulesteix A-L, Strimmer K. Partial least squares: a versatile tool for the analysis of high-dimensional genomic data. Brief Bioinform. 2007; 8: 32-44. doi: 10.1093/bib/bbl016 PMID: 16772269
29. Kosse NM, de Groot MH, Vuillerme N, Hortobágyi T, Lamoth CJC. Factors related to the high fall rate in long-term care residents with dementia. Int Psychogeriatrics. 2015; 27: 803-814. doi: 10.1017/S104161021400249X
30. Marzetti E, Lees HA, Manini TM, Buford TW, Aranda JM, Calvani R, et al. Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study. PLoS ONE. 2012; 7: e32829. doi: 10.1371/journal.pone.0032829 PMID: 22389725
31. Eriksson S, Gustafson Y, Lundin-Olsson L. Risk factors for falls in people with and without a diagnose of dementia living in residential care facilities: a prospective study. Arch Gerontol Geriatr. 2008; 46: 293-306. doi: 10.1016/j.archger.2007.05.002 PMID: 17602762
32. Beauchet O, Annweiler C, Lecordroch Y, Allali G, Dubost V, Herrmann FR, et al. Walking speed-related changes in stride time variability: effects of decreased speed. J Neuroeng Rehabil. 2009; 6: 32. doi: 10.1186/1743-0003-6-32 PMID: 19656364
33. Kang HG, Dingwell JB. Separating the effects of age and walking speed on gait variability. Gait Posture. 2008; 27: 572-577. doi: 10.1016/j.gaitpost.2007.07.009 PMID: 17768055
34. Allali G, Ayers EI, Verghese J. Multiple modes of assessment of gait are better than one to predict incident falls. Arch Gerontol Geriatr. 2015; 60: 389-393. doi: 10.1016/j.archger.2015.02.009 PMID: 25772422
35. Wold S, Sjöström M, Eriksson L. PLS-regression: a basic tool of chemometrics. Chemom Intell Lab Syst. 2001; 58: 109-30. doi: 10.1016/S0169-7439(01)00155-1
36. Abdi H. Partial least squares regression and projection on latent structure regression (PLS regression). WIREs Comp Stat. 2010; 2: 97-106.
37. Sturnieks DL, St George R, Lord SR. Balance disorders in the elderly. Clin Neurophysiol. 2008; 38: 467-478. doi: 10.1016/j.neucli.2008.09.001
38. Papegaaij S, Taube W, Baudry S, Otten E, Hortobágyi T. Aging causes a reorganization of cortical and spinal control of posture. Front Aging Neurosci. 2014; 6: 28. doi: 10.3389/fnagi.2014.00028 PMID: 24624082
39. Schwenk M, Howe C, Saleh A, Mohler J, Grewal G, Armstrong D, et al. Frailty and technology: a systematic review of gait analysis in those with frailty. Gerontology. 2014; 60: 79-89. doi: 10.1159/000354211 PMID: 23949441
40. Lader M, Tylee A, Donoghue J. Withdrawing benzodiazepines in primary care. CNS Drugs. 2009; 23: 19-34. doi: 10.2165/0023210-200923010-00002 PMID: 19062773
41. Wald A. Constipation in elderly patients. Pathogenesis and management. Drugs Aging. 1993; 3: 220-231. doi: 10.2165/00002512-199303030-00003 PMID: 8324297
42. Teramura-Grönblad M, Hosia-Randell H, Muurinen S, Pitkala K. Use of proton-pump inhibitors and their associated risks among frail elderly nursing home residents. Scand J Prim Health Care. 2010; 28: 154-159. doi: 10.3109/02813432.2010.493315 PMID: 20586539
43. Askari M, Eslami S, Scheffer AC, Medlock S, de Rooij SE, van der Velde N, et al. Different risk-increasing drugs in recurrent versus single fallers: are recurrent fallers a distinct population? Drugs Aging. 2013; 30: 845-851. doi: 10.1007/s40266-013-0110-z PMID: 23959914
44. Mouli VP, Ahuja V. Proton pump inhibitors: concerns over prolonged use. Trop Gastroenterol. 2011; 32: 175-84. PMID: 22332332
45. Kwok CS, Yeong JK-Y, Loke YK. Meta-analysis: risk of fractures with acid-suppressing medication. Bone. 2011; 48: 768-776. doi: 10.1016/j.bone.2010.12.015 PMID: 21185417
46. Lewis JR, Barre D, Zhu K, Ivey KL, Lim EEM, Hughes J, et al. Long-term proton-pump inhibitor therapy and falls and fractures in elderly women: a prospective cohort study. J Bone Miner Res. 2014; 29: 2489-2497. doi: 10.1002/jbmr.2279 PMID: 24825180