Analysis of the conservation of T cell receptor alpha and beta chain variable regions gene in pp65 peptide-specific HLA-A*0201-restricted CD8+ T cells

Cellular and Molecular Immunology

Volumn 6, Issue 2, 2009, Pages 105-110

  Luo, Wei ^a   Ma, Li ^a   Wen, Qian ^a   Zhou, Mingqian ^a   Wang, Xiaoning ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

CDR3; CMV; CTL; pp65 peptide; TCR

Indexed keywords

CYTOMEGALOVIRUS ANTIGEN PP65; HLA A ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; ALANINE; CD8 ANTIGEN; GLYCINE; LEUCINE; PEPTIDE; CYTOMEGALOVIRUS MATRIX PROTEIN 65KDA; HLA A*0201 ANTIGEN; HLA-A*0201 ANTIGEN; MATRIX PROTEIN; PHOSPHOPROTEIN; T LYMPHOCYTE RECEPTOR;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CD8+ T LYMPHOCYTE; CELL ISOLATION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; FEMALE; GENETIC CONSERVATION; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN MOTIF; T LYMPHOCYTE RECEPTOR GENE; ANTIGEN SPECIFICITY; GENETIC VARIABILITY; LYMPHOCYTE COUNT; MULTIGENE FAMILY; PROTEIN FAMILY; SEQUENCE HOMOLOGY; T LYMPHOCYTE ACTIVATION; CHEMISTRY; CYTOMEGALOVIRUS; DNA SEQUENCE; GENETICS; IMMUNOLOGY; METABOLISM; PROTEIN BINDING;

CYTOMEGALOVIRUS;

ADULT; AMINO ACID MOTIFS; COMPLEMENTARITY DETERMINING REGIONS; CYTOMEGALOVIRUS; FEMALE; GENES, T-CELL RECEPTOR ALPHA; GENES, T-CELL RECEPTOR BETA; HLA-A ANTIGENS; HUMANS; MALE; PEPTIDES; PHOSPHOPROTEINS; PROTEIN BINDING; SEQUENCE ANALYSIS, DNA; T-CELL ANTIGEN RECEPTOR SPECIFICITY; VIRAL MATRIX PROTEINS;

EID: 68549092730     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2009.14     Document Type: Article

References (13)

1. Egli A, Binet I, Binggeli S, et al. Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients. J Transl Med. 2008;6:29. (Pubitemid 351891438)
2. Holtappels R, Simon CO, Munks MW, et al. Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination. J Virol. 2008;82:5781-5796. (Pubitemid 351822253)
3. Peggs K, Verfuerth S, Mackinnon S. Induction of cytomegalovirus (CMV)-specific T-cell responses using dendritic cells pulsed with CMV antigen: a novel culture system free of live CMV virions. Blood. 2001;97:994-1000. (Pubitemid 32154284)
4. Einsele H, Roosnek E, Rufer N, et al. Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood. 2002;99:3916-3922. (Pubitemid 35332029)
5. Ruan GP, Ma L, Wen Q, Luo W, Zhou MQ, Wang XN. A modified peptides stimulation method for efficient amplification of cytomegalovirus (CMV)-specific CTLs. Cell Mol Immunol. 2008;5:197-201.
6. Assaf C, Hummel M, Dippel E, et al. High detection rate of T-cell receptor β chain rearrangements in T-cell lymphoproliferations by family specific polymerase chain reaction in combination with the GeneScan technique and DNA sequencing. Blood. 2000;96:640-646. (Pubitemid 30463386)
7. Luo W, Ma L, Wen Q, Wang N, Zhou MQ, Wang XN. Analysis of the interindividual conservation of T cell receptor alpha- and β-chain variable regions gene in the peripheral blood of patients with systemic lupus erythematosus. Clin Exp Immunol. 2008;154:316-324.
8. + T cell repertoire focusing and selection of high-affinity clones into memory following primary infection with a persistent human virus: human cytomegalovirus. J Immunol. 2007;179:3203-3213.
9. + T cell responses to cytomegalovirus and EBV. J Immunol. 2008;181:7853-7862.
10. Crompton L, Khan N, Khanna R, Nayak L, Moss PA. CD4+ T cells specific for glycoprotein B from cytomegalovirus exhibit extreme conservation of T-cell receptor usage between different individuals. Blood. 2008;111:2053-2061.
11. Brennan RM, Miles JJ, Silins SL, Bell MJ, Burrows JM, Burrows SR. Predictable αβ T-cell receptor selection toward an HLA-B*3501-restricted human cytomegalovirus epitope. J Virol. 2007;81:7269-7273.
12. Einsele H, Kapp M, Grigoleit GU. CMV-specific T cell therapy. Blood Cells Mol Dis. 2008;40:71-75.
13. Carlsson B, Cheng WS, Totterman TH, Essand M. Ex vivo stimulation of cytomegalovirus (CMV)-specific T cells using CMV pp65-modified dendritic cells as stimulators. Br J Haematol. 2003;121:428-438.