Chemotherapeutic efficiency of drugs in vitro: Comparison of doxorubicin exposure in 3D and 2D culture matrices

Toxicology in Vitro

Volumn 33, Issue , 2016, Pages 99-104

  Casey, A ^a   Gargotti, M ^a   Bonnier, F ^b   Byrne, H J ^a  

^a DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^b UNIVERSITÉ DE TOURS   (France)

Author keywords

3D matrices; Collagen I; Confocal microscopy; Doxorubicin; In vitro screening

Indexed keywords

COLLAGEN GEL; DOXORUBICIN; ANTINEOPLASTIC AGENT;

ARTICLE; CANCER CHEMOTHERAPY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG UPTAKE; FEMALE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; REPRODUCIBILITY; CELL CULTURE TECHNIQUE; CELL SURVIVAL; COMPARATIVE STUDY; DRUG EFFECTS; HELA CELL LINE; PROCEDURES;

ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; DOXORUBICIN; HELA CELLS; HUMANS;

EID: 84960443544     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2016.02.022     Document Type: Article

References (22)

1. Black J.W., Leff P. Operational models of pharmacological agonism. Proc. R. Soc. Lond. Ser. B Biol. Sci. 1983, 220(1219):141-162. (Dec. 22).
2. Bonnier F., Keating M., Wróbel T.P., Majzner K., Baranska M., Garcia-Munoz A., Blanco A., Byrne H.J. Cell viability assessment using the Alamar blue assay: a comparison of 2D and 3D cell culture. Toxicol. in Vitro 2015, 29(1):124-131.
3. Breslin S., O'Driscoll L. 3-Dimensional cell culture: the missing link in drug discovery. Drug Discov. Today 2013, 18(5-6):240-249.
4. Brown Robert A. In the beginning there were soft collagen-cell gels: towards better 3D connective tissue models?. Exp. Cell Res. 2013, 319(16):2460-2469. (1 October).
5. Casey A., Herzog E., Davoren M., Lyng F.M., Byrne H.J., Chambers G. Spectroscopic analysis confirms the interactions between single walled carbon nanotubes and various dyes commonly used to assess cytotoxicity. Carbon 2007, 45(7):1425-1432.
6. Casey A., Herzog E., Lyng F.M., Byrne H.J., Chambers G., Davoren M. Single walled carbon nanotubes induce indirect cytotoxicity by medium depletion in A549 lung. Toxicol. Lett. 2008, 179(2):78-84. (30).
7. Chen S., Nakamoto T., Kawazoe N., Chen G. Engineering multi-layered skeletal muscle tissue by using 3D microgrooved collagen scaffolds. Biomaterials 2015, 73:23-31.
8. Davoren M., Herzog E., Casey A., Cottineau B., Chambers G., Byrne H.J., Lyng F.M. Toxicology in vitro. In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells 2006, 21:438-448.
9. Elliott N.T., Yuan F. A review of three-dimensional in vitro tissue models for drug discovery and transport studies. J. Pharm. Sci. 2011, 100:59-74.
10. European Union - Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010.
11. Farhane Z., Bonnier F., Casey A., Byrne H.J. Raman micro spectroscopy for in vitro drug screening: subcellular localisation and interactions of doxorubicin. Analyst 2015, 140(12):4212-4223.
12. Fourre N., Millerot-Serrurot E., Garnotel R., Zahm J.M., Bonnet N., Millot J.M., Jeannesson P. Extracellular matrix proteins protect human HT1080 cells against the antimigratory effect of doxorubicin. Cancer Sci. 2008, 99:1699-1705.
13. Harisi R., Dudas J., Nagy-Olah J., Timar F., Szendroi M., Jeney A. Extracellular matrix induces doxorubicin-resistance in human osteosarcoma cells by suppression of p53 function. Cancer Biol. Ther. 2007, 6:1240-1246.
14. Kimlin L.C., Casagrande G., Virador V.M. In vitro three-dimensional (3D) models in cancer research: an update. Mol. Carcinog. 2011.
15. Maher M.A., Naha P.C., Mukerjee S.P., Byrne H.J. Numerical simulations of in vitro nanoparticle toxicity - the case of poly(amido amine) dendrimers. Toxicol. in Vitro 2014, 28:1449-1460.
16. Petersen O.W., Ronnov-Jessen L., Howlett A.R., Bissell M.J. Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 1992 Oct, 89(19):19064-19068.
17. Prestwich G.D. Evaluating drug toxicity and efficacy in three dimensions: Using synthetic extracellular matrices in drug discovery. Acc. Chem. Res. 2008, 41:139-148.
18. Russell W.M.S., Burch R.L. The Principles of Humane Experimental Technique 1959, Methuen, London, (ISBN 0900767782).
19. Sowa M.B., Chrisler W.B., Zens K.D., Ashjian E.J., Opresko L.K. Three-dimensional culture conditions lead to decreased radiation induced cytotoxicity in human mammary epithelial cells. Mutat. Res. 2010, 687:78-83.
20. United States 106th Congress Public Law 106-545 2000, (Dec. 19).
21. Wang F., Weaver V.M., Petersen O.W., Larabell C.A., Dedhar S., Briand P., Lupu R., Bissell M.J. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:14821-14826.
22. Weaver V.M., Howlett A.R., Langton-Webster B., Petersen O.W., Bissell M.J. The development of a functionally relevant cell culture model of progressive human breast cancer. Semin. Cancer Biol. 1995, 6(3):175-184.