Human pegivirus detected in a patient with severe encephalitis using a metagenomic pan-virus array

Journal of Clinical Virology

Volumn 77, Issue , 2016, Pages 5-8

  Fridholm, Helena ^a   Østergaard Sørensen, Line ^b   Rosenstierne, Maiken W ^a   Nielsen, Henrik ^b   Sellebjerg, Finn ^d   Bengård Andersen, Åse ^c   Fomsgaard, Anders ^a,c  

^a STATENS SERUM INSTITUT   (Denmark)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Encephalitis; HPgV; Metagenomics; Microarray

Indexed keywords

ACICLOVIR; DEXAMETHASONE; GENOMIC RNA; MEROPENEM; METHYLPREDNISOLONE; PREDNISOLONE;

ABDOMINAL PAIN; ADULT; ARTICLE; ATAXIA; BACTERIAL INFECTION; BEHAVIOR CHANGE; BLOOD SAMPLING; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; CHOLECYSTECTOMY; CLINICAL EXAMINATION; COMA; DIPLOPIA; DIZZINESS; FEMALE; FEVER; FLAVIVIRUS; HEADACHE; HOSPITAL ADMISSION; HUMAN; HUMAN PEGIVIRUS; LABORATORY TEST; LAPAROSCOPY; LEG PAIN; MENINGOENCEPHALITIS; MENTAL DETERIORATION; METAGENOMICS; MICROARRAY ANALYSIS; PAN VIRUS ARRAY; PHOTOSENSITIVITY; PHYSICAL EXAMINATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SOMNOLENCE; VIRUS DETECTION; VIRUS ENCEPHALITIS; VOMITING; CLASSIFICATION; ENCEPHALITIS, VIRAL; FLAVIVIRIDAE; GENETICS; PROCEDURES; REAL TIME POLYMERASE CHAIN REACTION; SEROLOGY; VIROLOGY;

ADULT; ENCEPHALITIS, VIRAL; FEMALE; FLAVIVIRIDAE; HUMANS; METAGENOMICS; REAL-TIME POLYMERASE CHAIN REACTION; SEROLOGIC TESTS;

EID: 84960439106     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2016.01.013     Document Type: Article

References (29)

1. Kriesel J.D., Hobbs M.R., Jones B.B., Milash B., Nagra R.M., Fischer K.F. Deep sequencing for the detection of virus-like sequences in the brains of patients with multiple sclerosis: detection of GBV-C in human brain. PLoS One 2012, 7:e31886. 10.1371/journal.pone.0031886.
2. Bhattarai N., Stapleton J.T. GB virus C: the good boy virus?. Trends Microbiol. 2012, 20:124-130. 10.1016/j.tim.2012.01.004.
3. Gómara M.J., Fernández L., Pérez T., Tenckhoff S., Casanovas A., Tillmann H.L., et al. Diagnostic value of anti-GBV-C antibodies in HIV-infected patients. Chem. Biol. Drug Design 2011, 78:277-282. 10.1111/j.1747-0285.2011.01143.x.
4. Lauck M., Bailey A.L., Andersen K.G., Goldberg T.L., Sabeti P.C., O'Connor D.H. GB virus C coinfections in West African Ebola patients. J. Virol. 2015, 89:2425-2429. 10.1128/JVI.02752-14.
5. Vahidnia F., Petersen M., Stapleton J.T., Rutherford G.W., Busch M., Custer B. Acquisition of GB virus type C and lower mortality in patients with advanced HIV disease. Clin. Infect. Dis. 2012, 55:1012-1019. 10.1093/cid/cis589.
6. Rosenstierne M.W., McLoughlin K.S., Olesen M.L., Papa A., Gardner S.N., Engler O., et al. The microbial detection array for detection of emerging viruses in clinical samples-a useful panmicrobial diagnostic tool. PLoS One 2014, 9:e100813. 10.1371/journal.pone.0100813.
7. Gardner S.N., Jaing C.J., McLoughlin K.S., Slezak T.R. A microbial detection array (MDA) for viral and bacterial detection. BMC Genomics 2010, 11:668. 10.1186/1471-2164-11-668.
8. Compston L.I., Sarkobie F., Li C., Candotti D., Opare-Sem O., Allain J.-P. Multiplex real-time PCR for the detection and quantification of latent and persistent viral genomes in cellular or plasma blood fractions. J. Virol. Methods 2008, 151:47-54. 10.1016/j.jviromet.2008.03.023.
9. Björkman P., Sundström G., Widell A. Hepatitis C virus and GB virus C/hepatitis G virus viremia in Swedish blood donors with different alanine aminotransferase levels. Transfusion 1998, 38:378-384.
10. Neibecker M., Schwarze-Zander C., Rockstroh J.K., Spengler U., Blackard J.T. Evidence for extensive genotypic diversity and recombination of GB virus C (GBV-C) in Germany. J. Med. Virol. 2011, 83:685-694. 10.1002/jmv.22029.
11. Stapleton J.T., Foung S., Muerhoff A.S., Bukh J., Simmonds P. The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae. J. Gen. Virol. 2011, 92:233-246. 10.1099/vir.0.027490-0.
12. Alter H.J. G-pers creepers, where'd you get those papers? A reassessment of the literature on the hepatitis G virus. Transfusion 1997, 37:569-572.
13. Jones J.F., Kulkarni P.S., Butera S.T., Reeves W.C. GB virus-C-a virus without a disease: we cannot give it chronic fatigue syndrome. BMC Infect. Dis. 2005, 5(78). 10.1186/1471-2334-5-78.
14. Radkowski M., Przyjalkowski W., Lipowski D., Wang L.F., Laskus T. Lack of GB virus C/hepatitis G virus sequences in cerebrospinal fluid in patients with central nervous system infections. Scand. J. Infect. Dis. 1998, 30:539.
15. Björkman P., Nauclér A., Winqvist N., Mushahwar I., Widell A. A case-control study of transmission routes for GB virus C/hepatitis G virus in Swedish blood donors lacking markers for hepatitis C virus infection. Vox Sang. 2001, 81:148-153.
16. Björkman P., Widell A., Veress B., Verbaan H., Hoffmann G., Elmståhl S., et al. GB virus C/hepatitis G virus infection in patients investigated for chronic liver disease and in the general population in southern Sweden. Scand. J. Infect. Dis. 2001, 33:611-617.
17. Nordbø S.A., Krokstad S., Winge P., Skjeldestad F.E., Dalen A.B. Prevalence of GB virus C (also called hepatitis G virus) markers in Norwegian blood donors. J. Clin. Microbiol. 2000, 38:2584-2590.
18. Gutierrez R.A., Dawson G.J., Knigge M.F., Melvin S.L., Heynen C.A., Kyrk C.R., et al. Seroprevalence of GB virus C and persistence of RNA and antibody. J. Med. Virol. 1997, 53:167-173. 10.1002/(SICI)1096-9071(199710)53:2<167:AID-JMV10>3.0.CO;2-G.
19. Stapleton J.T., Xiang J., McLinden J.H., Bhattarai N., Chivero E.T., Klinzman D., et al. A novel T cell evasion mechanism in persistent RNA virus infection. Trans. Am. Clin. Climatol. Assoc. 2014, 125:14-24. discussion 24-26.
20. Tacke M., Schmolke S., Schlueter V., Sauleda S., Esteban J.I., Tanaka E., et al. Humoral immune response to the E2 protein of hepatitis G virus is associated with long-term recovery from infection and reveals a high frequency of hepatitis G virus exposure among healthy blood donors. Hepatology 1997, 26:1626-1633. 10.1002/hep.510260635.
21. Christensen P.B., Fisker N., Mygind L.H., Krarup H.B., Wedderkopp N., Varming K., et al. GB Virus C epidemiology in denmark: different routes of transmission in children and low- and high-risk adults. J. Med. Virol. 2003, 70:156-162. 10.1002/jmv.10359.
22. Tacke M., Kiyosawa K., Stark K., Schlueter V., Ofenloch-Haehnle B., Hess G., et al. Detection of antibodies to a putative hepatitis G virus envelope protein. Lancet 1997, 349:318-320. 10.1016/S0140-6736(96)06461-6.
23. Hassoba H.M., Terrault N.A., el-Gohary A.M., Scheffel C., Jou C., Brackett J., et al. Antibody to GBV-C second envelope glycoprotein (anti-GBV-C E2): is it a marker for immunity?. J. Med. Virol. 1997, 53:354-360. 10.1002/(SICI)1096-9071(199712)53:4<354:AID-JMV7>3.0.CO;2-6.
24. Bourlet T., Guglielminotti C., Evrard M., Berthelot P., Grattard F., Frésard A., et al. Prevalence of GBV-C/hepatitis G virus RNA and E2 antibody among subjects infected with human immunodeficiency virus type 1 after parenteral or sexual exposure. J. Med. Virol. 1999, 58:373-377. 10.1002/(SICI)1096-9071(199908)58:4<373:AID-JMV9>3.0.CO;2-1.
25. Tucker T.J., Smuts H.E., Eedes C., Knobel G.D., Eickhaus P., Robson S.C., et al. Evidence that the GBV-C/Hepatitis G virus is primarily a lymphotropic virus. J. Med. Virol. 2000, 61:52-58. http://dx.doi.org/10.1002/(SICI)1096-9071(200005)61:1<52::AID-JMV8>3.0.CO;2-L.
26. Granerod J., Ambrose H.E., Davies N.W., Clewley J.P., Walsh A.L., Morgan D., et al. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect. Dis. 2010, 10:835-844. 10.1016/S1473-3099(10)70222-X.
27. Huppatz C., Durrheim D.N., Levi C., Dalton C., Williams D., Clements M.S., et al. Etiology of encephalitis in Australia 1990-2007. Emerg. Infect. Dis. 2009, 15:1359-1365. 10.3201/eid1509.081540.
28. Wilson M.R., Naccache S.N., Samayoa E., Biagtan M., Bashir H., Yu G., et al. Actionable diagnosis of neuroleptospirosis by next-generation sequencing. N. Engl. J. Med. 2014, 370:2408-2417. 10.1056/NEJMoa1401268.
29. Naccache S.N., Peggs K.S., Mattes F.M., Phadke R., Garson J.A., Grant P., et al. Diagnosis of neuroinvasive astrovirus infection in an immunocompromised adult with encephalitis by unbiased next-generation sequencing. Clin. Infect. Dis. 2015, 60:919-923. 10.1093/cid/ciu912.