Frailty markers and treatment decisions in patients seen in oncogeriatric clinics: Results from the ASRO pilot study

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Farcet, Anaïs ^a   De Decker, Laure ^b   Pauly, Vanessa ^c   Rousseau, Frédérique ^d   Bergman, Howard ^e   Molines, Catherine ^a   Retornaz, Frédérique ^a,c,f  

^a Centre Gerontologique Departemental   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d INSTITUT PAOLI CALMETTES   (France)

^e MCGILL UNIVERSITY   (Canada)

^f Unité de médecine interne Hôpital européen   (France)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR MARKER; BIOLOGICAL MARKER;

AGED; ARTICLE; CANCER CENTER; CANCER THERAPY; COGNITION; COMORBIDITY; COMPREHENSIVE GERIATRIC ASSESSMENT; CONTROLLED STUDY; ENERGY; FALLING; FEMALE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; GERIATRIC HOSPITAL; GRIP STRENGTH; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; MOOD; NUTRITION; ONCOLOGY; PALLIATIVE THERAPY; PATIENT AUTONOMY; PATIENT MOBILITY; PHYSICAL ACTIVITY; PILOT STUDY; SOCIAL STATUS; SOLID TUMOR; SOMATOSENSORY DISORDER; CLINICAL DECISION MAKING; METABOLISM; NEOPLASMS; OUTPATIENT DEPARTMENT; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; VERY ELDERLY;

AGED, 80 AND OVER; AMBULATORY CARE FACILITIES; BIOMARKERS; CLINICAL DECISION-MAKING; FEMALE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HUMANS; MALE; NEOPLASMS; PILOT PROJECTS; PROSPECTIVE STUDIES;

EID: 84960424208     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0149732     Document Type: Article

References (48)

1. Pal SK, Katheria V, Hurria A (2010) Evaluating the older patient with cancer: understanding frailty and the geriatric assessment. CA Cancer J Clin 60:120-32. doi: 10.3322/caac.20059 PMID: 20173172
2. Extermann M, Aapro M, Bernabei R, Cohen HJ, Droz JP, Litchman S et al. (2005) Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol 55:241-52. PMID: 16084735
3. Bernabei R, Venturiero V, Tarsitani P, Gambassi G (2000) The comprehensive geriatric assessment: when, where, how. Crit Rev Oncol Hematol 33:45-56. PMID: 10714961
4. Chen CC-H, Kenefick AL, Tang ST, McCorkile R (2004) Utilization of comprehensive geriatric assessment in cancer patients. Crit. Rev. Oncol Hematol 49:53-67. PMID: 14734155
5. Liu JJ, Extermann M (2012) Comprehensive geriatric assessment and its clinical impact in oncology. Clin Geriatr Med 28:19-31. doi: 10.1016/j.cger.2011.10.001 PMID: 22326033
6. Repetto L, Venturino A, Fratino, Serraino D, Troisi G, GianniWet al. (2003) Geriatric oncology: a clinical approach to the older patient with cancer. Eur J Cancer 39:870-80. PMID: 12706355
7. Puts MT, Hardt J, Monette J, Girre V, Springall E, Alibhai SM (2012) Use of geriatric assessment for older adults in the oncology setting: a systematic review. J Natl Cancer Inst 104:1133-63. doi: 10.1093/jnci/djs285 PMID: 22851269
8. Ferrucci L, Guralnik JM, Cavazzini C, Bandinelli S, Lautertani F, Bartali B et al. (2003) The frailty syndrome: a critical issue in geriatric oncology. Crit. Rev. Oncol Hematol 46:127-37. PMID: 12711358
9. Maas HA, Janssen-Heijnen ML, Olde Rikkert MG, Machteld Wymenga AN (2007) Comprehensive geriatric assessment and its clinical impact in oncology. Eur J Cancer 43:2161-9. PMID: 17855074
10. Aparicio T, Girard L, Bouarioua N, Patry C, Legrain S, Soule JC (2011) A mini geriatric assessment helps treatment decision in elderly patients with digestive cancer. A pilot study. Crit Rev Oncol Hematol 77:63-9. doi: 10.1016/j.critrevonc.2010.01.003 PMID: 20116276
11. Chaïbi P, Magné N, Breton S, Watson S, Duron JJ, Hannoun L et al. (2011) Influence of geriatric consultation with comprehensive geriatric assessment on final therapeutic decision in elderly cancer patients. Crit Rev Oncol Hematol. 79:302-7. doi: 10.1016/j.critrevonc.2010.08.004 PMID: 20888781
12. Girre V, Falcou MC, Gisselbrecht M, Gridel G, Mosseri V, Bouleuc C et al. (2008) Does a geriatric oncology consultation modify the cancer treatment plan for elderly patients? J Gerontol A Biol Sci Med Sci 63:724-30. PMID: 18693227
13. Barthelemy P, Heitz D, Mathelin C, Polesi H, Asmane I; Litique V et al. (2011) Adjuvant chemotherapy in elderly patients with early breast cancer. Impact of age and comprehensive geriatric assessment on tumor board proposals. Crit Rev Oncol Hematol 79:196-204. doi: 10.1016/j.critrevonc.2010.06.005 PMID: 20655243
14. Caillet P, Canoui-Poitrine F, Vouriot J, Berie M, Reinald N, Krypciak S et al. (2011) Comprehensive geriatric assessment in the decision-making process in elderly patients with cancer: ELCAPA study. J Clin Oncol 29:3636-42. doi: 10.1200/JCO.2010.31.0664 PMID: 21709194
15. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al. (2001) Frailty in older adults: evidence for a phenotype. J. Gerontol. A Biol Sci Med Sci 56:M146-56. PMID: 11253156
16. Bandeen-Roche K, Xue Q-L, Ferrucci L, Walston J, Guralnik JM, Chaves P et al. (2006) Phenotype of frailty: characterization in the women's health and aging studies. J. Gerontol. A Biol Sci Med 61:262-66.
17. Soubeyran P, Fonck M, Blanc-Bisson C, Blanc JF, Ceccaldi J, Mertens C et al. (2012) Predictors of Early Death Risk in Older Patients Treated With First-Line Chemotherapy for Cancer. J Clin Oncol 30:1829-34. doi: 10.1200/JCO.2011.35.7442 PMID: 22508806
18. Makary MA, Segev DL, Pronovost PJ, Syin D, Bandeen-Roche K, Patel P et al. (2010) Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg 210:901-8. doi: 10.1016/j.jamcollsurg. 2010.01.028 PMID: 20510798
19. Tan KY, Kawamura YJ, Tokomitsu A, Tang T (2012) Assessment for frailty is useful for predicting morbidity in elderly patients undergoing colorectal cancer resection whose comorbidities are already optimized. Am J Surg 204:139-43. doi: 10.1016/j.amjsurg.2011.08.012 PMID: 22178483
20. Retornaz F, Monette J, Batist G, Monette M, Sourial N, Small D et al. (2008) Usefulness of frailty markers in the assessment of the health and functional status of older cancer patients referred for chemotherapy: a pilot study. J. Gerontol. A Biol Sci Med Sci 63:518-22. PMID: 18511757
21. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden et al. (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5:649-55. PMID: 7165009
22. Katz S (1983) Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc 31:721-7. PMID: 6418786
23. Fillenbaum GG, Smyer MA (1981) The development, validity, and reliability of the OARS multidimensional functional assessment questionnaire. J Gerontol 36:428-34. PMID: 7252074
24. Retornaz F, Seux V, Sourial N, Braud AC, Monette J, Bergman H et al. (2007) Comparison of the health and functional status between older inpatients with and without cancer admitted to a geriatric/internal medicine unit. J. Gerontol. A Biol Sci Med Sci 62:917-22. PMID: 17702885
25. Falandry C, Weber B, Savoye AM, Tinquaut F, Tredan O, Sevin E et al. (2013) Development of a geriatric vulnerability score in elderly patients with advanced ovarian cancer treated with first-line carboplatin: a GINECO prospective trial. Ann Oncol 24:2808-13. doi: 10.1093/annonc/mdt360 PMID: 24061628
26. Folstein MF, Folstein SE, McMugh PR (1975) "Mini Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-98. PMID: 1202204
27. Borson S, Scanlan JM, Watanabe J, Tu SP, Lessig M (2005) Simplifying detection of cognitive impairment: comparison of the Mini-Cog and Mini-Mental State examination in a multiethnic sample. J Am Geriatric Soc 53:871-4.
28. Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I et al. (2005) The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53: 695-9. PMID: 15817019
29. Cahn DA, Salmon DP, Monsch AU, Butters N, Wiederholt WC, Corey-Bloom J et al. (1996) Screening for dementia of the Alzheimer type in the community: the utility of the Clock Drawing Test. Arch Clin Neuropsychol 11:529-39. PMID: 14588458
30. Sheikh JI, Yesavage JA (1986) Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version. Clinical Gerontology: A Guide to Assessment and Intervention. The Haworth Press 165-73.
31. Cook Z, Kirk S, Lawrenson S, Sandford S (2005) Use of BMI in the assessment of undernutrition in older subjects: reflecting on practice. Proc Nutr Soc 64:313-7. PMID: 16048662
32. Balducci L (2007) Aging, Frailty, and Chemotherapy. Cancer Control 14: 7-12 PMID: 17242666
33. Cornali C, Franzoni S, Frisoni GB, Trabucchi M (2005) Anorexia as an independent predictor of mortality. J Am Geriatr Soc 53:354-5. PMID: 15673368
34. Davis HS, MacPherson K, Merry HR, Wentzel C, Rockwood K (2001) Reliability and validity of questions about exercise in the Canadian Study of Health and Aging. Int Psychogeriatr 13 Supp 1:177-82.
35. Podsiadlo D, Richardson S (1991) The timed « Up & Go »: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39:142-8. PMID: 1991946
36. Vellas BJ, Wayne SJ, Romero L, Baumgartner RN, Rubenstein LZ, Garry PJ (1997) One-leg balance is an important predictor of injurious falls in older persons. J Am Geriatr Soc 45:735-8. PMID: 9180669
37. Repetto L, Venturino A, Vercelli M, Gianni W, Biancardi V, Casella C et al. (1998) Performance status and comorbidity in elderly cancer patients compared with young patients with neoplasia and elderly patients without neoplastic conditions. Cancer 82:760-5. PMID: 9477110
38. Retornaz F, Seux V, Sourial N, Braud AC, Monette J, Bergman H et al. (2007) Comparison of the health and functional status between older inpatients with and without cancer admitted to a geriatric/internal medicine unit. J Gerontol A Biol Sci Med Sci 62:917-22. PMID: 17702885
39. Kristjansson SR, Rønning B, Hurria A, Skovlund E, Jordhøy MS, Nesbakken A et al. (2012) A comparison of two pre-operative frailty measures in older surgical cancer patients. J Ger Oncol 3:1-7.
40. Retornaz F, Guillem O, Gholam D, Codoul JF, Brativesic C, Morvan F et al. (2014) Frailty markers predict 6-months mortality in first-line chemotherapy for colon cancer patients: results of MOST/ASRO 101 study. J Clin Oncol 32:5s (suppl; abstr 9553).
41. Boulahssass R, Mari V, Gonfrier S, Auben F, Rambaud C, Ferrero JM et al. (2014) Predictive factors of early death during 100 days after a comprehensive geriatric assessment in older patients with cancer: A prospective cohort study of 576 patients. J Clin Oncol 32:5s (suppl; abstr 9511).
42. Puts MTE, Monette J, Girre V, Pepe C, Monette M, Assouline S et al. (2011) Are frailty markers useful for predicting treatment toxicity and mortality in older newly diagnosed cancer patients? Results from a prospective pilot study. Crit Rev Oncol Hematol 78:138-49. doi: 10.1016/j.critrevonc.2010.04.003 PMID: 20444620
43. Guo CB, Zhang W, Ma DQ, Zhang KH Huang JQ (1996) Hand grip strength: an indicator of nutritional state and the mix of postoperative complications in patients with oral and maxillofacial cancers. Br J Oral Maxillofac Surg 34:325-7. PMID: 8866070
44. Kalfarentzos F, Spiliotis J, Velimezis G, Dougenis D, Androulakis J (1989) Comparison of forearm muscle dynamometry with nutritional prognostic index, as a preoperative indicator in cancer patients. JPEN J Parenter Enteral Nutr 13:34-6. PMID: 2926977
45. Bohannon RW (2008) Hand-grip dynamometry predicts future outcomes in aging adults. J Geriatr Phys Ther 31:3-10. PMID: 18489802
46. Balducci L (2013) Frailty: a common pathway in aging and cancer. Interdiscip Top Gerontol 38:61-72. doi: 10.1159/000343586 PMID: 23503516
47. Sourial N, Bergman H, Karunananthan S, Wolfson C, Payette H, Gutierrez-Robledo LM et al. (2013) Implementing frailty into clinical practice: a cautionary tale. J Gerontol A Biol Sci Med Sci 68: 1505-11. doi: 10.1093/gerona/glt053 PMID: 23640761
48. Rouge-Bugat ME, Gerard S, Balardy L, Beyne-Rauzy O, Boussier N, Perrin A et al. (2013) Impact of an oncogeriatric consulting team on therapeutic decision making. J Nutr Health Aging 17:473-8. doi: 10.1007/s12603-012-0435-z PMID: 23636550