Biomarkers of gut barrier failure in the ICU

Current Opinion in Critical Care

Volumn 22, Issue 2, 2016, Pages 152-160

  Piton, Gaël ^a,b,d   Capellier, Gilles ^a,b,c  

^a UNIVERSITY HOSPITAL OF BESANÇON   (France)

^b UNIVERSITÉ DE FRANCHE COMTÉ   (France)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY HOSPITAL JEAN MINJOZ   (France)

Author keywords

citrulline; critically ill; enterocyte; gut barrier; intestinal fatty acid binding protein

Indexed keywords

BIOLOGICAL MARKER; CITRULLINE; FATTY ACID BINDING PROTEIN 2; FABP2 PROTEIN, HUMAN; FATTY ACID BINDING PROTEIN;

ARTICLE; BACTERIAL TRANSLOCATION; CRITICALLY ILL PATIENT; GUT BARRIER FAILURE; HUMAN; INFLAMMATION; INTENSIVE CARE; INTENSIVIST; INTESTINE CELL; INTESTINE INJURY; MALABSORPTION; PATHOPHYSIOLOGY; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; ADVERSE EFFECTS; CRITICAL ILLNESS; ENTERIC FEEDING; ENTEROPATHY; IMMUNOLOGY; INTENSIVE CARE UNIT; METABOLISM; MULTIPLE ORGAN FAILURE; PROGNOSIS; SEPSIS;

BIOMARKERS; CRITICAL CARE; CRITICAL ILLNESS; ENTERAL NUTRITION; ENTEROCYTES; FATTY ACID-BINDING PROTEINS; HUMANS; INFLAMMATION; INTENSIVE CARE UNITS; INTESTINAL DISEASES; MULTIPLE ORGAN FAILURE; PROGNOSIS; SEPSIS;

EID: 84960418959     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/MCC.0000000000000283     Document Type: Article

References (58)

1. Deitch EA. Multiple organ failure. Pathophysiology and potential future therapy. Ann Surg 1992; 216:117-134.
2. Fiddian-Green RG. Splanchnic ischaemia and multiple organ failure in the critically ill. Ann R Coll Surg Engl 1988; 70:128-134.
3. Crawley SW, Mooseker MS, Tyska MJ. Shaping the intestinal brush border. J Cell Biol 2014; 207:441-451.
4. Vollmar B, Menger MD. Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences. Langenbecks Arch Surg Dtsch Ges Für Chir 2011; 396:13-29.
5. Thomson AB, Cheeseman CI, Keelan M, et al. Crypt cell production rate, enterocyte turnover time and appearance of transport along the jejunal villus of the rat. Biochim Biophys Acta 1994; 1191:197-204.
6. Odenwald MA, Turner JR. Intestinal permeability defects: is it time to treat? Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 2013; 11:1075-1083.
7. Johansson MEV, Sjövall H, Hansson GC. The gastrointestinal mucus system in health and disease. Nat Rev Gastroenterol Hepatol 2013; 10:352-361.
8. Clark JA, Coopersmith CM. Intestinal crosstalk: a new paradigm for understanding the gut as the 'motor' of critical illness. Shock Augusta Ga 2007; 28:384-393.
9. Doig CJ, Sutherland LR, Sandham JD, et al. Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am J Respir Crit Care Med 1998; 158:444-451.
10. Lemasters JJ. Dying a thousand deaths: redundant pathways from different organelles to apoptosis and necrosis. Gastroenterology 2005; 129:351-360.
11. Grimaldi D, Guivarch E, Neveux N, et al. Markers of intestinal injury are associated with endotoxemia in successfully resuscitated patients. Resuscitation 2013; 84:60-65.
12. Rahman SH, Ammori BJ, Holmfield J, et al. Intestinal hypoperfusion contributes to gut barrier failure in severe acute pancreatitis. J Gastrointest Surg Off J Soc Surg Aliment Tract 2003; 7:26-35; discussion 35-6.
13. Chiu CJ, McArdle AH, Brown R, et al. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg Chic Ill 1960 1970; 101:478-483.
14. Oltean M, Olausson M. The Chiu/Park scale for grading intestinal ischemia-reperfusion: if it ain't broke don't fix it! Intensive Care Med 2010; 36:1095.
15. Schellekens DHSM, Grootjans J, Dello SAWG, et al. Plasma intestinal fatty acid-binding protein levels correlate with morphologic epithelial intestinal damage in a human translational ischemia-reperfusion model. J Clin Gastroenterol 2013; 48:253-260.
16. Coopersmith CM, Stromberg PE, Davis CG, et al. Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Crit Care Med 2003; 31:1630-1637.
17. Coopersmith CM, Stromberg PE, Dunne WM, et al. Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA 2002; 287:1716-1721.
18. Dominguez JA, Samocha AJ, Liang Z, et al. Inhibition of IKKb in enterocytes exacerbates sepsis-induced intestinal injury and worsens mortality. Crit Care Med 2013; 41:e275-e285.
19. Leaphart CL, Qureshi F, Cetin S, et al. Interferon-gamma inhibits intestinal restitution by preventing gap junction communication between enterocytes. Gastroenterology 2007; 132:2395-2411.
20. Derikx JPM, Poeze M, van Bijnen AA, et al. Evidence for intestinal and liver epithelial cell injury in the early phase of sepsis. Shock Augusta Ga 2007; 28:544-548.
21. Curis E, Nicolis I, Moinard C, et al. Almost all about citrulline in mammals. Amino Acids 2005; 29:177-205.
22. van de Poll MCG, Ligthart-Melis GC, Boelens PG, et al. Intestinal and hepatic metabolism of glutamine and citrulline in humans. J Physiol 2007; 581 (Pt 2): 819-827.
23. Le Boucher J, Charret C, Coudray-Lucas C, et al. Amino acid determination in biological fluids by automated ion-exchange chromatography: performance of Hitachi L-8500A. Clin Chem 1997; 43:1421-1428.
24. Crenn P, Coudray-Lucas C, Thuillier F, et al. Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterology 2000; 119:1496-1505.
25. Crenn P, Messing B, Cynober L. Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Clin Nutr Edinb Scotl 2008; 27:328-339.
26. Crenn P, Vahedi K, Lavergne-Slove A, et al. Plasma citrulline: a marker of enterocyte mass in villous atrophy-associated small bowel disease. Gastroenterology 2003; 124:1210-1219.
27. Buttet M, Traynard V, Tran TTT, et al. From fatty-acid sensing to chylomicron synthesis: role of intestinal lipid-binding proteins. Biochimie 2014; 96:37-47.
28. Alpers DH, Bass NM, Engle MJ, De Schryver-Kecskemeti K. Intestinal fatty acid binding protein may favor differential apical fatty acid binding in the intestine. Biochim Biophys Acta 2000; 1483:352-362.
29. Kanda T, Fujii H, Tani T, et al. Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans. Gastroenterology 1996; 110:339-343.
30. Kanda T, Tsukahara A, Ueki K, et al. Diagnosis of ischemic small bowel disease by measurement of serum intestinal fatty acid-binding protein in patients with acute abdomen: a multicenter, observer-blinded validation study. J Gastroenterol 2011; 46:492-500.
31. Matsumoto S, Sekine K, Funaoka H, et al. Diagnostic performance of plasma biomarkers in patients with acute intestinal ischaemia. Br J Surg 2014; 101:232-238.
32. Güzel M, Sözüer EM, Salt O, et al. The value of the serum I-FABP level for diagnosing acute mesenteric ischemia. Surg Today 2013; 44:2072-2076.
33. Crenn P, Neveux N, Chevret S, et al. Plasma L-citrulline concentrations and its relationship with inflammation at the onset of septic shock: a pilot study. J Crit Care 2014; 29:315.
34. Luiking YC, Poeze M, Ramsay G, Deutz NEP. Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production. Am J Clin Nutr 2009; 89:142-152.
35. Kao CC, Bandi V, Guntupalli KK, et al. Arginine, citrulline and nitric oxide metabolism in sepsis. Clin Sci Lond Engl 1979 2009; 117:23-30.
36. Piton G, Belon F, Cypriani B, et al. Enterocyte damage in critically ill patients is associated with shock condition and 28-day mortality. Crit Care Med 2013; 41:2169-2176.
37. Piton G, Manzon C, Monnet E, et al. Plasma citrulline kinetics and prognostic value in critically ill patients. Intensive Care Med 2010; 36:702-706.
38. Piton G, Belin N, Barrot L, et al. Enterocyte damage: a piece in the puzzle of post-cardiac arrest syndrome. Shock Augusta Ga 2015; 44:438-444.
39. Poole A, Deane A, Summers M, et al. The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill. Crit Care Lond Engl 2015; 19:16.
40. Noordally SO, Sohawon S, Semlali H, et al. Is there a correlation between circulating levels of citrulline and intestinal dysfunction in the critically ill? Nutr Clin Pract Off Publ Am Soc Parenter Enter Nutr 2012; 27:527-532.
41. Blasco-Alonso J, Sánchez Yáñez P, Rosa Camacho V, et al. Citrulline and arginine kinetics and its value as a prognostic factor in pediatric critically ill patients. An Pediatr Barc Spain 2015; 83:257-263.
42. van Waardenburg DA, de Betue CT, Luiking YC, et al. Plasma arginine and citrulline concentrations in critically ill children: strong relation with inflammation. Am J Clin Nutr 2007; 86:1438-1444.
43. Lieberman JM, Marks WH, Cohn S, et al. Organ failure, infection, and the systemic inflammatory response syndrome are associated with elevated levels of urinary intestinal fatty acid binding protein: study of 100 consecutive patients in a surgical intensive care unit. J Trauma 1998; 45:900-906.
44. Gollin G, Zieg PM, Cohn SM, et al. Intestinal mucosal injury in critically ill surgical patients: preliminary observations. Am Surg 1999; 65:19-21.
45. De Haan JJ, Lubbers T, Derikx JP, et al. Rapid development of intestinal cell damage following severe trauma: a prospective observational cohort study. Crit Care Lond Engl 2009; 13:R86.
46. van Haren FMP, Pickkers P, Foudraine N, et al. The effects of methylene blue infusion on gastric tonometry and intestinal fatty acid binding protein levels in septic shock patients. J Crit Care 2010; 25:358.
47. Piton G, Cypriani B, Regnard J, et al. Catecholamine use is associated with enterocyte damage in critically ill patients. Shock Augusta Ga 2015; 43:437-442.
48. Timmermans K, Sir Ö, Kox M, et al. Circulating iFABP Levels as a marker of intestinal damage in trauma patients. Shock Augusta Ga 2015; 43:117-120.
49. Derikx JPM, Bijker EM, Vos GD, et al. Gut mucosal cell damage in meningococcal sepsis in children: relation with clinical outcome. Crit Care Med 2010; 38:133-137.
50. Derikx JPM, van Waardenburg DA, Thuijls G, et al. New insight in loss of gut barrier during major non-abdominal surgery. PloS One 2008; 3:e3954.
51. Kao C, Hsu J, Bandi V, Jahoor F. Alterations in glutamine metabolism and its conversion to citrulline in sepsis. Am J Physiol Endocrinol Metab 2013; 304:E1359-E1364.
52. Boutry C, Matsumoto H, Bos C, et al. Decreased glutamate, glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: a primary intestinal defect? Amino Acids 2012; 43:1485-1498.
53. Shen L-J, Guan Y-Y, Wu X-P, et al. Serum citrulline as a diagnostic marker of sepsis-induced intestinal dysfunction. Clin Res Hepatol Gastroenterol 2015; 39:230-236.
54. Derikx JPM, Matthijsen RA, de Bruine AP, et al. A new model to study intestinal ischemia-reperfusion damage in man. J Surg Res 2011; 166:222-226.
55. Piton G, Capellier G. Plasma citrulline in the critically ill: intriguing biomarker, cautious interpretation. Crit Care Lond Engl 2015; 19:204.
56. Leone M, Bechis C, Baumstarck K, et al. Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases. Intensive Care Med 2015; 41:667-676.
57. Lau T, Owen W, Yu YM, et al. Arginine, citrulline, and nitric oxide metabolism in end-stage renal disease patients. J Clin Invest 2000; 105:1217-1225.
58. Ceballos I, Chauveau P, Guerin V, et al. Early alterations of plasma free amino acids in chronic renal failure. Clin Chim Acta Int J Clin Chem 1990; 188:101-108.