Intestinal and hepatic metabolism of glutamine and citrulline in humans

Journal of Physiology

Volumn 581, Issue 2, 2007, Pages 819-827

  Van De Poll, Marcel C G ^a   Ligthart melis, Gerdien C ^b   Boelens, Petra G ^b   Deutz, Nicolaas E P ^a   Van Leeuwen, Paul A M ^b   Dejong, Cornelis H C ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CITRULLINE; GLUTAMINE; GLUTAMINE DERIVATIVE; CARBON 13; NITROGEN 15;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; GASTROINTESTINAL SURGERY; HUMAN; INTESTINE ABSORPTION; LIVER BLOOD FLOW; LIVER METABOLISM; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; AMINO ACID TRANSPORT; ARTERIAL BLOOD; INTESTINE FUNCTION; ISOTOPE LABELING; LIVER FUNCTION; LIVER VEIN; PORTAL VEIN BLOOD; VEIN BLOOD FLOW; VENOUS BLOOD;

ARGININE; BIOTRANSFORMATION; BLOOD FLOW VELOCITY; CARBON ISOTOPES; CITRULLINE; GLUTAMINE; HEPATIC VEINS; HUMANS; INFUSIONS, INTRAVENOUS; INTESTINES; LASER-DOPPLER FLOWMETRY; LIVER; LIVER CIRCULATION; MIDDLE AGED; NITROGEN ISOTOPES; PORTAL VEIN; SPLANCHNIC CIRCULATION;

EID: 34249657496     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.126029     Document Type: Article

References (29)

1. Biolo G, Fleming RY, Maggi SP & Wolfe RR (1995). Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am J Physiol Endocrinol Metab 268, E75-E84.
2. 15 N]glutamine in mice. Am J Physiol Gastrointest Liver Physiol 289, G679-G685.
3. Bourreille A, Humbert B, Maugere P, Galmiche JP & Darmaun D (2004). Glutamine metabolism in Crohn's disease: A stable isotope study. Clin Nutr 23, 1167-1175.
4. Bruins MJ, Soeters PB, Lamers WH & Deutz NE (2002). L-Arginine supplementation in pigs decreases liver protein turnover and increases hindquarter protein turnover both during and after endotoxemia. Am J Clin Nutr 75, 1031-1044.
5. 15N]citrulline labeling. Proc Natl Acad Sci U S A 93, 11460-11465.
6. Castillo L, Sanchez M, Vogt J, Chapman TE, DeRojas-Walker TC, Tannenbaum SR, Ajami AM & Young VR (1995). Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis. Am J Physiol Endocrinol Metab 268, E360-E367.
7. Cynober. (1994). Can arginine and ornithine support gut functions? Gut Suppl 1, S42-S45.
8. Dejong CHC, Dowidar N, Wigmore SJ, Redhead DN, Garden OJ, Soeters PB, Ross JA, Deutz NEP & Fearon KCH (2001). Virtual hepatectomy and in vivo urea synthesis in patients with colorectal liver metastases. HPB 3, 114.
9. Dhanakoti SN, Brosnan JT, Herzberg GR & Brosnan ME (1990). Renal arginine synthesis: Studies in vitro and in vivo. Am J Physiol Endocrinol Metab 259, E437-E442.
10. Haussinger D, Sies H & Gerok W (1985). Functional hepatocyte heterogeneity in ammonia metabolism. The intercellular glutamine cycle. J Hepatol 1, 3-14.
11. Houdijk APJ, van Leeuwen PAM, Teerlink T, Flinkerbusch EL, Boermeester MA, Sauerwein HP & Wesdorp RIC (1994). Glutamine-enriched enteral diet increases renal arginine production. JPEN J Parenter Enteral Nutr 18, 422-426.
12. Luiking YC & Deutz NE (2003). Isotopic investigation of nitric oxide metabolism in disease. Curr Opin Clin Nutr Metab Care 6, 103-108.
13. Melis GC, Boelens PG, van der Sijp JR, Popovici T, De Bandt JP, Cynober L & van Leeuwen PA (2005). The feeding route (enteral or parenteral) affects the plasma response of the dipetide Ala-Gln and the amino acids glutamine, citrulline and arginine, with the administration of Ala-Gln in preoperative patients. Br J Nutr 94, 19-26.
14. Mistry SK, Greenfeld Z, Morris SM Jr & Baylis C (2002). The 'intestinal-renal' arginine biosynthetic axis in the aging rat. Mech Ageing Dev 123, 1159-1165.
15. Olde Damink SW, Jalan R, Redhead DN, Hayes PC, Deutz NE & Soeters PB (2002). Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS. Hepatology 36, 1163-1171.
16. Raj DS, Welbourne T, Dominic EA, Waters D, Wolfe R & Ferrando A (2005). Glutamine kinetics and protein turnover in end-stage renal disease. Am J Physiol Endocrinol Metab 288, E37-E46.
17. Remesy C, Demigne C & Aufrere J (1978). Inter-organ relationships between glucose, lactate and amino acids in rats fed on high-carbohydrate or high-protein diets. Biochem J 170, 321-329.
18. Schindl MJ, Millar A, Redhead DN, Fearon KCH, Ross JA, Dejong CHC, Garden OJ & Wigmore SJ (2006). The adaptive response of the reticulo-endothelial system to major liver resection in man. Ann Surg 243, 507-514.
19. Siroen MP, van der Sijp JR, Teerlink T, van Schaik C, Nijveldt RJ & van Leeuwen PA (2005). The human liver clears both asymmetric and symmetric dimethylarginine. Hepatology 41, 559-565.
20. Van Acker BA, Hulsewe KW, Wagenmakers AJ, Deutz NE, Van Kreel BK, Halliday D, Matthews DE, Soeters PB & Von Meyenfeldt MF (1998). Absence of glutamine isotopic steady state: Implications for the assessment of whole-body glutamine production rate. Clin Sci (Lond) 95, 339-346.
21. van Acker BA, Hulsewe KW, Wagenmakers AJ, Soeters PB & von Meyenfeldt MF (2000). Glutamine appearance rate in plasma is not increased after gastrointestinal surgery in humans. J Nutr 130, 1566-1571.
22. van der Hulst RR, von Meyenfeldt MF, Deutz NE & Soeters PB (1997). Glutamine extraction by the gut is reduced in depleted [corrected] patients with gastrointestinal cancer. Ann Surg 225, 112-121.
23. van de Poll MCG, Siroen MP, Van Leeuwen PA, Soeters PB, Melis GC, Boelens PG, Deutz NEP & Dejong CHC (2007). Interorgan amino acid exchange in humans: Consequences for arginine and citrulline metabolism. Am J Clin Nutr 85, 167-172.
24. van de Poll MC, Soeters PB, Deutz NE, Fearon KC & Dejong CH (2004). Renal metabolism of amino acids: Its role in interorgan amino acid exchange. Am J Clin Nutr 79, 185-197.
25. van Eijk HM, Rooyakkers DR & Deutz NE (1993). Rapid routine determination of amino acids in plasma by high-performance liquid chromatography with a 2-3 microns Spherisorb ODS II column. J Chromatogr 620, 143-148.
26. van Eijk HM, Rooyakkers DR, Soeters PB & Deutz NE (1999). Determination of amino acid isotope enrichment using liquid chromatography-mass spectrometry. Anal Biochem 271, 8-17.
27. Vogt JA, Chapman TE, Wagner DA, Young VR & Burke JF (1993). Determination of the isotope enrichment of one or a mixture of two stable labelled tracers of the same compound using the complete isotopomer distribution of an ion fragment; theory and application to in vivo human tracer studies. Biol Mass Spectrom 22, 600-612.
28. Windmueller HG & Spaeth AE (1974). Uptake and metabolism of plasma glutamine by the small intestine. J Biol Chem 249, 5070-5079.
29. Windmueller HG & Spaeth AE (1981). Source and fate of circulating citrulline. Am J Physiol Endocrinol Metab 241, E473-E480.