Plasma concentrations of transforming growth factor beta 1 in non-progressive HIV-1 infection correlates with markers of disease progression

Cytokine

Volumn 81, Issue , 2016, Pages 109-116

  Maina, Edward K ^a,c   Abana, C Z ^a   Bukusi, E A ^c   Sedegah, M ^d   Lartey, M ^b   Ampofo, W K ^a  

^a University of Ghana   (Ghana)

^b UNIVERSITY OF GHANA   (Ghana)

^c KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^d Naval Medical Center   (United States)

Author keywords

CD4+ T cells; CD8+ T cells; Cytokines; HIV 1 infection; HIV 1 RNA

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 1BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; VIRUS RNA; ANTIRETROVIRUS AGENT; CYTOKINE;

ADULT; AGED; ARTICLE; CD4 CD8 RATIO; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE COURSE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; BLOOD; DRUG EFFECTS; GENETICS; HIV INFECTIONS; LYMPHOCYTE COUNT; METABOLISM; MIDDLE AGED; PHYSIOLOGY; TH1 CELL; TH2 CELL; VIROLOGY; YOUNG ADULT;

ADULT; AGED; ANTI-RETROVIRAL AGENTS; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CROSS-SECTIONAL STUDIES; CYTOKINES; DISEASE PROGRESSION; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; RNA, VIRAL; TH1 CELLS; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA1; YOUNG ADULT;

EID: 84960410894     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2016.02.009     Document Type: Article

References (26)

1. Stevenson M. HIV-1 pathogenesis. Nat. Med. 2003, 9:853-860.
2. Okulicz J.F. Elite controllers and long-term nonprogressors: models for HIV vaccine development?. J. AIDS Clin. Res. 2012, 01:8-11. 10.4172/2155-6113.S8-005.
3. Lotz M., Seth P. TGFβ and HIV infection. Ann. N.Y. Acad. Sci. 1993, 501-511. .
4. Jenabian M.-A., Ancuta P., Gilmore N., Routy J.-P. Regulatory T cells in HIV infection: can immunotherapy regulate the regulator?. Clin. Dev. Immunol. 2012, 2012:908314. 10.1155/2012/908314.
5. Michelson S., Alcami J., Kim S.J., Danielpour D., Bachelerie F., Picard L., et al. Human cytomegalovirus infection induces transcription and secretion of transforming growth factor beta 1. J. Virol. 1994, 68:5730-5737.
6. McCartney-Francis N.L., Frazier-Jessen M., Wahl S.M. TGF-β: a balancing act. Int. Rev. Immunol. 1998, 16:553-580. .
7. Reed S.G. TGF-β in infections and infectious diseases. Microbes Infect. 1999, 1:1313-1325.
8. Blobe G.C., et al. Role of transforming growth factor beta in human disease. New Engl. J. Med. 2000, 342:1350-1358.
9. Toossi Z., Ellner J.J. The role of TGF beta in the pathogenesis of human tuberculosis. Clin. Immunol. Immunopathol. 1998, 87:107-114.
10. Furler R.L., Uittenbogaart C.H. GLI2 regulates TGF-β1 in human CD4+ T cells: implications in cancer and HIV. Pathogenesis 2012, 7. 10.1371/journal.pone.0040874.
11. Do Yoo Y., Ueda H., Park K., Flanders K.C., Lee Y.I., Jay G., et al. Regulation of transforming growth factor-β1 expression by the hepatitis B virus (HBV) X transactivator: role in HBV pathogenesis. J. Clin. Invest. 1996, 97:388-395. .
12. Kekow J., Wachsman W., Allen McCutchan J., Gross W.L., Zachariah M., Carson D.A., et al. Transforming growth factor-β and suppression of humoral immune responses in HIV infection. J. Clin. Invest. 1991, 87:1010-1016. .
13. Navikas V., Link J., Wahren B., Persson C., Link H. Increased levels of interferon-gamma (IFN-γ), IL-4 and transforming growth factor-beta (TGF-β) mRNA expressing blood mononuclear cells in human HIV infection. Clin. Exp. Immunol. 1994, 96:59-63.
14. Lazdins J.K., Klimkait T., Woods-Cook K., Walker M., Alteri E., Cox D., et al. In vitro effect of transforming growth factor-β on progression of HIV-1 infection in primary mononuclear phagocytes. J. Immunol. 1991, 147:1201-1207. .
15. Wiercińska-Drapalo A., Flisiak R., Jaroszewicz J., Prokopowicz D. Increased plasma transforming growth factor-beta1 is associated with disease progression in HIV-1-infected patients. Viral Immunol. 2004, 17:109-113.
16. Serrano-Villar S., Sainz T., Lee S.a., Hunt P.W., Sinclair E., Shacklett B.L., et al. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 2014, 10. 10.1371/journal.ppat.1004078.
17. Emu B., Moretto W.J., Hoh R., Krone M., Martin J.N., Nixon D.F., et al. Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease. PLoS ONE 2014, 9:e85613. 10.1371/journal.pone.0085613.
18. Wang J., Guan E., Roderiquez G., Norcross M.a. Synergistic induction of apoptosis in primary CD4(+) T cells by macrophage-tropic HIV-1 and TGF-beta1. J. Immunol. 2001, 167:3360-3366. 10.4049/jimmunol.167.6.3360.
19. Elrefaei M., Burke C.M., Baker C.A.R., Jones N.G., Bousheri S., Bangsberg D.R., et al. TGF-β and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells. PLoS ONE 2009, 4:4-10. 10.1371/journal.pone.0008194.
20. Ross T.M. Using death to one's advantage: HIV modulation of apoptosis. Leukemia 2001, 15:332-341.
21. Bailer R.T., Holloway A., Sun J., Margolick J.B., Martin M., Kostman J., et al. IL-13 and IFN-gamma secretion by activated T cells in HIV-1 infection associated with viral suppression and a lack of disease progression. J. Immunol. 1999, 162:7534-7542.
22. Kornbluth R.S., Oh P.S., Munis J.R., Cleveland P.H., Richman D.D. Interferons and bacterial lipopolysaccharide protect macrophages from pro- ductive infection by human immunodeficiency virus in vitro. J. Exp. Med. 1989, 169(3):1137-1151.
23. de Waal Malefyt R., Figdor C.G., Huijbens R., Mohan-Peterson S., Bennett B., Culpepper J., et al. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes: comparison with IL-4 and modulation by IFN-γ or IL-10. J. Immunol. 1993, 6370.
24. Ullum H., Cozzi Lepri A., Bendtzen K., Victor J., Gøtzsche P., Phillips A., et al. Low production of interferon gamma is related to disease progression in HIV infection: evidence from a cohort of 347 HIV-infected individuals. AIDS 1997, 13:1039-1046.
25. Tripp C.S., Wolf S.F., Unanue E.R. Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 1993, 90:3725-3729.
26. Manetti R., Gerosa F., Giudizi M.G., Biagiotti R., Parronchi P., Piccinni M.P., et al. Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones. J. Exp. Med. 1994, 179:1273-1283. 10.1084/jem.179.4.1273.