To the editor: Suppression of plasma hepcidin by venesection during steady-state hypoxia

Blood

Volumn 127, Issue 9, 2016, Pages 1206-1207

  Talbot, Nick P ^a   Smith, Thomas G ^a   Lakhal Littleton, Samira ^a   Gülsever, Cafer ^a   Rivera Ch, Maria ^b   Dorrington, Keith L ^a   Mole, David R ^c   Robbins, Peter A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; GROWTH DIFFERENTIATION FACTOR 15; HEPCIDIN; HYPOXIA INDUCIBLE FACTOR; IRON; TRANSFERRIN RECEPTOR;

ALTITUDE; ALTITUDE DISEASE; BLOOD VISCOSITY; DRUG BLOOD LEVEL; DRUG INHIBITION; ERYTHROCYTOSIS; ERYTHROPOIESIS; HUMAN; HYPOXIA; LETTER; PHLEBOTOMY; POLYCYTHEMIA VERA; PRIORITY JOURNAL; SEA LEVEL; ADULT; ANOXIA; BLOOD; MALE;

ADULT; ALTITUDE; ALTITUDE SICKNESS; ANOXIA; HEPCIDINS; HUMANS; MALE; PHLEBOTOMY;

EID: 84960401486     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-05-647404     Document Type: Letter

References (13)

1. Piperno A, Galimberti S, Mariani R, et al; HIGHCARE Investigators. Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood. 2011;117(10):2953-2959.
2. Talbot NP, Lakhal S, Smith TG, et al. Regulation of hepcidin expression at high altitude. Blood. 2012;119(3):857-860.
3. Peyssonnaux C, Zinkernagel AS, Schuepbach RA, et al. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest. 2007;117(7):1926-1932.
4. Gordeuk VR, Miasnikova GY, Sergueeva AI, et al. Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. Blood. 2011;118(19):5278-5282.
5. Volke M, Gale DP, Maegdefrau U, et al. Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors. PLoS One. 2009;4(11):e7875.
6. Liu Q, Davidoff O, Niss K, Haase VH. Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest. 2012;122(12):4635-4644.
7. Tanno T, Bhanu NV, Oneal PA, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007;13(9):1096-1101.
8. Lundgrin EL, Janocha AJ, Koch CD, et al. Plasma hepcidin of Ethiopian highlanders with steady-state hypoxia. Blood. 2013;122(11):1989-1991.
9. Tarkun P, Mehtap O, Atesoʇlu EB, Geduk A, Musul MM, Hacihanefioglu A. Serum hepcidin and growth differentiation factor-15 (GDF-15) levels in polycythemia vera and essential thrombocythemia. Eur J Haematol. 2013;91(3):228-235.
10. Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014;46(7):678-684.
11. León-Velarde F, Maggiorini M, Reeves JT, et al. Consensus statement on chronic and subacute high altitude diseases. High Alt Med Biol. 2005;6(2):147-157.
12. Smith TG, Talbot NP, Privat C, et al. Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. JAMA. 2009;302(13):1444-1450.
13. Finch C. Regulators of iron balance in humans. Blood. 1994;84(6):1697-1702.