Interleukin-1β increases the risk of gastric cancer through induction of aberrant DNA methylation in a mouse model

Oncology Letters

Volumn 11, Issue 4, 2016, Pages 2919-2924

  Huang, Fung Yu ^a   Chan, Annie On On ^a,b   Rashid, Asif ^c   Wong, Danny Ka Ho ^a   Seto, Wai Kay ^a   Cho, Chi Hin ^d   Lai, Ching Lung ^a   Yuen, Man Fung ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b HONG KONG SANATORIUM AND HOSPITAL   (Hong Kong)

^c UNIVERSITY OF TEXAS   (United States)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

DNA methylation; Gastric cancer; Inflammation; Interleukin 1 receptor type 1 knockout mice; Interleukin 1

Indexed keywords

DNA METHYLTRANSFERASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NITRIC OXIDE; UVOMORULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RISK; CONTROLLED STUDY; DNA METHYLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER;

EID: 84960385488     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2016.4296     Document Type: Article

References (34)

1. Mantovani A, Marchesi F, Portal C, Allavena P and Sica A: Linking inflammation reactions to cancer: Novel targets for therapeutic strategies. Adv Exp Med Biol 610: 112-127, 2008.
2. Mantovani A, Allavena P, Sica A and Balkwill F: Cancer-related inflammation. Nature 454: 436-444, 2008.
3. March CJ, Mosley B, Larsen A, et al: Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 315: 641-647, 1985.
4. Noach LA, Bosma NB, Jansen J, et al: Mucosal tumor necrosis factor-α, interleukin-1 β, and interleukin-8 production in patients with Helicobacter pylori infection. Scand J Gastroenterol 29: 425-429, 1994.
5. Huang FY, Chan AO, Lo RC, et al: Characterization of interleukin-1β in Helicobacter pylori-induced gastric inflammation and DNA methylation in interleukin-1 receptor type 1 knockout (IL-1R1(-/-)) mice. Eur J Cancer 49: 2760-2770, 2013.
6. Shigematsu Y, Niwa T, Rehnberg E, et al: Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. Cancer Lett 340: 141-147, 2013.
7. Tu S, Bhagat G, Cui G, et al: Overexpression of interleukin-1β induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell 14: 408-419, 2008.
8. Kohase M, May LT, Tamm I, Vilcek J and Sehgal PB: A cytokine network in human diploid fibroblasts: Interactions of β-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1. Mol Cell Biol 7: 273-280, 1987.
9. Jaiswal M, LaRusso NF and Gores GJ: Nitric oxide in gastrointestinal epithelial cell carcinogenesis: Linking inflammation to oncogenesis. Am J Physiol Gastrointest Liver Physiol 281: G626-G634, 2001.
10. Wink DA and Mitchell JB: Nitric oxide and cancer: An introduction. Free Radic Biol Med 34: 951-954, 2003.
11. Chan AO, Lam SK, Wong BC, et al: Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut 52: 502-506, 2003.
12. Park SY, Yoo EJ, Cho NY, Kim N and Kang GH: Comparison of CpG island hypermethylation and repetitive DNA hypomethylation in premalignant stages of gastric cancer, stratified for Helicobacter pylori infection. J Pathol 219: 410-416, 2009.
13. Maekita T, Nakazawa K, Mihara M, et al: High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res 12: 989-995, 2006.
14. Choi IS and Wu TT: Epigenetic alterations in gastric carcinogenesis. Cell Res 15: 247-254, 2005.
15. Chan AO, Peng JZ, Lam SK, et al: Eradication of Helicobacter pylori infection reverses E-cadherin promoter hypermethylation. Gut 55: 463-468, 2006.
16. Hmadcha A, Bedoya FJ, Sobrino F and Pintado E: Methylation-dependent gene silencing induced by interleukin 1β via nitric oxide production. J Exp Med 190: 1595-1604, 1999.
17. Qian X, Huang C, Cho CH, Hui WM, Rashid A and Chan AO: E-cadherin promoter hypermethylation induced by interleukin-1β treatment or H. pylori infection in human gastric cancer cell lines. Cancer Lett 263: 107-113, 2008.
18. Huang FY, Chan AO, Rashid A, et al: Helicobacter pylori induces promoter methylation of E-cadherin via interleukin-1β activation of nitric oxide production in gastric cancer cells. Cancer 118: 4969-4980, 2012.
19. Kwon KH, Murakami A, Hayashi R and Ohigashi H: Interleukin-1β targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis. Biochem Biophys Res Commun 337: 647-654, 2005.
20. Huang H, Ushijima T, Nagao M, Sugimura T and Ohgaki H: β-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice. Cancer Lett 198: 29-35, 2003.
21. Yamada H, Vijayachandra K, Penner C and Glick A: Increased sensitivity of transforming growth factor (TGF) β 1 null cells to alkylating agents reveals a novel link between TGFβ signaling and O(6)-methylguanine methyltransferase promoter hypermethylation. J Biol Chem 276: 19052-19058, 2001.
22. Livak Schmittgen: Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method. Methods 25: 402-408, 2001.
23. Chan AO, Chu KM, Huang C, et al: Association between Helicobacter pylori infection and interleukin 1β polymorphism predispose to CpG island methylation in gastric cancer. Gut 56: 595-597, 2007.
24. Griess P: Comments on the discussion of HH Weselsky and Benedict 'On some Azo Compounds'. Ber Deutsch Chem Ges 12: 426-428, 1879.
25. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
26. Epstein NJ, Warme BA, Spanogle J, et al: Interleukin-1 modulates periprosthetic tissue formation in an intramedullary model of particle-induced inflammation. J Orthop Res 23: 501-510, 2005.
27. El-Omar EM: The importance of interleukin 1β in Helicobacter pylori associated disease. Gut 48: 743-747, 2001.
28. Skelly DT, Hennessy E, Dansereau MA and Cunningham C: A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1β, TNF-β and IL-6 challenges in C57BL/6 mice. PloS One 8: e69123, 2013.
29. Klapproth J, Castell J, Geiger T, Andus T and Heinrich PC: Fate and biological action of human recombinant interleukin 1 β in the rat in vivo. Eur J Immunol 19: 1485-1490, 1989.
30. Hur K, Niwa T, Toyoda T, et al: Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation. Carcinogenesis 32: 35-41, 2011.
31. Attwood J and Richardson B: Relative quantitation of DNA methyltransferase mRNA by real-time RT-PCR assay. Methods Mol Biol 287: 273-283, 2004.
32. Kanai Y and Hirohashi S: Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state. Carcinogenesis 28: 2434-2442, 2007.
33. Nakajima T, Yamashita S, Maekita T, et al: The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae. Int J Cancer 124: 905-910, 2009.
34. Niwa T, Tsukamoto T, Toyoda T, et al: Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res 70: 1430-1440, 2010.