Impact of cold ischemia time on outcomes of liver transplantation: A single center experience

Annals of Transplantation

Volumn 21, Issue , 2016, Pages 145-151

  Sibulesky, Lena ^a   Li, Meng ^b   Hansen, Ryan N ^b   Dick, Andre A S ^a,c   Montenovo, Martin I ^a   Rayhill, Stephen C ^a   Bakthavatsalam, Ramasamy ^a   Reyes, Jorge D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c SEATTLE CHILDREN S HOSPITAL   (United States)

Author keywords

Organ preservation; Tissue and organ procurement; Tissue donors

Indexed keywords

COLD ISCHEMIA; GRAFT SURVIVAL; HUMAN; HUMAN TISSUE; LIVER GRAFT; LIVER TRANSPLANTATION; ORGAN; OVERALL SURVIVAL; PROPORTIONAL HAZARDS MODEL; RECIPIENT; ADOLESCENT; ADULT; AGED; ALLOTRANSPLANTATION; DELAYED GRAFT FUNCTION; FEMALE; FOLLOW UP; MALE; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; ORGAN PRESERVATION; OUTCOME ASSESSMENT; PROCEDURES; RETROSPECTIVE STUDY; STATISTICS AND NUMERICAL DATA; SURVIVAL ANALYSIS; TIME FACTOR; VERY ELDERLY; WASHINGTON; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; COLD ISCHEMIA; DELAYED GRAFT FUNCTION; FEMALE; FOLLOW-UP STUDIES; GRAFT SURVIVAL; HUMANS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ORGAN PRESERVATION; OUTCOME ASSESSMENT (HEALTH CARE); PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS; WASHINGTON; YOUNG ADULT;

EID: 84960376155     PISSN: 14259524     EISSN: None     Source Type: Journal    
DOI: 10.12659/AOT.896190     Document Type: Article

References (24)

1. Kim WR, Smith JM, Skeans MA et al: OPTN/SRTR 2012 Annual Data Report: Liver. Am J Transplant, 2014; 14(Suppl.1): 69–96
2. Busuttil RW, Tanaka K: The utility of marginal donors in liver transplantation. Liver Transpl, 2003; 9: 651–63
3. Renz JF, Kin C, Kinkhabwala M et al: Utilization of extended donor criteria liver allografts maximizes donor use and patient access to liver transplantation. Ann Surg, 2005; 242: 556–65
4. Gastaca M: Extended criteria donors in liver transplantation: Adapting donor quality and recipient. Transplantat Proc, 2009; 41: 975–79
5. Jiménez-Romero C, Caso Maestro O et al: Using old liver grafts for liver transplantation: Where are the limits? World J Gastroenterol, 2014; 20: 10691–702
6. Nemes B, Gelley F, Zádori G et al: Outcome of liver transplantation based on donor graft quality and recipient status. Transplantat Proc, 2010; 42: 2327–30
7. Segev DL, Kucirka LM, Nguyen GC et al: Effect modification in liver allografts with prolonged cold ischemic time. Am J Transplant, 2008; 8: 658–66
8. Stahl JE, Kreke JE, Malek F et al: Consequences of cold-ischemia time on primary nonfunction and patient and graft survival in liver transplantation: A meta-analysis. PLoS One, 2008; 3: 1–11
9. Tekin K, Imber CJ, Atli M et al: A simple scoring system to evaluate the effects of cold ischemia time on marginal liver donors. Transplantation, 2004; 77: 411–16
10. Van Meter CH: The organ allocation controversy: How did we arrive here? Ochsner J, 1999; 1: 6–11
11. Gentry SE, Chow EKH, Wickliffe CE et al: Impact of broader sharing on the transport time for deceased donor livers. Liver Transpl, 2014; 20: 1237–43
12. SRTR Report 2014
13. Olthoff KM, Kulik L, Samstein B et al: Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl, 2010; 16: 943–49
14. Briceno J, Marchal T, Padillo J et al: Influence of marginal donors on liver preservation injury. Transplantation, 2002; 74: 522–26
15. Reese PP, Sonawane SB, Thomasson A et al: Donor age and cold ischemia interact to produce inferior 90-day liver allograft survival. Transplantation, 2008; 85: 1737–44
16. Peralta C, Jiménez-Castro MB, Gracia-Sancho J: Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu. J Hepatol, 2013; 59: 1094–106
17. Lee DD, Singh A, Burns MJ et al: Early allograft dysfunction in liver transplantation with donation after cardiac death donors results in inferior survival. Liver Transpl, 2014; 20: 1447–53
18. Salvalaggio P, Afonso RC, Felga G, Ferraz-Neto BH: A proposal to grade the severity of early allograft dysfunction after liver transplantation. Einstein (Sao Paulo), 2013; 11: 23–31
19. Mathur AK, Heimbach J, Steffick DE et al: Donation after cardiac death liver transplantation: Predictors of outcome. Am J Transplant, 2010; 10: 2512–19
20. Pine JK, Aldouri A, Young AL et al: Liver transplantation following donation after cardiac death: An analysis using matched pairs. Liver Transpl, 2009; 15: 1072–82
21. Graham JA, Guarrera JV: ‘‘Resuscitation’’ of marginal liver allografts for transplantation with machine perfusion technology. J Hepatol, 2014; 61: 418–31
22. Dutkowski P, Graf R, Clavien PA: Rescue of the cold preserved rat liver by hypothermic oxygenated machine perfusion. Am J Transplant, 2006; 6: 903–12
23. Guarrera JV, Estevez J, Boykin J et al: Hypothermic machine perfusion of liver grafts for transplantation: technical development in human discard and miniature swine models. Transplant Proc, 2005; 37: 323–25
24. Schon MR, Kollmar O, Wolf S et al: Liver transplantation after organ preservation with normothermic extracorporeal perfusion. Ann Surg, 2001; 233: 114–23