Donor age and cold ischemia interact to produce inferior 90-day liver allograft survival

Transplantation

Volumn 85, Issue 12, 2008, Pages 1737-1744

  Reese, Peter P ^a,c   Sonawane, Samsher B ^a   Thomasson, Arwin ^a   Yeh, Heidi ^b   Markmann, James F ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Donor age; Ischemia; Liver transplantation

Indexed keywords

ADULT; ARTICLE; COLD ISCHEMIA; FEMALE; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; LIVER GRAFT; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; ORGAN DONOR; PRIORITY JOURNAL; RISK ASSESSMENT; SENESCENCE; AGE; ALLOTRANSPLANTATION; COHORT ANALYSIS; DONOR; MULTIVARIATE ANALYSIS; PHYSIOLOGY; RETROSPECTIVE STUDY; STATISTICAL MODEL; TIME;

AGE FACTORS; COHORT STUDIES; COLD ISCHEMIA; FEMALE; GRAFT SURVIVAL; HUMANS; LIVER TRANSPLANTATION; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDIES; TIME FACTORS; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 49149088720     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181722f75     Document Type: Article

References (31)

1. Detre KM, Lombardero M, Belle S, et al. Influence of donor age on graft survival after liver transplantation - United Network for Organ Sharing Registry. Liver Transpl Surg 1995; 1: 311.
2. Hoofnagle JH, Lombardero M, Zetterman RK, et al. Donor age and outcome of liver transplantation. Hepatology 1996; 24: 89.
3. Velidedeoglu E, Mange KC, Frank A, et al. Factors differentially correlated with the outcome of liver transplantation in HCV+ and HCV - recipients. Transplantation 2004; 77: 1834.
4. Mateo R, Cho Y, Singh G, et al. Risk factors for graft survival after liver transplantation from donation after cardiac death donors: An analysis of OPTN/UNOS data. Am J Transplant 2006; 6: 791.
5. Merion RM, Goodrich NP, Feng S. How can we define expanded criteria for liver donors? J Hepatol 2006; 45: 484.
6. Russo MW, Galanko JA, Zacks SL, et al. Impact of donor age and year of transplant on graft survival in liver transplant recipients with chronic hepatitis C. Am J Transplant 2004; 4: 1133.
7. Renz JF, Kin C, Kinkhabwala M, et al. Utilization of extended donor criteria liver allografts maximizes donor use and patient access to liver transplantation. Ann Surg 2005; 242: 556.
8. Neipp M, Bektas H, Lueck R, et al. Liver transplantation using organs from donors older than 60 years. Transpl Int 2004; 17: 416.
9. Brown RS Jr, Lake JR. The survival impact of liver transplantation in the MELD era, and the future for organ allocation and distribution. Am J Transplant 2005; 5: 203.
10. Yersiz H, Shaked A, Olthoff K, et al. Correlation between donor age and the pattern of liver graft recovery after transplantation. Transplantation 1995; 60: 790.
11. Tsukamoto I, Nakata R, Kojo S. Effect of ageing on rat liver regeneration after partial hepatectomy. Biochem Mol Biol Int 1993; 30: 773.
12. Organ Procurement and Transplantation Network. Organ Distribution: Allocation of livers. http://www.optn.org/PoliciesandBylaws2/ policies/docs/policy-8.doc. Accessed 5/20/2008.
13. Edwards EB, Harper AM. The impact of MELD on OPTN liver allocation: Preliminary results. Clin Transpl 2002; 21.
14. Barshes NR, Becker NS, Washburn WK, et al. Geographic disparities in deceased donor liver transplantation within a single UNOS region. Liver Transpl 2007; 13: 747.
15. Trotter JF, Osgood MJ. MELD scores of liver transplant recipients according to size of waiting list: Impact of organ allocation and patient outcomes. JAMA 2004; 291: 1871.
16. Schaffer RL III, Kulkarni S, Harper A, et al. The sickest first? Disparities with model for end-stage liver disease-based organ allocation: One region's experience. Liver Transpl 2003; 9: 1211.
17. OPTN. OPTN Final Rule as Revised by Amendments, 1999.
18. Freeman RB, Wiesner RH, Edwards E, et al. Results of the first year of the new liver allocation plan. Liver Transpl 2004; 10: 7.
19. Brown RS, Rush SH, Rosen HR, et al. Liver and intestine transplantation. Am J Transplant 2004; 4(suppl 9): 81.
20. Merion RM, Schaubel DE, Dykstra DM, et al. The survival benefit of liver transplantation. Am J Transplant 2005; 5: 307.
21. Feng S, Goodrich NP, Bragg-Gresham JL, et al. Characteristics associated with liver graft failure: The concept of a donor risk index. Am J Transplant 2006; 6: 783.
22. Tector AJ, Mangus RS, Chestovich P, et al. Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival. Ann Surg 2006; 244: 439.
23. Austin MT, Poulose BK, Ray WA, et al. Model for end-stage liver disease: Did the new liver allocation policy affect waiting list mortality? Arch Surg 2007; 142: 1079.
24. Oh CK, Sanfey HA, Pelletier SJ, et al. Implication of advanced donor age on the outcome of liver transplantation. Clin Transplant 2000; 14(4 Pt 2): 386.
25. Busquets J, Xiol X, Figueras J, et al. The impact of donor age on liver transplantation: Influence of donor age on early liver function and on subsequent patient and graft survival. Transplantation 2001; 71: 1765.
26. Ghobrial RM, Yersiz H, Farmer DG, et al. Predictors of survival after In vivo split liver transplantation: Analysis of 110 consecutive patients. Ann Surg 2000; 232: 312.
27. Cholongitas E, Marelli L, Shusang V, et al. A systematic review of the performance of the model for end-stage liver disease (MELD) in the setting of liver transplantation. Liver Transpl 2006; 12: 1049.
28. Lee KW, Simpkins CE, Montgomery RA, et al. Factors affecting graft survival after liver transplantation from donation after cardiac death donors. Transplantation 2006; 82: 1683.
29. Woodward M. Epidemiology: Study design and data analysis [ed. 2]. Boca Raton, Chapman & Hall 2005; 7.
30. Stata Reference Manual A-J 9. College Station, TX, Stata Press Publication 2005.
31. Gordis L. Epidemiology, [ed. 3]. Philadelphia: Elsevier 2004; 233.