Vitamin D Status and Supplementation in the Critically Ill

Current Gastroenterology Reports

Volumn 18, Issue 4, 2016, Pages

  McKinney, T J ^a   Patel, Jayshil J ^b   Benns, Matthew V ^a   Nash, Nicholas A ^a   Miller, Keith R ^a  

^a University of Louisville School of Medicine   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Critical care; Hypovitaminosis D; Intensive care; Malnutrition; Vitamin D; Vitamin D deficiency

Indexed keywords

COLECALCIFEROL; ERGOCALCIFEROL; VITAMIN D; BIOLOGICAL MARKER;

CALCIUM HOMEOSTASIS; CLINICAL TRIAL (TOPIC); CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DRUG SAFETY; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; NUTRITIONAL STATUS; PROGNOSIS; REVIEW; TREATMENT OUTCOME; VITAMIN D DEFICIENCY; VITAMIN D METABOLISM; VITAMIN SUPPLEMENTATION; BLOOD; DIETARY SUPPLEMENT; INTENSIVE CARE; PHYSIOLOGY; PROCEDURES;

BIOMARKERS; CRITICAL CARE; CRITICAL ILLNESS; DIETARY SUPPLEMENTS; HUMANS; PROGNOSIS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84960336082     PISSN: 15228037     EISSN: 1534312X     Source Type: Journal    
DOI: 10.1007/s11894-016-0492-2     Document Type: Review

References (48)

1. Lee P, Eisman JA, Center JR. Vitamin D deficiency in critically ill patients. N Engl J Med. 2009;360(18):1912–4.
2. Amrein K, Christopher KB, McNally JD. Understanding vitamin D deficiency in intensive care patients. Intensive Care Med. 2015;41:1961–4.
3. Christopher KB. Vitamin D, supplementation in the ICU patient. Curr Opin Clin Nutr Metab Care. 2015;18(2):187–92.
4. Shivaprakash J. Mutt,1,2 Elina Hyppönen,3,4,5 Juha Saarnio,6 Marjo-Riitta Järvelin,2,7,8,9 and Karl- Heinz Herzig1,2,10,Vitamin D and adipose tissue—more than storage. Front Physiol. 2014; 5: 228
5. Rock CL, Jennifer JA, Flatt SW, Heath DD, Karanja N, Pakiz B, et al. Weight loss is associated with increased serum 25-hydroxyvitamin D in overweight or obese women. Obesity (Silver Spring). 2012;20(11):2296–301. doi:10.1038/oby.2012.57.
6. Quinn JM, Horwood NJ, Elliott J, Gillespie MT, Martin TJ. Fibroblastic stromal cells express receptor activator of NF-kappa B ligand and support osteoclast differentiation. J Bone Miner Res. 2000;15(8):1459–66.
7. Verstuyf A, Carmeliet G, Bouillon R, Mathieu C. Vitamin D: a pleiotropic hormone. Kidney Int. 2010;78(2):140–5.
8. Wang TT, Nestel FP, Bourdeau V, Nagai Y, Wang Q, Liao J, et al. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol. 2004;173(5):2909–12.
9. Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M. Impact of vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol. 2014;5:151.
10. Hewison M, Zehnder D, Chakraverty R, Adams JS. Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase. Mol Cell Endocrinol. 2004;215(1–2):31–8.
11. Holick MF. Vitamin D, deficiency. N Engl J Med. 2007;357(3):266–81.
12. Maroon JC, Mathyssek CM, Bost JW, Amos A, Winkelman R, Yates AP Duca MA, et al. Vitamin D profile in National Football League players. Am J Sports Med. 2015;43(5):1241–5.
13. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30. Erratum in: J Clin Endocrinol Metab. 2011;96(12):3908. Management guidelines from the Endocrine Society regarding Vitamin D deficiency in the inpatient and outpatient setting.
14. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96(1):53–8. This is an additional clinical reference discussing dietary reference intakes for calcium and vitamin D from the Institute of Medicine.
15. McKenna MJ, Murray BF, O’Keane M, Kilbane MT. Rising trend in vitamin D status from 1993 to 2013: dual concerns for the future. Endocr Connect. 2015;4(3):163–71.
16. Heijboer AC, Blankenstein MA, Kema IP, Buijs MM. Accuracy of 6 routine 25-hydroxyvitamin D assays: influence of vitamin D binding protein concentration. Clin Chem. 2012;58(3):543–8.
17. Blair D, Byham-Gray L, Lewis E, McCaffrey S. Prevalence of vitamin D [25(OH)D] deficiency and effects of supplementation with ergocalciferol (vitamin D2) in stage 5 chronic kidney disease patients. J Ren Nutr. 2008;18(4):375–82.
18. Iruzubieta P, Terán Á, Crespo J, Fábrega E. Vitamin D deficiency in chronic liver disease. World J Hepatol. 2014;6(12):901–15.
19. Abou-Raya A, Abou-Raya S, Helmii M. The effect of vitamin D supplementation on inflammatory and hemostatic markers and disease activity in patients with systemic lupus erythematosus: a randomized placebo-controlled trial. J Rheumatol. 2013;40(3):265–72.
20. Pappa HM, Grand RJ, Gordon CM. Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease. Inflamm Bowel Dis. 2006;12(12):1162–74.
21. Miñambres I, Sánchez-Quesada JL, Vinagre I, Sánchez-Hernández J, Urgell E, de Leiva A, et al. Hypovitaminosis D in type 2 diabetes: relation with features of the metabolic syndrome and glycemic control. Endocr Res. 2015;40(3):160–5.
22. Thomas MK, Lloyd-Jones DM, Thadhani R, Shaw AC, Deraska DJ, Kitch BT, et al. Hypovitaminosis D in medical inpatients. N Engl J Med. 1998;338(12):777–83.
23. Amrein K, Zajic P, Schnedl C, Waltensdorfer A, Fruhwald S, Holl A, et al. Vitamin D status and its association with season, hospital and sepsis mortality in critical illness. Crit Care. 2014;18(2):R47.
24. McNally JD, Menon K, Chakraborty P, Fisher L, Williams KA, Al-Dirbashi OY, et al. The association of vitamin D status with pediatric critical illness. Pediatrics. 2012;130(3):429–36.
25. Ghashut RA, Talwar D, Kinsella J, Duncan A, McMillan DC. The effect of the systemic inflammatory response on plasma vitamin 25 (OH) D concentrations adjusted for albumin. PLoS One. 2014;9(3):e92614.
26. Rousseau AF, Foidart-Desalle M, Ledoux D, Remy C, Croisier JL, Damas P, et al. Effects of cholecalciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: a one-year pilot randomized controlled trial in adults with severe burns. Burns. 2015;41(2):317–25.
27. Braun AB, Litonjua AA, Moromizato T, Gibbons FK, Giovannucci E, Christopher KB. Association of low serum 25-hydroxyvitamin D levels and acute kidney injury in the critically ill. Crit Care Med. 2012;40(12):3170–9.
28. Braun AB, Gibbons FK, Litonjua AA, Giovannucci E, Christopher KB. Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality. Crit Care Med. 2012;40(1):63–72.
29. Youssef D, Bailey B, El Abbassi A, Copeland R, Adebonojo L, Manning T, et al. Healthcare costs of Staphylococcus aureus and Clostridium difficile infections in veterans: role of vitamin D deficiency. Epidemiol Infect. 2010;138(9):1322–7.
30. Thickett DR, Moromizato T, Litonjua AA, Amrein K, Quraishi SA, Lee-Sarwar KA, et al. Association between prehospital vitamin D status and incident acute respiratory failure in critically ill patients: a retrospective cohort study. BMJ Open Respir Res. 2015;2(1):e000074.
31. Brook K, Camargo CA, Christopher KB, Quraishi SA. Admission vitamin D status is associated with discharge destination in critically ill surgical patients. Ann Intensive Care. 2015;5(1):23.
32. 3 levels and cardiac function, dysglycemia, length of stay, and 30-d readmissions in cardiac surgery patients. Nutrition. 2015;31(6):820–6.
33. Higgins DM, Wischmeyer PE, Queensland KM, Sillau SH, Sufit AJ, Heyland DK. Relationship of vitamin D deficiency to clinical outcomes in critically ill patients. JPEN J Parenter Enteral Nutr. 2012;36(6):713–20.
34. Quraishi SA, Bittner EA, Blum L, McCarthy CM, Bhan I, Camargo Jr CA. Prospective study of vitamin D status at initiation of care in critically ill surgical patients and risk of 90-day mortality. Crit Care Med. 2014;42(6):1365–71.
35. Flynn L, Zimmerman LH, McNorton K, Dolman M, Tyburski J, Baylor A, et al. Effects of vitamin D deficiency in critically ill surgical patients. Am J Surg. 2012;203(3):379–82. discussion 382.
36. Barnett N, Zhao Z, Koyama T, Janz DR, Wang CY, May AK, et al. Vitamin D deficiency and risk of acute lung injury in severe sepsis and severe trauma: a case–control study. Ann Intensive Care. 2014;4(1):5.
37. Verceles AC, Weiler B, Koldobskiy D, Goldberg AP, Netzer G, Sorkin JD. Association between vitamin D status and weaning from prolonged mechanical ventilation in survivors of critical illness. Respir Care. 2015;60(7):1033–9.
38. Hollis BW. Assessment and interpretation of circulation 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the clinical environment. Endocrinol Metab Clin North Am. 2010;39:271–86.
39. Van den Berghe G, Van Roosbroeck D, Vanhove P, Wouters PJ, De Pourcq L, Bouillon R. Bone turnover in prolonged critical illness: effect of vitamin D. J Clin Endocrinol Metab. 2003;88(10):4623–32.
40. Bacon CJ, Gamble GD, Horne AM, Scott MA, Reid IR. High-dose oral vitamin D3 supplementation in the elderly. Osteoporos Int. 2009;20(8):1407–15. doi:10.1007/s00198-008-0814-9.
41. von Restorff C, Bischoff-Ferrari HA, Theiler R. High-dose oral vitamin D3 supplementation in rheumatology patients with severe vitamin D3 deficiency. Bone. 2009;45(4):747–9.
42. Mata-Granados JM, Vargas-Vasserot J, Ferreiro-Vera C, de Castro MD L, Pavón RG, Quesada Gómez JM. Evaluation of vitamin D endocrine system (VDES) status and response to treatment of patients in intensive care units (ICUs) using an on-line SPE-LC-MS/MS method. J Steroid Biochem Mol Biol. 2010;121(1–2):452–5.
43. Leaf DE, Raed A, Donnino MW, Ginde AA, Waikar SS. Randomized controlled trial of calcitriol in severe sepsis. Am J Respir Crit Care Med. 2014;190(5):533–41.
44. Amrein K, Sourij H, Wagner G, Holl A, Pieber TR, Smolle KH, et al. Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: a randomized, double-blind, placebo-controlled pilot study. Crit Care. 2011;15(2):R104.
45. Rathi MS, Gonzalez S, Wright D, Ellis NR, Peacey SR. Management of hypovitaminosis D in patients with primary hyperparathyroidism. J Endocrinol Investig. 2014;37(5):467–71.
46. Dickerson RN, Berry SC, Ziebarth JD, Swanson JM, Maish 3rd GO, Minard G, et al. Dose-response effect of ergocalciferol therapy on serum 25-hydroxyvitamin D concentration during critical illness. Nutrition. 2015;31(10):1219–23.
47. Amrein K, Schnedl C, Holl A, Riedl R, Christopher KB, Pachler C, et al. Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA. 2014 Oct 15;312(15):1520–30. Erratum in: JAMA. 2014;312(18):1932. This is the largest randomized controlled trial to date examining vitamin D administration in the ICU. There was no difference in primary outcomes when vitamin D administration was compared with placebo.
48. Rousseau AF, Damas P, Ledoux D, Cavalier E. Effect of cholecalciferol recommended daily allowances on vitamin D status and fibroblast growth factor-23: an observational study in acute burn patients. Burns. 2014;40(5):865–70.