Structural Characterization and Immunomodulatory Activity of a Novel Polysaccharide from Lepidium meyenii

Journal of Agricultural and Food Chemistry

Volumn 64, Issue 9, 2016, Pages 1921-1931

  Zhang, Mengmeng ^a   Wang, Guang ^a   Lai, Furao ^a,b   Wu, Hui ^a  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^b Guangdong Provincial Key Laboratory of Green Agricultural Products Processing   (China)

Author keywords

immunomodulatory activity; Lepidium meyenii; polysaccharide; structural characterization

Indexed keywords

ALKYLATION; EXTRACTION; GAS CHROMATOGRAPHY; POLYSACCHARIDES;

AVERAGE MOLECULAR WEIGHT; IMMUNOMODULATORY ACTIVITIES; LEPIDIUM MEYENII; METHYLATION ANALYSIS; PHAGOCYTIC CAPACITY; STRUCTURAL CHARACTERIZATION; TOLL-LIKE RECEPTOR 2; WATER EXTRACTION METHODS;

CHARACTERIZATION;

ARABINOSE; GALACTOSE; GLUCOSE; IMMUNOLOGIC FACTOR; INTERLEUKIN 6; MANNOSE; NITRIC OXIDE; POLYSACCHARIDE; TUMOR NECROSIS FACTOR;

ANIMAL; CHEMISTRY; CONFORMATION; DRUG EFFECTS; ISOLATION AND PURIFICATION; LEPIDIUM; MACROPHAGE; MOLECULAR WEIGHT; MOUSE; PHAGOCYTOSIS; PINOCYTOSIS; PLANT ROOT; RAW 264.7 CELL LINE; SECRETION (PROCESS);

ANIMALS; ARABINOSE; CARBOHYDRATE CONFORMATION; GALACTOSE; GLUCOSE; IMMUNOLOGIC FACTORS; INTERLEUKIN-6; LEPIDIUM; MACROPHAGES; MANNOSE; MICE; MOLECULAR WEIGHT; NITRIC OXIDE; PHAGOCYTOSIS; PINOCYTOSIS; PLANT ROOTS; POLYSACCHARIDES; RAW 264.7 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84960334783     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.5b05610     Document Type: Article

References (41)

1. Zha, S.; Zhao, Q.; Chen, J.; Wang, L.; Zhang, G.; Zhang, H.; Zhao, B. Extraction, purification and antioxidant activities of the polysaccharides from maca (Lepidium meyenii) Carbohydr. Polym. 2014, 111, 584-587 10.1016/j.carbpol.2014.05.017
2. Flores, H. E.; Walker, T. S.; Guimarães, R. L.; Bais, H. P.; Vivanco, J. M. Andean root and tuber crops: Underground rainbows HortScience 2003, 38, 161-168
3. Bai, N.; He, K.; Roller, M.; Lai, C.-S.; Bai, L.; Pan, M.-H. Flavonolignans and Other Constituents from Lepidium meyenii with Activities in Anti-inflammation and Human Cancer Cell Lines J. Agric. Food Chem. 2015, 63, 2458-2463 10.1021/acs.jafc.5b00219
4. del Valle Mendoza, J.; Pumarola, T.; Gonzales, L. A.; Del Valle, L. J. Antiviral activity of maca (Lepidium meyenii) against human influenza virus Asian Pac. J. Trop. Med. 2014, 7, S415-S420 10.1016/S1995-7645(14)60268-6
5. Choi, E. H.; Kang, J. I.; Cho, J. Y.; Lee, S. H.; Kim, T. S.; Yeo, I. H.; Chun, H. S. Supplementation of standardized lipid-soluble extract from maca (Lepidium meyenii) increases swimming endurance capacity in rats J. Funct. Foods 2012, 4, 568-573 10.1016/j.jff.2012.03.002
6. Gonzales, G. F.; Gasco, M.; Lozada-Requena, I. Role of maca (Lepidium meyenii) consumption on serum interleukin-6 levels and health status in populations living in the Peruvian Central Andes over 4000 m of altitude Plant Foods Hum. Nutr. 2013, 68, 347-351 10.1007/s11130-013-0378-5
7. Liu, H.; Jin, W.; Fu, C.; Dai, P.; Yu, Y.; Huo, Q.; Yu, L. Discovering anti-osteoporosis constituents of maca (Lepidium meyenii) by combined virtual screening and activity verification Food Res. Int. 2015, 77, 215-220 10.1016/j.foodres.2015.06.028
8. Ai, Z.; Cheng, A.-F.; Yu, Y.-T.; Yu, L.-J.; Jin, W. Antidepressant-like behavioral, anatomical, and biochemical effects of petroleum ether extract from Maca (Lepidium meyenii) in mice exposed to chronic unpredictable mild stress J. Med. Food 2014, 17, 535-542 10.1089/jmf.2013.2950
9. Rubio, J.; Qiong, W.; Liu, X.; Jiang, Z.; Dang, H.; Chen, S.-L.; Gonzales, G. F., Aqueous extract of black maca (Lepidium meyenii) on memory impairment induced by ovariectomy in mice. Evid-Based Compl Alt 2011, 2011. 1 10.1093/ecam/nen063
10. Uchiyama, F.; Jikyo, T.; Takeda, R.; Ogata, M. Lepidium meyenii (Maca) enhances the serum levels of luteinising hormone in female rats J. Ethnopharmacol. 2014, 151, 897-902 10.1016/j.jep.2013.11.058
11. Noratto, G.; Condezo-Hoyos, L.; Gasco, M.; Gonzales, G. Lepidium meyenii (maca) consumption prevent benign prostatic hyperplasia FASEB J. 2013, 27, 861.25
12. Stojanovska, L.; Law, C.; Lai, B.; Chung, T.; Nelson, K.; Day, S.; Apostolopoulos, V.; Haines, C. Maca reduces blood pressure and depression, in a pilot study in postmenopausal women Climacteric 2015, 18, 69-78 10.3109/13697137.2014.929649
13. Muhammad, I.; Zhao, J. P.; Dunbar, D. C.; Khan, I. A. Constituents of Lepidium meyenii 'maca' Phytochemistry 2002, 59, 105-110 10.1016/S0031-9422(01)00395-8
14. Zhao, J.; Muhammad, I.; Dunbar, D. C.; Mustafa, J.; Khan, I. A. New alkamides from maca (Lepidium meyenii) J. Agric. Food Chem. 2005, 53, 690-693 10.1021/jf048529t
15. Piacente, S.; Carbone, V.; Plaza, A.; Zampelli, A.; Pizza, C. Investigation of the tuber constituents of maca (Lepidium meyenii Walp) J. Agric. Food Chem. 2002, 50, 5621-5625 10.1021/jf020280x
16. Cui, B. L.; Zheng, B. L.; He, K.; Zheng, Q. Y. Imidazole alkaloids from Lepidium meyenii J. Nat. Prod. 2003, 66, 1101-1103 10.1021/np030031i
17. Biswas, S. K.; Sodhi, A. In vitro activation of murine peritoneal macrophages by monocyte chemoattractant protein-1: Upregulation of CD11b, production of proinflammatory cytokines, and the signal transduction pathway J. Interferon Cytokine Res. 2002, 22, 527-538 10.1089/10799900252982007
18. Wu, T. T.; Chen, T. L.; Chen, R. M. Lipopolysaccharide triggers macrophage activation of inflammatory cytokine expression, chemotaxis, phagocytosis, and oxidative ability via a toll-like receptor 4-dependent pathway: Validated by RNA interference Toxicol. Lett. 2009, 191, 195-202 10.1016/j.toxlet.2009.08.025
19. Kuan, Y. H.; Huang, F. M.; Li, Y. C.; Chang, Y. C. Proinflammatory activation of macrophages by bisphenol A-glycidyl-methacrylate involved NF kappa B activation via PI3K/Akt pathway Food Chem. Toxicol. 2012, 50, 4003-4009 10.1016/j.fct.2012.08.019
20. Seedevi, P.; Sudharsan, S.; Kumar, S. V.; Srinivasan, A.; Vairamani, S.; Shanmugam, A., Isolation and characterization of sulphated polysaccharides from Codium tomentosum. J. Stackhouse, 1797, collected from southeast coast of India.
21. Lee, H. H.; Lee, J. S.; Cho, J. Y.; Kim, Y. E.; Hong, E. K. Structural characteristics of immunostimulating polysaccharides from Lentinus edodes J. Microbiol. Biotechnol. 2009, 19, 455-461 10.4014/jmb.0809.542
22. Nie, S.-P.; Cui, S. W.; Phillips, A. O.; Xie, M.-Y.; Phillips, G. O.; Al-Assaf, S.; Zhang, X.-L. Elucidation of the structure of a bioactive hydrophilic polysaccharide from Cordyceps sinensis by methylation analysis and NMR spectroscopy Carbohydr. Polym. 2011, 84, 894-899 10.1016/j.carbpol.2010.12.033
23. Xu, X.; Yan, H.; Zhang, X. Structure and immuno-stimulating activities of a new heteropolysaccharide from Lentinula edodes J. Agric. Food Chem. 2012, 60, 11560-11566 10.1021/jf304364c
24. Okajima-Kaneko, M.; Ono, M.; Kabata, K.; Kaneko, T. Extraction of novel sulfated polysaccharides from Aphanothece sacrum (Sur.) Okada, and its spectroscopic characterization Pure Appl. Chem. 2007, 79, 2039-2046 10.1351/pac200779112039
25. Li, W.; Xia, X.; Tang, W.; Ji, J.; Rui, X.; Chen, X.; Jiang, M.; Zhou, J.; Zhang, Q.; Dong, M. Structural Characterization and Anticancer Activity of Cell-Bound Exopolysaccharide from Lactobacillus helveticus MB2-1 J. Agric. Food Chem. 2015, 63, 3454-3463 10.1021/acs.jafc.5b01086
26. Gong, L.; Zhang, H.; Niu, Y.; Chen, L.; Liu, J.; Alaxi, S.; Shang, P.; Yu, W.; Yu, L. A Novel Alkali Extractable Polysaccharide from Plantago asiatic L. Seeds and Its Radical-Scavenging and Bile Acid-Binding Activities J. Agric. Food Chem. 2015, 63, 569-577 10.1021/jf505909k
27. Hawker, C.; Lee, R.; Fréchet, J. One-step synthesis of hyperbranched dendritic polyesters J. Am. Chem. Soc. 1991, 113, 4583-4588 10.1021/ja00012a030
28. Niu, Y.; Shang, P.; Chen, L.; Zhang, H.; Gong, L.; Zhang, X.; Yu, W.; Xu, Y.; Wang, Q.; Yu, L. Characterization of a novel alkali-soluble heteropolysaccharide from tetraploid Gynostemma pentaphyllum makino and its potential anti-inflammatory and antioxidant properties J. Agric. Food Chem. 2014, 62, 3783-3790 10.1021/jf500438s
29. Sof'ya, N. S.; Shashkov, A. S.; Shneider, M. M.; Arbatsky, N. P.; Popova, A. V.; Miroshnikov, K. A.; Volozhantsev, N. V.; Knirel, Y. A. Structure of the capsular polysaccharide of Acinetobacter baumannii ACICU containing di-N-acetylpseudaminic acid Carbohydr. Res. 2014, 391, 89-92 10.1016/j.carres.2014.04.002
30. Zhang, X.; Liu, L.; Lin, C. Isolation, structural characterization and antioxidant activity of a neutral polysaccharide from Sisal waste Food Hydrocolloids 2014, 39, 10-18 10.1016/j.foodhyd.2013.12.012
31. Sica, A.; Mantovani, A. Macrophage plasticity and polarization: in vivo veritas J. Clin. Invest. 2012, 122, 787-795 10.1172/JCI59643
32. Mills, C., M1 and M2 macrophages: oracles of health and disease. Crit. Rev. Immunol. 2012, 32. 463 10.1615/CritRevImmunol.v32.i6.10
33. Schepetkin, I. A.; Faulkner, C. L.; Nelson-Overton, L. K.; Wiley, J. A.; Quinn, M. T. Macrophage immunomodulatory activity of polysaccharides isolated from Juniperus scopolorum Int. Immunopharmacol. 2005, 5, 1783-1799 10.1016/j.intimp.2005.05.009
34. Bohn, J. A.; BeMiller, J. N. (1→ 3)-β-D-Glucans as biological response modifiers: a review of structure-functional activity relationships Carbohydr. Polym. 1995, 28, 3-14 10.1016/0144-8617(95)00076-3
35. Gantner, B. N.; Simmons, R. M.; Canavera, S. J.; Akira, S.; Underhill, D. M. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2 J. Exp. Med. 2003, 197, 1107-1117 10.1084/jem.20021787
36. Thornton, B. P.; Větvicka, V.; Pitman, M.; Goldman, R. C.; Ross, G. D. Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18) J. Immunol 1996, 156, 1235-1246
37. Schepetkin, I. A.; Quinn, M. T. Botanical polysaccharides: Macrophage immunomodulation and therapeutic potential Int. Immunopharmacol. 2006, 6, 317-333 10.1016/j.intimp.2005.10.005
38. Liao, W.; Luo, Z.; Liu, D.; Ning, Z.; Yang, J.; Ren, J. Structure Characterization of a Novel Polysaccharide from Dictyophora indusiata and Its Macrophage Immunomodulatory Activities J. Agric. Food Chem. 2015, 63, 535-544 10.1021/jf504677r
39. Gordon, S. Pattern recognition receptors: doubling up for the innate immune response Cell 2002, 111, 927-930 10.1016/S0092-8674(02)01201-1
40. Ferreira, S. S.; Passos, C. P.; Madureira, P.; Vilanova, M.; Coimbra, M. A. Structure-function relationships of immunostimulatory polysaccharides: A review Carbohydr. Polym. 2015, 132, 378-396 10.1016/j.carbpol.2015.05.079
41. Figueiredo, R. T.; Bittencourt, V. C. B.; Lopes, L. C. L.; Sassaki, G.; Barreto-Bergter, E. Toll-like receptors (TLR2 and TLR4) recognize polysaccharides of Pseudallescheria boydii cell wall Carbohydr. Res. 2012, 356, 260-264 10.1016/j.carres.2012.02.028