Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells

Journal of Toxicological Sciences

Volumn 41, Issue 2, 2016, Pages 225-232

  Fujie, Tomoya ^a   Segawa, Yukino ^a   Yoshida, Eiko ^a   Kimura, Tomoki ^b   Fujiwara, Yasuyuki ^c   Yamamoto, Chika ^d   Satoh, Masahiko ^e   Naka, Hiroshi ^f   Kaji, Toshiyuki ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b SETSUNAN UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^d TOHO UNIVERSITY   (Japan)

^e AICHI GAKUIN UNIVERSITY   (Japan)

^f NAGOYA UNIVERSITY   (Japan)

Author keywords

Bio organometallics; Copper complex; Endothelial cell; Metallothionein

Indexed keywords

COPPER; COPPER(II) BIS(DIETHYLDITHIOCARBAMATE); DIETHYLDITHIOCARBAMIC ACID; MESSENGER RNA; METALLOTHIONEIN; METALLOTHIONEIN I; METALLOTHIONEIN II; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; HEAVY METAL; ISOPROTEIN; NFE2L2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MTF-1;

ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BOVINE; CONTROLLED STUDY; LUCIFERASE ASSAY; NONHUMAN; PLASMID; PROTEIN EXPRESSION; PROTEIN INDUCTION; REAL TIME POLYMERASE CHAIN REACTION; RENILLA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM; WESTERN BLOTTING; ZINC METABOLISM; ANIMAL; CELL CULTURE; DRUG EFFECTS; ENDOTHELIUM CELL; GENE EXPRESSION; GENE SILENCING; GENETICS; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CATTLE; CELLS, CULTURED; COPPER; DITIOCARB; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; METALLOTHIONEIN; METALS, HEAVY; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84960191909     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.41.225     Document Type: Article

References (29)

1. Bittel, D., Dalton, T., Samson, S.L., Gedamu, L. and Andrews, G.K. (1998): The DNA binding activity of metal response elementbinding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals. J. Biol. Chem., 273, 7127-7133.
2. Fujie, T., Murakami, M., Yoshida, E., Tachinami, T., Shinkai, Y., Fujiwara, Y., Yamamoto, C., Kumagai, Y., Naka, H. and Kaji, T. (2016a): Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells. J. Biol. Inorg. Chem., doi: 10.1007/s00775-016-1337-z
3. Fujie, T., Segawa, Y., Uehara, A., Nakamura, T., Kimura, T., Yoshida, E., Yamamoto, C., Uchiyama, M., Naka, H. and Kaji, T. (2016b): Zinc diethyldithiocarbamate as an inducer of metallothionein in cultured vascular endothelial cells. J. Toxicol. Sci., 41, 217-224.
4. Fujiwara, Y., Mitani, M., Yasuike, S., Kurita, J. and Kaji, T. (2005): An organobismuth compound that exhibits selective cytotoxicity to vascular endothelial cells in vitro. J. Health Sci., 51, 333-340.
5. Fukada, T. and Kambe, T. (2011): Molecular and genetic features of zinc transporters in physiology and pathogenesis. Metallomics, 3, 662-674.
6. Grotz, N., Fox, T., Connolly, E., Park, W., Guerinot, M.L. and Eide, D. (1998): Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency. Proc. Natl. Acad. Sci. USA, 95, 7220-7224.
7. Heuchel, R., Radtke, F., Georgiev, O., Stark, G., Aguet, M. and Schaffner, W. (1994): The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J., 13, 2870-2875
8. Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., Yamamoto, M. and Nabeshima, Y. (1997): An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun., 236, 313-322.
9. Kägi, J.H.R. (1991). Overview of metallothionein. Methods Enzymol., 205, 613-626.
10. Kaji, T., Mishima, A., Koyanagi, E., Yamamoto, C., Sakamoto, M. and Kozuka, H. (1992): Possible mechanism for zinc protection against cadmium cytotoxicity in cultured vascular endothelial cells. Toxicology, 76, 257-270.
11. Kimura, T., Itoh, N., Takehara, M., Oguro, I., Ishizaki, J., Nakanishi, T. and Tanaka, K. (2002): MRE-binding transcription factor-1 is activated during endotoxemia: a central role for metallothionein. Toxicol. Lett., 129, 77-84.
12. Kimura, T., Kawasaki, Y., Okumura, F., Sone, T., Natsuki, R. and Isobe, M. (2009): Ethanol-induced expression of glutamatecysteine ligase catalytic subunit gene is mediated by NF-κB. Toxicol. Lett., 185, 110-115.
13. Kimura, T., Yoshida, K., Yamamoto, C., Suzuki, M., Uno, T., Isobe, M., Naka, H., Yasuike, S., Satoh, M., Kaji, T. and Uchiyama, M. (2012): Bis(L-cysteinato)zincate(II) as a coordination compound that induces metallothionein gene transcription without inducing cell-stress-related gene transcription. J. Inorg. Biochem., 117, 140-146.
14. Kohri, K., Yoshida, E., Yasuike, S., Fujie, T., Yamamoto, C. and Kaji, T. (2015): The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules. J. Toxicol. Sci., 40, 321-327.
15. Margoshes, M. and Vallee, B.L. (1957): A cadmium protein from equine kidney cortex. J. Am. Chem. Soc., 79, 4813-4814.
16. Martin, D., Li, Y., Yang, J., Wang, G., Margariti, A., Jiang, Z., Yu, H., Zampetaki, A., Hu, Y., Xu, Q. and Zeng, L. (2014): Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3. J. Biol. Chem., 289, 30625-30634.
17. Motohashi, H., O'Connor, T., Katsuoka, F., Engel, J.D. and Yamamoto, M. (2002): Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene, 294, 1-12.
18. Murakami, M., Fujie, T., Matsumura, M., Yoshida, E., Yamamoto, C., Fujiwara, Y., Yasuike, S. and Kaji, T. (2015): Comparative cytotoxicity of triphenylstibane and fluorine-substituted triarylpnictogens in cultured vascular endothelial cells. Fundam. Toxicol. Sci., 2, 61-66.
19. Ohtsuji, M., Katsuoka, F., Kobayashi, A., Aburatani, H., Hayes, J.D. and Yamamoto, M. (2008): Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J. Biol. Chem., 283, 33554-33562.
20. Quaife, C.J., Findley, S.D., Erickson, J.C., Froelick, G.J., Kelly, E.J., Zambrowicz, B.P. and Palmiter, R.D. (1994): Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry, 33, 7250-7259.
21. Redtke, F., Heuchel, R., Georgiev, O., Hergersberg, M., Gariglio, M., Dembic, Z. and Schaffner, W. (1993): Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter. EMBO J., 12, 1355-1362.
22. Sato, M. and Bremner, I. (1993): Oxygen free radicals and metallothionein. Free Radic. Biol. Med., 14, 325-337.
23. Stennard, F.A., Holloway, A.F., Hamilton, J. and West, A.K. (1994): Characterisation of six additional human metallothionein genes. Biochim. Biophys. Acta, 1218, 357-365.
24. Sun, Z., Chin, Y.E. and Zhang, D.D. (2009): Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol. Cell. Biol., 29, 2658-2672.
25. Taniguchi, M., Fukunaka, A., Hagihara, M., Watanabe, K., Kamino, S., Kambe, T., Enomoto, S. and Hironuma, M. (2013): Essential role of the zinc transporter ZIP9/SLC39A9 in regulating the activations of Akt and Erk in B-cell receptor signaling pathway in DT40 cells. PLoS One, 8, e5822.
26. Taylor, K.M., Morgan, H.E., Johnson, A. and Nicholson, R.I. (2004): Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters. Biochem. J., 377, 131-139.
27. Yeiser, E.C., Fitch, C.A., Horning, M.S., Rutkoski, N. and Levenson, C.W. (1999): Regulation of metallothionein-3 mRNA by thyroid hormone in developing rat brain and primary cultures of rat astrocytes and neurons. Brain Res. Dev. Brain Res., 115, 195-200.
28. Zhang, B., Egli, D., Georgiev, O. and Schaffner, W. (2001): The drosophila homolog of mammalian zinc finger factor MTF-1 activates transcription in response to heavy metals. Mol. Cell. Biol., 21, 4505-4514.
29. Zhang, J., Ohta, T., Maruyama, A., Hosoya, T., Nishikawa, K., Maher, J.M., Shibahara, S., Itoh, K. and Yamamoto, M. (2006): BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress. Mol. Cell. Biol., 26, 7942-7952.