Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes

Diabetologia

Volumn 58, Issue 9, 2015, Pages 2133-2143

  Giesbertz, Pieter ^a   Padberg, Inken ^b   Rein, Dietrich ^b   Ecker, Josef ^a   Höfle, Anja S ^a   Spanier, Britta ^a   Daniel, Hannelore ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Biomarker Program   (Germany)

Author keywords

Adipose tissue; Branched chain amino acids; Insulin resistance; Liver; Metabolomics; Muscle

Indexed keywords

1,5 ANHYDROSORBITOL; 18 HYDROXYDEOXYCORTICOSTERONE; 3 HYDROXY 2 METHYLPROPIONIC ACID; 3 HYDROXYBUTYRIC ACID; ARGININE; BEHENIC ACID; BRANCHED CHAIN AMINO ACID; BRANCHED CHAIN FATTY ACID; CERAMIDE; CHOLESTEROL; CHOLESTEROL ESTER; CORTICOSTERONE; FATTY ACID; FATTY ALCOHOL; GLUCOSE; GLYCINE; GLYOXYLIC ACID; HYDROXYPROLINE; INSULIN; LEPTIN; LIGNOCERIC ACID; LINOLEIC ACID; LYSINE; LYSOPHOSPHATIDYLCHOLINE; N(G),N(G) DIMETHYLARGININE; PHOSPHOLIPID; PHOSPHOTYROSINE; SERINE; SPHINGOLIPID; SPHINGOMYELIN; UNCLASSIFIED DRUG; GLYOXYLIC ACID DERIVATIVE; SORBITOL;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DB/DB MOUSE; EPIDIDYMIS FAT; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIQUID CHROMATOGRAPHY; LIVER; LIVER LOBE; MALE; MASS FRAGMENTOGRAPHY; METABOLOMICS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OB/OB MOUSE; OBESITY; PHENOTYPE; PLASMA; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; REAL TIME POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; ADIPOSE TISSUE; ANIMAL; BLOOD; C57BL MOUSE; GENE EXPRESSION REGULATION; GENETICS; INSULIN RESISTANCE; METABOLISM; METABOLOME; MOUSE MUTANT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

3-HYDROXYBUTYRIC ACID; ADIPOSE TISSUE; ANIMALS; DIABETES MELLITUS, TYPE 2; FATTY ACIDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENE EXPRESSION REGULATION; GLYOXYLATES; INSULIN RESISTANCE; LEPTIN; LIVER; LYSINE; MALE; METABOLOME; METABOLOMICS; MICE; MICE, INBRED C57BL; MICE, OBESE; MUSCLE, SKELETAL; OBESITY; PHOSPHOTYROSINE; SIGNAL TRANSDUCTION; SORBITOL;

EID: 84938741145     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3656-y     Document Type: Article

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