Silencing MicroRNA-155 Attenuates Cardiac Injury and Dysfunction in Viral Myocarditis via Promotion of M2 Phenotype Polarization of Macrophages

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Zhang, Yingying ^a   Zhang, Mengying ^a   Li, Xueqin ^a   Tang, Zongsheng ^a   Wang, Xiangmin ^a   Zhong, Min ^a   Suo, Qifeng ^a   Zhang, Yao ^a   Lv, Kun ^a  

^a WANNAN MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MIRN155 MICRORNA, MOUSE;

ANIMAL; CARDIAC MUSCLE; GENE SILENCING; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; MOUSE; MYOCARDITIS; PATHOLOGY; PATHOPHYSIOLOGY; VIROLOGY;

ANIMALS; GENE SILENCING; MACROPHAGES; MICE; MICE, KNOCKOUT; MICRORNAS; MYOCARDITIS; MYOCARDIUM;

EID: 84960155764     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep22613     Document Type: Article

References (48)

1. Frisancho-Kiss, S. et al. Sex differences in coxsackievirus B3-induced myocarditis: IL-12R beta1 signaling and IFN-gamma increase inflammation in males independent from STAT 4. Brain Res. 1126, 139-147 (2006).
2. Fairweather, D., Afanasyeva, M., Rose, N. R. Cellular immunity: a role for cytokines. The Heart in Systemic Autoimmune Diseases. (ed. Doria, A.) 3-17 (Elsevier, 2004).
3. Fairweather, D., Rose, N. R. Inflammatory heart disease: a role for cytokines. Lupus. 14, 646-651 (2005).
4. Feldman, A. M., McNamara, D. Myocarditis. N Engl J Med. 343, 1388-1398 (2000).
5. Huber, S., Sartini, D. T cells expressing the Vgamma1 T-cell receptor enhance virus-neutralizing antibody response during coxsackievirus B3 infection of BALB/c mice: differences in male and female mice. Viral Immunol. 18, 730-739 (2005).
6. Wynn, T. A., Barron, L. Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis. 30, 245-257 (2010).
7. Gordon, S. Alternative activation of macrophages. Nat Rev Immunol. 3, 23-35 (2003).
8. Martinez, F. O., Sica, A., Mantovani, A., Locati, M. Macrophage activation and polarization. Front Biosci. 13, 453-461 (2008).
9. Martinez, F. O., Helming, L., Gordon, S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol. 27, 451-483 (2009).
10. Gordon, S., Taylor, P. R. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 5, 953-964 (2005).
11. Mantovani, A., Sica, A., Locati, M. Macrophage polarization comes of age. Immunity. 23, 344-346 (2005).
12. Mosser, D. M., Edwards, J. P. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 8, 958-969 (2008).
13. Vats, D. et al. Oxidative metabolism and PGC-1 beta attenuate macrophage-mediated inflammation. Cell Metab. 4, 13-24 (2006).
14. Fairweather, D. et al. IL-12 receptor beta 1 and Toll-like receptor 4 increase IL-1beta-and IL-18-associated myocarditis and coxsackievirus replication. J Immunol. 170, 4731-4737 (2003).
15. Hirasawa, K. et al. Depletion of Mac1-positive macrophages protects DBA/2 mice from encephalomyocarditis virus-induced myocarditis and diabetes. J Gen Virol. 77, 737-741 (1996).
16. Li, K. et al. Differential Macrophage Polarization in Male and Female BALB/c Mice Infected With Coxsackievirus B3 Defines Susceptibility to Viral Myocarditis. Circ Res. 105, 353-364 (2009).
17. O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., Baltimore, D. Physiological and pathological roles for microRNAs in the immune system. Nat. Rev. Immunol. 10, 111-122 (2010).
18. Xiao, C., Rajewsky, K. MicroRNA control in the immune system: Basic principles. Cell. 136, 26-36 (2009).
19. Haasch, D. et al. T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC. Cell Immunol. 217, 78-86 (2002).
20. O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., Baltimore, D. MicroRNA-155 is induced during the macrophage inflammatory response. Proc. Natl. Acad. Sci. USA 104, 1604-1609 (2007).
21. Wang, P. et al. Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1. J Immunol. 185, 6226-6233 (2010).
22. O'Connell, R. M. et al. Inositol phosphatase SHIP1 is a primary target of miR-155. Proc. Natl. Acad. Sci. USA 106, 7113-7118 (2009).
23. Zhang, Y. Y. Expression profiles of miRNAs in polarized macrophages. Int J Mol Med. 31, 797-802 (2013).
24. Cihakova, D. et al. Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation. Am J Pathol. 172, 1195-1208 (2008).
25. Mosser, D. M., Edwards J. P. Exploring the full spectrum of macrophage activation. Na. Rev Immunol. 8, 958-969 (2008).
26. Satoh, T. et al. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol. 11, 936-944 (2010).
27. Ishii, M. et al. Epigenetic regulation of the alternatively activated macrophage phenotype. Blood. 114, 3244-3254 (2009).
28. Corsten, M. F. et al. MicroRNA Profiling Identifies MicroRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis. Circ Res. 111, 415-425 (2012).
29. Kearney, M. T., Cotton, J. M., Richardson, P. J., Shah, A. M. Viral myocarditis and dilated cardiomyopathy: mechanisms, manifestations, and management. Postgrad Med J. 77, 4-10 (2001).
30. Mariola, K. S. et al. MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc. Natl. Acad. Sci. USA 108, 11193-11198 (2011).
31. Gopal, M., Vanessa, B., Akanksha, M., Nicole, J., Howard, L. W. Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis. J Immunol. 187, 2213-2221(2011).
32. Kun, Lv. et al. Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells. Clin Immunol. 140, 92-101 (2011).
33. Shi, Y. et al. Regulatory t cells protect mice against coxsackievirus-induced myocarditis through the transforming growth factor {beta}-coxsackie-adenovirus receptor pathway. Circulation. 121, 2624-2634 (2010).
34. Huber, S. A. Coxsackievirus b3-induced myocarditis: infection of females during the estrus phase of the ovarian cycle leads to activation of t regulatory cells. Virology. 378, 292-298 (2008).
35. Giovine, F. S., Nuki, G., Duff, G. W. Tumour necrosis factor in synovial exudates. Ann Rheum Dis. 47, 768-772 (1988).
36. Yokota, K., Miyazaki, T., Hirano, M., Akiyama, Y., Mimura, T. Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Rheumatol. 33, 463-471 (2006).
37. Rathanaswami, P., Hachicha, M., Wong, W. L., Schall, T. J., McColl, S. R. Synergistic effect of interleukin-1 beta and tumor necrosis factor alpha on interleukin-8 gene expression in synovial fibroblasts. Evidence that interleukin-8 is the major neutrophil-activating chemokine released in response to monokine activation. Arthritis Rheum. 36, 1295-1304 (1993).
38. Katrib, A. et al. Expression of chemokines and matrix metalloproteinases in early rheumatoid arthritis. Rheumatology (Oxford). 40, 988-994 (2001).
39. Henke, A., Zell, R., Ehrlich, G., Stelzner, A. Expression of immunoregulatory cytokines by recombinant coxsackievirus B3 variants confers protection against virus-caused myocarditis. J Virol. 75, 8187-8194 (2001).
40. Nishio, R., Matsumori, A., Shioi, T., Ishida, H., Sasayama, S. Treatment of experimental viral myocarditis with interleukin-10. Circulation. 100, 1102-1108 (1999).
41. Henke, A., Huber, S., Stelzner, A., Whitton, J. L. The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis. J Virol. 69, 6720-6728 (1995).
42. Koenders, M. I. et al. Interleukin-17 acts independently of TNF-alpha under arthritic conditions. J Immunol. 176, 6262-6269 (2006).
43. Komiyama, Y. et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol. 177, 566-573(2006).
44. Lunding, L. P. et al. Poly (inosinic-cytidylic) Acid-Triggered Exacerbation of Experimental Asthma Depends on IL-17A Produced by NK Cells. J Immunol. 194, 5615-5625 (2015).
45. Rangachari, M. et al. T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin17. J Exp Med. 203, 2009-2019 (2006).
46. Vigorito, E. et al. Microrna-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity. 27, 847-859 (2007).
47. Rodriguez, A. et al. Requirement of bic/microrna-155 for normal immune function. Science. 316, 608-611 (2007).
48. Yuan, J. et al. Phosphorothioate antisense oligodeoxynucleotide specifically inhibits coxsackievirus B3 replication in cardiomyocytes and mouse hearts. Lab Investig. 84, 703-714 (2004).