5-HT(1A) receptor antagonist improves behavior performance of delirium rats through inhibiting PI3K/Akt/mTOR activation-induced NLRP3 activity

IUBMB Life

Volumn 68, Issue 4, 2016, Pages 311-319

  Qiu, Yimin ^a   Huang, Xiaojing ^a   Huang, Lina ^a   Tang, Liang ^a   Jiang, Jihong ^a   Chen, Lianhua ^a   Li, Shitong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

5 HT(1A) receptor antagonist; amygdala; hippocampus; neuroinflammation; neurotransmitter

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; CRYOPYRIN; DOPAMINE; HOMOVANILLIC ACID; INTERLEUKIN 1BETA; MAMMALIAN TARGET OF RAPAMYCIN; MONOAMINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCOPOLAMINE; IL1B PROTEIN, RAT; MTOR PROTEIN, RAT; N-(2-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-N-(2-PYRIDINYL)CYCLOHEXANECARBOXAMIDE; NLRP3 PROTEIN, RAT; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SCOPOLAMINE BROMIDE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN ANTAGONIST; TARGET OF RAPAMYCIN KINASE;

ADULT; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASOLATERAL AMYGDALA; BRAIN REGION; CEREBROSPINAL FLUID; CONTROLLED STUDY; DELIRIUM; DRUG MECHANISM; ENZYME PHOSPHORYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; MALE; NONHUMAN; RAT; TASK PERFORMANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DRUG EFFECTS; EMERGENCE DELIRIUM; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MAZE TEST; METABOLISM; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; STEREOTACTIC PROCEDURE; WISTAR RAT;

3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; BASOLATERAL NUCLEAR COMPLEX; EMERGENCE DELIRIUM; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HOMOVANILLIC ACID; HUMANS; HYDROXYINDOLEACETIC ACID; INJECTIONS, INTRAVENTRICULAR; INTERLEUKIN-1BETA; MALE; MAZE LEARNING; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PHOSPHATIDYLINOSITOL 3-KINASE; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; SCOPOLAMINE HYDROBROMIDE; SEROTONIN; SEROTONIN ANTAGONISTS; SIGNAL TRANSDUCTION; STEREOTAXIC TECHNIQUES; TOR SERINE-THREONINE KINASES;

EID: 84960146239     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1491     Document Type: Article

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