Optimizing indomethacin-loaded chitosan nanoparticle size, encapsulation, and release using Box-Behnken experimental design

International Journal of Biological Macromolecules

Volumn 87, Issue , 2016, Pages 329-340

  Abul Kalam, Mohd ^a   Khan, Abdul Arif ^a   Khan, Shahanavaj ^a   Almalik, Abdulaziz ^b   Alshamsan, Aws ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY   (Saudi Arabia)

Author keywords

Box Behnken design; Chitosan; Indomethacin; Nanoparticles

Indexed keywords

CHITOSAN NANOPARTICLE; INDOMETACIN; TRIPOLYPHOSPHATE; CHITOSAN; DRUG CARRIER; MICROCAPSULE; NANOPARTICLE; POLYPHOSPHATE; TRIPHOSPHORIC ACID;

ARTICLE; BOX BEHNKEN DESIGN; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); DATA ANALYSIS; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; ENCAPSULATION; EXPERIMENTAL DESIGN; IN VITRO STUDY; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; RESPONSE SURFACE METHOD; STIRRING TIME; TIME; TRANSMISSION ELECTRON MICROSCOPY; VALIDATION STUDY; ZETA POTENTIAL; CHEMICAL PHENOMENA; CHEMISTRY; KINETICS; MICROCAPSULE; THEORETICAL MODEL;

CAPSULES; CHITOSAN; DRUG CARRIERS; DRUG LIBERATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INDOMETHACIN; KINETICS; MODELS, THEORETICAL; NANOPARTICLES; PARTICLE SIZE; POLYPHOSPHATES;

EID: 84960130103     PISSN: 01418130     EISSN: 18790003     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2016.02.033     Document Type: Article

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