Measuring Information Processing Speed in Mild Cognitive Impairment: Clinical Versus Research Dichotomy

Journal of Alzheimer's Disease

Volumn 51, Issue 1, 2016, Pages 263-275

  Haworth, Judy ^a   Phillips, Michelle ^b   Newson, Margaret ^a   Rogers, Peter J ^b   Torrens Burton, Anna ^c   Tales, Andrea ^c  

^a SOUTHMEAD HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

Dementia; information processing speed; mild cognitive impairment; reaction time

Indexed keywords

AGED; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DEMENTIA; ELECTROENCEPHALOGRAPHY; EXPERIENCE; FEEDBACK SYSTEM; FEMALE; HUMAN; HUMAN EXPERIMENT; INFORMATION PROCESSING; MALE; MILD COGNITIVE IMPAIRMENT; NEUROIMAGING; PERFORMANCE; PRIORITY JOURNAL; REACTION TIME; RESPONSE TIME; SEX DIFFERENCE; TRAIL MAKING TEST; ATTENTION; COGNITIVE DEFECT; DEMOGRAPHY; DIAGNOSTIC IMAGING; MENTAL FUNCTION; MENTAL HEALTH; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PHOTOSTIMULATION; PHYSIOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ATTENTION; COGNITIVE DYSFUNCTION; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; MALE; MENTAL PROCESSES; MENTAL STATUS SCHEDULE; MIDDLE AGED; NEUROIMAGING; NEUROPSYCHOLOGICAL TESTS; PHOTIC STIMULATION; REACTION TIME; RESIDENCE CHARACTERISTICS;

EID: 84960125528     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-150791     Document Type: Article

References (82)

1. Ferreira D, Molina Y, Machado A,Westman E,Wahlund LO, Nieto A, Carreia R, Junqué C, Dáz-Flores L, Barroso J (2014) Cognitive decline is mediated by gray matter changes during middle age. Neurobiol Aging 35, 1086-1094
2. Salthouse TA (1996) The processing-speed theory of adult age differences in cognition. Psychol Rev 103, 403-428
3. Zimprich DM (2002) Can longitudinal changes in processing speed explain longitudinal changes in fluid intelligence?. Psychol Aging 17, 690-695
4. Wahl HW, Schmitt M, Danner D, Coppin A (2010) Is the emergence of functional ability decline in early old age related to change in speed of cognitive processing and also to change in personality? J Aging Health 22, 691-712
5. Salthouse TA (1994) The nature of the influence of speed on adult age-differences in cognition. Develop Psychol 30, 240-259
6. Warkentin S, Erikson C, Janciauskiene S (2008) rCBF pathology in Alzheimer's disease is associated with slow processing speed. Neuropsychologia 46, 1193-1200
7. Amieva H, Rouch-Leroyer I, Fabrigoule C, Daetigues JF (2000) Deterioration of controlled processes in the preclinical phase of dementia: A confirmatory analysis. Dement Geriatr Cogn Disord 11, 46-52
8. Phillips M, Rogers P, Haworth J, Bayer A, Tales A (2013) Intra-individual reaction time variability in mild cognitive impairment and Alzheimer's disease: Gender, processing load and speed factors. PLOS One 8, e65712
9. Van Deursen JA, Vuurman EFPM, Smits LL, Verhey FRJ, RiedelWJ(2009) Response speed, contingent negative variation and P300 in Alzheimer's disease and MCI. Brain Cogn 69, 592-599
10. Kochan N, Bunce D, Pont S, Slavin M, Reppermund S, Brodaty H, Crawford J, Mather K, Kang K, Sachdev P (2013) Reaction-time measures predict incident dementia over 4 years: The Sydney Memory and Ageing Study. Alzheimers Dement 9(Suppl) 536
11. Rosler A, Billino J, Muller NG, Weidauer S, Steinmetz H, Kleinschmidt A (2005) Visual search in patients with sub cortical vascular dementia: Short fixations but long reaction times. Dement Geriatr Cogn Disord 20, 375-380
12. Duering M, Gesierich B, Seiler S, Pirpamer L, Gonik M, Hofer E, Jouvent E, Duchesnay E, Chabriat H, Ropele S, Schmidt R, DichgansM(2014) Strategic white matter tracts for processing speed deficits in age-related small vessel disease. Neurology 82, 1946-1950
13. Jacobs HIL, Leritz EC, Williams VJ, Van Boxtel MPJ, van der Elst W, Jolles J, Verhey FRJ, McGlinchey RE, Milberg WP, Salat DH (2013) Association between white matter microstructure, executive functions, and processing speed in older adults: The impact of vascular health. Hum Brain Mapp 34, 77-95
14. Righart R, Duering M, Gonik M, Jouvent E, Reyes S, Hervé D, Chabriat H, DichgansM(2013) Impact of regional cortical and subcortical changes on processing speed in cerebral small vessel disease. Neuroimage Clin 2, 854-861
15. Parikh M, Hynan LS, Weiner MF, Lacritz L, Ringe W, Cullum CM (2014) Single neuropsychological test scores associated with rate of cognitive decline in early Alzheimer's disease. Clin Neuropsychol 28, 926-940
16. Caramelli P, Chaves ML, Engelhardt E, Machado JC, Schultz RR, Vale FA, Charchat-Fichman H (2004) Effects of galantamine on attention and memory in Alzheimer's disease measured by computerised neuropsychological tests: Results of the Brazilian multi-center galantamine study [GAL-BRA-01]. Arq Neuropsiquiatr 62, 379-384
17. Edwards JD, Delahunt PB, Mahncke HW(2009) Cognitive speed of processing delays driving cessation. J Gerontol A Sci Med Sci 64, 1262-1267
18. Edwards JD, Bart E, O'Connor ML, Cissell G (2010) Ten years down the road: Predictors of driving cessation. Gerontologist 50, 393-399
19. Iwasa H, Kai I, Yoshida Y, Suzuki T, Kim H, Yoshida H (2014) Information processing speed and 8-year mortality among community-dwelling elderly Japanese. J Epidemiol 24, 52-59
20. Iwasa H, Gondo T, Yoshida Y, Kwon J, Inagaki H, Kawaai C, Masui Y, Kim H, Yoshida H, Suzuki T (2008) Cognitive performance as a predictor of functional decline among the non-disabled elderly dwelling in a Japanese community: A 4-year population-based prospective cohort study. Arch Gerontol Geriatr 47, 139-149
21. Welmer A-K, Rizzuto D, Qui C, Caracciolo B, Laukka EJ (2014) Walking speed, processing speed, and dementia: A population-based longitudinal study. J Gerontol A Biol Sci Med Sci 69, 1503-1510
22. Cumming TB, Brodtmann A, Darby D, Bernhardt J (2012) Cutting a long story short: Reaction times in acute stroke are associated with longer term cognitive outcomes. J Neurol Sci 322, 102-106
23. Reuter-Lorenz P, Park DC (2010) Human neuroscience and the aging mind: A new look at old problems. J Gerontol B Psychol Sci Soc Sci 64B 405-415
24. Lu PH, Lee GJ, Tishler TA, Meghpara M, Thompson PM, BartzokisG(2013) Myelin breakdown mediates age-related slowing in cognitive processing speed in healthy elderly men. Brain Cogn 81, 131-138
25. Ritchie SJ, Bates TC, Der G, Starr JM, Deary IJ (2013) Education is associated with higher later life IQ scores but not with faster cognitive processing speed. Psychol Aging 28, 515-521
26. Kerchner GA, Racine CA, Hale S, Wilheim R, Laluz V, Miller BL, Kramer JH (2012) Cognitive processing speed in older adults: Relationship with white matter integrity. PLOS One 7, e50425
27. Kochunov P, Coyle T, Lancaster J, Robin DA, Hardies J, Kochunov V, Bartzokis J, Royall D, Schlosser AE, Null M, Fox PT (2010) Processing speed is correlated with cerebral health markers in the frontal lobes as quantified by neuroimaging. Neuroimage 49, 1190-1199
28. Schneider KK, Schote AB, Meyer J, Markett S, Reuter M, Frings C (2015) Individual response speed is modulated by variants of the gene encoding the alpha 4 sub-unit of the nicotinic acetylcholine receptor (CHRNA4). Behav Brain Res 284, 11-18
29. Bartzokis G, Lu PH, Geschwind DH, Tingus K, Huang D, Mendez M, Edwards N, Mintz J (2007) Apolipoprotein E affects both myelin breakdown and cognition: Implications for age-related trajectories of decline into dementia. Biol Psychiatr 63, 1380-1387
30. Bartzokis G, Lu PH, Tingus K, Mendez MF, Richard A, Peters DG, Oluwadara B, Barrall KA, Finn JP,Villablanca P, Thompson PM, Mintz J (2010) Lifespan transition of myelin integrity and maximum motor speed. Neurobiol Aging 31, 1554-1562
31. Wolinsky FD, Vander Weg MW, Bryant Howren M, Jones MP, Dotson MM (2013) A randomized controlled trial of cognitive training using a visual speed of processing intervention in middle aged and older adults. PLOS One 8, e61624
32. Reitan RM, Wolfson D (1993) The Halstead-Reitan neuropsychological test battery: Theory and clinical interpretations. Neuropsychology Press, Tuscon, AZ
33. Tombaugh TN (2004) Trail Making Test A and B: Normative data stratified by age and education. Arch Clin Neuropsychol 19, 203-214
34. Hagen K, Ehlis AC, Haeussinger FB, Heinzel S, Dresler T, Mueller LD, Herrmann MJ, Fallgatter AJ, Metzger FG (2014) Activation during the Trail Making Test measured with functional near-infra-red spectroscopy in healthy elderly subjects. Neuroimage 85, 583-591
35. Salthouse TA (2011) What cognitive abilities are involved in trail-making performance? Intelligence 39, 222-232
36. Müller LD, Guhn A, Zeller JBM, Biehl SC, Dresler T, Hahn T, Fallgatter AJ, Polak T, Deckert J, Herrmann MJ (2014) Neural correlates of a standardized version of the trail making test in young and elderly adults: A functional near-infra-red spectroscopy study. Neuropsychologia 56, 271-279
37. Rabin LA, Barr WB, Burton LA (2005) Assessment practices of clinical neuropsychologists in the united states and Canada:Asurvey of INS,NAN, and APADivision 40 members. Arch Clin Neuropsychol 1, 33-65
38. Schmid NS, Ehrensperger MM, Berres M, Beck IR, Monsch AU (2014) The extension of the German CERAD Neuropsychological assessment battery with tests assessing subcortical, executive and frontal functions improves accuracy in dementia diagnosis. Dement Geriatr Cogn Dis Extra 4, 322-334
39. Lezak MD (1995) Neuropsychological Assessment. Oxford University Press, New York Oxford
40. Sofko C, Boettcher A, Hoadley R, Hil B (2014) Differential rates of age-related decline on Trail Making tests. Arch Clin Neuropsychol 29, 511
41. Bezdicek O, Motak L, Axelrod BN, Preiss M, Nikolai T, Vyhnalek M, Poreh A, Ruzicka E (2012) Czech version of the trail making test: Normative data and clinical utility. Arch Clin Neuropsychol 27, 906-914
42. Baudic S, Dalla Barba G, Thibaudet MC, Smagghe A, Remy P, Traykov L (2006) Executive function deficits in early Alzheimer's disease and their relations with episodic memory. Arch Clin Neuropsychol 21, 15-21
43. Boyle PA, Cohen RA, Paul R, Moser D, Gordon N (2002) Cognitive and motor impairments predict functional declines in patients with vascular dementia. Int J Geriatr Psychiatry 17, 164-169
44. Barr A, Benedict R, Tune L, Brandt J (1992) Neuropsychological differentiation of Alzheimer's disease from vascular dementia. Int J Geriatr Psychiatry 7, 621-627
45. Spreen O, Strauss E (1998) A Compendium of Neuropsychological Tests, Oxford University Press, Oxford
46. Mendez MF, Cherrier MM, Perryman KM (1997) Differences between Alzheimer's disease and vascular dementia on information processing measures. Brain Cogn 34, 301-310
47. Yuspeh RL, Vanderploeg RD, Crowel TA, MullanM(2002) Differences in executive functioning between Alzheimer's disease and subcortical ischemic vascular dementia. J Clin Exp Neuropsychol 24, 745-754
48. Greenlief CL, Margolis RB, Erker GJ (1985) Application of the Trail Making Test in differentiating neuropsychological impairment of elderly persons. Percept Mot Skills 61, 1283-1289
49. Paul R, Moser D, Cohen R, Browndyke J, Zawacki T, Gordon N (2001) Dementia severity and pattern of cognitive performance in vascular dementia. Appl Neuropsychol 8, 211-217
50. Johnstone B, Hogg JR, Schopp LH, Kapila C, Edwards S (2002) Neuropsychological deficit profiles in senile dementia of the Alzheimer's type. Arch Clin Neuropsychol 17, 273-281
51. Nestor PG, Parasuraman R, Haxby JV (1991) Speed of information processing and attention in early Alzheimer's dementia. Dev Neuropsychol 7, 243-356
52. Rasmusson XD, Zonderman AB, Kawas C, Resnick SM (1998) Effects of age & dementia on the Trail Making Test. Clin Neuropsychol 12, 169-178
53. Classen S, Wang Y, Winter SM, Velozo CA, Lanford DN, Bédard M (2013) Concurrent criterion validity of the safe driving behavior measure: A predictor of on-road driving outcomes. Am J Occup Ther 67, 108-116
54. Pillon B, Gouider-Khouja N, Deweer B, Vidailhet M, Malapani C, Dubois B, Agid Y (1995) Neuropsychological pattern of striatonigral degeneration: Comparison with Parkinson's disease and progressive supranuclear palsy. J Neurol Neurosurg Psychiatry 58, 174-179
55. Schmid N (2013) Neuropsychological signs of Alzheimer's disease 8 years prior to diagnosis. J Alzheimers Dis 34, 537-546
56. Lee H, Baniqued PL, Cosman J, Mullen S, McAuley E, Severson, Kramer AF (2012) Examining cognitive function across the lifespan using a mobile application. Comp Hum Behav 28, 1934-1946
57. PtotekW, tyskawaW, Kluzik A, Grzéskowiak M, Podlewski R, Zaba Z, Drobnik L (2014) Evaluation of the trail making test and interval timing as a measures of cognition in healthy adults: Comparisons by age, education, and gender. Med Sci Monit 20, 173-181
58. Cangoz B, Karakoc E, Selekler K (2009) Trail making test: Normative data for Turkish elderly population by age, sex and education. J Neurol Sci 283, 73-78
59. Ashendorf L, Jefferson AL, O'Connor MK, Chaisson C, Green RC, Stern RA (2008) Trial making test errors in normal aging, mild cognitive impairment, and dementia. Arch Clin Neuropsychol 23, 129-137
60. Seo EH, LeeDY, KimKW, Lee JH, Jhoo JH,Youn JC, Choo IH, Ha J, Woo JI (2006) A normative study of the Trail Making Test in Korean elders. Int J Geriatr Psychiatry 21, 844-852
61. Liu Y, Julkunen V, Paajanen T, Westman E, Wahlund L-O, Aitken A (2012) Education increases reserve against Alzheimer's disease-evidence from structural MRI analysis. Neurorad 54, 929-938
62. Corrigan JD, Hinkeldey NS (1987) Relationships between parts A and B of the Trail Making Test. J Clin Psychol 43, 402-409
63. Lu P, Lee G, Raven E, Tingus K, Khoo T, Thompson PM, Bartzokis G (2011) Age-related slowing in cognitive processing speed is associated with myelin integrity in a very healthy elderly sample. J Clin Exp Neuropsychol 33, 1059-1068
64. Der G, Deary IJ (2006) Age and sex differences in reaction time in adulthood: Results from the United Kingdom Health and Lifestyle Survey. Psychol Ageing 21, 62-73
65. Dykiert D, Der G, Starr JM, Deary IJ (2012) Sex differences in reaction time mean and intraindividual variability across the lifespan. Dev Psychol 48, 1262-1276
66. Roivainen E (2011) Gender differences in processing speed: A review of recent research. Learn Individ Differ 21, 145-149
67. Mitrushina M, Boone K (2005) Handbook of normative data for neuropsychological assessment, Oxford University Press, New York
68. Nelson HE, Willison JR (1991) National Adult Reading Test (NART). Test manual including new data supplement, NFER-NELSON, Windsor
69. Dykiert D, Deary IJ (2013) Retrospective validation of WTAR and NART scores as estimators of prior cognitive ability using the Lothian Birth Cohort 1936. Psychol Assess 25, 1361-1366
70. van Deursen JA, Vuurman EFPM, Smits LL, Verhey FRJ, RiedelWJ(2009) Response speed, contingent negative variation and P300 in Alzheimer's disease and MCI. Brain Cogn 69, 592-599
71. Levinoff E, Saumier D, Chertkow H (2005) Focused attention deficits in patients with Alzheimer's disease and mild cognitive impairment. Brain Cogn 57, 127-130
72. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198
73. Wechsler D (1998) Adult Intelligence Scale-III. The Psychological Corporation, London, UK
74. Brandt J (1991) The Hopkins Verbal Learning Test: Development of a new memory test with six equivalent forms. Clin Neuropsychol 5, 125-142
75. Royall DR, Cordes JA, Polk M (1988) An executive clock drawing task. J Neurol Neurosurg Psychiatry 64, 588-594
76. Benton AL, Sivan AB, Hamshere KD, Varney NR, Spreen O (1994) Visual Form Discrimination Test. Contributions to Neuropsychological Assessment, 2nd ed, Oxford University Press, Oxford
77. Coughlan AK, Hollows S (1995) The adult memory and information processing battery. St. James University Hospital, Leeds, UK
78. Bucks RS, Ashworth DL, Wilcock GK, Siegfried K (1996) Assessment of activities of daily living in dementia: Development of the Bristol Activities of Daily Living Scale. Age Ageing 25, 113-120
79. Adshead F, Cody DD, Pitt B (1992) BASDEC: A novel screening instrument for depression in elderly medical inpatients. BMJ 305, 397
80. Tales A, Bayer AJ, Haworth J, Snowden RJ, Philips M, Wilcock G (2011) Visual search in mild cognitive impairment: A longitudinal study. J Alzheimers Dis 24, 151-160
81. Tales A, Haworth J, Nelson S, Snowden R, Wilcock G (2005) Abnormal visual search in mild cognitive impairment in Alzheimer's disease. NeuroCase 11, 80-84
82. Rabbitt P, Osman P, Moore B (2001) There are stable individual differences in performance variability, both from moment to moment and from day to day. Q J Exp Psychol A 54A, 981-1003.