Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis

Annals of the Rheumatic Diseases

Volumn 75, Issue 3, 2016, Pages 578-585

  Rombouts, Yoann ^a   Willemze, Annemiek ^a   Van Beers, Joyce J B C ^b   Shi, Jing ^a   Kerkman, Priscilla F ^a   Van Toorn, Linda ^a   Janssen, George M C ^a,c   Zaldumbide, Arnaud ^a   Hoeben, Rob C ^a   Pruijn, Ger J M ^b   Deelder, André M ^a   Wolbink, Gertjan ^d,e   Rispens, Theo ^d   Van Veelen, Peter A ^a   Huizinga, Tom W J ^a   Wuhrer, Manfred ^a   Trouw, Leendert A ^a   Scherer, Hans U ^a   Toes, René E M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c NETHERLANDS PROTEOMICS CENTRE   (Netherlands)

^d SANQUIN RESEARCH   (Netherlands)

^e Jan Van Breemen Research Institute/Reade   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC CITRULLINATED PEPTIDE ANTIBODY; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; AUTOANTIBODY; AUTOANTIGEN; CITRULLINE; IMMUNOGLOBULIN G; POLYSACCHARIDE;

ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FRACTIONATION; GEL ELECTROPHORESIS; GLYCOSYLATION; HUMAN; MASS SPECTROMETRY; MOLECULAR WEIGHT; PLASMA; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; RHEUMATOID ARTHRITIS; SERUM; SIZE EXCLUSION CHROMATOGRAPHY; SURFACE PLASMON RESONANCE; SYNOVIAL FLUID; ADULT; AGED; CHEMISTRY; ELECTROPHORESIS; FEMALE; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED;

ADULT; AGED; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOANTIGENS; CHROMATOGRAPHY, GEL; CITRULLINE; ELECTROPHORESIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN G; MALE; MASS SPECTROMETRY; MIDDLE AGED; MOLECULAR WEIGHT; POLYSACCHARIDES; SURFACE PLASMON RESONANCE; SYNOVIAL FLUID;

EID: 84960109858     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2014-206598     Document Type: Article

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