Mixing test specific cut-off is more sensitive at detecting lupus anticoagulants than index of circulating anticoagulant

Thrombosis Research

Volumn 139, Issue , 2016, Pages 98-101

  Moore, Gary W ^a   Culhane, Aidan P ^a   Daw, Christopher R ^a   Noronha, Charlotte P ^a   Kumano, Osamu ^b  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b SYSMEX CORPORATION   (Japan)

Author keywords

Antiphospholipid antibodiesd; APTT; Index of circulating anticoagulant; Mixing tests; RVVT

Indexed keywords

LUPUS ANTICOAGULANT; PHOSPHOLIPID ANTIBODY; BLOOD CLOTTING INHIBITOR; IMMUNOGLOBULIN;

ANALYTIC METHOD; ARTICLE; BLOOD CLOTTING PARAMETERS; BLOOD SAMPLING; CONTROLLED STUDY; DILUTE RUSSELL VIPER VENOM TIME; DRUG BLOOD LEVEL; HUMAN; INDEX OF CIRCULATING ANTICOAGULANT; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MIXING TEST SPECIFIC CUT OFF; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; THROMBOCYTE POOR PLASMA; ANTIPHOSPHOLIPID SYNDROME; BLOOD; BLOOD CLOTTING TEST; PROCEDURES;

ANTIPHOSPHOLIPID SYNDROME; BLOOD COAGULATION TESTS; HUMANS; IMMUNOGLOBULINS; LUPUS COAGULATION INHIBITOR; PARTIAL THROMBOPLASTIN TIME;

EID: 84960100160     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2016.01.019     Document Type: Article

References (36)

1. M. Greaves, H. Cohen, S.J. Machin, and I. Mackie Guidelines on the investigation and management of the antiphospholipid syndrome Br. J. Haematol. 109 2000 704 715
2. K.M. Devreese Standardization of antiphospholipid antibody assays. Where do we stand? Lupus 21 2012 718 721
3. P.G. de Groot, and R.T. Urbanus The future of antiphospholipid antibody testing Semin. Thromb. Hemost. 38 2012 412 420
4. V. Pengo, A. Tripodi, G. Reber, J.H. Rand, T.L. Ortel, M. Galli, and P.G. de Groot Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis J. Thromb. Haemost. 7 2009 1737 1740
5. D. Keeling, I. Mackie, G.W. Moore, I.A. Greer, and M. Greaves British Committee for Standards in Haematology. Guidelines on the investigation and management of antiphospholipid syndrome Br. J. Haematol. 157 2012 47 58
6. CLSI Laboratory testing for the lupus anticoagulant; approved guideline CLSI document H60-A 2014 Clinical and Laboratory Standards Institute Wayne, PA
7. K.M.J. Devreese No more mixing tests required for integrated assay systems in the laboratory diagnosis of lupus anticoagulants? J. Thromb. Haemost. 8 2010 1120 1122
8. A. Tripodi To mix or not to mix in lupus anticoagulant testing? That is the question Semin. Thromb. Hemost. 38 2012 385 389
9. G. Reber, and P. Meijer In ECAT veritas? Lupus 21 2012 722 724
10. S.K. Hong, S.M. Hwang, J.E. Kim, and H.K. Kim Clinical significance of the mixing test in laboratory diagnoses of lupus anticoagulant: The fate of the mixing test in integrated lupus anticoagulant test systems Blood Coagul. Fibrinolysis 23 2012 739 744
11. M.T. Pennings, P.G. De Groot, J.C. Meijers, A. Huisman, R.H. Derksen, and R.T. Urbanus Optimisation of lupus anticoagulant tests: Should test samples always be mixed with normal plasma? Thromb. Haemost. 112 2014 736 742
12. M. Aboud, M.C. Morel-Kopp, C. Ward, and L. Coyle False-negative or false-positive: Laboratory diagnosis of lupus anticoagulant at the time of commencement of anticoagulant J. Thromb. Haemost. 8 2010 2070 2073
13. E.J. Favaloro, R. Bonar, D. Zebeljan, G. Kershaw, and K. Marsden Laboratory investigation of lupus anticoagulants: Mixing studies are sometimes required J. Thromb. Haemost. 8 2010 2828 2831
14. K.M.J. Devreese, and B. De Laat Mixing studies in lupus anticoagulant testing are required at least in some type of samples J. Thromb. Haemost. 13 2015 1475 1478
15. K.M. Devreese Interpretation of normal plasma mixing studies in the laboratory diagnosis of lupus anticoagulants Thromb. Res. 119 2007 369 376
16. G.W. Moore, and G.F. Savidge The dilution effect of equal volume mixing studies compromises confirmation of inhibition by lupus anticoagulants even when mixture specific reference ranges are applied Thromb. Res. 118 2006 523 528
17. E. Rosner, R. Pauzner, A. Lusky, M. Modan, and A. Many Detection and quantitative evaluation of lupus circulating anticoagulant activity Thromb. Haemost. 57 1987 144 147
18. G.W. Moore, K.L. Brown, E.S. Bromidge, A.J. Drew, and M.R. Ledford-Kraemer Lupus anticoagulant detection: Out of control? Int. J. Lab. Haematol. 35 2013 128 136
19. J. Thom, L. Ivey, and J. Eikelboom Normal plasma mixing studies in the laboratory diagnosis of lupus anticoagulant J. Thromb. Haemost. 1 2003 2689 2691
20. CLSI Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline-Third Edition. CLSI Document C28-A3 2008 Wayne, PA Clinical and Laboratory Standards Institute
21. G.A. Fritsma, F.R. Dembitzer, A. Randhawa, M.B. Marques, E.M. Van Cott, D. Adcock-Funk, and E.I. Peerschke Recommendations for appropriate activated partial thromboplastin time reagent selection and utilization Am. J. Clin. Pathol. 137 2012 904 908
22. P. Pradella, G. Azzarini, L. Santarossa, L. Caberlotto, C. Bardin, A. Poz, F. D'Aurizio, and R. Giacomello Cooperation experience in a multicentre study to define the upper limits in a normal population for the diagnostic assessment of the functional lupus anticoagulant assays Clin. Chem. Lab. Med. 51 2013 379 385
23. O. Kumano, M. Ieko, S. Naito, M. Yoshida, N. Takahashi, and T. Aoki Index of circulating anticoagulant cut-off value establishment in activated partial thromboplastin time mixing test for lupus anticoagulant diagnosis J. Thromb. Haemost. 11 2013 1919 1922
24. O. Kumano, M. Ieko, S. Naito, M. Yoshida, N. Takahashi, T. Suzuki, and T. Aoki Verification of the guidelines for lupus anticoagulant detection: Usefulness of index for circulating anticoagulant in APTT mixing test Thromb. Res. 134 2014 503 509
25. M.E. Martinuzzo, G.S. Cerrato, M.L. Varela, Y.P. Adamczuk, and R.R. Forastiero New guidelines for lupus anticoagulant: Sensitivity and specificity of cut-off values calculated with plasmas from healthy controls in mixing and confirmatory tests Int. J. Lab. Hematol. 34 2012 208 213
26. R. Li, C. Swaelens, F. Vandermijnsbrugge, and B. Cantinieaux Applying a direct aPTT ratio (PlatelinLS/ActinFS) permits to identify rapidly and reliably a bleeding-related factor deficiency or a lupus anticoagulant sequential to an isolated prolongation of aPTT in paediatric pre-operative screening Eur. J. Haematol. 2015 Jul 14 10.1111/ejh.12634 (Epub ahead of print)
27. B.M. Alving, B. Banerji, W.E. Fogler, and C.R. Alving Lupus anticoagulant activities of murine monoclonal antibodies to liposomal phosphatidylinositol phosphate Clin. Exp. Immunol. 69 1987 403 408
28. I. Jennings, I. Mackie, J. Arnout, F.E. Preston, and UK National External Quality Assessment Scheme for Blood Coagulation Lupus anticoagulant testing using plasma spiked with monoclonal antibodies: Performance in the UK NEQAS proficiency testing programme J. Thromb. Haemost. 2 2004 2178 2184
29. A. Lambrianides, T. Turner-Stokes, C. Pericleous, J. Ehsanullah, E. Papadimitraki, K. Poulton, Y. Ioannou, A. Lawrie, I. Mackie, P. Chen, D. Latchman, D. Isenberg, A. Rahman, and I. Giles Interactions of human monoclonal and polyclonal antiphospholipid antibodies with serine proteases involved in hemostasis Arthritis Rheum. 63 2011 3512 3521
30. M. Aboud, C. Roddie, C. Ward, and L. Coyle To mix with pooled normal plasma or not to mix: A comparative study of two approaches to assess lupus anticoagulant inhibitory activity in the dilute Russell Viper venom method Clin. Chem. 53 2007 143 145
31. K. Devreese, K. Peerlinck, and M.F. Hoylaerts Thrombotic risk assessment in the antiphospholipid syndrome requires more than the quantification of lupus anticoagulants Blood 115 2010 870 878
32. M. Van Blerk, E. Bailleul, B. Chatelain, A. Demulder, K. Devreese, J. Douxfils, K. Jochmans, F. Mullier, W. Wijns, M.R. Soumali, W. Coucke, K. Vernelen, and P. Van de Walle Influence of dabigatran and rivaroxaban on routine coagulation assays. A nationwide Belgian survey Thromb. Haemost. 113 2015 154 164
33. M.E. Martinuzzo, L.H. Barrera, M.A. D'adamo, J.C. Otaso, M.I. Gimenez, and J. Oyhamburu Frequent false-positive results of lupus anticoagulant tests in plasmas of patients receiving the new oral anticoagulants and enoxaparin Int. J. Lab. Hematol. 36 2014 144 150
34. H. Mani, C. Hesse, G. Stratmann, and E. Lindhoff-Last Ex vivo effects of low-dose rivaroxaban on specific coagulation assays and coagulation factor activities in patients under real life conditions Thromb. Haemost. 109 2013 127 136
35. F.R. Dembitzer, M.R. Ledford Kraemer, P. Meijer, and E.I. Peerschke Lupus anticoagulant testing: Performance and practices by North American Clinical Laboratories Am. J. Clin. Pathol. 134 2010 764 773
36. E.J. Favaloro, R. Bonar, and K. Marsden Internal quality control and external quality assurance in testing for antiphospholipid antibodies: Part II-lupus anticoagulant Semin. Thromb. Hemost. 38 2012 404 411