Rapid Molecular Diagnostics, Antibiotic Treatment Decisions, and Developing Approaches to Inform Empiric Therapy: PRIMERS i and II

Clinical Infectious Diseases

Volumn 62, Issue 2, 2016, Pages 181-189

  Evans, Scott R ^a   Hujer, Andrea M ^b,c   Jiang, Hongyu ^a   Hujer, Kristine M ^b,c   Hall, Thomas ^d   Marzan, Christine ^d   Jacobs, Michael R ^b   Sampath, Rangarajan ^d   Ecker, David J ^d   Manca, Claudia ^e   Chavda, Kalyan ^e   Zhang, Pan ^f   Fernandez, Helen ^f   Chen, Liang ^e   Mediavilla, Jose R ^e   Hill, Carol B ^g   Perez, Federico ^b,c   Caliendo, Angela M ^h   Fowler, Vance G ^g   Chambers, Henry F ⁱ   Kreiswirth, Barry N ^e   Bonomo, Robert A ^b,c   more..

^a CENTER FOR BIOSTATISTICS IN AIDS RESEARCH   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^d ABBOTT LABORATORIES   (United States)

^e PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^f WEILL CORNELL MEDICAL COLLEGE   (United States)

^g DUKE UNIVERSITY MEDICAL CENTER   (United States)

^h BROWN UNIVERSITY   (United States)

ⁱ SAN FRANCISCO GENERAL HOSPITAL   (United States)

Author keywords

lactams; empiric therapy; molecular diagnostics;

Indexed keywords

BETA LACTAM ANTIBIOTIC; CARBAPENEM DERIVATIVE; CEFTAZIDIME; IMIPENEM; PIPERACILLIN PLUS TAZOBACTAM; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM ISOLATE; CLINICAL PRACTICE; COMPARATIVE STUDY; ELECTROSPRAY MASS SPECTROMETRY; EMPIRIC THERAPY; ESCHERICHIA COLI; GENOTYPE PHENOTYPE CORRELATION; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DIAGNOSIS; MOLECULAR DIAGNOSTICS; NONHUMAN; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PREVALENCE; PRIORITY JOURNAL; QUALITY CONTROL; DRUG EFFECTS; ENTEROBACTERIACEAE INFECTIONS; GENETICS; GENOTYPING TECHNIQUE; HUMAN; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PROCEDURES; TIME FACTOR;

ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; ENTEROBACTERIACEAE INFECTIONS; ESCHERICHIA COLI; GENOTYPING TECHNIQUES; HUMANS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MOLECULAR DIAGNOSTIC TECHNIQUES; TIME FACTORS;

EID: 84960088435     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ837     Document Type: Article

References (20)

1. Nathan C, Cars O. Antibiotic resistance-problems, progress, and prospects. New Engl J Med 2014; 371:1761-3.
2. Bartlett JG, Gilbert DN, Spellberg B. Seven ways to preserve the miracle of antibiotics. Clin Infect Dis 2013; 56:1445-50.
3. Caliendo AM, Gilbert DN, Ginocchio CC, et al. Better tests, better care: improved diagnostics for infectious diseases. Clin Infect Dis 2013; 57(suppl 3):S139-70.
4. Baldwin CD, Howe GB, Sampath R, et al. Usefulness of multilocus polymerase chain reaction followed by electrospray ionization mass spectrometry to identify a diverse panel of bacterial isolates. Diagn Microbiol Infect Dis 2009; 63:403-8.
5. Endimiani A, Hujer AM, Hujer KM, et al. Evaluation of a commercial microarray system for detection of SHV-, TEM-, CTX-M-, and KPC-type beta-lactamase genes in gram-negative isolates. J Clin Microbiol 2010; 48:2618-22.
6. Endimiani A, Hujer KM, Hujer AM, et al. Are we ready for novel detection methods to treat respiratory pathogens in hospital-acquired pneumonia? Clin Infect Dis 2011; 52(suppl 4):S373-83.
7. Chen L, Mediavilla JR, Endimiani A, et al. Multiplex real-time PCR assay for detection and classification of Klebsiella pneumoniae carbapenemase gene (bla KPC) variants. J Clin Microbiol 2011; 49:579-85.
8. Chen L, Chavda KD, Findlay J, et al.Multiplex PCR for identification of two capsular types in epidemic KPC-producing Klebsiella pneumoniae sequence type 258 strains. Antimicrob Agents Chemother 2014; 58:4196-9.
9. Chen L, Chavda KD, Melano RG, et al. Comparative genomic analysis of KPC-encoding pKpQIL-like plasmids and their distribution in New Jersey and New York hospitals. Antimicrob Agents Chemother 2014; 58:2871-7.
10. Deleo FR, Chen L, Porcella SF, et al. Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae. ProcNatl Acad Sci U S A 2014; 111:4988-93.
11. CLSI. Performance Standards for Antimicrobial Susceptibility Testing. In: 22nd Informational Supplement. Wayne, PA: Clinical and Laboratory Standards Institute, 2012.
12. Lascols C, Hackel M, Hujer AM, et al. Using nucleic acid microarrays to perform molecular epidemiology and detect novel beta-lactamases: A snapshot of extendedspectrum beta-lactamases throughout the world. J Clin Microbiol 2012; 50:1632-9.
13. Lascols C, Hackel M, Marshall SH, et al. Increasing prevalence and dissemination of NDM-1 metallo-beta-lactamase in India: data from the SMART study (2009). J Antimicrob Chemother 2011; 66:1992-7.
14. Endimiani A, Hujer AM, Perez F, et al. Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the eastern USA. J Antimicrob Chemother 2009; 63:427-37.
15. Chambers HF, Bartlett JG, Bonomo RA, et al. Antibacterial resistance leadership group: open for business. Clin Infect Dis 2014; 58:1571-6.
16. Bauer KA, Perez KK, Forrest GN, Goff DA. Review of rapid diagnostic tests used by antimicrobial stewardship programs. Clin Infect Dis 2014; 59(suppl 3): S134-45.
17. Poulou A, Voulgari E, Vrioni G, et al. Outbreak caused by an ertapenem-resistant, CTX-M-15-producing Klebsiella pneumoniae sequence type 101 clone carrying an OmpK36 porin variant. J Clin Microbiol 2013; 51:3176-82.
18. Girometti N, Lewis RE, Giannella M, et al. Klebsiella pneumoniae bloodstream infection: epidemiology and impact of inappropriate empirical therapy. Medicine (Baltimore) 2014; 93:298-309.
19. Bacconi A, Richmond GS, Baroldi MA, et al. Improved sensitivity for molecular detection of bacterial and Candida infections in blood. J Clin Microbiol 2014; 52:3164-74.
20. O'Brien TF, Stelling J. Integrated multilevel surveillance of the world's infecting microbes and their resistance to antimicrobial agents. Clin Microbiol Rev 2011; 24:281-95.