Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts

Cell Stem Cell

Volumn 18, Issue 3, 2016, Pages 368-381

  Zhang, Yu ^a,b   Cao, Nan ^a,b   Huang, Yu ^a   Spencer, C Ian ^a   Fu, Ji Dong ^a,e   Yu, Chen ^a,b   Liu, Kai ^a,b   Nie, Baoming ^a,b   Xu, Tao ^a,b   Li, Ke ^a,b   Xu, Shaohua ^a,b   Bruneau, Benoit G ^a,b,c,d   Srivastava, Deepak ^a,c,d   Ding, Sheng ^a,b  

^a GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GLADSTONE INSTITUTES   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; BONE MORPHOGENETIC PROTEIN; DOXYCYCLINE; FIBROBLAST GROWTH FACTOR; NODAL SIGNALING PROTEIN; NOTCH RECEPTOR; PLATELET DERIVED GROWTH FACTOR; TROPONIN T; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR SYSTEM; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FATE; CELL ISOLATION; CELL POPULATION; CELL PROLIFERATION; CELL SELF-RENEWAL; CELL TRANSDIFFERENTIATION; CELL TRANSPLANTATION; CONTROLLED STUDY; ENDOTHELIUM CELL; EXPANDABLE CARDIOVASCULAR PROGENITOR CELL; FIBROBLAST; GENE EXPRESSION; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE CELL; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; STEM CELL; ANIMAL; CARDIAC MYOBLAST; CELL REPROGRAMMING TECHNIQUE; INDUCED PLURIPOTENT STEM CELL; METABOLISM; MYOCARDIAL INFARCTION; STEM CELL TRANSPLANTATION; TRANSPLANTATION;

ANIMALS; CELLULAR REPROGRAMMING; CELLULAR REPROGRAMMING TECHNIQUES; FIBROBLASTS; INDUCED PLURIPOTENT STEM CELLS; MYOBLASTS, CARDIAC; MYOCARDIAL INFARCTION; STEM CELL TRANSPLANTATION;

EID: 84960077143     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.02.001     Document Type: Article

References (23)

1. M.J. Birket, M.C. Ribeiro, A.O. Verkerk, D. Ward, A.R. Leitoguinho, S.C. den Hartogh, V.V. Orlova, H.D. Devalla, V. Schwach, M. Bellin, and et al. Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells Nat. Biotechnol. 33 2015 970 979
2. G. Blin, D. Nury, S. Stefanovic, T. Neri, O. Guillevic, B. Brinon, V. Bellamy, C. Rücker-Martin, P. Barbry, A. Bel, and et al. A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates J. Clin. Invest. 120 2010 1125 1139
3. B.G. Bruneau Signaling and transcriptional networks in heart development and regeneration Cold Spring Harb. Perspect. Biol. 5 2013 a008292
4. P.W. Burridge, G. Keller, J.D. Gold, and J.C. Wu Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming Cell Stem Cell 10 2012 16 28
5. N. Cao, H. Liang, J. Huang, J. Wang, Y. Chen, Z. Chen, and H.T. Yang Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions Cell Res. 23 2013 1119 1132
6. S.S. Chan, X. Shi, A. Toyama, R.W. Arpke, A. Dandapat, M. Iacovino, J. Kang, G. Le, H.R. Hagen, D.J. Garry, and M. Kyba Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner Cell Stem Cell 12 2013 587 601
7. C. Cheung, A.S. Bernardo, M.W. Trotter, R.A. Pedersen, and S. Sinha Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility Nat. Biotechnol. 30 2012 165 173
8. W.P. Devine, J.D. Wythe, M. George, K. Koshiba-Takeuchi, and B.G. Bruneau Early patterning and specification of cardiac progenitors in gastrulating mesoderm eLife 3 2014 3
9. J.A. Efe, S. Hilcove, J. Kim, H. Zhou, K. Ouyang, G. Wang, J. Chen, and S. Ding Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy Nat. Cell Biol. 13 2011 215 222
10. H. Hirata, S. Kawamata, Y. Murakami, K. Inoue, A. Nagahashi, M. Tosaka, N. Yoshimura, Y. Miyamoto, H. Iwasaki, T. Asahara, and Y. Sawa Coexpression of platelet-derived growth factor receptor alpha and fetal liver kinase 1 enhances cardiogenic potential in embryonic stem cell differentiation in vitro J. Biosci. Bioeng. 103 2007 412 419
11. S.J. Kattman, A.D. Witty, M. Gagliardi, N.C. Dubois, M. Niapour, A. Hotta, J. Ellis, and G. Keller Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines Cell Stem Cell 8 2011 228 240
12. D.S. Kaufman, R.L. Lewis, E.T. Hanson, R. Auerbach, J. Plendl, and J.A. Thomson Functional endothelial cells derived from rhesus monkey embryonic stem cells Blood 103 2004 1325 1332
13. A. Kuzmenkin, H. Liang, G. Xu, K. Pfannkuche, H. Eichhorn, A. Fatima, H. Luo, T. Saric, M. Wernig, R. Jaenisch, and J. Hescheler Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro FASEB J. 23 2009 4168 4180
14. J.T. Lam, A. Moretti, and K.L. Laugwitz Multipotent progenitor cells in regenerative cardiovascular medicine Pediatr. Cardiol. 30 2009 690 698
15. K.L. Laugwitz, A. Moretti, J. Lam, P. Gruber, Y. Chen, S. Woodard, L.Z. Lin, C.L. Cai, M.M. Lu, M. Reth, and et al. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages Nature 433 2005 647 653
16. A. Moretti, L. Caron, A. Nakano, J.T. Lam, A. Bernshausen, Y. Chen, Y. Qyang, L. Bu, M. Sasaki, S. Martin-Puig, and et al. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification Cell 127 2006 1151 1165
17. C.E. Murry, and G. Keller Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development Cell 132 2008 661 680
18. A.T. Naito, I. Shiojima, H. Akazawa, K. Hidaka, T. Morisaki, A. Kikuchi, and I. Komuro Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis Proc. Natl. Acad. Sci. U S A 103 2006 19812 19817
19. Y. Qyang, S. Martin-Puig, M. Chiravuri, S. Chen, H. Xu, L. Bu, X. Jiang, L. Lin, A. Granger, A. Moretti, and et al. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway Cell Stem Cell 1 2007 165 179
20. L.W. van Laake, R. Passier, J. Monshouwer-Kloots, A.J. Verkleij, D.J. Lips, C. Freund, K. den Ouden, D. Ward-van Oostwaard, J. Korving, L.G. Tertoolen, and et al. Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction Stem Cell Res. (Amst.) 1 2007 9 24
21. J.A. Wamstad, J.M. Alexander, R.M. Truty, A. Shrikumar, F. Li, K.E. Eilertson, H. Ding, J.N. Wylie, A.R. Pico, J.A. Capra, and et al. Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage Cell 151 2012 206 220
22. H. Wang, N. Cao, C.I. Spencer, B. Nie, T. Ma, T. Xu, Y. Zhang, X. Wang, D. Srivastava, and S. Ding Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4 Cell Rep. 6 2014 951 960
23. L. Yang, M.H. Soonpaa, E.D. Adler, T.K. Roepke, S.J. Kattman, M. Kennedy, E. Henckaerts, K. Bonham, G.W. Abbott, R.M. Linden, and et al. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population Nature 453 2008 524 528