Effect of zinc and multivitamin supplementation on the growth of Tanzanian children aged 6-84 wk: A randomized, placebo-controlled, double-blind trial

American Journal of Clinical Nutrition

Volumn 103, Issue 3, 2016, Pages 910-918

  Locks, Lindsey M ^a   Manji, Karim P ^e   McDonald, Christine M ^g   Kupka, Roland ^a,h   Kisenge, Rodrick ^e   Aboud, Said ^f   Wang, Molin ^b   Fawzi, Wafaie W ^a,c,d   Duggan, Christopher P ^a,d,g  

^a Departments of Nutrition   (United States)

^b Biostatistics Solutions   (United States)

^c Epidemiology Research Institute   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e Departments of Pediatrics   (Tanzania)

^f MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^g BOSTON CHILDREN S HOSPITAL   (United States)

^h UNICEF   (United States)

Author keywords

Growth; Infancy; Multiple micronutrients; Supplementation; Zinc

Indexed keywords

MULTIVITAMIN; PLACEBO; ZINC; TRACE ELEMENT; VITAMIN;

ARTICLE; BIRTH WEIGHT; CHILD; CHILD GROWTH; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; PREVALENCE; PROPORTIONAL HAZARDS MODEL; RANDOMIZED CONTROLLED TRIAL; STUNTING; TANZANIAN; UNDERWEIGHT; VITAMIN SUPPLEMENTATION; ADULT; BODY HEIGHT; BODY WEIGHT; DIETARY SUPPLEMENT; DRUG EFFECTS; GROWTH; GROWTH DISORDERS; MALE; PREGNANCY; PRESCHOOL CHILD; TANZANIA; WASTING SYNDROME; YOUNG ADULT;

ADULT; BODY HEIGHT; BODY WEIGHT; CHILD; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GROWTH; GROWTH DISORDERS; HUMANS; MALE; PREGNANCY; TANZANIA; THINNESS; TRACE ELEMENTS; VITAMINS; WASTING SYNDROME; YOUNG ADULT; ZINC;

EID: 84959876906     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.115.120055     Document Type: Article

References (40)

1. Black RE, Victora CG, Walker SP, Bhutta ZA, Christian P, de Onis M, Ezzati M, Grantham-McGregor S, Katz J, Martorell R. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet 2013;382:427-51
2. Olofin I, McDonald CM, Ezzati M, Flaxman S, Black RE, Fawzi WW, Caulfield LE, Danaei G. Associations of suboptimal growth with allcause and cause-specific mortality in children under five years: a pooled analysis of ten prospective studies. PLoS One 2013;88:e64636
3. Victora CG, Adair L, Fall C, Hallal PC, Martorell R, Richter L, Sachdev HS. Maternal and child undernutrition: consequences for adult health and human capital. Lancet 2008;371:340-57
4. Christian P, Tielsch JM. Evidence for multiple micronutrient effects based on randomized controlled trials and meta-analyses in developing countries. J Nutr 2012;142:173S-7S
5. Gibson RS. Zinc: the missing link in combating micronutrient malnutrition in developing countries. Proc Nutr Soc 2006;65:51-60
6. Clinical management of acute diarrhoea. Geneva (Switzerland): World Health Organisation and United Nations Childrens Fund; 2004;WHO/FCH/CSH 04.7
7. Lazzerini M, Luca R. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev 2013
8. Brown HK, Peerson J, Rivera J, Allen L. Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2002; 75:1062-71
9. Imdad A, Bhutta Z. Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries: a meta-analysis of studies for input to the lives saved tool. BMC Public Health 2011;11(Suppl 3):S22
10. Mayo-Wilson E, Junior JA, Imdad A, Dean S, Chan XHS, Chan ES, Jaswal A, Bhutta ZA. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age. Cochrane Database Syst Rev 2014;5:CD009384
11. Allen LH, Peerson JM, Olney DK. Provision of multiple rather than two or fewer micronutrients more effectively improves growth and other outcomes in micronutrient-deficient children and adults. J Nutr 2009;139:1022-30
12. Harrison GG. Public health interventions to combat micronutrient deficiencies. Public Health Reviews 2010;32;256-66
13. World Health Organisation Guideline. Use of multiple micronutrient powders for home fortification of foods consumed by infants and children 6-23 months of age. Geneva (Switzerland): World Health Organsation; 2011
14. Fawzi WW, Msamanga GI, Urassa W, Hertzmark E, Petraro P, Willett WC, Spiegelman D. Vitamins and perinatal outcomes among HIVnegative women in Tanzania. N Engl J Med 2007;356:1423-31
15. Villamor E, Saathoff E, Bosch RJ, Hertzmark E, Baylin A, Manji K, Msamanga G, Hunter DJ, Fawzi WW. Vitamin supplementation of HIV-infected women improves postnatal child growth. Am J Clin Nutr 2005;81:880-8
16. McDonald CM, Manji KP, Kisenge R, Aboud S, Spiegelman D, Fawzi WW, Duggan CP. Daily Zinc but not multivitamin supplementation reduces diarrhea and upper respiratory infections in Tanzanian infants: a randomized, double-blind, placebo-controlled clinical Trial. J Nutr 2015;145:2153-60
17. World Health Organisation. Physical status: the use and interpretation of anthropometry: report of a WHO Expert Committee. Geneva (Switzerland): World Health Organization; 1995
18. Basaga'a X, Spiegelman D. Power and sample size calculations for longitudinal studies comparing rates of change with a time-varying exposure. Statist Med 2010;29:181-92
19. De Onis M. WHO child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development. World Health Organisation; 2006
20. World Health Organisation. WHO child growth standards SAS macro (version 3.2.2). Geneva (Switzerland): World Health Organization. [Internet]. Updated January 2011 [cited 2012 Sep]. Available from: http://www.who.int/childgrowth/software/readme- sas.pdf
21. Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med 1989;8:551-61
22. Streiner DL. Best (but oft-forgotten) practices: the multiple problems of multiplicity-whether and how to correct for many statistical tests. Am J Clin Nutr 2015;102:721-8
23. Oken E, Kleinman KP, Rich-Edwards J, Gillman MW. A nearly continuous measure of birth weight for gestational age using a United States national reference. BMC Pediatr 2003;3:6
24. Brown KH, Peerson JM, Baker SK, Hess SY. Preventive zinc supplementation among infants, preschoolers, and older prepubertal children. Food Nutr Bull 2009;30:S12S-40
25. Ramakrishnan U, Goldenberg T, Allen LH. Do multiple micronutrient interventions improve child health, growth, and development? J Nutr 2011;141:2066-75
26. Krebs NF, Miller LV, Hambidge KM. Zinc deficiency in infants and children: a review of its complex and synergistic interactions. Paediatr Int Child Health 2014;34:279-88
27. Herman S, Griffin IJ, Suwarti S, Ernawati F, Permaesih D, Pambudi D, Abrams SA. Cofortification of iron-fortified flour with zinc sulfate, but not zinc oxide, decreases iron absorption in Indonesian children. Am J Clin Nutr 2002;76:813-7
28. Wapnir RA, Balkman C. Inhibition of copper absorption by zinc. Biol Trace Elem Res 1991;29:193-202
29. Sandström B. Micronutrient interactions: effects on absorption and bioavailability. Br J Nutr 2001;85(Suppl 2):S181-5
30. Ramakrishnan U. Prevalence of micronutrient malnutrition worldwide. Nutr Rev 2002;60:S46-52
31. Menon P, Ruel MT, Loechl CU, Arimond M, Habicht J-P, Pelto G, Michaud L. Micronutrient sprinkles reduce anemia among 9- to 24-moold children when delivered through an integrated health and nutrition program in Rural Haiti. J Nutr 2007;137:1023-30
32. Lombard CJ, Benadé AJ, Dhansay MA, Berger J, Hop le T, López de Roma'a G, Untoro J, Karyadi E, Erhardt J, et al. Efficacy of a foodlet-based multiple micronutrient supplement for preventing growth faltering, anemia, and micronutrient deficiency of infants: the four country IRIS trial pooled data analysis. J Nutr 2005;135:631S-8S
33. Untoro J, Karyadi E, Wibowo L, Erhardt M, Gross R. Multiple micronutrient supplements improve micronutrient status and anemia but not growth and morbidity of Indonesian infants: a randomized, doubleblind, placebo-controlled trial. J Nutr 2005;135:639S-45S
34. ChhaganMK, Van den Broeck J, Luabeya K-K, Mpontshane N, Tomkins A, Bennish M. Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: a randomized controlled trial in children aged 6-24 months. BMC Public Health 2010;10:145
35. López de Roma'a G, Cusirramos S, Lopez de Romana D, Gross R. Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, growth, and morbidity of Peruvian infants. J Nutr 2005;135:646S-52S
36. Hop T, Berger J.Multiple micronutrient supplementation improves anemia, micronutrient nutrient status, and growth of Vietnamese infants: doubleblind, randomized, placebo-controlled trial. J Nutr 2005;135:660S-5S
37. Soofi S, Cousens S, Iqbal SP, Akhund T, Khan J, Ahmed I, Zaidi AKM, Bhutta ZA. Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial. Lancet 2013;382:29-40
38. Ramakrishnan U, Nguyen P, Martorell R. Effects of micronutrients on growth of children under 5 y of age: meta-analyses of single and multiple nutrient interventions. Am J Clin Nutr 2009; 89:191-203
39. Kupka R, Manji KP, Bosch RJ, Aboud S, Kisenge R, Okuma J, Fawzi WW, Duggan C. Multivitamin supplements have no effect on growth of Tanzanian children born to HIV-infected mothers. J Nutr 2013;143:722-7
40. Bhutta ZA, Ahmed T, Black RE, Cousens S, Dewey K, Giugliani E, Haider BA, Kirkwood B, Morris SS, Sachdev H. What works? Interventions for maternal and child undernutrition and survival. Lancet 2008;371:417-40