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Volumn 65, Issue 8, 2016, Pages 1161-1171

Similarities and differences between pediatric and adult nonalcoholic fatty liver disease

Author keywords

Children; Liver fibrosis; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Noninvasive diagnosis

Indexed keywords

ALPHA TOCOPHEROL; PIOGLITAZONE; PLACEBO;

EID: 84959571598     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2016.01.008     Document Type: Article
Times cited : (62)

References (83)
  • 1
    • 84861901590 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
    • [PubMed PMID: 22641309]
    • [1] Chalasani, N., Younossi, Z., Lavine, J.E., Diehl, A.M., Brunt, E.M., Cusi, K., et al. The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Am J Gastroenterol 107:6 (2012), 811–826, 10.1038/ajg.2012.128 [PubMed PMID: 22641309].
    • (2012) Am J Gastroenterol , vol.107 , Issue.6 , pp. 811-826
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Diehl, A.M.4    Brunt, E.M.5    Cusi, K.6
  • 2
    • 84941925457 scopus 로고    scopus 로고
    • Diagnosis and Assessment of NAFLD: Definitions and Histopathological Classification
    • Epub 2015/09/18, PubMed PMID: 26378639
    • [2] Burt, A.D., Lackner, C., Tiniakos, D.G., Diagnosis and Assessment of NAFLD: Definitions and Histopathological Classification. Semin Liver Dis 35:3 (2015), 207–220, 10.1055/s-0035-1562942 Epub 2015/09/18, PubMed PMID: 26378639.
    • (2015) Semin Liver Dis , vol.35 , Issue.3 , pp. 207-220
    • Burt, A.D.1    Lackner, C.2    Tiniakos, D.G.3
  • 3
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease
    • [PubMed PMID: 7382552]
    • [3] Ludwig, J., Viggiano, T.R., McGill, D.B., Oh, B.J., Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 55:7 (1980), 434–438 [PubMed PMID: 7382552].
    • (1980) Mayo Clin Proc , vol.55 , Issue.7 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3    Oh, B.J.4
  • 4
    • 0020635233 scopus 로고
    • Steatohepatitis in obese children: a cause of chronic liver dysfunction
    • [PubMed PMID: 6859017]
    • [4] Moran, J.R., Ghishan, F.K., Halter, S.A., Greene, H.L., Steatohepatitis in obese children: a cause of chronic liver dysfunction. Am J Gastroenterol 78:6 (1983), 374–377 [PubMed PMID: 6859017].
    • (1983) Am J Gastroenterol , vol.78 , Issue.6 , pp. 374-377
    • Moran, J.R.1    Ghishan, F.K.2    Halter, S.A.3    Greene, H.L.4
  • 5
    • 84922321997 scopus 로고    scopus 로고
    • Non alcoholic fatty liver: epidemiology and natural history
    • [PubMed PMID: 25514916]
    • [5] Masarone, M., Federico, A., Abenavoli, L., Loguercio, C., Persico, M., Non alcoholic fatty liver: epidemiology and natural history. Rev Recent Clin Trials 9:3 (2014), 126–133 [PubMed PMID: 25514916].
    • (2014) Rev Recent Clin Trials , vol.9 , Issue.3 , pp. 126-133
    • Masarone, M.1    Federico, A.2    Abenavoli, L.3    Loguercio, C.4    Persico, M.5
  • 6
    • 84983123731 scopus 로고    scopus 로고
    • Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups
    • [PubMed PMID: 26454786]
    • [6] non-alcoholic fatty liver disease study group dttmoPPL, Lonardo, A., Bellentani, S., CK, Argo, Ballestri, S., Byrne, C.D., et al. Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups. Dig Liver Dis 47:12 (2015), 997–1006, 10.1016/j.dld.2015.08.004 [PubMed PMID: 26454786].
    • (2015) Dig Liver Dis , vol.47 , Issue.12 , pp. 997-1006
    • non-alcoholic fatty liver disease study group dttmoPPL1    Lonardo, A.2    Bellentani, S.3    CK, A.4    Ballestri, S.5    Byrne, C.D.6
  • 7
    • 33750002388 scopus 로고    scopus 로고
    • Prevalence of fatty liver in children and adolescents
    • [PubMed PMID: 17015527]
    • [7] Schwimmer, J.B., Deutsch, R., Kahen, T., Lavine, J.E., Stanley, C., Behling, C., Prevalence of fatty liver in children and adolescents. Pediatrics 118:4 (2006), 1388–1393 [PubMed PMID: 17015527].
    • (2006) Pediatrics , vol.118 , Issue.4 , pp. 1388-1393
    • Schwimmer, J.B.1    Deutsch, R.2    Kahen, T.3    Lavine, J.E.4    Stanley, C.5    Behling, C.6
  • 8
    • 84874645372 scopus 로고    scopus 로고
    • Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988-1994 to 2007-2010
    • [PubMed PMID: 23084707; PubMed Central PMCID: PMC3649872]
    • [8] Welsh, J.A., Karpen, S., Vos, M.B., Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988-1994 to 2007-2010. J Pediatr 162:3 (2013), 496–500 e1, 10.1016/j.jpeds.2012.08.043 [PubMed PMID: 23084707; PubMed Central PMCID: PMC3649872].
    • (2013) J Pediatr , vol.162 , Issue.3 , pp. 496-500 e1
    • Welsh, J.A.1    Karpen, S.2    Vos, M.B.3
  • 9
    • 84899814782 scopus 로고    scopus 로고
    • Lifetime direct medical costs of childhood obesity
    • [PubMed PMID: 24709935]
    • [9] Finkelstein, E.A., Graham, W.C., Malhotra, R., Lifetime direct medical costs of childhood obesity. Pediatrics 133:5 (2014), 854–862, 10.1542/peds.2014-0063 [PubMed PMID: 24709935].
    • (2014) Pediatrics , vol.133 , Issue.5 , pp. 854-862
    • Finkelstein, E.A.1    Graham, W.C.2    Malhotra, R.3
  • 10
    • 84920120003 scopus 로고    scopus 로고
    • Nonalcoholic Fatty Liver Disease In Children: Recent Practice Guidelines, Where Do They Take Us?
    • [10] Aggarwal, A., Puri, K., Thangada, S., Zein, N., Alkhouri, N., Nonalcoholic Fatty Liver Disease In Children: Recent Practice Guidelines, Where Do They Take Us?. Current pediatric reviews, Volume 10, (4 Issues), 2014, 151–161.
    • (2014) Current pediatric reviews , vol.10 , pp. 151-161
    • Aggarwal, A.1    Puri, K.2    Thangada, S.3    Zein, N.4    Alkhouri, N.5
  • 11
    • 49149114288 scopus 로고    scopus 로고
    • Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease
    • [PubMed PMID: 18591439]
    • [11] Schwimmer, J.B., Pardee, P.E., Lavine, J.E., Blumkin, A.K., Cook, S., Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. Circulation 118:3 (2008), 277–283 [PubMed PMID: 18591439].
    • (2008) Circulation , vol.118 , Issue.3 , pp. 277-283
    • Schwimmer, J.B.1    Pardee, P.E.2    Lavine, J.E.3    Blumkin, A.K.4    Cook, S.5
  • 12
    • 84893679656 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in obese adolescents: a looming marker of cardiac dysfunction
    • [PubMed PMID: 23913480]
    • [12] Santoro, N., Caprio, S., Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in obese adolescents: a looming marker of cardiac dysfunction. Hepatology 59:2 (2014), 372–374, 10.1002/hep.26663 [PubMed PMID: 23913480].
    • (2014) Hepatology , vol.59 , Issue.2 , pp. 372-374
    • Santoro, N.1    Caprio, S.2
  • 13
    • 84923918979 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a precursor of the metabolic syndrome
    • [PubMed PMID: 25739820]
    • [13] Lonardo, A., Ballestri, S., Marchesini, G., Angulo, P., Loria, P., Nonalcoholic fatty liver disease: a precursor of the metabolic syndrome. Dig Liver Dis 47:3 (2015), 181–190, 10.1016/j.dld.2014.09.020 [PubMed PMID: 25739820].
    • (2015) Dig Liver Dis , vol.47 , Issue.3 , pp. 181-190
    • Lonardo, A.1    Ballestri, S.2    Marchesini, G.3    Angulo, P.4    Loria, P.5
  • 14
    • 84888438359 scopus 로고    scopus 로고
    • Polycystic ovary syndrome and nonalcoholic fatty liver in obese adolescents: association with metabolic risk profile
    • [PubMed PMID: 24034940; PubMed Central PMCID: PMC3844059]
    • [14] Michaliszyn, S.F., Lee, S., Tfayli, H., Arslanian, S., Polycystic ovary syndrome and nonalcoholic fatty liver in obese adolescents: association with metabolic risk profile. Fertil Steril 100:6 (2013), 1745–1751, 10.1016/j.fertnstert.2013.08.015 [PubMed PMID: 24034940; PubMed Central PMCID: PMC3844059].
    • (2013) Fertil Steril , vol.100 , Issue.6 , pp. 1745-1751
    • Michaliszyn, S.F.1    Lee, S.2    Tfayli, H.3    Arslanian, S.4
  • 15
    • 84956891878 scopus 로고    scopus 로고
    • Evidence that non-alcoholic fatty liver disease and polycystic ovary syndrome are associated by necessity rather than chance: a novel hepato-ovarian axis?
    • [PubMed PMID: 26024975]
    • [15] Targher, G., Rossini, M., Lonardo, A., Evidence that non-alcoholic fatty liver disease and polycystic ovary syndrome are associated by necessity rather than chance: a novel hepato-ovarian axis?. Endocrine, 2015, 10.1007/s12020-015-0640-8 [PubMed PMID: 26024975].
    • (2015) Endocrine
    • Targher, G.1    Rossini, M.2    Lonardo, A.3
  • 16
    • 1842480297 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction
    • [PubMed PMID: 15057893]
    • [16] Adams, L.A., Feldstein, A., Lindor, K.D., Angulo, P., Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction. Hepatology. 39:4 (2004), 909–914 [PubMed PMID: 15057893].
    • (2004) Hepatology. , vol.39 , Issue.4 , pp. 909-914
    • Adams, L.A.1    Feldstein, A.2    Lindor, K.D.3    Angulo, P.4
  • 17
    • 84896542144 scopus 로고    scopus 로고
    • Obstructive sleep apnea and hypoxemia are associated with advanced liver histology in pediatric nonalcoholic fatty liver disease
    • e1 [PubMed PMID: 24321532; PubMed Central PMCID: PMC4014349]
    • [17] Sundaram, S.S., Sokol, R.J., Capocelli, K.E., Pan, Z., Sullivan, J.S., Robbins, K., et al. Obstructive sleep apnea and hypoxemia are associated with advanced liver histology in pediatric nonalcoholic fatty liver disease. J Pediatr 164:4 (2014), 699–706, 10.1016/j.jpeds.2013.10.072 e1 [PubMed PMID: 24321532; PubMed Central PMCID: PMC4014349].
    • (2014) J Pediatr , vol.164 , Issue.4 , pp. 699-706
    • Sundaram, S.S.1    Sokol, R.J.2    Capocelli, K.E.3    Pan, Z.4    Sullivan, J.S.5    Robbins, K.6
  • 18
    • 84894091047 scopus 로고    scopus 로고
    • Psoriasis is independently associated with nonalcoholic fatty liver disease in patients 55 years old or older: Results from a population-based study
    • [PubMed PMID: 24373781]
    • [18] van der Voort, E.A., Koehler, E.M., Dowlatshahi, E.A., Hofman, A., Stricker, B.H., Janssen, H.L., et al. Psoriasis is independently associated with nonalcoholic fatty liver disease in patients 55 years old or older: Results from a population-based study. J Am Acad Dermatol 70:3 (2014), 517–524, 10.1016/j.jaad.2013.10.044 [PubMed PMID: 24373781].
    • (2014) J Am Acad Dermatol , vol.70 , Issue.3 , pp. 517-524
    • van der Voort, E.A.1    Koehler, E.M.2    Dowlatshahi, E.A.3    Hofman, A.4    Stricker, B.H.5    Janssen, H.L.6
  • 19
    • 84938057875 scopus 로고    scopus 로고
    • Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
    • [PubMed PMID: WOS:000358429600032]
    • [19] Angulo, P., Kleiner, D.E., Dam-Larsen, S., Adams, L.A., Bjornsson, E.S., Charatcharoenwitthaya, P., et al. Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology, 149(2), 2015, 389-+, 10.1053/j.gastro.2015.04.043 [PubMed PMID: WOS:000358429600032].
    • (2015) Gastroenterology , vol.149 , Issue.2 , pp. 389-+
    • Angulo, P.1    Kleiner, D.E.2    Dam-Larsen, S.3    Adams, L.A.4    Bjornsson, E.S.5    Charatcharoenwitthaya, P.6
  • 20
    • 80053581540 scopus 로고    scopus 로고
    • Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States
    • [PubMed PMID: 21726509]
    • [20] Charlton, M.R., Burns, J.M., Pedersen, R.A., Watt, K.D., Heimbach, J.K., Dierkhising, R.A., Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology 141:4 (2011), 1249–1253, 10.1053/j.gastro.2011.06.061 [PubMed PMID: 21726509].
    • (2011) Gastroenterology , vol.141 , Issue.4 , pp. 1249-1253
    • Charlton, M.R.1    Burns, J.M.2    Pedersen, R.A.3    Watt, K.D.4    Heimbach, J.K.5    Dierkhising, R.A.6
  • 21
    • 84901616858 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S
    • [PubMed PMID: 24375711]
    • [21] Wong, R.J., Cheung, R., Ahmed, A., Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S. Hepatology 59:6 (2014), 2188–2195, 10.1002/hep.26986 [PubMed PMID: 24375711].
    • (2014) Hepatology , vol.59 , Issue.6 , pp. 2188-2195
    • Wong, R.J.1    Cheung, R.2    Ahmed, A.3
  • 22
    • 77952730428 scopus 로고    scopus 로고
    • The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    • [PubMed PMID: 20209604]
    • [22] Ascha, M.S., Hanouneh, I.A., Lopez, R., Tamimi, T.A., Feldstein, A.F., Zein, N.N., The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 51:6 (2010), 1972–1978 [PubMed PMID: 20209604].
    • (2010) Hepatology , vol.51 , Issue.6 , pp. 1972-1978
    • Ascha, M.S.1    Hanouneh, I.A.2    Lopez, R.3    Tamimi, T.A.4    Feldstein, A.F.5    Zein, N.N.6
  • 23
    • 84881171445 scopus 로고    scopus 로고
    • Population-attributable fractions of risk factors for hepatocellular carcinoma in the United States
    • [PubMed PMID: 23752878; PubMed Central PMCID: PMC4105976]
    • [23] Welzel, T.M., Graubard, B.I., Quraishi, S., Zeuzem, S., Davila, J.A., El-Serag, H.B., et al. Population-attributable fractions of risk factors for hepatocellular carcinoma in the United States. Am J Gastroenterol 108:8 (2013), 1314–1321, 10.1038/ajg.2013.160 [PubMed PMID: 23752878; PubMed Central PMCID: PMC4105976].
    • (2013) Am J Gastroenterol , vol.108 , Issue.8 , pp. 1314-1321
    • Welzel, T.M.1    Graubard, B.I.2    Quraishi, S.3    Zeuzem, S.4    Davila, J.A.5    El-Serag, H.B.6
  • 24
    • 0036735880 scopus 로고    scopus 로고
    • Obese children with steatohepatitis can develop cirrhosis in childhood
    • [PubMed PMID: 12358273]
    • [24] Molleston, J.P., White, F., Teckman, J., Fitzgerald, J.F., Obese children with steatohepatitis can develop cirrhosis in childhood. Am J Geriatr Cardiol 97:9 (2002), 2460–2462 [PubMed PMID: 12358273].
    • (2002) Am J Geriatr Cardiol , vol.97 , Issue.9 , pp. 2460-2462
    • Molleston, J.P.1    White, F.2    Teckman, J.3    Fitzgerald, J.F.4
  • 25
    • 84908031482 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and hepatocellular carcinoma in a 7-year-old obese boy: coincidence or comorbidity?
    • [PubMed PMID: 24302697]
    • [25] Nobili, V., Alisi, A., Grimaldi, C., Liccardo, D., Francalanci, P., Monti, L., et al. Non-alcoholic fatty liver disease and hepatocellular carcinoma in a 7-year-old obese boy: coincidence or comorbidity?. Pediatr Obes 9:5 (2014), e99–e102, 10.1111/j.2047-6310.2013.00209.x [PubMed PMID: 24302697].
    • (2014) Pediatr Obes , vol.9 , Issue.5 , pp. e99-e102
    • Nobili, V.1    Alisi, A.2    Grimaldi, C.3    Liccardo, D.4    Francalanci, P.5    Monti, L.6
  • 26
    • 70350241227 scopus 로고    scopus 로고
    • The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years
    • [PubMed PMID: 19625277]
    • [26] Feldstein, A.E., Charatcharoenwitthaya, P., Treeprasertsuk, S., Benson, J.T., Enders, F.B., Angulo, P., The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 58:11 (2009), 1538–1544 [PubMed PMID: 19625277].
    • (2009) Gut , vol.58 , Issue.11 , pp. 1538-1544
    • Feldstein, A.E.1    Charatcharoenwitthaya, P.2    Treeprasertsuk, S.3    Benson, J.T.4    Enders, F.B.5    Angulo, P.6
  • 27
    • 84881232944 scopus 로고    scopus 로고
    • Cardiovascular and systemic risk in nonalcoholic fatty liver disease - atherosclerosis as a major player in the natural course of NAFLD
    • [PubMed PMID: 23432668]
    • [27] Lonardo, A., Sookoian, S., Chonchol, M., Loria, P., Targher, G., Cardiovascular and systemic risk in nonalcoholic fatty liver disease - atherosclerosis as a major player in the natural course of NAFLD. Curr Pharm Des 19:29 (2013), 5177–5192 [PubMed PMID: 23432668].
    • (2013) Curr Pharm Des , vol.19 , Issue.29 , pp. 5177-5192
    • Lonardo, A.1    Sookoian, S.2    Chonchol, M.3    Loria, P.4    Targher, G.5
  • 28
    • 65449156905 scopus 로고    scopus 로고
    • NAFLD as a Risk Factor for the Development of Diabetes and the Metabolic Syndrome: An Eleven-Year Follow-up Study
    • [28] Adams, L.A., Waters, O.R., Knuiman, M.W., Elliott, R.R., Olynyk, J.K., NAFLD as a Risk Factor for the Development of Diabetes and the Metabolic Syndrome: An Eleven-Year Follow-up Study. Am J Gastroenterol 104:4 (2009), 861–867.
    • (2009) Am J Gastroenterol , vol.104 , Issue.4 , pp. 861-867
    • Adams, L.A.1    Waters, O.R.2    Knuiman, M.W.3    Elliott, R.R.4    Olynyk, J.K.5
  • 29
    • 84939806038 scopus 로고    scopus 로고
    • Cardiovascular risk in pediatric nonalcoholic fatty liver disease: recent advances
    • [29] Baskar, S., Jhaveri, S., Alkhouri, N., Cardiovascular risk in pediatric nonalcoholic fatty liver disease: recent advances. J Clin Lipidol 10:4 (2015), 351–362.
    • (2015) J Clin Lipidol , vol.10 , Issue.4 , pp. 351-362
    • Baskar, S.1    Jhaveri, S.2    Alkhouri, N.3
  • 30
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two "hits"?
    • [PubMed PMID: 9547102]
    • [30] Day, C.P., James OF, Steatohepatitis: a tale of two "hits"?. Gastroenterology 114:4 (1998), 842–845 [PubMed PMID: 9547102].
    • (1998) Gastroenterology , vol.114 , Issue.4 , pp. 842-845
    • Day, C.P.1    James OF2
  • 31
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • [PubMed PMID: 17476695]
    • [31] Yamaguchi, K., Yang, L., McCall, S., Huang, J., Yu, X.X., Pandey, S.K., et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 45:6 (2007), 1366–1374 [PubMed PMID: 17476695].
    • (2007) Hepatology , vol.45 , Issue.6 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3    Huang, J.4    Yu, X.X.5    Pandey, S.K.6
  • 32
    • 84877920825 scopus 로고    scopus 로고
    • A 360-degree overview of paediatric NAFLD: recent insights
    • [PubMed PMID: 23238106]
    • [32] Nobili, V., Svegliati-Baroni, G., Alisi, A., Miele, L., Valenti, L., Vajro, P., A 360-degree overview of paediatric NAFLD: recent insights. J Hepatol 58:6 (2013), 1218–1229, 10.1016/j.jhep.2012.12.003 [PubMed PMID: 23238106].
    • (2013) J Hepatol , vol.58 , Issue.6 , pp. 1218-1229
    • Nobili, V.1    Svegliati-Baroni, G.2    Alisi, A.3    Miele, L.4    Valenti, L.5    Vajro, P.6
  • 33
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
    • [PubMed PMID: 21038418]
    • [33] Tilg, H., Moschen, A.R., Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 52:5 (2010), 1836–1846, 10.1002/hep.24001 [PubMed PMID: 21038418].
    • (2010) Hepatology , vol.52 , Issue.5 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 34
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • [PubMed PMID: 19291785]
    • [34] Miele, L., Valenza, V., La Torre, G., Montalto, M., Cammarota, G., Ricci, R., et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49:6 (2009), 1877–1887, 10.1002/hep.22848 [PubMed PMID: 19291785].
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 1877-1887
    • Miele, L.1    Valenza, V.2    La Torre, G.3    Montalto, M.4    Cammarota, G.5    Ricci, R.6
  • 35
    • 70349238777 scopus 로고    scopus 로고
    • Adipokines in liver diseases
    • [PubMed PMID: 19585655]
    • [35] Marra, F., Bertolani, C., Adipokines in liver diseases. Hepatology 50:3 (2009), 957–969, 10.1002/hep.23046 [PubMed PMID: 19585655].
    • (2009) Hepatology , vol.50 , Issue.3 , pp. 957-969
    • Marra, F.1    Bertolani, C.2
  • 36
    • 79954514102 scopus 로고    scopus 로고
    • Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
    • [PubMed PMID: 21476915]
    • [36] Alkhouri, N., Carter-Kent, C., Feldstein, A.E., Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications. Expert Rev Gastroenterol Hepatol 5:2 (2011), 201–212 [PubMed PMID: 21476915].
    • (2011) Expert Rev Gastroenterol Hepatol , vol.5 , Issue.2 , pp. 201-212
    • Alkhouri, N.1    Carter-Kent, C.2    Feldstein, A.E.3
  • 37
    • 84887319657 scopus 로고    scopus 로고
    • From NAFLD to NASH to cirrhosis-new insights into disease mechanisms
    • [PubMed PMID: 23958599]
    • [37] Wree, A., Broderick, L., Canbay, A., Hoffman, H.M., Feldstein, A.E., From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol 10:11 (2013), 627–636, 10.1038/nrgastro.2013.149 [PubMed PMID: 23958599].
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , Issue.11 , pp. 627-636
    • Wree, A.1    Broderick, L.2    Canbay, A.3    Hoffman, H.M.4    Feldstein, A.E.5
  • 38
    • 84949959656 scopus 로고    scopus 로고
    • Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study
    • [PubMed PMID: 26299412]
    • [38] Loomba, R., Schork, N., Chen, C.H., Bettencourt, R., Bhatt, A., Ang, B., et al. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology 149:7 (2015), 1784–1793, 10.1053/j.gastro.2015.08.011 [PubMed PMID: 26299412].
    • (2015) Gastroenterology , vol.149 , Issue.7 , pp. 1784-1793
    • Loomba, R.1    Schork, N.2    Chen, C.H.3    Bettencourt, R.4    Bhatt, A.5    Ang, B.6
  • 39
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • [PubMed PMID: 18820647]
    • [39] Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L.A., et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 40:12 (2008), 1461–1465 [PubMed PMID: 18820647].
    • (2008) Nat Genet , vol.40 , Issue.12 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3    Pertsemlidis, A.4    Cox, D.5    Pennacchio, L.A.6
  • 40
    • 77957936457 scopus 로고    scopus 로고
    • I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease
    • [Epub 2010/07/22 PubMed PMID: 20648474]
    • [40] Valenti, L., Alisi, A., Galmozzi, E., Bartuli, A., Del Menico, B., Alterio, A., et al. I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease. Hepatology 52:4 (2010), 1274–1280, 10.1002/hep.23823 [Epub 2010/07/22 PubMed PMID: 20648474].
    • (2010) Hepatology , vol.52 , Issue.4 , pp. 1274-1280
    • Valenti, L.1    Alisi, A.2    Galmozzi, E.3    Bartuli, A.4    Del Menico, B.5    Alterio, A.6
  • 41
    • 84876814186 scopus 로고    scopus 로고
    • The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants
    • [PubMed PMID: 23275357; PubMed Central PMCID: PMC3631865]
    • [41] Santoro, N., Feldstein, A.E., Enoksson, E., Pierpont, B., Kursawe, R., Kim, G., et al. The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants. Diabetes Care 36:5 (2013), 1353–1360, 10.2337/dc12-1791 [PubMed PMID: 23275357; PubMed Central PMCID: PMC3631865].
    • (2013) Diabetes Care , vol.36 , Issue.5 , pp. 1353-1360
    • Santoro, N.1    Feldstein, A.E.2    Enoksson, E.3    Pierpont, B.4    Kursawe, R.5    Kim, G.6
  • 42
    • 84861421970 scopus 로고    scopus 로고
    • Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake
    • e37827, [PubMed PMID: 22629460; PubMed Central PMCID: PMC3357343]
    • [42] Santoro, N., Savoye, M., Kim, G., Marotto, K., Shaw, M.M., Pierpont, B., et al. Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake. PLoS One, 7(5), 2012, e37827, 10.1371/journal.pone.0037827 [PubMed PMID: 22629460; PubMed Central PMCID: PMC3357343].
    • (2012) PLoS One , vol.7 , Issue.5
    • Santoro, N.1    Savoye, M.2    Kim, G.3    Marotto, K.4    Shaw, M.M.5    Pierpont, B.6
  • 43
    • 84896546184 scopus 로고    scopus 로고
    • Histological Abnormalities in Children with Nonalcoholic Fatty Liver Disease and Normal or Mildly Elevated Alanine Aminotransferase Levels
    • [PubMed PMID: 24360992]
    • [43] Molleston, J.P., Schwimmer, J.B., Yates, K.P., KF, Murray, Cummings, O.W., Lavine, J.E., et al. Histological Abnormalities in Children with Nonalcoholic Fatty Liver Disease and Normal or Mildly Elevated Alanine Aminotransferase Levels. J Pediatr, 2014 [PubMed PMID: 24360992].
    • (2014) J Pediatr
    • Molleston, J.P.1    Schwimmer, J.B.2    Yates, K.P.3    KF, M.4    Cummings, O.W.5    Lavine, J.E.6
  • 44
    • 24144444669 scopus 로고    scopus 로고
    • Histopathology of pediatric nonalcoholic fatty liver disease
    • [PubMed PMID: 16116629]
    • [44] Schwimmer, J.B., Behling, C., Newbury, R., Deutsch, R., Nievergelt, C., Schork, N.J., et al. Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology 42:3 (2005), 641–649 [PubMed PMID: 16116629].
    • (2005) Hepatology , vol.42 , Issue.3 , pp. 641-649
    • Schwimmer, J.B.1    Behling, C.2    Newbury, R.3    Deutsch, R.4    Nievergelt, C.5    Schork, N.J.6
  • 45
    • 70350077457 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study
    • [PubMed PMID: 19637190]
    • [45] Carter-Kent, C., Yerian, L.M., Brunt, E.M., Angulo, P., Kohli, R., Ling, S.C., et al. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology 50:4 (2009), 1113–1120 [PubMed PMID: 19637190].
    • (2009) Hepatology , vol.50 , Issue.4 , pp. 1113-1120
    • Carter-Kent, C.1    Yerian, L.M.2    Brunt, E.M.3    Angulo, P.4    Kohli, R.5    Ling, S.C.6
  • 46
    • 33747077203 scopus 로고    scopus 로고
    • NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice
    • [PubMed PMID: 16871574]
    • [46] Nobili, V., Marcellini, M., Devito, R., Ciampalini, P., Piemonte, F., Comparcola, D., et al. NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice. Hepatology 44:2 (2006), 458–465 [PubMed PMID: 16871574].
    • (2006) Hepatology , vol.44 , Issue.2 , pp. 458-465
    • Nobili, V.1    Marcellini, M.2    Devito, R.3    Ciampalini, P.4    Piemonte, F.5    Comparcola, D.6
  • 47
    • 84862704364 scopus 로고    scopus 로고
    • Association between puberty and features of nonalcoholic fatty liver disease
    • [PubMed PMID: 22343513; PubMed Central PMCID: PMC3382041]
    • [47] Suzuki, A., Abdelmalek, M.F., Schwimmer, J.B., Lavine, J.E., Scheimann, A.O., Unalp-Arida, A., et al. Association between puberty and features of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 10:7 (2012), 786–794, 10.1016/j.cgh.2012.01.020 [PubMed PMID: 22343513; PubMed Central PMCID: PMC3382041].
    • (2012) Clin Gastroenterol Hepatol , vol.10 , Issue.7 , pp. 786-794
    • Suzuki, A.1    Abdelmalek, M.F.2    Schwimmer, J.B.3    Lavine, J.E.4    Scheimann, A.O.5    Unalp-Arida, A.6
  • 48
    • 38449095758 scopus 로고    scopus 로고
    • Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report
    • [PubMed PMID: 18055651]
    • [48] Barlow, S.E., Expert, C., Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 120:Suppl. 4 (2007), S164–S192, 10.1542/peds.2007-2329C [PubMed PMID: 18055651].
    • (2007) Pediatrics , vol.120 , pp. S164-S192
    • Barlow, S.E.1    Expert, C.2
  • 49
    • 77949816251 scopus 로고    scopus 로고
    • SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease
    • [64 e1-2. PubMed PMID: 20064512]
    • [49] Schwimmer, J.B., Dunn, W., Norman, G.J., Pardee, P.E., Middleton, M.S., Kerkar, N., et al. SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease. Gastroenterology 138:4 (2010), 1357–1364 [64 e1-2. PubMed PMID: 20064512].
    • (2010) Gastroenterology , vol.138 , Issue.4 , pp. 1357-1364
    • Schwimmer, J.B.1    Dunn, W.2    Norman, G.J.3    Pardee, P.E.4    Middleton, M.S.5    Kerkar, N.6
  • 50
    • 71849092184 scopus 로고    scopus 로고
    • Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study
    • [PubMed PMID: 19846234]
    • [50] Dasarathy, S., Dasarathy, J., Khiyami, A., Joseph, R., Lopez, R., McCullough, A.J., Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study. J Hepatol 51:6 (2009), 1061–1067 [PubMed PMID: 19846234].
    • (2009) J Hepatol , vol.51 , Issue.6 , pp. 1061-1067
    • Dasarathy, S.1    Dasarathy, J.2    Khiyami, A.3    Joseph, R.4    Lopez, R.5    McCullough, A.J.6
  • 51
    • 84898640575 scopus 로고    scopus 로고
    • Non-Invasive Assessment of Hepatic Steatosis in Patients with NAFLD Using Controlled Attenuation Parameter and 1H-MR Spectroscopy
    • e91987, [PubMed PMID: 24637477; PubMed Central PMCID: PMC3956815]
    • [51] Karlas, T., Petroff, D., Garnov, N., Bohm, S., Tenckhoff, H., Wittekind, C., et al. Non-Invasive Assessment of Hepatic Steatosis in Patients with NAFLD Using Controlled Attenuation Parameter and 1H-MR Spectroscopy. PLoS One, 9(3), 2014, e91987, 10.1371/journal.pone.0091987 [PubMed PMID: 24637477; PubMed Central PMCID: PMC3956815].
    • (2014) PLoS One , vol.9 , Issue.3
    • Karlas, T.1    Petroff, D.2    Garnov, N.3    Bohm, S.4    Tenckhoff, H.5    Wittekind, C.6
  • 52
    • 84941894714 scopus 로고    scopus 로고
    • Noninvasive Evaluation of Nonalcoholic Fatty Liver Disease
    • [PubMed PMID: 26378645]
    • [52] Castera, L., Noninvasive Evaluation of Nonalcoholic Fatty Liver Disease. Semin Liver Dis 35:3 (2015), 291–303, 10.1055/s-0035-1562948 [PubMed PMID: 26378645].
    • (2015) Semin Liver Dis , vol.35 , Issue.3 , pp. 291-303
    • Castera, L.1
  • 53
    • 84931574623 scopus 로고    scopus 로고
    • Noninvasive Diagnosis of Nonalcoholic Fatty Liver Disease and Quantification of Liver Fat Using a New Quantitative Ultrasound Technique
    • [PubMed PMID: 25478922; PubMed Central PMCID: PMC4454635]
    • [53] Lin, S.C., Heba, E., Wolfson, T., Ang, B., Gamst, A., Han, A., et al. Noninvasive Diagnosis of Nonalcoholic Fatty Liver Disease and Quantification of Liver Fat Using a New Quantitative Ultrasound Technique. Clin Gastroenterol Hepatol, 13(7), 2015, 133745 e6, 10.1016/j.cgh.2014.11.027 [PubMed PMID: 25478922; PubMed Central PMCID: PMC4454635].
    • (2015) Clin Gastroenterol Hepatol , vol.13 , Issue.7 , pp. 133745 e6
    • Lin, S.C.1    Heba, E.2    Wolfson, T.3    Ang, B.4    Gamst, A.5    Han, A.6
  • 54
    • 84889264686 scopus 로고    scopus 로고
    • Analysis of breath volatile organic compounds as a noninvasive tool to diagnose nonalcoholic fatty liver disease in children
    • [54] Alkhouri, N., Cikach, F., Eng, K., Moses, J., Patel, N., Yan, C., et al. Analysis of breath volatile organic compounds as a noninvasive tool to diagnose nonalcoholic fatty liver disease in children. Eur J Gen Pract 26:1 (2014), 82–87.
    • (2014) Eur J Gen Pract , vol.26 , Issue.1 , pp. 82-87
    • Alkhouri, N.1    Cikach, F.2    Eng, K.3    Moses, J.4    Patel, N.5    Yan, C.6
  • 55
    • 84868008620 scopus 로고    scopus 로고
    • Noninvasive Diagnosis of NASH and Liver Fibrosis Within the Spectrum of NAFLD
    • [55] Alkhouri, N., McCullough, A., Noninvasive Diagnosis of NASH and Liver Fibrosis Within the Spectrum of NAFLD. J Gastroenterol Hepatol 8:10 (2012), 661–668.
    • (2012) J Gastroenterol Hepatol , vol.8 , Issue.10 , pp. 661-668
    • Alkhouri, N.1    McCullough, A.2
  • 56
    • 84876293750 scopus 로고    scopus 로고
    • Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal
    • [PubMed PMID: 23183525]
    • [56] Machado, M.V., Cortez-Pinto, H., Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal. J Hepatol 58:5 (2013), 1007–1019, 10.1016/j.jhep.2012.11.021 [PubMed PMID: 23183525].
    • (2013) J Hepatol , vol.58 , Issue.5 , pp. 1007-1019
    • Machado, M.V.1    Cortez-Pinto, H.2
  • 57
    • 84890547086 scopus 로고    scopus 로고
    • Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease
    • [PubMed PMID: 23973932]
    • [57] Cusi, K., Chang, Z., Harrison, S., Lomonaco, R., Bril, F., Orsak, B., et al. Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease. J Hepatol 60:1 (2014), 167–174, 10.1016/j.jhep.2013.07.042 [PubMed PMID: 23973932].
    • (2014) J Hepatol , vol.60 , Issue.1 , pp. 167-174
    • Cusi, K.1    Chang, Z.2    Harrison, S.3    Lomonaco, R.4    Bril, F.5    Orsak, B.6
  • 58
    • 84891889855 scopus 로고    scopus 로고
    • Systematic review with meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease–the role of transient elastography and plasma cytokeratin-18 fragments
    • [PubMed PMID: 24308774]
    • [58] Kwok, R., Tse, Y.K., Wong, G.L., Ha, Y., Lee, A.U., Ngu, M.C., et al. Systematic review with meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease–the role of transient elastography and plasma cytokeratin-18 fragments. Aliment Pharmacol Ther 39:3 (2014), 254–269, 10.1111/apt.12569 [PubMed PMID: 24308774].
    • (2014) Aliment Pharmacol Ther , vol.39 , Issue.3 , pp. 254-269
    • Kwok, R.1    Tse, Y.K.2    Wong, G.L.3    Ha, Y.4    Lee, A.U.5    Ngu, M.C.6
  • 59
    • 79251535913 scopus 로고    scopus 로고
    • Non-invasive Diagnosis of Nonalcoholic Fatty Liver and Nonalcoholic Steatohepatitis
    • [PubMed PMID: 21091933]
    • [59] Adams, L.A., Feldstein, A.E., Non-invasive Diagnosis of Nonalcoholic Fatty Liver and Nonalcoholic Steatohepatitis. J Dig Dis, 2011 [PubMed PMID: 21091933].
    • (2011) J Dig Dis
    • Adams, L.A.1    Feldstein, A.E.2
  • 60
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • [PubMed PMID: 16799979]
    • [60] Wieckowska, A., Zein, N.N., Yerian, L.M., Lopez, A.R., McCullough, A.J., Feldstein, A.E., In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 44:1 (2006), 27–33 [PubMed PMID: 16799979].
    • (2006) Hepatology , vol.44 , Issue.1 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3    Lopez, A.R.4    McCullough, A.J.5    Feldstein, A.E.6
  • 61
    • 84883740164 scopus 로고    scopus 로고
    • Serum cytokeratin-18 fragment levels are useful biomarkers for nonalcoholic steatohepatitis in children
    • [PubMed PMID: 23752877]
    • [61] Feldstein, A.E., Alkhouri, N., De Vito, R., Alisi, A., Lopez, R., Nobili, V., Serum cytokeratin-18 fragment levels are useful biomarkers for nonalcoholic steatohepatitis in children. Am J Gastroenterol 108:9 (2013), 1526–1531 [PubMed PMID: 23752877].
    • (2013) Am J Gastroenterol , vol.108 , Issue.9 , pp. 1526-1531
    • Feldstein, A.E.1    Alkhouri, N.2    De Vito, R.3    Alisi, A.4    Lopez, R.5    Nobili, V.6
  • 62
    • 84937513998 scopus 로고    scopus 로고
    • Circulating Soluble Fas and Fas Ligand Levels Are Elevated in Children with Nonalcoholic Steatohepatitis
    • [Epub 2015/03/13, PubMed PMID: 25764498]
    • [62] Alkhouri, N., Alisi, A., Okwu, V., Matloob, A., Ferrari, F., Crudele, A., et al. Circulating Soluble Fas and Fas Ligand Levels Are Elevated in Children with Nonalcoholic Steatohepatitis. Dig Dis Sci, 2015, 10.1007/s10620-015-3614-z [Epub 2015/03/13, PubMed PMID: 25764498].
    • (2015) Dig Dis Sci
    • Alkhouri, N.1    Alisi, A.2    Okwu, V.3    Matloob, A.4    Ferrari, F.5    Crudele, A.6
  • 63
    • 84859324858 scopus 로고    scopus 로고
    • Noninvasive parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease
    • [PubMed PMID: 22509085]
    • [63] Yang, H.R., Kim, H.R., Kim, M.J., Ko, J.S., Seo, J.K., Noninvasive parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease. World J Gastroenterol 18:13 (2012), 1525–1530 [PubMed PMID: 22509085].
    • (2012) World J Gastroenterol , vol.18 , Issue.13 , pp. 1525-1530
    • Yang, H.R.1    Kim, H.R.2    Kim, M.J.3    Ko, J.S.4    Seo, J.K.5
  • 64
    • 84905980605 scopus 로고    scopus 로고
    • The Evaluation of Hepatic Fibrosis Scores in Children with Nonalcoholic Fatty Liver Disease
    • [Abstrac 2055]
    • [64] Mansoor, S., Yerian, L., Lopez, R., Kohli, R., Xanthakos, S., Angulo, P., et al. The Evaluation of Hepatic Fibrosis Scores in Children with Nonalcoholic Fatty Liver Disease. Am J Gastroenterol, 108(S1), 2013 [Abstrac 2055].
    • (2013) Am J Gastroenterol , vol.108 , Issue.S1
    • Mansoor, S.1    Yerian, L.2    Lopez, R.3    Kohli, R.4    Xanthakos, S.5    Angulo, P.6
  • 65
    • 84905976072 scopus 로고    scopus 로고
    • The development of the pediatric NAFLD fibrosis score (PNFS) to predict the presence of advanced fibrosis in children with nonalcoholic fatty liver disease
    • e104558, [PubMed PMID: 25121514; PubMed Central PMCID: PMC4133235]
    • [65] Alkhouri, N., Mansoor, S., Giammaria, P., Liccardo, D., Lopez, R., Nobili, V., The development of the pediatric NAFLD fibrosis score (PNFS) to predict the presence of advanced fibrosis in children with nonalcoholic fatty liver disease. PLoS One, 9(8), 2014, e104558, 10.1371/journal.pone.0104558 [PubMed PMID: 25121514; PubMed Central PMCID: PMC4133235].
    • (2014) PLoS One , vol.9 , Issue.8
    • Alkhouri, N.1    Mansoor, S.2    Giammaria, P.3    Liccardo, D.4    Lopez, R.5    Nobili, V.6
  • 66
    • 49649105500 scopus 로고    scopus 로고
    • Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis
    • [PubMed PMID: 18563842]
    • [66] Nobili, V., Vizzutti, F., Arena, U., Abraldes, J.G., Marra, F., Pietrobattista, A., et al. Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. Hepatology 48:2 (2008), 442–448 [PubMed PMID: 18563842].
    • (2008) Hepatology , vol.48 , Issue.2 , pp. 442-448
    • Nobili, V.1    Vizzutti, F.2    Arena, U.3    Abraldes, J.G.4    Marra, F.5    Pietrobattista, A.6
  • 67
    • 84890829992 scopus 로고    scopus 로고
    • Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease
    • [PubMed PMID: 24064151; PubMed Central PMCID: PMC3872246]
    • [67] Xanthakos, S.A., Podberesky, D.J., Serai, S.D., Miles, L., King, E.C., Balistreri, W.F., et al. Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease. J Pediatr 164:1 (2014), 186–188, 10.1016/j.jpeds.2013.07.050 [PubMed PMID: 24064151; PubMed Central PMCID: PMC3872246].
    • (2014) J Pediatr , vol.164 , Issue.1 , pp. 186-188
    • Xanthakos, S.A.1    Podberesky, D.J.2    Serai, S.D.3    Miles, L.4    King, E.C.5    Balistreri, W.F.6
  • 68
    • 84876693676 scopus 로고    scopus 로고
    • Acoustic radiation force impulse (ARFI) elastography for the noninvasive diagnosis of liver fibrosis in children
    • [PubMed PMID: 23271404]
    • [68] Hanquinet, S., Rougemont, A.L., Courvoisier, D., Rubbia-Brandt, L., McLin, V., Tempia, M., et al. Acoustic radiation force impulse (ARFI) elastography for the noninvasive diagnosis of liver fibrosis in children. Pediatr Radiol 43:5 (2013), 545–551, 10.1007/s00247-012-2595-8 [PubMed PMID: 23271404].
    • (2013) Pediatr Radiol , vol.43 , Issue.5 , pp. 545-551
    • Hanquinet, S.1    Rougemont, A.L.2    Courvoisier, D.3    Rubbia-Brandt, L.4    McLin, V.5    Tempia, M.6
  • 69
    • 47149086771 scopus 로고    scopus 로고
    • Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial
    • [PubMed PMID: 18537181]
    • [69] Nobili, V., Manco, M., Devito, R., Di Ciommo, V., Comparcola, D., Sartorelli, M.R., et al. Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial. Hepatology 48:1 (2008), 119–128, 10.1002/hep.22336 [PubMed PMID: 18537181].
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 119-128
    • Nobili, V.1    Manco, M.2    Devito, R.3    Di Ciommo, V.4    Comparcola, D.5    Sartorelli, M.R.6
  • 70
    • 84855886297 scopus 로고    scopus 로고
    • American Society for M, et al. ASMBS pediatric committee best practice guidelines
    • [PubMed PMID: 22030146]
    • [70] Michalsky, M., Reichard, K., Inge, T., Pratt, J., Lenders, C., American Society for M, et al. ASMBS pediatric committee best practice guidelines. Surg Obes Relat Dis 8:1 (2012), 1–7, 10.1016/j.soard.2011.09.009 [PubMed PMID: 22030146].
    • (2012) Surg Obes Relat Dis , vol.8 , Issue.1 , pp. 1-7
    • Michalsky, M.1    Reichard, K.2    Inge, T.3    Pratt, J.4    Lenders, C.5
  • 71
    • 84892687680 scopus 로고    scopus 로고
    • Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study
    • [PubMed PMID: 24189578]
    • [71] Inge, T.H., Zeller, M.H., Jenkins, T.M., Helmrath, M., Brandt, M.L., Michalsky, M.P., et al. Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. JAMA Pediatr 168:1 (2014), 47–53, 10.1001/jamapediatrics.2013.4296 [PubMed PMID: 24189578].
    • (2014) JAMA Pediatr , vol.168 , Issue.1 , pp. 47-53
    • Inge, T.H.1    Zeller, M.H.2    Jenkins, T.M.3    Helmrath, M.4    Brandt, M.L.5    Michalsky, M.P.6
  • 72
    • 84938070225 scopus 로고    scopus 로고
    • Bariatric Surgery Reduces Features of Non-alcoholic Steatohepatitis in Morbidly Obese Patients
    • [PubMed PMID: 25917783]
    • [72] Lassailly, G., Caiazzo, R., Buob, D., Pigeyre, M., Verkindt, H., Labreuche, J., et al. Bariatric Surgery Reduces Features of Non-alcoholic Steatohepatitis in Morbidly Obese Patients. Gastroenterology, 2015, 10.1053/j.gastro.2015.04.014 [PubMed PMID: 25917783].
    • (2015) Gastroenterology
    • Lassailly, G.1    Caiazzo, R.2    Buob, D.3    Pigeyre, M.4    Verkindt, H.5    Labreuche, J.6
  • 73
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • [PubMed PMID: 20427778]
    • [73] Sanyal, A.J., Chalasani, N., Kowdley, K.V., McCullough, A., Diehl, A.M., Bass, N.M., et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 362:18 (2010), 1675–1685 [PubMed PMID: 20427778].
    • (2010) N Engl J Med , vol.362 , Issue.18 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3    McCullough, A.4    Diehl, A.M.5    Bass, N.M.6
  • 74
    • 79955446251 scopus 로고    scopus 로고
    • Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    • [PubMed PMID: 21521847; PubMed Central PMCID: PMC3110082]
    • [74] Lavine, J.E., Schwimmer, J.B., Van Natta, M.L., Molleston, J.P., Murray, K.F., Rosenthal, P., et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA 305:16 (2011), 1659–1668, 10.1001/jama.2011.520 [PubMed PMID: 21521847; PubMed Central PMCID: PMC3110082].
    • (2011) JAMA , vol.305 , Issue.16 , pp. 1659-1668
    • Lavine, J.E.1    Schwimmer, J.B.2    Van Natta, M.L.3    Molleston, J.P.4    Murray, K.F.5    Rosenthal, P.6
  • 75
    • 80053954605 scopus 로고    scopus 로고
    • Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    • [PubMed PMID: 21990298; PubMed Central PMCID: PMC4169010]
    • [75] Klein, E.A., Thompson, I.M. Jr., Tangen, C.M., Crowley, J.J., Lucia, M.S., Goodman, P.J., et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 306:14 (2011), 1549–1556, 10.1001/jama.2011.1437 [PubMed PMID: 21990298; PubMed Central PMCID: PMC4169010].
    • (2011) JAMA , vol.306 , Issue.14 , pp. 1549-1556
    • Klein, E.A.1    Thompson, I.M.2    Tangen, C.M.3    Crowley, J.J.4    Lucia, M.S.5    Goodman, P.J.6
  • 76
    • 19944427642 scopus 로고    scopus 로고
    • Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality
    • [PubMed PMID: 15537682]
    • [76] Miller, E.R. III, Pastor-Barriuso, R., Dalal, D., Riemersma, R.A., Appel, L.J., Guallar, E., Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 142:1 (2005), 37–46 [PubMed PMID: 15537682].
    • (2005) Ann Intern Med , vol.142 , Issue.1 , pp. 37-46
    • Miller, E.R.1    Pastor-Barriuso, R.2    Dalal, D.3    Riemersma, R.A.4    Appel, L.J.5    Guallar, E.6
  • 77
    • 79953177813 scopus 로고    scopus 로고
    • Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial
    • [PubMed PMID: 21233083]
    • [77] Nobili, V., Bedogni, G., Alisi, A., Pietrobattista, A., Rise, P., Galli, C., et al. Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. Arch Dis Child 96:4 (2011), 350–353, 10.1136/adc.2010.192401 [PubMed PMID: 21233083].
    • (2011) Arch Dis Child , vol.96 , Issue.4 , pp. 350-353
    • Nobili, V.1    Bedogni, G.2    Alisi, A.3    Pietrobattista, A.4    Rise, P.5    Galli, C.6
  • 78
    • 84887609640 scopus 로고    scopus 로고
    • Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children
    • [PubMed PMID: 23220074]
    • [78] Nobili, V., Alisi, A., Della Corte, C., Rise, P., Galli, C., Agostoni, C., et al. Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children. Nutr Metab Cardiovasc Dis 23:11 (2013), 1066–1070, 10.1016/j.numecd.2012.10.010 [PubMed PMID: 23220074].
    • (2013) Nutr Metab Cardiovasc Dis , vol.23 , Issue.11 , pp. 1066-1070
    • Nobili, V.1    Alisi, A.2    Della Corte, C.3    Rise, P.4    Galli, C.5    Agostoni, C.6
  • 79
    • 84904661185 scopus 로고    scopus 로고
    • No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial
    • [Epub 2014/05/14, PubMed PMID: 24818764]
    • [79] Sanyal, A.J., Abdelmalek, M.F., Suzuki, A., Cummings, O.W., Chojkier, M., No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial. Gastroenterology, 147(2), 2014, 37784.e1, 10.1053/j.gastro.2014.04.046 [Epub 2014/05/14, PubMed PMID: 24818764].
    • (2014) Gastroenterology , vol.147 , Issue.2 , pp. 37784.e1
    • Sanyal, A.J.1    Abdelmalek, M.F.2    Suzuki, A.3    Cummings, O.W.4    Chojkier, M.5
  • 80
    • 84929266699 scopus 로고    scopus 로고
    • Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
    • [PubMed PMID: 25468160]
    • [80] Neuschwander-Tetri, B.A., Loomba, R., Sanyal, A.J., Lavine, J.E., Van Natta, M.L., Abdelmalek, M.F., et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet 385:9972 (2015), 956–965, 10.1016/S0140-6736(14)61933-4 [PubMed PMID: 25468160].
    • (2015) Lancet , vol.385 , Issue.9972 , pp. 956-965
    • Neuschwander-Tetri, B.A.1    Loomba, R.2    Sanyal, A.J.3    Lavine, J.E.4    Van Natta, M.L.5    Abdelmalek, M.F.6
  • 81
    • 84945185644 scopus 로고    scopus 로고
    • Comparative effectiveness of pharmacological interventions for nonalcoholic steatohepatitis: A systematic review and network meta-analysis
    • [PubMed PMID: 26189925]
    • [81] Singh, S., Khera, R., Allen, A.M., Murad, M.H., Loomba, R., Comparative effectiveness of pharmacological interventions for nonalcoholic steatohepatitis: A systematic review and network meta-analysis. Hepatology 62:5 (2015), 1417–1432, 10.1002/hep.27999 [PubMed PMID: 26189925].
    • (2015) Hepatology , vol.62 , Issue.5 , pp. 1417-1432
    • Singh, S.1    Khera, R.2    Allen, A.M.3    Murad, M.H.4    Loomba, R.5
  • 82
    • 84866731997 scopus 로고    scopus 로고
    • Treating pediatric nonalcoholic fatty liver disease with cysteamine: is adiponectin the key?
    • [PubMed PMID: 22738945]
    • [82] Xanthakos, S.A., Kohli, R., Treating pediatric nonalcoholic fatty liver disease with cysteamine: is adiponectin the key?. J Pediatr 161:4 (2012), 579–581, 10.1016/j.jpeds.2012.05.052 [PubMed PMID: 22738945].
    • (2012) J Pediatr , vol.161 , Issue.4 , pp. 579-581
    • Xanthakos, S.A.1    Kohli, R.2


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