Natural selection of K13 mutants of Plasmodium falciparum in response to artemisinin combination therapies in Thailand

Clinical Microbiology and Infection

Volumn 22, Issue 3, 2016, Pages 285.e1-285.e8

  Putaporntip, C ^a   Kuamsab, N ^a   Kosuwin, R ^a   Tantiwattanasub, W ^b   Vejakama, P ^c   Sueblinvong, T ^a   Seethamchai, S ^d   Jongwutiwes, S ^a   Hughes, A L ^e  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b Umphang Hospital   (Thailand)

^c Bundarik Hospital   (Thailand)

^d NARESUAN UNIVERSITY   (Thailand)

^e UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Artemisinin resistance; K13 propeller; Malaria; Natural selection; Plasmodium falciparum; Thailand

Indexed keywords

ARTEMISININ; ASPARAGINE; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; CODON;

ARTICLE; BLOOD SAMPLING; COMBINATION CHEMOTHERAPY; GENE; GENE LOCUS; GENE MUTATION; GENETIC ANALYSIS; HAPLOTYPE; HUMAN; K 13 GENE; NATURAL SELECTION; NONHUMAN; PHENOTYPE; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEQUENCE ANALYSIS; THAILAND; AMINO ACID SUBSTITUTION; CODON; COMBINATION DRUG THERAPY; DNA SEQUENCE; DRUG EFFECTS; DRUG RESISTANCE; GENETIC POLYMORPHISM; GENETIC SELECTION; GENETICS; MALARIA, FALCIPARUM; MUTATION; PARASITOLOGY;

AMINO ACID SUBSTITUTION; ANTIMALARIALS; ARTEMISININS; CODON; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; GENES, PROTOZOAN; HUMANS; MALARIA, FALCIPARUM; MUTATION; PLASMODIUM FALCIPARUM; POLYMORPHISM, GENETIC; SELECTION, GENETIC; SEQUENCE ANALYSIS, DNA; THAILAND;

EID: 84959569225     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1016/j.cmi.2015.10.027     Document Type: Article

References (28)

1. Balint G.A. Artemesinin and its derivatives: an important new class of antmalarial agents. Pharmacol Therapeut 2001, 90:261-265.
2. Meshnick S.R. Artemesinin: mechanisms of action, resistance and toxicity. Int J Parasitol 2002, 32:1655-1660.
3. Golesner J., Waknine J.H., Krugliak M., Hunt N.H., Grau G.E. Current perspectives on the mechanism of action of artemesinins. Int J Parasitol 2006, 36:1427-1441.
4. Noedl H., Se Y., Schaecher K., Smith B.L., Socheat D., Fukuda M.M. Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med 2008, 359:2619-2620.
5. Dondorp A.M., Nosten F., Yi P., Das D., Phyo A.P., Tarning J., et al. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 2009, 361:455-467.
6. Ariey F., Witkowski B., Amaratunga C., Beghain J., Langlois A.C., Khim N., et al. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature 2014, 505:50-55.
7. Straimer J., Gnädig N.F., Witkowski B., Amaratunga C., Duru V., Ramadani A.P., et al. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Science 2015, 347:428-431.
8. Miotto O., Amato R., Ashley E.A., MacInnis B., Almagro-Garcia J., Amaratunga C., et al. Genetic architecture of artemisinin-resistant Plasmodium falciparum. Nat Genet 2015, 47:226-234.
9. Takala-Harrison S., Jacob C.G., Arze C., Cummings M.P., Silva J.C., Dondorp A.M., et al. Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia. J Infect Dis 2014, 211:670-679.
10. Tun K.M., Imwong M., Lwin K.M., Win A.A., Hlaing T.M., Hlaing T., et al. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker. Lancet Infect Dis 2015, 15:415-421.
11. Talundzic E., Okoth S.A., Congpuong K., Plucinski M.M., Morton L., Goldman I.F., et al. Selection and spread of artemisinin-resistant alleles in Thailand prior to the global artemisinin resistance containment campaign. PLoS Pathog 2015, 11:e1004789.
12. Wang Z., Shrestha S., Li X., Miao J., Yuan L., Cabrera M., et al. Prevalence of K13-propeller polymorphisms in Plasmodium falciparum from China-Myanmar border in 2007-2012. Malar J 2015, 14:168.
13. Ouattara A., Kone A., Adams M., Fofana B., Maiga A.W., Hampton S., et al. Polymorphisms in the K13-propeller gene in artemisinin-susceptible Plasmodium falciparum parasites from Bougoula-Hameau and Bandiagara, Mali. Am J Trop Med Hyg 2015, 92:1202-1206.
14. Wongsrichanalai C., Sibley C.H. Fighting drug-resistant Plasmodium falciparum: the challenge of artemisinin resistance. Clin Microbiol Infect 2013, 19:908-916.
15. Thimasarn K. Treatment of malaria during control program. Malariology 2542: commemoration of the 50th anniversary of malaria control in Thailand [in Thai] 1999, 88-102. Agricultural Cooperative Federation of Thailand Printing House, Bangkok. S. Malikul (Ed.).
16. World Health Organization Status report on artemisinin resistance: September 2014 2014, World Health Organization, Geneva.
17. Putaporntip C., Buppan P., Jongwutiwes S. Improved performance with saliva and urine as alternative DNA sources for malaria diagnosis by mitochondrial DNA-based PCR assays. Clin Microbiol Infect 2011, 17:1484-1491.
18. Li W.H. Unbiased estimates of the rates of synonymous and nonsynonymous substitution. J Mol Evol 1993, 36:96-99.
19. Nei M., Kumar S. Molecular evolution and phylogenetics 2000, Oxford University Press, New York.
20. Sokal R.R., Rohlf F.J. Biometry: the principles and practice in of statistics in biological research 1981, W. H. Freeman, San Francisco.
21. Wang Z., Wang Y., Cabrera M., Zhang Y., Gupta B., Wu Y., et al. Artemisinin resistance at the China-Myanmar border and association with mutations in the K13-propeller gene. Antimicrob Agents Chemother 2015, In press.
22. Isozumi R., Uemura H., Kimata I., Ichinose Y., Logedi J., Omar A.H., et al. Novel mutations in K13 propeller gene of artemisinin-resistant Plasmodium falciparum. Emerg Infect Dis 2015, 21:490-492.
23. Jongwutiwes S., Putaporntip C., Hughes A.L. Bottleneck effects on vaccine-candidate antigen diversity of malaria parasites in Thailand. Vaccine 2010, 28:3112-3117.
24. Levin B., Perrot V., Walker N. Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria. Genetics 2000, 154:985-997.
25. Maisnier-Patin S., Andersson D.I. Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution. Res Microbiol 2004, 155:360-669.
26. Phyo A.P., Nkhoma S., Stepniewska K., Ashley E.A., Nair S., McGready R., et al. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet 2012, 379:1960-1966.
27. Carrara V.I., Zwang J., Ashley E.A., Price R.N., Stepniewska K., Barends M., et al. Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment. PLoS One 2009, 4:e4551.
28. Carrara V.I., Lwin K.M., Phyo A.P., Ashley E., Wiladphaingern J., Sriprawat K., et al. Malaria burden and artemisinin resistance in the mobile and migrant population on the Thai-Myanmar border, 1999-2011: an observational study. PLoS Med 2013, 10:e1001398.