Insights into the substrate specificity of the MutT pyrophosphohydrolase using structural analogues of 8-oxo-2′-deoxyguanosine nucleotide

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 8, 2016, Pages 2014-2017

  Hamm, Michelle L ^a   McFadden, Emily J ^a   Ghio, Michael ^a   Lindell, Maria A M ^a   Gerien, Kenneth S ^b   O'Handley, Suzanne F ^b  

^a UNIVERSITY OF RICHMOND   (United States)

^b ROCHESTER INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

8 Oxo 2 deoxyguanosine; DNA repair; MutT; Oxidized nucleotides

Indexed keywords

8 HYDROXYGUANINE; BACTERIAL ENZYME; DEOXYGUANOSINE; DEOXYGUANOSINE TRIPHOSPHATE; ENZYME MUTT; INORGANIC PYROPHOSPHATASE; UNCLASSIFIED DRUG; 8-OXO-7-HYDRODEOXYGUANOSINE; ESCHERICHIA COLI PROTEIN; MUTT PROTEIN, E COLI;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; HYDROGEN BOND; HYDROLYSIS; NONHUMAN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEADY STATE; ANALOGS AND DERIVATIVES; CHEMISTRY; CONFORMATION; METABOLISM; MOLECULAR MODEL;

DEOXYGUANOSINE; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYROPHOSPHATASES; SUBSTRATE SPECIFICITY;

EID: 84959465595     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.02.083     Document Type: Article

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