Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and rhythm

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Zhou, Juan ^a   Wang, Longfei ^a   Zuo, Mengxia ^a   Wang, Xiaojing ^a   Ahmed, Abu Shufian Ishtiaq ^a   Chen, Qiuyun ^b,c   Wang, Qing K ^a,b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; FISH PROTEIN; GATA4 PROTEIN, ZEBRAFISH; HAND2 PROTEIN, ZEBRAFISH; HOMEOBOX PROTEIN NKX-2.5; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; MORPHOLINO OLIGONUCLEOTIDE; RAN PROTEIN; RANGNRF PROTEIN, HUMAN; SODIUM CHANNEL NAV1.5; TRANSCRIPTION FACTOR GATA; ZEBRAFISH PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; EMBRYOLOGY; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION; GENETICS; HEART; HEART RATE; HUMAN; METABOLISM; MICROINJECTION; MUTATION; NONMAMMALIAN EMBRYO; NUCLEOCYTOPLASMIC TRANSPORT; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; SEQUENCE ALIGNMENT; ZEBRA FISH;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; EMBRYO, NONMAMMALIAN; FISH PROTEINS; GATA TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC COMPLEMENTATION TEST; HEART; HEART RATE; HOMEOBOX PROTEIN NKX-2.5; HUMANS; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; MICROINJECTIONS; MORPHOLINOS; MUTATION; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; ORGANOGENESIS; RAN GTP-BINDING PROTEIN; SEQUENCE ALIGNMENT; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84959440353     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep21538     Document Type: Article

References (46)

1. Baker, R. P., Harreman, M. T., Eccleston, J. F., Corbett, A. H. & Stewart, M. Interaction between Ran and Mog1 is required for efficient nuclear protein import. J Biol Chem 276, 41255-41262 (2001).
2. Moore, M. S. & Blobel, G. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature 365, 661-663 (1993).
3. Oki, M. & Nishimoto, T. A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae Ran homologue. P Natl Acad Sci USA 95, 15388-15393 (1998).
4. Marfatia, K. A., Harreman, M. T., Fanara, P., Vertino, P. M. & Corbett, A. H. Identification and characterization of the human MOG1 gene. Gene 266, 45-56 (2001).
5. Wu, L. et al. Identification of a New Co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5. J Biol Chem 283, 6968-6978 (2008).
6. Chen, Q. Y. et al. Genetic basis and molecular mechanism for idiopathic: ventricular fibrillation. Nature 392, 293-296 (1998).
7. Gellens, M. E. et al. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. P Natl Acad Sci USA 89, 554-558 (1992).
8. Tian, X. L. et al. Mechanisms by which SCN5A mutation N1325S causes cardiac arrhythmias and sudden death in vivo. Cardiovasc Res 61, 256-267 (2004).
9. Tian, X. L. et al. Optical mapping of ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S. Biochem Bioph Res Comm 352, 879-883 (2007).
10. Yong, S. L. et al. Characterization of the cardiac sodium channel SCN5A mutation, N1325S, in single murine ventricular myocytes. Biochem Bioph Res Comm 352, 378-383 (2007).
11. Zhang, T. et al. LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte apoptosis, cardiac fibrosis and contractile dysfunction in mice. Int J Cardiol 147, 239-245 (2011).
12. Wang, Q. et al. Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. Hum Mol Genet 4, 1603-1607 (1995).
13. Wang, Q. et al. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 8, 805-811 (1995).
14. Pambrun, T. et al. Myotonic dystrophy type 1 mimics and exacerbates Brugada phenotype induced by Na(v)1.5 sodium channel loss-of-function mutation. Heart Rhythm 11, 1393-1400 (2014).
15. Ziyadeh-Isleem, A. et al. A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation. Heart Rhythm 11, 1015-1023 (2014).
16. Zumhagen, S. et al. A heterozygous deletion mutation in the cardiac sodium channel gene SCN5A with loss- and gain-of-function characteristics manifests as isolated conduction disease, without signs of Brugada or long QT syndrome. PLoS ONE 8, e67963 (2013).
17. Chakrabarti, S. et al. MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome. Circ Arrhythm Electrophysiol 6, 392-401 (2013).
18. Kattygnarath, D. et al. MOG1: a new susceptibility gene for Brugada syndrome. Circ Cardiovasc Genet 4, 261-268 (2011).
19. Keegan, B. R., Meyer, D. & Yelon, D. Organization of cardiac chamber progenitors in the zebrafish blastula. Development 131, 3081-3091 (2004).
20. Glickman, N. S. & Yelon, D. Cardiac development in zebrafish: coordination of form and function. Semin Cell Dev Biol 13, 507-513 (2002).
21. Stainier, D. Y. Zebrafish genetics and vertebrate heart formation. Nat Rev Genet 2, 39-48 (2001).
22. Wang, Q., Chen, Q. Y., Li, H. & Towbin, J. A. Molecular genetics of long QT syndrome from genes to patients. Curr Opin Cardiol 12, 310-320 (1997).
23. Wang, Q., Chen, Q. Y. & Towbin, J. A. Genetics, molecular mechanisms and management of long QT syndrome. Ann Med 30, 58-65 (1998).
24. Stieber, J., Hofmann, F. & Ludwig, A. Pacemaker channels and sinus node arrhythmia. Trends Cardiovas Med 14, 23-28 (2004).
25. Ishii, T. M., Takano, M., Xie, L. H., Noma, A. & Ohmori, H. Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node. J Biol Chem 274, 12835-12839 (1999).
26. Stieber, J. et al. The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. P Natl Acad Sci USA 100, 15235-15240 (2003).
27. Schweizer, P. A. et al. The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel. J Am Coll Cardiol 64, 757-767 (2014).
28. Milanesi, R., Baruscotti, M., Gnecchi-Ruscone, T. & DiFrancesco, D. Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. New Engl J Med 354, 151-157 (2006).
29. Zhang, Z. et al. Functional roles of Ca(v)1.3 (alpha(1D)) calcium channel in sinoatrial nodes-Insight gained using gene-targeted null mutant mice. Circ Res 90, 981-987 (2002).
30. Mangoni, M. E. et al. Functional role of L-type Cav1.3 Ca2 + channels in cardiac pacemaker activity. P Natl Acad Sci USA 100, 5543-5548 (2003).
31. Li, J., McLerie, M. & Lopatin, A. N. Transgenic upregulation of IK1 in the mouse heart leads to multiple abnormalities of cardiac excitability. Am J Physiol Heart Circ Physiol 287, H2790-H2802 (2004).
32. Chopra, S. S. et al. Voltage-gated sodium channels are required for heart development in zebrafish. Circ Res 106, 1342-1350 (2010).
33. Gui, J. H. et al. Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome. PLoS ONE 5, e10985 (2010).
34. Schoenebeck, J. J., Keegan, B. R. & Yelon, D. Vessel and blood specification override cardiac potential in anterior mesoderm. Dev Cell 13, 254-267 (2007).
35. Reiter, J. F. et al. Gata5 is required for the development of the heart and endoderm in zebrafish. Gene Dev 13, 2983-2995 (1999).
36. Holtzinger, A. & Evans, T. Gata4 regulates the formation of multiple organs. Development 132, 4005-4014 (2005).
37. Tu, S. & Chi, N. C. Zebrafish models in cardiac development and congenital heart birth defects. Differentiation 84, 4-16 (2012).
38. Targoff, K. L., Schell, T. & Yelon, D. Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number. Dev Biol 322, 314-321 (2008).
39. George, V., Colombo, S. & Targoff, K. L. An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood. Dev Biol 400, 10-22 (2015).
40. Reiter, J. F., Verkade, H. & Stainier, Y. R. Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5. Dev Biol 234, 330-338 (2001).
41. Olesen, M. S., Holst, A. G. & Schmitt, N. Letter by Olesen et al. Regarding Article, "MOG1: a new susceptibility gene for Brugada syndrome". Circ Cardiovasc Genet 4, e22 (2011).
42. Chen, D., Li, L., Tu, X., Yin, Z. & Wang, Q. Functional characterization of KlippelTrenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis. Hum Mol Genet 22, 963-976 (2013).
43. Li, L. et al. Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish. Blood 123, 501-508 (2014).
44. Su, Z. H. et al. MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development. Int J Biochem Cell B 49, 53-63 (2014).
45. Wang, F. et al. Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet 43, 345-349 (2011).
46. Zhou, B. S. et al. MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth. Cancer Lett 333, 159-169 (2013).