4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1)

Journal of Medicinal Chemistry

Volumn 59, Issue 4, 2016, Pages 1518-1530

  Hügle, Martin ^a   Lucas, Xavier ^b   Weitzel, Gerhard ^a   Ostrovskyi, Dmytro ^a   Breit, Bernhard ^a   Gerhardt, Stefan ^a   Einsle, Oliver ^a   Günther, Stefan ^a   Wohlwend, Daniel ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 ACYL PYRROLE DERIVATIVE; ACETIC ACID DERIVATIVE; BROMODOMAIN INHIBITOR; LYSINE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; BRD4 PROTEIN, HUMAN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; ATOM; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; FLUOROMETRY; MOLECULAR MODEL; MOLECULAR RECOGNITION; X RAY CRYSTALLOGRAPHY; ACYLATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR DOCKING;

ACYLATION; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MOLECULAR DOCKING SIMULATION; NUCLEAR PROTEINS; PYRROLES; TRANSCRIPTION FACTORS;

EID: 84959386977     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01267     Document Type: Article

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