SAR650984 directly induces multiple myeloma cell death via lysosomal-associated and apoptotic pathways, which is further enhanced by pomalidomide

Leukemia

Volumn 30, Issue 2, 2016, Pages 399-408

  Jiang, H ^a,b   Acharya, C ^a   An, G ^a   Zhong, M ^a   Feng, X ^a   Wang, L ^a   Dasilva, N ^a   Song, Z ^c   Yang, G ^c   Adrian, F ^c   Qiu, L ^d   Richardson, P ^a   Munshi, N C ^a   Tai, Y T ^a   Anderson, K C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c Sanofi Oncology   (United States)

^d INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; CATHEPSIN B; CD38 ANTIGEN; IMMUNOGLOBULIN F(AB')2 FRAGMENT; INTERLEUKIN 6; ISATUXIMAB; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MEMBRANE LIPID; POMALIDOMIDE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; ACTIN; CD38 PROTEIN, HUMAN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; THALIDOMIDE;

ACTIN FILAMENT; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW STROMA CELL; CANCER INHIBITION; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL SURFACE; CONTROLLED STUDY; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; LYSOSOME; LYSOSOME MEMBRANE; MULTIPLE MYELOMA; MYELOMA CELL; PRIORITY JOURNAL; UPREGULATION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CELL MEMBRANE; CHEMISTRY; DRUG EFFECTS; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR SUPPRESSOR GENE;

ACTINS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIGENS, CD38; APOPTOSIS; GENES, P53; HUMANS; LYSOSOMES; MEMBRANE GLYCOPROTEINS; MEMBRANE MICRODOMAINS; MULTIPLE MYELOMA; REACTIVE OXYGEN SPECIES; THALIDOMIDE;

EID: 84959362725     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2015.240     Document Type: Article

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