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Volumn 374, Issue 1, 2016, Pages 96-106

Reprogramming carcinoma associated fibroblasts by AC1MMYR2 impedes tumor metastasis and improves chemotherapy efficacy

Author keywords

AC1MMYR2; Carcinoma associated fibroblasts; Metastasis; NF kB; VHL

Indexed keywords

AC1MMYR2; ALPHA SMOOTH MUSCLE ACTIN; ANTINEOPLASTIC AGENT; BETA CATENIN; F ACTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA 21; PACLITAXEL; SEPRASE; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; VON HIPPEL LINDAU PROTEIN; AC1MMYR2 COMPOUND; PYRIMIDINE DERIVATIVE;

EID: 84959353005     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2016.02.003     Document Type: Article
Times cited : (44)

References (43)
  • 1
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: building a framework
    • Gupta G.P., Massague J. Cancer metastasis: building a framework. Cell 2006, 127:679-695.
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 2
    • 84867115486 scopus 로고    scopus 로고
    • Microenvironmental regulation of epithelial-mesenchymal transitions in cancer
    • Gao D., Vahdat L.T., Wong S., Chang J.C., Mittal V. Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer Res 2012, 72:4883-4889.
    • (2012) Cancer Res , vol.72 , pp. 4883-4889
    • Gao, D.1    Vahdat, L.T.2    Wong, S.3    Chang, J.C.4    Mittal, V.5
  • 3
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce J.A., Pollard J.W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 2009, 9:239-252.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 5
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A., Gupta P.B., Sgroi D.C., Arenzana-Seisdedos F., Delaunay T., Naeem R., et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121:335-348.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6
  • 6
    • 84890281217 scopus 로고    scopus 로고
    • Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
    • Feig C., Jones J.O., Kraman M., Wells R.J., Deonarine A., Chan D.S., et al. Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:20212-20217.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 20212-20217
    • Feig, C.1    Jones, J.O.2    Kraman, M.3    Wells, R.J.4    Deonarine, A.5    Chan, D.S.6
  • 7
    • 60949101225 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts and tumor growth - bystanders turning into key players
    • Ostman A., Augsten M. Cancer-associated fibroblasts and tumor growth - bystanders turning into key players. Curr. Opin. Genet. Dev 2009, 19:67-73.
    • (2009) Curr. Opin. Genet. Dev , vol.19 , pp. 67-73
    • Ostman, A.1    Augsten, M.2
  • 8
    • 84925287388 scopus 로고    scopus 로고
    • TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer
    • Busch S., Acar A., Magnusson Y., Gregersson P., Ryden L., Landberg G. TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer. Oncogene 2015, 34:27-38.
    • (2015) Oncogene , vol.34 , pp. 27-38
    • Busch, S.1    Acar, A.2    Magnusson, Y.3    Gregersson, P.4    Ryden, L.5    Landberg, G.6
  • 9
    • 84874336387 scopus 로고    scopus 로고
    • STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer
    • Pena C., Cespedes M.V., Lindh M.B., Kiflemariam S., Mezheyeuski A., Edqvist P.H., et al. STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer. Cancer Res 2013, 73:1287-1297.
    • (2013) Cancer Res , vol.73 , pp. 1287-1297
    • Pena, C.1    Cespedes, M.V.2    Lindh, M.B.3    Kiflemariam, S.4    Mezheyeuski, A.5    Edqvist, P.H.6
  • 10
    • 84928695162 scopus 로고    scopus 로고
    • Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression
    • Yamamura Y., Asai N., Enomoto A., Kato T., Mii S., Kondo Y., et al. Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression. Cancer Res 2015, 75:813-823.
    • (2015) Cancer Res , vol.75 , pp. 813-823
    • Yamamura, Y.1    Asai, N.2    Enomoto, A.3    Kato, T.4    Mii, S.5    Kondo, Y.6
  • 11
    • 80051587832 scopus 로고    scopus 로고
    • ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma
    • Sanz-Moreno V., Gaggioli C., Yeo M., Albrengues J., Wallberg F., Viros A., et al. ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma. Cancer Cell 2011, 20:229-245.
    • (2011) Cancer Cell , vol.20 , pp. 229-245
    • Sanz-Moreno, V.1    Gaggioli, C.2    Yeo, M.3    Albrengues, J.4    Wallberg, F.5    Viros, A.6
  • 12
    • 79959917275 scopus 로고    scopus 로고
    • HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis
    • Hartman Z.C., Yang X.Y., Glass O., Lei G., Osada T., Dave S.S., et al. HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis. Cancer Res 2011, 71:4380-4391.
    • (2011) Cancer Res , vol.71 , pp. 4380-4391
    • Hartman, Z.C.1    Yang, X.Y.2    Glass, O.3    Lei, G.4    Osada, T.5    Dave, S.S.6
  • 13
    • 84900335537 scopus 로고    scopus 로고
    • A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis
    • Su S., Liu Q., Chen J., Chen J., Chen F., He C., et al. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell 2014, 25:605-620.
    • (2014) Cancer Cell , vol.25 , pp. 605-620
    • Su, S.1    Liu, Q.2    Chen, J.3    Chen, J.4    Chen, F.5    He, C.6
  • 14
    • 84880570961 scopus 로고    scopus 로고
    • MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling
    • Song S.J., Poliseno L., Song M.S., Ala U., Webster K., Ng C., et al. MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell 2013, 154:311-324.
    • (2013) Cell , vol.154 , pp. 311-324
    • Song, S.J.1    Poliseno, L.2    Song, M.S.3    Ala, U.4    Webster, K.5    Ng, C.6
  • 15
    • 79952198180 scopus 로고    scopus 로고
    • Metastasis-related miRNAs, active players in breast cancer invasion, and metastasis
    • Shi M., Liu D., Duan H., Shen B., Guo N. Metastasis-related miRNAs, active players in breast cancer invasion, and metastasis. Cancer Metastasis Rev 2010, 29:785-799.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 785-799
    • Shi, M.1    Liu, D.2    Duan, H.3    Shen, B.4    Guo, N.5
  • 16
    • 84948571622 scopus 로고    scopus 로고
    • MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment
    • Kohlhapp F.J., Mitra A.K., Lengyel E., Peter M.E. MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment. Oncogene 2015, 34:5857-5868.
    • (2015) Oncogene , vol.34 , pp. 5857-5868
    • Kohlhapp, F.J.1    Mitra, A.K.2    Lengyel, E.3    Peter, M.E.4
  • 17
    • 84893645257 scopus 로고    scopus 로고
    • Small molecule with big role: MicroRNAs in cancer metastatic microenvironments
    • Su Y., Li X., Ji W., Sun B., Xu C., Li Z., et al. Small molecule with big role: MicroRNAs in cancer metastatic microenvironments. Cancer Lett 2014, 344:147-156.
    • (2014) Cancer Lett , vol.344 , pp. 147-156
    • Su, Y.1    Li, X.2    Ji, W.3    Sun, B.4    Xu, C.5    Li, Z.6
  • 18
    • 78650977713 scopus 로고    scopus 로고
    • Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer
    • Asaga S., Kuo C., Nguyen T., Terpenning M., Giuliano A.E., Hoon D.S. Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer. Clin. Chem 2011, 57:84-91.
    • (2011) Clin. Chem , vol.57 , pp. 84-91
    • Asaga, S.1    Kuo, C.2    Nguyen, T.3    Terpenning, M.4    Giuliano, A.E.5    Hoon, D.S.6
  • 19
    • 69049120925 scopus 로고    scopus 로고
    • High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1
    • Qian B., Katsaros D., Lu L., Preti M., Durando A., Arisio R., et al. High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1. Breast Cancer Res. Treat 2009, 117:131-140.
    • (2009) Breast Cancer Res. Treat , vol.117 , pp. 131-140
    • Qian, B.1    Katsaros, D.2    Lu, L.3    Preti, M.4    Durando, A.5    Arisio, R.6
  • 20
    • 84879644246 scopus 로고    scopus 로고
    • MiR-21/Smad 7 signaling determines TGF-beta1-induced CAF formation
    • Li Q., Zhang D., Wang Y., Sun P., Hou X., Larner J., et al. MiR-21/Smad 7 signaling determines TGF-beta1-induced CAF formation. Sci. Rep 2013, 3:2038.
    • (2013) Sci. Rep , vol.3 , pp. 2038
    • Li, Q.1    Zhang, D.2    Wang, Y.3    Sun, P.4    Hou, X.5    Larner, J.6
  • 21
    • 84928203641 scopus 로고    scopus 로고
    • AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21/CDK5 axis
    • Ren Y., Zhou X., Yang J.J., Liu X., Zhao X.H., Wang Q.X., et al. AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21/CDK5 axis. Cancer Lett 2015, 362:174-182.
    • (2015) Cancer Lett , vol.362 , pp. 174-182
    • Ren, Y.1    Zhou, X.2    Yang, J.J.3    Liu, X.4    Zhao, X.H.5    Wang, Q.X.6
  • 22
    • 84883479886 scopus 로고    scopus 로고
    • AC1MMYR2, an inhibitor of dicer-mediated biogenesis of oncomir miR-21, reverses epithelial-mesenchymal transition and suppresses tumor growth and progression
    • Shi Z., Zhang J., Qian X., Han L., Zhang K., Chen L., et al. AC1MMYR2, an inhibitor of dicer-mediated biogenesis of oncomir miR-21, reverses epithelial-mesenchymal transition and suppresses tumor growth and progression. Cancer Res 2013, 73:5519-5531.
    • (2013) Cancer Res , vol.73 , pp. 5519-5531
    • Shi, Z.1    Zhang, J.2    Qian, X.3    Han, L.4    Zhang, K.5    Chen, L.6
  • 23
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-Dependent manner
    • Erez N., Truitt M., Olson P., Arron S.T., Hanahan D. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-Dependent manner. Cancer Cell 2010, 17:135-147.
    • (2010) Cancer Cell , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 24
    • 84883202669 scopus 로고    scopus 로고
    • Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo
    • Cufi S., Bonavia R., Vazquez-Martin A., Oliveras-Ferraros C., Corominas-Faja B., Cuyas E., et al. Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo. Sci. Rep 2013, 3:2459.
    • (2013) Sci. Rep , vol.3 , pp. 2459
    • Cufi, S.1    Bonavia, R.2    Vazquez-Martin, A.3    Oliveras-Ferraros, C.4    Corominas-Faja, B.5    Cuyas, E.6
  • 25
    • 84871261049 scopus 로고    scopus 로고
    • Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment
    • Bao B., Ali S., Ahmad A., Azmi A.S., Li Y., Banerjee S., et al. Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment. PLoS ONE 2012, 7:e50165.
    • (2012) PLoS ONE , vol.7 , pp. e50165
    • Bao, B.1    Ali, S.2    Ahmad, A.3    Azmi, A.S.4    Li, Y.5    Banerjee, S.6
  • 26
    • 84902528910 scopus 로고    scopus 로고
    • MiR-21 overexpression enhances TGF-beta1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy
    • Wang J.Y., Gao Y.B., Zhang N., Zou D.W., Wang P., Zhu Z.Y., et al. miR-21 overexpression enhances TGF-beta1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy. Mol. Cell. Endocrinol 2014, 392:163-172.
    • (2014) Mol. Cell. Endocrinol , vol.392 , pp. 163-172
    • Wang, J.Y.1    Gao, Y.B.2    Zhang, N.3    Zou, D.W.4    Wang, P.5    Zhu, Z.Y.6
  • 27
    • 84947808033 scopus 로고    scopus 로고
    • MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients
    • De Mattos-Arruda L., Bottai G., Nuciforo P.G., Di Tommaso L., Giovannetti E., Peg V., et al. MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients. Oncotarget 2015, 6:37269-37280.
    • (2015) Oncotarget , vol.6 , pp. 37269-37280
    • De Mattos-Arruda, L.1    Bottai, G.2    Nuciforo, P.G.3    Di Tommaso, L.4    Giovannetti, E.5    Peg, V.6
  • 28
    • 84883239228 scopus 로고    scopus 로고
    • Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFkappaB target stromal MCT4
    • Martinez-Outschoorn U.E., Curry J.M., Ko Y.H., Lin Z., Tuluc M., Cognetti D., et al. Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFkappaB target stromal MCT4. Cell Cycle 2013, 12:2580-2597.
    • (2013) Cell Cycle , vol.12 , pp. 2580-2597
    • Martinez-Outschoorn, U.E.1    Curry, J.M.2    Ko, Y.H.3    Lin, Z.4    Tuluc, M.5    Cognetti, D.6
  • 30
    • 84862689246 scopus 로고    scopus 로고
    • DNA damage induces NF-kappaB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion
    • Niu J., Shi Y., Tan G., Yang C.H., Fan M., Pfeffer L.M., et al. DNA damage induces NF-kappaB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion. J. Biol. Chem 2012, 287:21783-21795.
    • (2012) J. Biol. Chem , vol.287 , pp. 21783-21795
    • Niu, J.1    Shi, Y.2    Tan, G.3    Yang, C.H.4    Fan, M.5    Pfeffer, L.M.6
  • 31
    • 84919466750 scopus 로고    scopus 로고
    • Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth
    • Srivastava K., Hu J., Korn C., Savant S., Teichert M., Kapel S.S., et al. Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell 2014, 26:880-895.
    • (2014) Cancer Cell , vol.26 , pp. 880-895
    • Srivastava, K.1    Hu, J.2    Korn, C.3    Savant, S.4    Teichert, M.5    Kapel, S.S.6
  • 33
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420:860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 34
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • Quail D.F., Joyce J.A. Microenvironmental regulation of tumor progression and metastasis. Nat. Med 2013, 19:1423-1437.
    • (2013) Nat. Med , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 35
    • 84897504519 scopus 로고    scopus 로고
    • The role of reactive oxygen species and metabolism on cancer cells and their microenvironment
    • Costa A., Scholer-Dahirel A., Mechta-Grigoriou F. The role of reactive oxygen species and metabolism on cancer cells and their microenvironment. Semin. Cancer Biol 2014, 25:23-32.
    • (2014) Semin. Cancer Biol , vol.25 , pp. 23-32
    • Costa, A.1    Scholer-Dahirel, A.2    Mechta-Grigoriou, F.3
  • 36
  • 37
    • 77954162846 scopus 로고    scopus 로고
    • Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
    • Martinez-Outschoorn U.E., Balliet R.M., Rivadeneira D.B., Chiavarina B., Pavlides S., Wang C., et al. Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle 2010, 9:3256-3276.
    • (2010) Cell Cycle , vol.9 , pp. 3256-3276
    • Martinez-Outschoorn, U.E.1    Balliet, R.M.2    Rivadeneira, D.B.3    Chiavarina, B.4    Pavlides, S.5    Wang, C.6
  • 38
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006, 441:431-436.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 40
    • 36349034540 scopus 로고    scopus 로고
    • Stromal fibroblasts in colorectal liver metastases originate from resident fibroblasts and generate an inflammatory microenvironment
    • Mueller L., Goumas F.A., Affeldt M., Sandtner S., Gehling U.M., Brilloff S., et al. Stromal fibroblasts in colorectal liver metastases originate from resident fibroblasts and generate an inflammatory microenvironment. Am. J. Pathol 2007, 171:1608-1618.
    • (2007) Am. J. Pathol , vol.171 , pp. 1608-1618
    • Mueller, L.1    Goumas, F.A.2    Affeldt, M.3    Sandtner, S.4    Gehling, U.M.5    Brilloff, S.6
  • 41
    • 84871528926 scopus 로고    scopus 로고
    • MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer
    • Mitra A.K., Zillhardt M., Hua Y., Tiwari P., Murmann A.E., Peter M.E., et al. MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov 2012, 2:1100-1108.
    • (2012) Cancer Discov , vol.2 , pp. 1100-1108
    • Mitra, A.K.1    Zillhardt, M.2    Hua, Y.3    Tiwari, P.4    Murmann, A.E.5    Peter, M.E.6
  • 42
    • 80054032535 scopus 로고    scopus 로고
    • Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer
    • Musumeci M., Coppola V., Addario A., Patrizii M., Maugeri-Sacca M., Memeo L., et al. Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer. Oncogene 2011, 30:4231-4242.
    • (2011) Oncogene , vol.30 , pp. 4231-4242
    • Musumeci, M.1    Coppola, V.2    Addario, A.3    Patrizii, M.4    Maugeri-Sacca, M.5    Memeo, L.6
  • 43
    • 84887615282 scopus 로고    scopus 로고
    • Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas
    • Zhang K.L., Han L., Chen L.Y., Shi Z.D., Yang M., Ren Y., et al. Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas. Cancer Lett 2014, 342:139-149.
    • (2014) Cancer Lett , vol.342 , pp. 139-149
    • Zhang, K.L.1    Han, L.2    Chen, L.Y.3    Shi, Z.D.4    Yang, M.5    Ren, Y.6


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