Acute Blockage of Notch Signaling by DAPT Induces Neuroprotection and Neurogenesis in the Neonatal Rat Brain After Stroke

Translational Stroke Research

Volumn 7, Issue 2, 2016, Pages 132-140

  Li, Zhongxia ^a   Wang, Jiangping ^a   Zhao, Congying ^a   Ren, Keming ^a   Xia, Zhezhi ^a   Yu, Huimin ^a   Jiang, Kewen ^a  

^a CHILDREN S HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Angiogenesis; Ischemia; N N (3, 5 difluorophenacetyl) l alanyl S phenylglycine t butyl ester; Neurogenesis; Neuroprotection; Notch signaling

Indexed keywords

BIOLOGICAL MARKER; GAMMA SECRETASE INHIBITOR; N [N (3,5 DIFLUOROPHENACETYL)ALANYL]S PHENYLGLYCINE TERT BUTYL ESTER; NOTCH RECEPTOR; UNCLASSIFIED DRUG; 24-DIAMINO-5-PHENYLTHIAZOLE; DIAMINE; MESSENGER RNA; NEUROPROTECTIVE AGENT; THIAZOLE DERIVATIVE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOACCUMULATION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLIA; MALE; MICROGLIA; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ANIMAL; BRAIN INFARCTION; DISEASE MODEL; DNA MICROARRAY; DRUG EFFECTS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; STROKE; TUNEL ASSAY;

ANIMALS; ANIMALS, NEWBORN; BRAIN INFARCTION; DIAMINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IN SITU NICK-END LABELING; MALE; NEUROGENESIS; NEUROPROTECTIVE AGENTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NOTCH; RNA, MESSENGER; SIGNAL TRANSDUCTION; STROKE; THIAZOLES;

EID: 84959339826     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-015-0441-7     Document Type: Article

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