Hepatitis B Virus-Specific and Global T-Cell Dysfunction in Chronic Hepatitis B

Gastroenterology

Volumn 150, Issue 3, 2016, Pages 684-695.e5

  Park, Jang June ^a,b   Wong, David K ^c   Wahed, Abdus S ^d   Lee, William M ^e   Feld, Jordan J ^c   Terrault, Norah ^f   Khalili, Mandana ^f   Sterling, Richard K ^g   Kowdley, Kris V ^h   Bzowej, Natalie ⁱ   Lau, Daryl T ^j   Kim, W Ray ^k   Smith, Coleman ^l   Carithers, Robert L ^m   Torrey, Keith W ^a,b   Keith, James W ^a,b   Levine, Danielle L ^a,b   Traum, Daniel ^a,b   Ho, Suzanne ^a,b   Valiga, Mary E ^a,b   Johnson, Geoffrey S ^d   Doo, Edward ⁿ   Lok, Anna S F ^o   Chang, Kyong Mi ^a,b   more..

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^h VIRGINIA MASON MEDICAL CENTER   (United States)

ⁱ CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^j BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^k MAYO CLINIC   (United States)

^l UNIVERSITY OF MINNESOTA   (United States)

^m UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

ⁿ NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^o UNIVERSITY OF MICHIGAN   (United States)

more..

Author keywords

HBRN; IFN; IL10; LPS

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; HEPATITIS B(E) ANTIGEN; INTERLEUKIN 10; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; IFNG PROTEIN, HUMAN; IL10 PROTEIN, HUMAN; LIPOPOLYSACCHARIDE;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHRONIC HEPATITIS B; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; VIRUS IMMUNITY; BLOOD; CASE CONTROL STUDY; CELL CULTURE; CELL PROLIFERATION; CLINICAL TRIAL; DRUG EFFECTS; HEPATITIS B VIRUS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MULTICENTER STUDY; ORTHOMYXOVIRIDAE; PATHOGENICITY; PHENOTYPE; T LYMPHOCYTE; UNITED STATES; VIROLOGY;

ADULT; CASE-CONTROL STUDIES; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MALE; ORTHOMYXOVIRIDAE; PHENOTYPE; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY; UNITED STATES;

EID: 84959336489     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.11.050     Document Type: Article

References (52)

1. B. Rehermann Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells Nat Med 19 2013 859 868
2. F.V. Chisari, M. Isogawa, and S.F. Wieland Pathogenesis of hepatitis B virus infection Pathol Biol (Paris) 58 2010 258 266
3. J.H. Hoofnagle, E. Doo, T.J. Liang, and et al. Management of hepatitis B: summary of a clinical research workshop Hepatology 45 2007 1056 1075
4. F.V. Chisari, and C. Ferrari Hepatitis B virus immunopathogenesis Annu Rev Immunol 13 1995 29 60
5. R. Liang How I treat and monitor viral hepatitis B infection in patients receiving intensive immunosuppressive therapies or undergoing hematopoietic stem cell transplantation Blood 113 2009 3147 3153
6. A.S. Lok, and B.J. McMahon Chronic hepatitis B: update 2009 Hepatology 50 2009 661 662
7. EASL clinical practice guidelines: management of chronic hepatitis B virus infection. J Hepatol;57:167-185.
8. S.F. Wieland, A. Eustaquio, C. Whitten-Bauer, and et al. Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids Proc Natl Acad Sci U S A 102 2005 9913 9917
9. L.G. Guidotti, and F.V. Chisari Immunobiology and pathogenesis of viral hepatitis Annu Rev Pathol 1 2006 23 61
10. B. Rehermann, and M. Nascimbeni Immunology of hepatitis B virus and hepatitis C virus infection Nat Rev Immunol 5 2005 215 229
11. M.K. Maini, and A. Schurich The molecular basis of the failed immune response in chronic HBV: therapeutic implications J Hepatol 52 2010 616 619
12. K.M. Chang Hepatitis B immunology for clinicians Clin Liver Dis 14 2010 409 424
13. N. Nakamoto, H. Cho, A. Shaked, and et al. Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade PLoS Pathog 5 2009 e1000313
14. A.R. Lopes, P. Kellam, A. Das, and et al. Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection J Clin Invest 118 2008 1835 1845
15. A. Schurich, L.J. Pallett, M. Lubowiecki, and et al. The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells PLoS Pathog 9 2013 e1003208
16. A. Schurich, P. Khanna, A.R. Lopes, and et al. Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection Hepatology 53 2011 1494 1503
17. A. Das, M. Hoare, N. Davies, and et al. Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection J Exp Med 205 2008 2111 2124
18. C. Boni, P. Fisicaro, C. Valdatta, and et al. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection J Virol 81 2007 4215 4225
19. P. Fisicaro, C. Valdatta, M. Massari, and et al. Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B Gastroenterology 138 2010 682 693 693 e1-e4
20. P. Fisicaro, C. Valdatta, M. Massari, and et al. Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV Gastroenterology 143 2012 1576 1585 e4
21. D. Xu, J. Fu, L. Jin, and et al. Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B J Immunol 177 2006 739 747
22. J. Fu, D. Xu, Z. Liu, and et al. Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients Gastroenterology 132 2007 2328 2339
23. J.N. Stoop, R.G. van der Molen, C.C. Baan, and et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection Hepatology 41 2005 771 778
24. J.N. Stoop, M.A. Claassen, A.M. Woltman, and et al. Intrahepatic regulatory T cells are phenotypically distinct from their peripheral counterparts in chronic HBV patients Clin Immunol 129 2008 419 427
25. M.G. Ghany, R. Perrillo, R. Li, and et al. Characteristics of adults in the Hepatitis B Research Network in North America Reflect their country of origin and hepatitis B virus genotype Clin Gastroenterol Hepatol 13 2015 183 192
26. G. Winter, and S. Fields Cloning of influenza cDNA ino M13: the sequence of the RNA segment encoding the A/PR/8/34 matrix protein Nucleic Acids Res 8 1980 1965 1974
27. D.E. Kaplan, K. Sugimoto, F. Ikeda, and et al. T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C Hepatology 41 2005 1365 1375
28. K. Sugimoto, J. Stadanlick, F. Ikeda, and et al. Influence of ethnicity in the outcome of hepatitis C virus infection and cellular immune response Hepatology 37 2003 590 599
29. K.M. Chang, R. Thimme, J.J. Melpolder, and et al. Differential CD4(+) and CD8(+) T-cell responsiveness in hepatitis C virus infection Hepatology 33 2001 267 276
30. K. Sugimoto, F. Ikeda, J. Stadanlick, and et al. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection Hepatology 38 2003 1437 1448
31. N. Nakamoto, D.E. Kaplan, J. Coleclough, and et al. Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization Gastroenterology 134 2008 1927 1937 1937 e1-e2
32. D.E. Kaplan, F. Ikeda, Y. Li, and et al. Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis J Hepatol 48 2008 903 913
33. M. Chen, M. Sallberg, J. Hughes, and et al. Immune tolerance split between hepatitis B virus precore and core proteins J Virol 79 2005 3016 3027
34. M.T. Chen, J.N. Billaud, M. Sallberg, and et al. A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen Proc Natl Acad Sci U S A 101 2004 14913 14918
35. D. Milich, and T.J. Liang Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection Hepatology 38 2003 1075 1086
36. S. Asabe, S.F. Wieland, P.K. Chattopadhyay, and et al. The size of the viral inoculum contributes to the outcome of hepatitis B virus infection J Virol 83 2009 9652 9662
37. R. Thimme, S. Wieland, C. Steiger, and et al. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection J Virol 77 2003 68 76
38. C. Ferrari, A. Penna, A. Bertoletti, and et al. Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection J Immunol 145 1990 3442 3449
39. C. Boni, A. Bertoletti, A. Penna, and et al. Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B J Clin Invest 102 1998 968 975
40. A.T. Tan, E. Loggi, C. Boni, and et al. Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire J Virol 82 2008 10986 10997
41. J.Y. Lau, G.L. Bird, G.J. Alexander, and et al. Effects of immunosuppressive therapy on hepatic expression of hepatitis B viral genome and gene products Clin Invest Med 16 1993 226 236
42. W.K. Seto, T.S. Chan, Y.Y. Hwang, and et al. Hepatitis B reactivation in patients with previous hepatitis B virus exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study J Clin Oncol 32 2014 3736 3743
43. R.P. Perrillo, R. Gish, and Y.T. Falck-Ytter American Gastroenterological Association Institute technical review on prevention and treatment of hepatitis B virus reactivation during immunosuppressive drug therapy Gastroenterology 148 2015 221 244 e3
44. H. Ebinuma, N. Nakamoto, Y. Li, and et al. Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection J Virol 82 2008 5043 5053
45. P.T. Kennedy, E. Sandalova, J. Jo, and et al. Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B Gastroenterology 143 2012 637 645
46. E. Sandalova, D. Laccabue, C. Boni, and et al. Increased levels of arginase in patients with acute hepatitis B suppress antiviral T cells Gastroenterology 143 2012 78 87 e3
47. M. Isogawa, Y. Furuichi, and F.V. Chisari Oscillating CD8(+) T cell effector functions after antigen recognition in the liver Immunity 23 2005 53 63
48. A.J. Gehring, M. Haniffa, P.T. Kennedy, and et al. Mobilizing monocytes to cross-present circulating viral antigen in chronic infection J Clin Invest 123 2013 3766 3776
49. M.R. Brunetto, F. Moriconi, F. Bonino, and et al. Hepatitis B virus surface antigen levels: a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B Hepatology 49 2009 1141 1150
50. H.L. Chan, V.W. Wong, G.L. Wong, and et al. A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B Hepatology 52 2010 1232 1241
51. Martinot-Peignoux M, Lapalus M, Asselah T, et al. The role of HBsAg quantification for monitoring natural history and treatment outcome. Liver Int;33(Suppl 1):125-132.
52. M.J. Sonneveld, V. Rijckborst, C.A. Boucher, and et al. Prediction of sustained response to peginterferon alfa-2b for hepatitis B e antigen-positive chronic hepatitis B using on-treatment hepatitis B surface antigen decline Hepatology 52 2010 1251 1257