Association of red blood cell transfusion, anemia, and necrotizing enterocolitis in very low-birth-weight infants

JAMA - Journal of the American Medical Association

Volumn 315, Issue 9, 2016, Pages 889-897

  Patel, Ravi M ^a   Knezevic, Andrea ^b   Shenvi, Neeta ^b   Hinkes, Michael ^c   Keene, Sarah ^a   Roback, John D ^a   Easley, Kirk A ^b   Josephson, Cassandra D ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c NORTHSIDE HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; HEMOGLOBIN; ANTIINFECTIVE AGENT; HEMOGLOBIN A;

ANEMIA; APGAR SCORE; ARTICLE; BREAST FEEDING; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; DISEASE SEVERITY ASSESSMENT; ENTERIC FEEDING; ERYTHROCYTE TRANSFUSION; FEMALE; GAMMA IRRADIATION; GESTATIONAL AGE; HEMOGLOBIN BLOOD LEVEL; HUMAN; INCIDENCE; INFANT; INFANT MORTALITY; MAJOR CLINICAL STUDY; MALE; NECROTIZING ENTEROCOLITIS; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCORE FOR NEONATAL ACUTE PHYSIOLOGY; SEX DIFFERENCE; TREATMENT DURATION; VERY LOW BIRTH WEIGHT; ADVERSE EFFECTS; BIRTH WEIGHT; BLOOD; CLINICAL TRIAL; COMPLICATION; ENTEROCOLITIS, NECROTIZING; GEORGIA; MULTICENTER STUDY; NEWBORN; NEWBORN INTENSIVE CARE; PROPORTIONAL HAZARDS MODEL; RISK FACTOR;

ANEMIA; ANTI-BACTERIAL AGENTS; BIRTH WEIGHT; ENTEROCOLITIS, NECROTIZING; ERYTHROCYTE TRANSFUSION; FEMALE; GEORGIA; GESTATIONAL AGE; HEMOGLOBIN A; HUMANS; INCIDENCE; INFANT, NEWBORN; INFANT, VERY LOW BIRTH WEIGHT; INTENSIVE CARE UNITS, NEONATAL; MALE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84959303877     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2016.1204     Document Type: Article

References (26)

1. Patel RM, Kandefer S, Walsh MC, et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Causes and timing of death in extremely premature infants from 2000 through 2011. N Engl J Med. 2015;372(4):331-340.
2. Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med. 2011;364(3):255-264.
3. Lin PW, Stoll BJ. Necrotising enterocolitis. Lancet. 2006;368(9543):1271-1283.
4. Mohamed A, Shah PS. Transfusion associated necrotizing enterocolitis: a meta-analysis of observational data. Pediatrics. 2012;129(3):529-540.
5. Wallenstein MB, Arain YH, Birnie KL, et al. Red blood cell transfusion is not associated with necrotizing enterocolitis: a review of consecutive transfusions in a tertiary neonatal intensive care unit. J Pediatr. 2014;165(4):678-682.
6. Sharma R, Kraemer DF, Torrazza RM, et al Packed red blood cell transfusion is not associated with increased risk of necrotizing enterocolitis in premature infants. J Perinatol. 2014;34(11):858-862.
7. AlFaleh K, Al-Jebreen A, Baqays A, et al. Association of packed red blood cell transfusion and necrotizing enterocolitis in very low birth weight infants. J Neonatal Perinatal Med. 2014;7(3):193-198.
8. Sood BG, Rambhatla A, Thomas R, Chen X. Decreased hazard of necrotizing enterocolitis in preterm neonates receiving red cell transfusions. J Matern Fetal Neonatal Med. 2015;29(5):737-744.
9. Kirpalani H, Zupancic JA. Do transfusions cause necrotizing enterocolitis? Semin Perinatol. 2012;36 (4):269-276.
10. Strauss RG. Practical issues in neonatal transfusion practice. Am J Clin Pathol. 1997;107(4) (suppl1):S57-S63.
11. Josephson CD, Castillejo MI, Caliendo AM, et al. Prevention of transfusion-transmitted cytomegalovirus in low-birth weight infants (<1500g) using cytomegalovirus-seronegative and leukoreduced transfusions. Transfus Med Rev. 2011; 25(2): 125-132.
12. Josephson CD, Caliendo AM, Easley KA, et al. Blood transfusion and breast milktransmission of cytomegalovirus in very low-birth-weight infants: a prospective cohort study. JAMA Pediatr. 2014;168 (11):1054-1062.
13. Bell MJ, Ternberg JL, Feigin RD, et al. Neonatal necrotizing enterocolitis: therapeutic decisions based upon clinical staging. Ann Surg. 1978;187(1):1-7
14. Kirpalani H, Whyte RK, Andersen C, et al. The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr. 2006;149(3):301-307.
15. Bell EF, Strauss RG, Widness JA, et al. Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. Pediatrics. 2005;115(6):1685-1691.
16. Richardson DK, Gray JE, McCormick MC, Workman K, Goldmann DA. Score for Neonatal Acute Physiology: a physiologic severity index for neonatal intensive care. Pediatrics. 1993;91(3):617-623.
17. Allison PD. Survival Analysis Using SAS: A Practical Guide. 2nd ed. Cary, NC: SAS Institute; 2010.
18. Fine JP, Gray RJ. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc. 1999;94:496-509. doi:10.1080/01621459.1999.10474144
19. Gray RJ. A class of k-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat. 1988;16:1141-1154. doi:10.1214/aos/1176350951
20. Blackstone EH. Breaking down barriers: helpful breakthrough statistical methods you need to understand better. J Thorac Cardiovasc Surg. 2001; 122(3):430-439.
21. Brookhart MA, Schneeweiss S, Rothman KJ, Glynn RJ, Avorn J, Stürmer T. Variable selection for propensity score models. Am J Epidemiol. 2006;163 (12):1149-1156.
22. Olsen IE, Groveman SA, Lawson ML, Clark RH, Zemel BS. New intrauterine growth curves based on United States data. Pediatrics. 2010;125(2):e214-e224.
23. Singh R, Visintainer PF, Frantz ID, 3rd, et al Association of necrotizing enterocolitis with anemia and packed red blood cell transfusions in preterm infants. J Perinatol. 2011;31(3):176-182.
24. Derienzo C, Smith PB, Tanaka D, et al. Feeding practices and other risk factors for developing transfusion-associated necrotizing enterocolitis. Early Hum Dev. 2014;90(5):237-240.
25. Klein HG, Flegel WA, Natanson C. Red blood cell transfusion: precision vs imprecision medicine. JAMA. 2015;314(15):1557-1558.
26. Ramani M, Ambalavanan N. Feeding practices and necrotizing enterocolitis. Clin Perinatol. 2013; 40(1):1-10.