Supplementation with Micronutrients in Addition to Iron and Folic Acid Does Not Further Improve the Hematologic Status of Pregnant Women in Rural Nepal

Journal of Nutrition

Volumn 133, Issue 11, 2003, Pages 3492-3498

  Christian, Parul ^a   Shrestha, Jaibar ^b   LeClerq, Steven C ^a   Khatry, Subarna K ^b   Jiang, Tianan ^a   Wagner, Tracey ^a   Katz, Joanne ^a   West Jr , Keith P ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b Nepal Nutrition Intervention Project Sarlahi   (Nepal)

Author keywords

Anemia; Iron status; Micronutrients; Nepal; Postpartum; Pregnancy

Indexed keywords

FOLIC ACID; HEMOGLOBIN; IRON; RETINOL; RETINOL ACETATE; TRACE ELEMENT; ZINC;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; IRON BLOOD LEVEL; IRON DEFICIENCY ANEMIA; IRON THERAPY; MAJOR CLINICAL STUDY; NEPAL; PATIENT COMPLIANCE; POSTNATAL CARE; PREGNANCY; PRENATAL CARE; RANDOMIZED CONTROLLED TRIAL; RURAL AREA; THIRD TRIMESTER PREGNANCY;

EID: 0242661847     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.11.3492     Document Type: Article

References (18)

1. Sloan, N. L., Jordan, E. & Winikoff, B. (2002) Effects of iron supplementation on maternal hematologic status in pregnancy. Am. J. Public Health 92; 288-293.
2. Fishman, S., Christian, P. & West, K. P., Jr. (2000) The role of vitamin supplementation in the prevention and treatment of anemia. Public Health Nutr. 3: 125-150.
3. Suharno, D., West, C. E., Muhilal, Karyadi, D., & Hautvast J.G.A.J. (1993) Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in West Java, Indonesia. Lancet 342: 1325-1328.
4. Christian, P., Khatry, S. K., Katz, J., Pradhan, E. K., LeClerq, S. C., Shrestha, S. R., Adhikari, R. K., Sommer, A. & West, K. P., Jr. (2003) Effects of alternative maternal micronutrient supplements on low birth weight in rural Nepal. A double-blind randomized community trial. BMJ 326: 571-576.
5. Christian, P., West, K. P., Jr., Khatry, S. K., LeClerq, S. C., Pradhan, E. K., Katz, J., Shrestha, S. R. & Sommer, A. Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal. Am. J. Clin. Nutr. (in press)
6. West, K. P., Jr., Katz, J., Khatry, S. K., LeClerq, S. C., Pradhan, E. K., Shrestha, S. R., Connor, P. B., Dali, S. M., Christian, P., Pokhrel, R. P. & Sommer, A. A. On behalf of the NNIPS2 Study Group. (1999) Low dose vitamin A or β-carotene supplementation reduces pregnancy-related mortality: a double-masked, cluster randomized Prevention Trial in Nepal. BMJ 318: 570-575.
7. Christian, P., West, K. P., Jr., Khatry, S. K., Katz, J., LeClerq, S. C., Pradhan, E. K. & Shrestha, S. R. (1998) Vitamin A or β-carotene reduces but does not eliminate maternal night blindness in Nepal. J. Nutr. 128: 1458-1463.
8. Stoltzfus, R. J., Dreyfuss, M. L., Shrestha, J. B., Khatry, S. K., Schulze, K. & West, K. P., Jr. (1997) Effect of maternal vitamin A or β-carotene supplementation on iron deficiency anaemia in Nepalese pregnant women, postpartum mothers and infants. (abstract). In: Report of the XVIII International Vitamin A Consultative Group Meeting. Cairo, Egypt. ISLI Research Foundation, Washington D.C.
9. Katz, J., West, K. P., Jr., Khatry, S. K., Pradhan, E. K., LeClerq, S. C., Christian, P., Wu, L. S., Adhikari, R. K., Shrestha, S. R., Sommer, A. and the NNIPS-2 Study Group. (2000) Low-dose vitamin A or beta-carotene supplementation does not reduce early infant mortality: a double-masked, randomized, controlled community trial in Nepal. Am. J. Clin. Nutr. 71: 1570-1576.
10. Sari, M., de Pee, S., Martini, E., Herman, S., Sugiatmi, Bloem, M. W., Yip, R. (2001) Estimating the prevalence of anaemia: a comparison of 3 methods. Bull. WHO 79: 506-511.
11. Stoltzfus, R. J. & Dreyfuss, M. L. (1998) Guidelines for the use of iron supplements to prevent and treat iron deficiency anaemia. INACG/WHO/UNICEF: ILSI Press, Washington D.C.
12. Dreyfuss, M. L., Stoltzfus, R. J., Shrestha, J. B., Pradhan, E. K., LeClerq, S. C., Khatry, S. K., Shrestha, S. R., Katz, J. K., Albonico, M. & West, K. P., Jr. (2000) Hookworms, malaria and vitamin A deficiency contribute to anemia and iron deficiency among pregnant women in the plains of Nepal. J. Nutr. 130: 2527-2536.
13. Liang, K. Y. & Zeger, S. L. (1986) Longitudinal data analysis using generalized linear models. Biometrika 73: 13-22.
14. Pryor J. A. & Morrison J. C. (1990) Nutritional anemias. In: Hematologic Disorders i9n Maternal-Fetal Medicine (Bern, M. M. & Frigoletto, F. D., Jr.) Wiley-Liss, New York.
15. Solomons, N. W. & Ruz, M. (1997) Zinc and iron interaction: concepts and perspectives in the developing world. Nutr. Res. 17: 177-185.
16. Solomons, N. W. (1986) Competitive interaction of iron and zinc in the diet: consequences for human nutrition. J. Nutr. 116: 927-935.
17. Christian, P., Khatry, S. K., LeClerq, S. C., Shrestha, S. R., Kimbrough-Pradhan, E. & West, K. P., Jr. (2001) Iron and zinc interactions among pregnant Nepali women. Nutr. Res. 21: 141-148.
18. Lind, T., Lonnerdal, B., Stenlund, H., Ismail, D., Seswandhana, R., Ekstrom, E. C. & Presson, L. A. (2003) A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: interactions between iron and zinc. Am. J. Clin. Nutr. 77: 883-890.