Clinical significance of Clostridium difficile in children less than 2 years old: A case-control study

Pediatric Infectious Disease Journal

Volumn 35, Issue 3, 2016, Pages 281-285

  González Del Vecchio, Marcela ^a,b,c   Álvarez Uria, Ana ^a   Marin, Mercedes ^a,b,c   Alcalá, Luis ^a,c,d   Martín, Adoración ^a   Montilla, Pedro ^a,b,d   Bouza, Emilio ^a,b,c,d  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Clostridium difficile; Pediatric population

Indexed keywords

METRONIDAZOLE;

ARTICLE; CAMPYLOBACTER JEJUNI; CASE CONTROL STUDY; CHILD; CLOSTRIDIUM INFECTION; CONTROLLED STUDY; DIARRHEA; FECES; FEMALE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RIBOTYPING; RISK FACTOR; STOMACH ACID; CLOSTRIDIUM INFECTIONS; COMMUNITY ACQUIRED INFECTION; CROSS INFECTION; ISOLATION AND PURIFICATION; MICROBIOLOGY; NEWBORN;

CASE-CONTROL STUDIES; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; DIARRHEA; FECES; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; RISK FACTORS;

EID: 84959230411     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0000000000001008     Document Type: Article

References (31)

1. Schutze GE, Willoughby RE; Committee on Infectious Diseases; American Academy of Pediatrics. Clostridium difficile infection in infants and children. Pediatrics. 2013;131:196-200.
2. Bignardi GE. Risk factors for Clostridium difficile infection. J Hosp Infect. 1998;40:1-15.
3. Cohen SH, Gerding DN, Johnson S, et al.; Society for Healthcare Epidemiology of America; Infectious Diseases Society of America. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31:431-455.
4. Ghose C. Clostridium difficile infection in the twenty-first century. Emerg Microbes Infect. 2013;2:e62.
5. Al-Jumaili IJ, Shibley M, Lishman AH, et al. Incidence and origin of Clostridium difficile in neonates. J Clin Microbiol. 1984;19:77-78.
6. Larson HE, Barclay FE, Honour P, et al. Epidemiology of Clostridium difficile in infants. J Infect Dis. 1982;146:727-733.
7. Bryant K, McDonald LC. Clostridium difficile infections in children. Pediatr Infect Dis J. 2009;28:145-146.
8. Collignon A, Ticchi L, Depitre C, et al. Heterogeneity of Clostridium difficile isolates from infants. Eur J Pediatr. 1993;152:319-322.
9. Kim J, Smathers SA, Prasad P, et al. Epidemiological features of Clostridium difficile-associated disease among inpatients at children's hospitals in the United States, 2001-2006. Pediatrics. 2008;122:1266-1270.
10. Tamma PD, Sandora TJ. Infection in children: current state and unanswered questions. J Pediatric Infect Dis Soc. 2012;1:230-243.
11. (INE), I.N.E. Anuario Estadístico de España. http://www.ine.es 2013. Accessed September 1, 2014.
12. Crobach MJ, Dekkers OM, Wilcox MH, et al. European Society of Clinical Microbiology and Infectious Diseases (ESCMID): data review and recommendations for diagnosing Clostridium difficile-infection (CDI). Clin Microbiol Infect. 2009;15:1053-1066.
13. Ruuska T, Vesikari T. Rotavirus disease in Finnish children: use of numerical scores for clinical severity of diarrhoeal episodes. Scand J Infect Dis. 1990;22:259-267.
14. Alcalá L. Laboratory tests for diagnosis of Clostridium difficile infection: past, present, and future. Enferm Infecc Microbiol Clin. 2013;31:65-67.
15. Rupnik M, Braun V, Soehn F, et al. Characterization of polymorphisms in the toxin A and B genes of Clostridium difficile. FEMS Microbiol Lett. 1997;148:197-202.
16. Stubbs SL, Brazier JS, O'Neill GL, et al. PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes. J Clin Microbiol. 1999;37:461-463.
17. Rousseau C, Lemée L, Le Monnier A, et al. Prevalence and diversity of Clostridium difficile strains in infants. J Med Microbiol. 2011; 60(Pt 8):1112-1118.
18. Rousseau C, Levenez F, Fouqueray C, et al. Clostridium difficile colonization in early infancy is accompanied by changes in intestinal microbiota composition. J Clin Microbiol. 2011;49:858-865.
19. Matsuki S, Ozaki E, Shozu M, et al. Colonization by Clostridium difficile of neonates in a hospital, and infants and children in three day-care facilities of Kanazawa, Japan. Int Microbiol. 2005;8:43-48.
20. Pothoulakis C, Lamont JT. Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins. Am J Physiol Gastrointest Liver Physiol. 2001;280:G178-G183.
21. McFarland LV, Brandmarker SA, Guandalini S. Pediatric Clostridium difficile: a phantom menace or clinical reality? J Pediatr Gastroenterol Nutr. 2000;31:220-231.
22. Klein EJ, Boster DR, Stapp JR, et al. Diarrhea etiology in a Children's Hospital Emergency Department: a prospective cohort study. Clin Infect Dis. 2006;43:807-813.
23. de Graaf H, Pai S, Burns DA, et al. Co-infection as a confounder for the role of Clostridium difficile infection in children with diarrhoea: a summary of the literature. Eur J Clin Microbiol Infect Dis. 2015;34:1281-1287.
24. Shim JO. Clostridium difficile in children: to treat or not to treat? Pediatr Gastroenterol Hepatol Nutr. 2014;17:80-84.
25. Sundram F, Guyot A, Carboo I, et al. Clostridium difficile ribotypes 027 and 106: clinical outcomes and risk factors. J Hosp Infect. 2009;72:111-118.
26. Freeman J, Bauer MP, Baines SD, et al. The changing epidemiology of Clostridium difficile infections. Clin Microbiol Rev. 2010;23:529-549.
27. Jafari NV, Songane M, Stabler RA, et al. Host immunity to Clostridium difficile PCR ribotype 017 strains. Infect Immun. 2014;82:4989-4996.
28. Collins DA, Hawkey PM, Riley TV. Epidemiology of Clostridium difficile infection in Asia. Antimicrob Resist Infect Control. 2013;2:21.
29. Arvand M, Hauri AM, Zaiss NH, et al. Clostridium difficile ribotypes 001, 017, and 027 are associated with lethal C. difficile infection in Hesse, Germany. Euro Surveill. 2009;14:4.
30. Goorhuis A, Bakker D, Corver J, et al. Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078. Clin Infect Dis. 2008;47:1162-1170.
31. Goorhuis A, Van der Kooi T, Vaessen N, et al. Spread and epidemiology of Clostridium difficile polymerase chain reaction ribotype 027/toxinotype III in The Netherlands. Clin Infect Dis. 2007;45:695-703.