In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents

European Radiology

Volumn 26, Issue 12, 2016, Pages 4577-4584

  Tedeschi, Enrico ^a   Palma, Giuseppe ^b   Canna, Antonietta ^a   Cocozza, Sirio ^a   Russo, Carmela ^a   Borrelli, Pasquale ^c   Lanzillo, Roberta ^a   Angelini, Valentina ^a   Postiglione, Emanuela ^a   Morra, Vincenzo Brescia ^a   Salvatore, Marco ^c   Brunetti, Arturo ^a   Quarantelli, Mario ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

^c IRCCS SDN   (Italy)

Author keywords

Dentate nucleus; Gadolinium; MRI contrast media; Multiple Sclerosis; Relaxometry

Indexed keywords

GADOBUTROL; GADOLINIUM PENTETATE MEGLUMINE; GADOTERATE MEGLUMINE; CONTRAST MEDIUM; GADOLINIUM;

ADULT; ARTICLE; BRAIN STEM; CONTRAST ENHANCEMENT; CORRELATION ANALYSIS; DENTATE NUCLEUS; DISEASE DURATION; EXPANDED DISABILITY STATUS SCALE; FEMALE; HUMAN; IN VIVO STUDY; MAGNETIC RESONANCE RELAXOMETRY; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; MULTIVARIATE ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; REGRESSION ANALYSIS; RETROSPECTIVE STUDY; THREE DIMENSIONAL IMAGING; CEREBELLUM NUCLEUS; DIAGNOSTIC IMAGING; IMAGE ENHANCEMENT; PATHOLOGY; PROCEDURES;

ADULT; CEREBELLAR NUCLEI; CONTRAST MEDIA; FEMALE; GADOLINIUM; HUMANS; IMAGE ENHANCEMENT; MAGNETIC RESONANCE IMAGING; MALE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; RETROSPECTIVE STUDIES;

EID: 84959147891     PISSN: 09387994     EISSN: 14321084     Source Type: Journal    
DOI: 10.1007/s00330-016-4245-2     Document Type: Article

References (47)

1. Kanal E, Maravilla K, Rowley HA (2014) Gadolinium contrast agents for CNS imaging: current concepts and clinical evidence. AJNR Am J Neuroradiol 35:2215–2226
2. Giesel FL, Mehndiratta A, Essig M (2010) High-relaxivity contrast-enhanced magnetic resonance neuroimaging: a review. Eur Radiol 20:2461–2474
3. Hao D, Ai T, Goerner F, Hu X, Runge VM, Tweedle M (2012) MRI contrast agents: basic chemistry and safety. J Magn Reson Imaging 36:1060–1071
4. Brown RW, Cheng Y C N, Haacke E M, Thompson M R, Venkatesan R (2014) Magnetic Resonance Imaging: Physical Principles and Sequence Design. John Wiley & Sons
5. Reiser MF, Semmler, W, Hricak, H (2008) Magnetic Resonance Tomography. Springer
6. Errante Y, Cirimele V, Mallio CA, Di Lazzaro V, Zobel BB, Quattrocchi CC (2014) Progressive increase of T1 signal intensity of the dentate nucleus on unenhanced magnetic resonance images is associated with cumulative doses of intravenously administered gadodiamide in patients with normal renal function, suggesting dechelation. Invest Radiol 49:685–690
7. Kanda T, Ishii K, Kawaguchi H, Kitajima K, Takenaka D (2014) High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology 270:834–841
8. Kanda T, Osawa M, Oba H et al (2015) High Signal Intensity in Dentate Nucleus on Unenhanced T1-weighted MR Images: Association with Linear versus Macrocyclic Gadolinium Chelate Administration. Radiology 275:803–809
9. Radbruch A, Weberling LD, Kieslich PJ et al (2015) Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent. Radiology 275:783–791
10. Ramalho J, Castillo M, AlObaidy M et al (2015) High Signal Intensity in Globus Pallidus and Dentate Nucleus on Unenhanced T1-weighted MR Images: Evaluation of Two Linear Gadolinium-based Contrast Agents. Radiology:150872
11. Stojanov DA, Aracki-Trenkic A, Vojinovic S, Benedeto-Stojanov D, Ljubisavljevic S (2015) Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol. Eur Radiol
12. Weberling LD, Kieslich PJ, Kickingereder P et al (2015) Increased Signal Intensity in the Dentate Nucleus on Unenhanced T1-Weighted Images After Gadobenate Dimeglumine Administration. Invest Radiol
13. Radbruch A, Weberling LD, Kieslich PJ et al (2015) High-Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Images: Evaluation of the Macrocyclic Gadolinium-Based Contrast Agent Gadobutrol. Invest Radiol 50:805–810
14. Tofts P (2005) Quantitative MRI of the brain: measuring changes caused by disease. John Wiley & Sons
15. Ginat DT, Meyers SP (2012) Intracranial lesions with high signal intensity on T1-weighted MR images: differential diagnosis. Radiographics 32:499–516
16. Ogg RJ, McDaniel CB, Wallace D, Pitot P, Neel MD, Kaste SC (2005) MR safety and compatibility of a noninvasively expandable total-joint endoprosthesis. Magn Reson Imaging 23:789–794
17. Diedrichsen J, Maderwald S, Kuper M et al (2011) Imaging the deep cerebellar nuclei: a probabilistic atlas and normalization procedure. Neuroimage 54:1786–1794
18. Maschke M, Weber J, Dimitrova A et al (2004) Age-related changes of the dentate nuclei in normal adults as revealed by 3D fast low angle shot (FLASH) echo sequence magnetic resonance imaging. J Neurol 251:740–746
19. Ward RJ, Zucca FA, Duyn JH, Crichton RR, Zecca L (2014) The role of iron in brain ageing and neurodegenerative disorders. Lancet Neurol 13:1045–1060
20. Roccatagliata L, Vuolo L, Bonzano L, Pichiecchio A, Mancardi GL (2009) Multiple sclerosis: hyperintense dentate nucleus on unenhanced T1-weighted MR images is associated with the secondary progressive subtype. Radiology 251:503–510
21. Borrelli P, Palma G, Tedeschi E et al (2015) Improving Signal-to-Noise Ratio in Susceptibility Weighted Imaging: A Novel Multicomponent Non-Local Approach. PLoS ONE 10, e0126835
22. Palma G, Tedeschi E, Borrelli P et al (2015) A Novel Multiparametric Approach to 3D Quantitative MRI of the Brain. PLoS ONE 10, e0134963
23. Tjoa CW, Benedict RH, Weinstock-Guttman B, Fabiano AJ, Bakshi R (2005) MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis. J Neurol Sci 234:17–24
24. Langkammer C, Krebs N, Goessler W et al (2010) Quantitative MR imaging of brain iron: a postmortem validation study. Radiology 257:455–462
25. Khalil M, Langkammer C, Ropele S et al (2011) Determinants of brain iron in multiple sclerosis: a quantitative 3T MRI study. Neurology 77:1691–1697
26. Quattrocchi CC, Mallio CA, Errante Y et al (2015) Gadodiamide and Dentate Nucleus T1 Hyperintensity in Patients With Meningioma Evaluated by Multiple Follow-Up Contrast-Enhanced Magnetic Resonance Examinations With No Systemic Interval Therapy. Invest Radiol 50:470–472
27. McDonald RJ, McDonald JS, Kallmes DF et al (2015) Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging. Radiology 275:772–782
28. Kanda T, Fukusato T, Matsuda M et al (2015) Gadolinium-based Contrast Agent Accumulates in the Brain Even in Subjects without Severe Renal Dysfunction: Evaluation of Autopsy Brain Specimens with Inductively Coupled Plasma Mass Spectroscopy. Radiology 276:228–232
29. Kanal E, Tweedle MF (2015) Residual or retained gadolinium: practical implications for radiologists and our patients. Radiology 275:630–634
30. Birka M, Wentker KS, Lusmoller E et al (2015) Diagnosis of nephrogenic systemic fibrosis by means of elemental bioimaging and speciation analysis. Anal Chem 87:3321–3328
31. van Horssen J, Brink BP, de Vries HE, van der Valk P, Bo L (2007) The blood-brain barrier in cortical multiple sclerosis lesions. J Neuropathol Exp Neurol 66:321–328
32. Cheng HL, Stikov N, Ghugre NR, Wright GA (2012) Practical medical applications of quantitative MR relaxometry. J Magn Reson Imaging 36:805–824
33. Deoni SC (2010) Quantitative relaxometry of the brain. Top Magn Reson Imaging 21:101–113
34. Bonnier G, Roche A, Romascano D et al (2014) Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis. Ann Clin Transl Neurol 1:423–432
35. Walsh AJ, Blevins G, Lebel RM, Seres P, Emery DJ, Wilman AH (2014) Longitudinal MR imaging of iron in multiple sclerosis: an imaging marker of disease. Radiology 270:186–196
36. Deoni SC, Mercure E, Blasi A et al (2011) Mapping infant brain myelination with magnetic resonance imaging. J Neurosci 31:784–791
37. Saito N, Sakai O, Ozonoff A, Jara H (2009) Relaxo-volumetric multispectral quantitative magnetic resonance imaging of the brain over the human lifespan: global and regional aging patterns. Magn Reson Imaging 27:895–906
38. Davies GR, Hadjiprocopis A, Altmann DR et al (2007) Normal-appearing grey and white matter T1 abnormality in early relapsing-remitting multiple sclerosis: a longitudinal study. Mult Scler 13:169–177
39. Manfredonia F, Ciccarelli O, Khaleeli Z et al (2007) Normal-appearing brain t1 relaxation time predicts disability in early primary progressive multiple sclerosis. Arch Neurol 64:411–415
40. Vrenken H, Geurts JJ, Knol DL et al (2006) Whole-brain T1 mapping in multiple sclerosis: global changes of normal-appearing gray and white matter. Radiology 240:811–820
41. Absinta M, Rocca MA, Filippi M (2011) Dentate nucleus T1 hyperintensity in multiple sclerosis. AJNR Am J Neuroradiol 32:E120–121
42. Yan Y, Shao E, Deng X, Liu J, Zhang Y, Tang Y (2014) Microwave-assisted synthesis of Gd(III)-loaded nanozeolite SOD as MRI contrast agent with remarkable stability in vivo. J Mater Chem B 2:3041–3049
43. Arsenault TM, King BF, Marsh JW Jr et al (1996) Systemic gadolinium toxicity in patients with renal insufficiency and renal failure: retrospective analysis of an initial experience. Mayo Clin Proc 71:1150–1154
44. Maramattom BV, Manno EM, Wijdicks EF, Lindell EP (2005) Gadolinium encephalopathy in a patient with renal failure. Neurology 64:1276–1278
45. Swaminathan S, High WA, Ranville J et al (2008) Cardiac and vascular metal deposition with high mortality in nephrogenic systemic fibrosis. Kidney Int 73:1413–1418
46. Ropele S, Kilsdonk ID, Wattjes MP et al (2014) Determinants of iron accumulation in deep grey matter of multiple sclerosis patients. Mult Scler 20:1692–1698
47. Marques JP, Kober T, Krueger G, van der Zwaag W, Van de Moortele PF, Gruetter R (2010) MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field. Neuroimage 49:1271–1281