High-signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted images: Evaluation of the macrocyclic gadolinium-based contrast agent gadobutrol

Investigative Radiology

Volumn 50, Issue 12, 2015, Pages 805-810

  Radbruch, Alexander ^a,b   Weberling, Lukas D ^a   Kieslich, Pascal J ^c   Hepp, Johanna ^a   Kickingereder, Philipp ^a   Wick, Wolfgang ^a   Schlemmer, Heinz Peter ^b   Bendszus, Martin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF MANNHEIM   (Germany)

Author keywords

Dentate nucleus; Gadobutrol; Gadoliniumretention; Globus pallidus; Macrocyclic gadolinium based contrast agents

Indexed keywords

GADOBUTROL; GADOLINIUM; CONTRAST MEDIUM; ORGANOMETALLIC COMPOUND;

ADULT; ARTICLE; BRAIN TUMOR; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; COMPARATIVE STUDY; CONTROLLED STUDY; DENTATE NUCLEUS; FEMALE; GLOBUS PALLIDUS; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PONS; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; RADIOLOGICAL PARAMETERS; RETROSPECTIVE STUDY; THALAMUS; CEREBELLUM NUCLEUS; MIDDLE AGED; PATHOLOGY; PROCEDURES; REPRODUCIBILITY;

CEREBELLAR NUCLEI; CEREBROSPINAL FLUID; CONTRAST MEDIA; FEMALE; GADOLINIUM; GLOBUS PALLIDUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ORGANOMETALLIC COMPOUNDS; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; THALAMUS;

EID: 84947493962     PISSN: 00209996     EISSN: 15360210     Source Type: Journal    
DOI: 10.1097/RLI.0000000000000227     Document Type: Article

References (22)

1. Runge VM. Commentary on T1-weighted hypersignal in the deep cerebellar nuclei after repeated administrations of gadolinium-based contrast agents in healthy rats: difference between linear and macrocyclic agents. Invest Radiol. 2015;50: 481-482.
2. Rocklage SM, Worah D, Kim SH. Metal ion release from paramagnetic chelates: what is tolerable? Magn Reson Med. 1991;22:216-221; discussion 229-232.
3. Biagi BA, Enyeart JJ. Gadolinium blocks low-and high-threshold calcium currents in pituitary cells. Am J Physiol. 1990;259(3 Pt 1):C515-C520.
4. Frenzel T, Lengsfeld P, Schirmer H, et al. Stability of gadolinium-based magnetic resonance imaging contrast agentsin human serumat 37 degreesC.Invest Radiol. 2008;43:817-828.
5. Thomsen HS, Morcos SK, Almén T, et al. Nephrogenic systemic fibrosis and gadolinium-based contrast media: updated ESUR Contrast Medium Safety Committee guidelines. Eur Radiol. 2013;23:307-318.
6. Radbruch A, Weberling LD, Kieslich PJ, et al. Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent. Radiology. 2015;275:783-791.
7. Kanda T, Osawa M, Oba H, et al. High signal intensity in dentate nucleus on unenhanced T1-weighted MR images: association with linear versus macrocyclic gadolinium chelate administration. Radiology. 2015;275:803-809.
8. Kanda T, Ishii K, Kawaguchi H, et al. High signal intensity in the dentate nucleus and globus pallidus on unenhanced T 1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology. 2014;270:834-841.
9. McDonald RJ, McDonald JS, Kallmes DF, et al. Intracranial gadolinium deposition after contrast-enhanced MR imaging. Radiology. 2015;275:772-782.
10. Kanda T, Fukusato T, Matsuda M, et al. Gadolinium-based contrast agent accumulates in the brain even in subjects without severe renal dysfunction: evaluation of autopsy brain specimens with inductively coupled plasma mass spectroscopy. Radiology. 2015;276:228-232.
11. Errante Y, Cirimele V, Mallio CA, et al. Progressive increase of T1 signal intensity of the dentate nucleus on unenhanced magnetic resonance images is associated with cumulative doses of intravenously administered gadodiamide in patients with normal renal function, suggesting dechelation. Invest Radiol. 2014;49:685-690.
12. Quattrocchi CC, Mallio CA, Errante Y, et al. Gadodiamide and dentate nucleus T1 hyperintensity in patients with meningioma evaluated by multiple follow-up contrast-enhanced magnetic resonance examinations with no systemic interval therapy. Invest Radiol. 2015;50:470-472.
13. Ramalho J, Castillo M, AlObaidy M, et al. High signal intensity in globus pallidus and dentate nucleus on unenhanced T1-weighted MR images: evaluation of two linear gadolinium-based contrast agents. Radiology. 2015;276:836-844.
14. Stojanov DA, Aracki-Trenkic A, Vojinovic S, et al. Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobu-trol. Eur Radiol. 2015. [Epub ahead of print].
15. Weberling LD, Kieslich PJ, Kickingereder P, et al. Increased signal intensity in the dentate nucleus on unenhanced T1-weighted images after gadobenate dimeglumine administration. Invest Radiol. 2015;50:743-748.
16. Robert P, Lehericy S, Grand S, et al. T1-weighted hypersignal in the deep cerebellar nuclei after repeated administrations of gadolinium-based contrast agents in healthy rats: difference between linear and macrocyclic agents. Invest Radiol. 2015;50:473-480.
17. Rouder JN, Speckman PL, Sun D, et al. Bayesianttests for accepting and rejecting the null hypothesis. Psychon Bull Rev. 2009;16:225-237.
18. Wetzels R, Wagenmakers EJ. A default Bayesian hypothesis test for correlations and partial correlations. Psychon Bull Rev. 2012;19:1057-1064.
19. Roccatagliata L, Vuolo L, Bonzano L, et al. Multiple sclerosis: hyperintense dentate nucleus on unenhanced T1-weighted MR images is associated with the secondary progressive subtype. Radiology. 2009;251:503-510.
20. Enzmann DR, Pelc NJ. Normal flow patterns of intracranial and spinal cerebrospinal fluid defined with phase-contrast cine MR imaging. Radiology. 1991;178:467-474.
21. Reeder SB, Gulani V Gadolinium deposition in the brain-do we know enough to change practice? Radiology. 2015. In press.
22. Radbruch A, Weberling LD, Kieslich PJ, et al. Answer to: "Gadolinium deposition in the brain-do we know enough to change practice?" Radiology. 2015. In press.