Infection exposure is a causal factor in B-cell precursor acute lymphoblastic leukemia as a result of Pax5-inherited susceptibility

Cancer Discovery

Volumn 5, Issue 12, 2015, Pages 1328-1343

  Martín Lorenzo, Alberto ^a,b   Hauer, Julia ^c   Vicente Dueñas, Carolina ^a,b   Auer, Franziska ^c   González Herrero, Inés ^a,b   García Ramírez, Idoia ^a,b   Ginzel, Sebastian ^c,d   Thiele, Ralf ^d   Constantinescu, Stefan N ^e   Bartenhagen, Christoph ^f   Dugas, Martin ^f   Gombert, Michael ^c   Schäfer, Daniel ^c   Blanco, Oscar ^a   Mayado, Andrea ^g   Orfao, Alberto ^g   Alonso López, Diego ^h   De Las Rivas, Javier ^h   Cobaleda, César ⁱ   García Cenador, Maria Begoña ^a   García Criado, Francisco Javier ^a   Sánchez García, Isidro ^a,b   Borkhardt, Arndt ^c   more..

^a UNIVERSITY OF SALAMANCA   (Spain)

^b INSTITUTO DE INVESTIGACIÓN BIOMÉDICA DE SALAMANCA IBSAL   (Spain)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d BONN RHEIN SIEG UNIVERSITY OF APPLIED SCIENCES   (Germany)

^e DE DUVE INSTITUTE   (Belgium)

^f UNIVERSITY OF MÜNSTER   (Germany)

^g UNIVERSITY OF SALAMANCA   (Spain)

^h CSIC   (Spain)

ⁱ UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR PAX5; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; JANUS KINASE 3; PAX5 PROTEIN, MOUSE; PROTEIN KINASE INHIBITOR; STAT5 PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B CELL CULTURE; CANCER THERAPY; CELL PROLIFERATION ASSAY; COMORBIDITY; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; GENE AMPLIFICATION; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC SUSCEPTIBILITY; HISTOPATHOLOGY; IMMUNOBLOTTING; INFECTION; MALE; MICROARRAY ANALYSIS; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; RAT; RNA ISOLATION; SEQUENCE ANALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE MARROW TRANSPLANTATION; CELL TRANSFORMATION; CLUSTER ANALYSIS; DISEASE MODEL; DISEASE PREDISPOSITION; DRUG RESISTANCE; EXOME; FEMALE; GENE EXPRESSION PROFILING; GENETICS; GENOTYPE; HIGH THROUGHPUT SEQUENCING; HOST PATHOGEN INTERACTION; KNOCKOUT MOUSE; METABOLISM; MOUSE; MUTATION; PATHOLOGY; PHENOTYPE; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TUMOR CELL LINE; VIRUS DNA CELL DNA INTERACTION;

ANIMALS; B-CELL-SPECIFIC ACTIVATOR PROTEIN; BONE MARROW TRANSPLANTATION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; DRUG RESISTANCE, NEOPLASM; EXOME; FEMALE; GENE EXPRESSION PROFILING; GENOTYPE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HOST-PATHOGEN INTERACTIONS; INTERLEUKIN-7; JANUS KINASE 3; MALE; MICE; MICE, KNOCKOUT; MUTATION; PHENOTYPE; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN KINASE INHIBITORS; RECEPTORS, INTERLEUKIN-7; STAT5 TRANSCRIPTION FACTOR; VIRUS INTEGRATION;

EID: 84959114858     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-15-0892     Document Type: Article

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