Adverse reactions to snake antivenom, and their prevention and treatment

British Journal of Clinical Pharmacology

Volumn 81, Issue 3, 2016, Pages 446-452

  De Silva, H Asita ^a   Ryan, Nicole M ^b   De Silva, H Janaka ^a  

^a UNIVERSITY OF KELANIYA   (Sri Lanka)

^b UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

acute reactions; antivenom reactions; prophylaxis; serum; snakebite envenoming

Indexed keywords

ANTIHISTAMINIC AGENT; PREDNISONE; SNAKE VENOM ANTISERUM; STEROID; VENOM ANTISERUM;

ADVERSE DRUG REACTION; ANAPHYLAXIS; ARTICLE; CHILL; CYANOSIS; FEVER; HEADACHE; HUMAN; HYPOTENSION; MYALGIA; NAUSEA; PREMEDICATION; PRIORITY JOURNAL; PYROGENIC REACTION; RIGOR; SERUM SICKNESS; SNAKEBITE; STEROID THERAPY; TACHYCARDIA; VOMITING; CHEMICALLY INDUCED;

ANAPHYLAXIS; ANTIVENINS; FEVER; HUMANS; SERUM SICKNESS;

EID: 84959088990     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/bcp.12739     Document Type: Article

References (50)

1. Kasturiratne A, Wickremasinghe AR, de Silva N, Gunawardena NK, Pathmeswaran A, Premaratna R, Savioli L, Lalloo DG, de Silva HJ,. Estimation of the global burden of snakebite. PLoS Med 2008; 5: E218.
2. Chippaux JP,. Estimate of the burden of snakebites in sub-Saharan Africa: A meta-analytic approach. Toxicon 2011; 57: 586-99.
3. Williams SS, Wijesinghe CA, Jayamanne SF, Buckley NA, Dawson AH, Lalloo DG, de Silva HJ,. Delayed psychological morbidity associated with snakebite envenoming. PLoS Negl Trop Dis 2011; 5: E1255.
4. Chippaux JP,. Estimating the global burden of snakebite can help to improve management. PLoS Med 2008; 5: E221.
5. Gutiérrez JM, Theakston RD, Warrell DA,. Confronting the neglected problem of snake bite envenoming: The need for a global partnership. PLoS Med 2006; 3: E150.
6. Malasit P, Warrell DA, Chanthavanich P, Viravan C, Mongkolsapaya J, Singhthong B, Supich C,. Prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites. BMJ (Clin Res Ed) 1986; 292: 17-20.
7. Lalloo D, Theakston RDG,. Snake antivenoms J Toxicol Clin Toxicol 2003; 41: 277-90.
8. Theakston RDG, Warrell DA, Griffiths E,. Report of a WHO workshop on the standardization and control of antivenoms. Toxicon 2003; 41: 541-57.
9. Sampson HA, Muñoz-Furlong A, Campbell RL, Adkinson NF Jr, Bock SA, Branum A, Brown SG, Camargo CA Jr, Cydulka R, Galli SJ, Gidudu J, Gruchalla RS, Harlor AD Jr, Hepner DL, Lewis LM, Lieberman PL, Metcalfe DD, O'Connor R, Muraro A, Rudman A, Schmitt C, Scherrer D, Simons FE, Thomas S, Wood JP, Decker WW,. Second symposium on the definition and management of anaphylaxis: Summary report-Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol 2006; 117: 391-7.
10. Premawardena AP, de Silva CE, Fonseka MMD, Gunatilake SB, de Silva HJ,. Low dose subcutaneous adrenaline to prevent acute adverse reactions to antivenom serum in snake bite: A randomized placebo-controlled trial. BMJ 1999; 318: 730-3.
11. Ariaratnam CA, Sjöström L, Raziek Z, Kularatne SA, Arachchi RW, Sheriff MH, Theakston RD, Warrell DA,. An open, randomized controlled trial of two antivenoms for the treatment of envenoming by Sri Lankan Russell's viper (Daboia russelli russelli). Trans R Soc Trop Med Hyg 2011; 95: 74-80.
12. Gawarammana IB, Kularatne SA, Dissanayake WP, Kumarasiri RP, Senanayake N, Ariyasena H,. Parallel infusion of hydrocortisone +/- chlorpheniramine bolus injection to prevent acute adverse reactions to antivenom for snakebites: A randomized, double-blind, placebo-controlled study. Med J Aust 2004; 180: 20-3.
13. de Silva HA, Pathmeswaran A, Ranasinha CD, Jayamanne S, Samarakoon SB, Hittharage A, Kalupahana R, Ratnatilaka GA, Uluwatthage W, Aronson JK, Armitage JM, Lalloo DG, de Silva HJ,. Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: A randomized, double-blind, placebo-controlled trial. PLoS Med 2011; 8: E1000435.
14. Sutherland SK,. Serum reactions: An analysis of commercial antivenoms and the possible role of anticomplementary activity in de novo reactions to antivenom and venom. Med J Aust 1977; 1: 613-5.
15. Pugh RN, Theakston RDG,. Antivenom reactions and complement depletion in snake bite. Ann Trop Med Parasitol 1987; 81: 73-5.
16. Theakston RDG, Smith DC,. Antivenoms. A review of current status and future developments. Biopharmaceuticals 1997; 7: 366-75.
17. Lalloo DG, Theakston RDG,. Snake antivenoms. J Toxicol Clin Toxicol 2003; 41: 317-21.
18. Otero-Patiño R, Cardoso JL, Higashi HG, Nunez V, Diaz A, Toro MF, Garcia ME, Sierra A, Garcia LF, Moreno AM, Medina MC, Castañeda N, Silva-Diaz JF, Murcia M, Cardenas SY,. Dias da Silva WD. A randomized, blinded, comparative trial of one pepsin-digested and two whole IgG antivenoms for Bothrops snake bites in Uraba, Colombia. The Regional Group on Antivenom Therapy Research (REGATHER). Am J Trop Med Hyg 1998; 58: 183-9.
19. Otero-Patiño R, Segura A, Herrera M, Angulo Y, León G, Gutiérrez JM, Barona J, Estrada S, Pereañez A, Quintana JC, Vargas LJ, Gómez JP, Díaz A, Suárez AM, Fernández J, Ramírez P, Fabra P, Perea M, Fernández D, Arroyo Y, Betancur D, Pupo L, Córdoba EA, Ramírez CE, Arrieta AB, Rivero A, Mosquera DC, Conrado NL, Ortiz R,. Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab')2] antivenoms, in Bothrops asper bites in Colombia. Toxicon 2012; 59: 344-55.
20. Stone SF, Isbister GK, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Ariaratnam A, Jacoby-Alner TE, Cotterrell CL, Brown SG,. Immune response to snake envenoming and treatment with antivenom; complement activation, cytokine production and mast cell degranulation. PLoS Negl Trop Dis 2013; 7: E2326.
21. Isbister GK, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Ariaratnam A,. A randomised controlled trial of two infusion rates to decrease reactions to antivenom. PLoS One 2012; 7: E38739.
22. Ariaratnam CA, Meyer WP, Perera G, Eddleston M, Kuleratne SA, Attapattu W, Sheriff R, Richards AM, Theakston RD, Warrell DA,. A new monospecific ovine Fab fragment antivenom for treatment of envenoming by the Sri Lankan Russell's viper (Daboiarusseliirusselii): A preliminary dose-finding and pharmacokinetic study. Am J Trop Med Hyg 1999; 61: 259-65.
23. Fan HW, Marcopito LF, Cardoso JL, França FO, Malaque CM, Ferrari RA, Theakston RD, Warrell DA,. Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for Bothrops snake bites. BMJ 1999; 318: 1451-2.
24. Sutherland SK,. Antivenom use in Australia: Premedication, adverse reactions and the use of venom detection kits. Med J Aust 1992; 157: 734-5.
25. Khanna R, Hawkins WJ,. A plea for caution in the use of adrenaline. BMJ 1999; 318: 1041.
26. Dassanayake AS, Karunanayake P, Kasturiratne KT, Fonseka MM, Wijesiriwardena B, Gunatilake SB, de Silva HJ,. Safety of subcutaneous adrenaline as prophylaxis against acute adverse reactions to anti-venom serum in snakebite. Ceylon Med J 2002; 47: 48-9.
27. Horowitz BZ, Jadallah S, Derlet RW,. Fatal intracranial bleeding associated with peripheral use of epinephrine. Ann Emerg Med 1996; 28: 725-7.
28. Williams DJ, Jensen JD, Nimorakiotakis B, Muller R, Winkel KD,. Antivenom use, premedication and early adverse reactions in the management of snake bites in rural Papua New Guinea. Toxicon 2007; 49: 780-92.
29. Simons FE, Ardusso LR, Bilo MB, El-Gamal YM, Ledford DK, Ring J, Sanchez-Borges M, Senna GE, Sheikh A, Thong BY, World Allergy O. World Allergy Organization anaphylaxis guidelines: Summary. J Allergy Clin Immunol 2011; 127: 587-93 e1-22.
30. Simons FE, Ardusso LR, Dimov V, Ebisawa M, El-Gamal YM, Lockey RF, Sanchez-Borges M, Senna GE, Sheikh A, Thong BY, Worm M, World Allergy O. World Allergy Organization Anaphylaxis Guidelines: 2013 update of the evidence base. Int Arch Allergy Immunol 2013; 162: 193-204.
31. Lee JK, Vadas P,. Anaphylaxis: Mechanisms and management. Clin Exp Allergy 2011; 41: 923-38.
32. Brown SG, Mullins RJ, Gold MS,. Anaphylaxis: Diagnosis and management. Med J Aust 2006; 185: 283-9.
33. León G, Herrera M, Segura Á, Villalta M, Vargas M, Gutiérrez JM,. Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms. Toxicon. 2013; 15: 63-76.
34. Silverstein AM,. Clemens Freiherr von Pirquet. Explaining immune complex disease in 1906. Nat Immunol 2000; 1: 453-5.
35. Lawley TJ, Bielory L, Gascon P, Yancey KB, Young NS, Frank MM,. A prospective clinical and immunologic analysis of patients with serum sickness. N Engl J Med 1984; 311: 1407-13.
36. Morais V, Berasain P, Ifran S, Carreira S, Tortorella MN, Negrin A, Massaldi H,. Humoral immune responses to venom and antivenom of patients bitten by Bothrops snakes. Toxicon 2012; 59: 315-9.
37. Dart RC, McNally J,. Efficacy, safety, and use of snake antivenoms in the United States. Ann Emerg Med 2001; 37: 181-8.
38. Lavonas EJ, Benson BE, Seifert SA,. Failure to develop sensitization despite repeated administration of ovine Fab snake antivenom: Update of a single-patient, multicenter case series. Ann Emerg Med 2013; 61: 371-2.
39. LoVecchio F, Klemens J, Roundy EB, Klemens A,. Serum sickness following administration of Antivenin (Crotalidae) Polyvalent in 181 cases of presumed rattlesnake envenomation. Wilderness Environ Med 2003; 14: 220-1.
40. Black RE, Gunn RA,. Hypersensitivity reactions associated with botulinal antitoxin. Am J Med 1980; 69: 567-70.
41. Trinca GF,. The treatment of snakebite. Med J Aust 1963; 50: 275-80.
42. Campbell CH,. Antivenene in the treatment of Australian and Papuan snakebite. Med J Aust 1967; 2: 106-10.
43. Dart RC, Seifert SA, Boyer LV, Clark RF, Hall E, McKinney P, McNally J, Kitchens CS, Curry SC, Bogdan GM, Ward SB, Porter RS,. A randomized multicenter trial of Crotalinae polyvalent immune Fab (ovine) antivenom for the treatment for crotaline snakebite in the United States. Arch Int Med 2001; 161: 2030-6.
44. Ruha AM, Curry SC, Beuhler M, Katz K, Brooks DE, Graeme KA, Wallace K, Gerkin R, LoVecchio F, Wax P, Selden B,. Initial postmarketing experience with Crotalidae polyvalent immune Fab for treatment of rattlesnake envenomation. Ann Emerg Med 2002; 39: 609-15.
45. Bush SP, Green SM, Moynihan JA, Hayes WK, Cardwell MD,. Crotalidae polyvalent immune Fab (ovine) antivenom is efficacious for envenomations by southern pacific rattlesnakes (Crotalushelleri). Ann Emerg Med 2002; 40: 619-24.
46. Lavonas EJ, Gerardo CJ, O'Malley G, Arnold TC, Bush SP, Banner W Jr, Steffens M, Kerns WP,. Initial experience with Crotalidae polyvalent immune Fab (ovine) antivenom in the treatment of copperhead snakebite. Ann Emerg Med 2004; 43: 200-6.
47. Lavonas EJ, Kokko J, Schaeffer TH, Mlynarchek SL, Bogdan GM, Dart RC,. Short-term outcomes after Fab antivenomtherapy for severe crotaline snakebite. Ann Emerg Med 2011; 57: 128-37.e3.
48. Isbister GK,. Snake bite: A current approach to management. Aust Prescr 2006; 29: 125-9.
49. Chao YK, Shyur SD, Wu CY, Wang CY,. Childhood serum sickness: A case report. J Microbiol Immunol Infect 2001; 34: 220-3.
50. Gold BS, Dart RC, Barish RA,. Bites of venomous snakes. N Engl J Med 2002; 347: 347-56.