Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: A randomised, double-blind, placebo-controlled trial

PLoS Medicine

Volumn 8, Issue 5, 2011, Pages

  de Silva, H Asita ^a   Pathmeswaran, Arunasalam ^a   Ranasinha, Channa D ^a   Jayamanne, Shaluka ^b   Samarakoon, Senarath B ^b   Hittharage, Ariyasena ^c   Kalupahana, Ranjith ^c   Ratnatilaka, G Asoka ^c   Uluwatthage, Wimalasiri ^d   Aronson, Jeffrey K ^e   Armitage, Jane M ^e   Lalloo, David G ^f   de Silva, H Janaka ^a  

^a UNIVERSITY OF KELANIYA   (Sri Lanka)

^b Polonnaruwa General Hospital   (Sri Lanka)

^c Teaching Hospital Kurunegala   (Sri Lanka)

^d Hambantota General Hospital   (Sri Lanka)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; HYDROCORTISONE; PLACEBO; PROMETHAZINE; SNAKE VENOM ANTISERUM; SNAKE VENOM; VENOM ANTISERUM;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ARTICLE; BRONCHOSPASM; CHILD; CONFUSION; CONTROLLED STUDY; CYANOSIS; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG HYPERSENSITIVITY; DRUG SAFETY; ENVENOMATION; FACE EDEMA; FACTORIAL DESIGN; FEMALE; FEVER; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; NAUSEA; PATIENT MONITORING; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RIGOR; SCHOOL CHILD; SIDE EFFECT; SNAKEBITE; SRI LANKA; STRIDOR; SYSTOLIC BLOOD PRESSURE; URTICARIA; VOMITING; ANAPHYLAXIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOSE RESPONSE; DRUG ANTAGONISM; METABOLISM; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANAPHYLAXIS; ANTIVENINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EPINEPHRINE; FEMALE; HUMANS; HYDROCORTISONE; MALE; PLACEBOS; PROMETHAZINE; SNAKE BITES; SNAKE VENOMS; SRI LANKA; TREATMENT OUTCOME;

EID: 79957979890     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1000435     Document Type: Article

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