Low-Dose Aspirin in Early Gestation for Prevention of Preeclampsia and Small-for-Gestational-Age Neonates: Meta-analysis of Large Randomized Trials

American Journal of Perinatology

Volumn 33, Issue 8, 2016, Pages 781-785

  Roberge, Stéphanie ^a   Sibai, Baha ^b   McCaw Binns, Affette ^c   Bujold, Emmanuel ^d  

^a UNIVERSITÉ LAVAL   (Canada)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF THE WEST INDIES   (Jamaica)

^d LAVAL UNIVERSITY   (Canada)

Author keywords

aspirin; fetal growth restriction; meta analysis; preeclampsia; pregnancy

Indexed keywords

ACETYLSALICYLIC ACID; PLACEBO; ANTITHROMBOCYTIC AGENT;

ARTICLE; DISEASE SEVERITY; FEMALE; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HUMAN; LOW DRUG DOSE; META ANALYSIS; NEWBORN; PREECLAMPSIA; PREGNANT WOMAN; PREMATURE LABOR; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; SMALL FOR DATE INFANT; INTRAUTERINE GROWTH RETARDATION; PREGNANCY;

ASPIRIN; FEMALE; FETAL GROWTH RETARDATION; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, SMALL FOR GESTATIONAL AGE; PLATELET AGGREGATION INHIBITORS; PRE-ECLAMPSIA; PREGNANCY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS;

EID: 84959064573     PISSN: 07351631     EISSN: 10988785     Source Type: Journal    
DOI: 10.1055/s-0036-1572495     Document Type: Article

References (19)

1. Bujold E.; Roberge S.; Lacasse Y.; et al. Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis. Obstet Gynecol: 2010; 116 (2 Pt 1): 402 414
2. Roberge S.; Nicolaides K. H.; Demers S.; Villa P.; Bujold E. Prevention of perinatal death and adverse perinatal outcome using low-dose aspirin: a meta-analysis. Ultrasound Obstet Gynecol: 2013; 41 5 491 499
3. Bujold E.; Morency A. M.; Roberge S.; Lacasse Y.; Forest J. C.; Giguère Y. Acetylsalicylic acid for the prevention of preeclampsia and intra-uterine growth restriction in women with abnormal uterine artery Doppler: a systematic review and meta-analysis. J Obstet Gynaecol Can: 2009; 31 9 818 826
4. Roberge S.; Giguère Y.; Villa P.; et al. Early administration of low-dose aspirin for the prevention of severe and mild preeclampsia: a systematic review and meta-analysis. Am J Perinatol: 2012; 29 7 551 556
5. Roberge S.; Villa P.; Nicolaides K.; et al. Early administration of low-dose aspirin for the prevention of preterm and term preeclampsia: a systematic review and meta-analysis. Fetal Diagn Ther: 2012; 31 3 141 146
6. Dickersin K. The existence of publication bias and risk factors for its occurrence. JAMA: 1990; 263 10 1385 1389
7. Meher S.; Alfirevic Z. Aspirin for pre-eclampsia: beware of subgroup meta-analysis. Ultrasound Obstet Gynecol: 2013; 41 5 479 485
8. Higgins J. P.; Thompson S. G.; Deeks J. J.; Altman D. G. Measuring inconsistency in meta-analyses. BMJ: 2003; 327 7414 557 560
9. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. Lancet: 1994; 343 8898 619 629
10. Golding J.; The Jamaica Low Dose Aspirin Study Group. A randomised trial of low dose aspirin for primiparae in pregnancy. Br J Obstet Gynaecol: 1998; 105 3 293 299
11. Caritis S.; Sibai B.; Hauth J.; et al. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Low-dose aspirin to prevent preeclampsia in women at high risk. N Engl J Med: 1998; 338 11 701 705
12. Sibai B. M.; Caritis S. N.; Thom E.; et al. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women. N Engl J Med: 1993; 329 17 1213 1218
13. Rotchell Y. E.; Cruickshank J. K.; Gay M. P.; et al. Barbados Low Dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications. Br J Obstet Gynaecol: 1998; 105 3 286 292
14. Subtil D.; Goeusse P.; Puech F.; et al. Essai Régional Aspirine Mère-Enfant (ERASME) Collaborative Group. Aspirin (100 mg) used for prevention of pre-eclampsia in nulliparous women: the Essai Régional Aspirine Mère-Enfant study (Part 1). BJOG: 2003; 110 5 475 484
15. Askie L. M.; Duley L.; Henderson-Smart D. J.; Stewart L. A.. PARIS Collaborative Group. Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data. Lancet: 2007; 369 9575 1791 1798
16. Rey E.; Rivard G. E. Is testing for aspirin response worthwhile in high-risk pregnancy? Eur J Obstet Gynecol Reprod Biol: 2011; 157 1 38 42
17. Dumont A.; Flahault A.; Beaufils M.; Verdy E.; Uzan S. Effect of aspirin in pregnant women is dependent on increase in bleeding time. Am J Obstet Gynecol: 1999; 180 1 Pt 1 135 140
18. Caron N.; Rivard G. E.; Michon N.; et al. Low-dose ASA response using the PFA-100 in women with high-risk pregnancy. J Obstet Gynaecol Can: 2009; 31 11 1022 1027
19. Wójtowicz A.; Undas A.; Huras H.; et al. Aspirin resistance may be associated with adverse pregnancy outcomes. Neuroendocrinol Lett: 2011; 32 3 334 339