A novel gene delivery composite system based on biodegradable folate-poly (ester amine) polymer and thermosensitive hydrogel for sustained gene release

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Yang, Yi ^a   Zhao, Hang ^a   Jia, Yanpeng ^a   Guo, Qingfa ^a   Qu, Ying ^a   Su, Jing ^b   Lu, Xiaoling ^b   Zhao, Yongxiang ^b   Qian, Zhiyong ^a  

^a SICHUAN UNIVERSITY   (China)

^b Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; FOLIC ACID; HYDROGEL; POLY(CAPROLACTONE-BLOCK-ETHYLENEIMINE); POLYAMINE; POLYESTER; POLYMER;

APOPTOSIS; CELL LINE; CHEMISTRY; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HYDROGEL; PROTON NUCLEAR MAGNETIC RESONANCE; REPORTER GENE; SYNTHESIS; TRANSGENE;

APOPTOSIS; BIOCOMPATIBLE MATERIALS; CELL LINE; FOLIC ACID; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENES, REPORTER; HUMANS; HYDROGEL; POLYAMINES; POLYESTERS; POLYMERS; PROTON MAGNETIC RESONANCE SPECTROSCOPY; TRANSFECTION; TRANSGENES;

EID: 84959036561     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep21402     Document Type: Article

References (38)

1. McCormick, F. Cancer gene therapy: fringe or cutting edge? Nature Reviews Cancer, 1(2), 130-141 (2001).
2. Wang, L., Takabe, K., Bidlingmaier, S. M., Ill, C. R., Verma, I. M. Sustained correction of bleeding disorder in hemophilia B mice by gene therapy. Proceedings of the National Academy of Sciences, 96(7), 3906-3910 (1999).
3. Lei, Y., Rahim, M., Ng, Q., Segura, T. Hyaluronic acid and fibrin hydrogels with concentrated DNA/PEI polyplexes for local gene delivery. Journal of Controlled Release, 153(3), 255-261 (2011).
4. Gupta, M., Gupta, A. K. Hydrogel pullulan nanoparticles encapsulating pBUDLacZ plasmid as an efficient gene delivery carrier. Journal of controlled release, 99(1), 157-166 (2004).
5. Guo, Q. et al. Synthesis of a novel biodegradable poly (ester amine)(PEAs) polymer based on low-molecular-weight polyethyleneimine for gene delivery. International journal of pharmaceutics, 379(1), 82-89 (2009).
6. Shi, S. et al. The use of cationic MPEG-PCL-g-PEI micelles for co-delivery of Msurvivin T34A gene and doxorubicin. Biomaterials, 35(15), 4536-4547 (2014).
7. Shi, S. et al. A novel Poly (?-caprolactone)-Pluronic-Poly (?-caprolactone) grafted Polyethyleneimine (PCFC-g-PEI), Part 1, synthesis, cytotoxicity, and in vitro transfection study. BMC biotechnology, 9(1), 65 (2009).
8. Guo, Q. F. et al. Synthesis and properties of a novel biodegradable poly (ester amine) polymer based on poly (L-lactide) and low molecular weight polyethylenimine for gene delivery. International journal of nanomedicine, 6, 1641 (2011).
9. Tolmachov, O. E. Self-focusing therapeutic gene delivery with intelligent gene vector swarms: Intra-swarm signalling through receptor transgene expression in targeted cells. Artificial intelligence in medicine, 63(1), 1-6 (2015).
10. Mallapragada, S. K., Agarwal, A. Synthetic sustained gene delivery systems. Current topics in medicinal chemistry, 8(4), 311-330 (2008).
11. Ta, H. T., Dass, C. R., Larson, I., Choong, P. F., Dunstan, D. E. A chitosan hydrogel delivery system for osteosarcoma gene therapy with pigment epithelium-derived factor combined with chemotherapy. Biomaterials, 30(27), 4815-4823 (2009).
12. Kim, S. H., Jeong, J. H., Lee, S. H., Kim, S. W., Park, T. G. LHRH receptor-mediated delivery of siRNA using polyelectrolyte complex micelles self-assembled from siRNA-PEG-LHRH conjugate and PEI. Bioconjugate chemistry, 19(11), 2156-2162 (2008).
13. Schiffelers, R. M. et al. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic acids research, 32(19), e149-e149 (2004).
14. Mok, H., Park, T. G. Self?crosslinked and reducible fusogenic peptides for intracellular delivery of siRNA. Biopolymers, 89(10), 881-888 (2008).
15. Simeoni, F., Morris, M. C., Heitz, F., Divita, G. Insight into the mechanism of the peptide?based gene delivery system MPG: implications for delivery of siRNA into mammalian cells. Nucleic acids research, 31(11), 2717-2724 (2003).
16. Mumper, R. J., Rolland, A. P. Plasmid delivery to muscle:: Recent advances in polymer delivery systems. Advanced drug delivery reviews, 30(1), 151-172 (1998).
17. Griffith, L. G., Naughton, G. Tissue engineering-current challenges and expanding opportunities. Science, 295(5557), 1009-1014 (2002).
18. Walter, E., Moelling, K., Pavlovic, J., Merkle, H. P. Microencapsulation of DNA using poly (DL-lactide-co-glycolide): stability issues and release characteristics. Journal of Controlled Release, 61(3), 361-374 (1999).
19. Nof, M., Shea, L. D. Drug?releasing scaffolds fabricated from drug?loaded microspheres. Journal of biomedical materials research, 59(2), 349-356 (2002).
20. Chun, K. W., Lee, J. B., Kim, S. H., Park, T. G. (2005). Controlled release of plasmid DNA from photo-cross-linked pluronic hydrogels. Biomaterials, 26(16), 3319-3326 (2005).
21. Blackburn, W. H., Dickerson, E. B., Smith, M. H., McDonald, J. F., Lyon, L. A. (2009). Peptide-functionalized nanogels for targeted siRNA delivery. Bioconjugate chemistry, 20(5), 960-968 (2009).
22. De Laporte, L., Shea, L. D. Matrices and scaffolds for DNA delivery in tissue engineering. Advanced drug delivery reviews, 59(4), 292-307 (2007).
23. Bonadio, J., Smiley, E., Patil, P., Goldstein, S. Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nature medicine, 5(7), 753-759 (1999).
24. Jang, J. H., Rives, C. B., Shea, L. D. Plasmid delivery in vivo from porous tissue-engineering scaffolds: transgene expression and cellular transfection. Molecular Therapy, 12(3), 475-483 (2005).
25. Gottschalk, S., Cristiano, R. J., Smith, L. C., Woo, S. Folate receptor mediated DNA delivery into tumor cells: potosomal disruption results in enhanced gene expression. Gene therapy, 1(3), 185-191 (1994).
26. Ratnam, M. et al. Receptor induction and targeted drug delivery: a new antileukaemiastrategy. Expert opinion on biological therapy, 3(4), 563-574 (2003).
27. Yao, V., Berkman, C. E., Choi, J. K., O'Keefe, D. S., Bacich, D. J. Expression of prostate?specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non?polyglutamated folate, folic acid. The Prostate, 70(3), 305-316 (2010).
28. Petersen, et al. Elevated physiological levels of folic acid can increase in vitro growth and invasiveness of prostate cancer cells. BJU international, 109(5), 788-795 (2012).
29. Gong, C. et al. Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel. International Journal of Pharmaceutics, 365(1), 89-99 (2009).
30. Gong, C. Y. et al. Thermosensitive PEG-PCL-PEG hydrogel controlled drug delivery system: sol-gel-sol transition and in vitro drug release study. Journal of pharmaceutical sciences, 98(10), 3707-3717 (2009).
31. Gong, C. Y. et al. Biodegradable thermosensitive injectable PEG-PCL-PEG hydrogel for bFGF antigen delivery to improve humoral immunity. Growth Factors, 27(6), 377-383 (2009).
32. Elstein, K. H., Zucker, R. M. Comparison of cellular and nuclear flow cytometric techniques for discriminating apoptotic subpopulations. Experimental cell research, 211(2), 322-331 (1994).
33. Otto, F. DAPI staining of fixed cells for high-resolution flow cytometry of nuclear DNA. Methods in cell biology, 33, 105-110 (1990).
34. Lei, Y. et al. Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffolds. Biomaterials, 31(34), 9106-9116 (2010).
35. Friedlander, S. K. Smoke, dust and haze: Fundamentals of aerosol dynamics. Oxford University Press. New York (2000).
36. Mazieres, J. et al. Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Research, 64(14), 4717-4720 (2004).
37. Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature, 487(7407), 330-337 (2012).
38. Penketh, P. G., Shyam, K., Sartorelli, A. C. Fluorometric assay for the determination of DNA-DNA cross-links utilizing Hoechst 33258 at neutral pH values. Analytical biochemistry, 252(1), 210-213 (1997).