Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin

Science

Volumn 351, Issue 6275, 2016, Pages 876-880

  Vogeley, Lutz ^a   El Arnaout, Toufic ^a   Bailey, Jonathan ^a   Stansfeld, Phillip J ^b   Boland, Coilin ^a   Caffrey, Martin ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLOBOMYCIN; LIPOPROTEIN; SIGNAL PEPTIDASE II; ANTIINFECTIVE AGENT; ASPARTIC PROTEINASE; BACTERIAL PROTEIN; PEPTIDE;

ANTIBIOTICS; BACTERIUM; CELLS AND CELL COMPONENTS; ENZYME; ENZYME ACTIVITY; GENOME; INHIBITION; PEPTIDE; PHYSIOLOGY; PROTEIN;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR MIMICRY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTON TRANSPORT; PSEUDOMONAS AERUGINOSA; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); PSEUDOMONAS AERUGINOSA;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ASPARTIC ACID ENDOPEPTIDASES; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; MUTAGENESIS; PEPTIDES; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PSEUDOMONAS AERUGINOSA; SUBSTRATE SPECIFICITY;

EID: 84959036430     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad3747     Document Type: Article

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